Incidental Mutation 'R0418:Dpp9'
ID 36898
Institutional Source Beutler Lab
Gene Symbol Dpp9
Ensembl Gene ENSMUSG00000001229
Gene Name dipeptidylpeptidase 9
Synonyms DPRP2, 6430584G11Rik
MMRRC Submission 038620-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R0418 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 56493807-56525905 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) C to T at 56501404 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000046604 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038794]
AlphaFold Q8BVG4
Predicted Effect probably benign
Transcript: ENSMUST00000038794
SMART Domains Protein: ENSMUSP00000046604
Gene: ENSMUSG00000001229

DomainStartEndE-ValueType
low complexity region 122 133 N/A INTRINSIC
Pfam:DPPIV_N 145 569 5.2e-109 PFAM
Pfam:Peptidase_S15 617 793 2.8e-10 PFAM
Pfam:Peptidase_S9 657 862 2.5e-57 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000223616
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 95.2%
Validation Efficiency 98% (64/65)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that is a member of the S9B family in clan SC of the serine proteases. The protein has been shown to have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Although the activity of this protein is similar to that of dipeptidyl peptidase 4 (DPP4), it does not appear to be membrane bound. In general, dipeptidyl peptidases appear to be involved in the regulation of the activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. Several transcript variants of this gene have been described but not fully characterized. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous mutants display partial neonatal lethality and complete lethality at preweaning stages with defects suckling due to undeveveloped tongue muscle. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A930018P22Rik G T 2: 103,953,675 (GRCm39) probably null Het
Abca14 T C 7: 119,806,657 (GRCm39) L19P probably damaging Het
Abcb1a T A 5: 8,763,281 (GRCm39) V603E probably damaging Het
Acsl5 A G 19: 55,261,238 (GRCm39) D65G probably benign Het
Acss3 T C 10: 106,859,773 (GRCm39) Y311C probably damaging Het
Ak8 T G 2: 28,623,868 (GRCm39) I151S possibly damaging Het
Aldh1a1 T C 19: 20,606,413 (GRCm39) probably benign Het
Aldh1l1 A G 6: 90,546,875 (GRCm39) R393G possibly damaging Het
Ankhd1 T A 18: 36,767,353 (GRCm39) L1164Q probably damaging Het
Ascc3 G T 10: 50,625,022 (GRCm39) V1637L probably benign Het
Atf5 A G 7: 44,462,821 (GRCm39) M101T possibly damaging Het
Det1 T C 7: 78,493,765 (GRCm39) T80A probably benign Het
Fam13c A G 10: 70,370,591 (GRCm39) R244G probably damaging Het
Fat3 A T 9: 16,158,192 (GRCm39) N1139K probably damaging Het
Fbxo17 A G 7: 28,432,916 (GRCm39) T146A possibly damaging Het
Fli1 T C 9: 32,363,425 (GRCm39) probably benign Het
Glb1l2 T G 9: 26,705,397 (GRCm39) D151A probably damaging Het
Gli2 G A 1: 118,768,220 (GRCm39) T669I possibly damaging Het
Igsf3 C A 3: 101,342,751 (GRCm39) R463S probably damaging Het
Il1rl2 T C 1: 40,365,662 (GRCm39) V3A unknown Het
Irx3 G A 8: 92,526,708 (GRCm39) S332F probably benign Het
Katnb1 C T 8: 95,822,286 (GRCm39) T303M possibly damaging Het
Lrrc31 A T 3: 30,743,383 (GRCm39) L194Q probably damaging Het
Lrrc37a T G 11: 103,394,264 (GRCm39) E387A probably benign Het
Mapk14 T C 17: 28,910,763 (GRCm39) I17T probably benign Het
Mtif2 A G 11: 29,483,401 (GRCm39) probably benign Het
Myo16 A G 8: 10,619,918 (GRCm39) T1490A probably benign Het
Nfasc A G 1: 132,539,333 (GRCm39) V399A probably damaging Het
Nhsl3 A G 4: 129,117,477 (GRCm39) S396P probably damaging Het
Nobox T C 6: 43,284,169 (GRCm39) K1E probably null Het
Nr2c1 A T 10: 94,017,374 (GRCm39) M371L probably benign Het
Oplah C T 15: 76,182,687 (GRCm39) R924H probably benign Het
Or10ak16 C T 4: 118,750,448 (GRCm39) T56I possibly damaging Het
Or51a10 G A 7: 103,698,979 (GRCm39) T194I probably benign Het
Pappa2 C A 1: 158,544,560 (GRCm39) C1756F probably damaging Het
Pdzd8 G A 19: 59,289,361 (GRCm39) R680C probably damaging Het
Rassf3 G A 10: 121,253,075 (GRCm39) T44M probably benign Het
Rmnd1 T C 10: 4,377,693 (GRCm39) probably null Het
Rnf126 C T 10: 79,598,477 (GRCm39) probably benign Het
Rnf144b T C 13: 47,397,966 (GRCm39) S299P probably benign Het
Ryr2 A G 13: 11,848,981 (GRCm39) probably benign Het
Scel T A 14: 103,840,690 (GRCm39) S511T probably benign Het
Slc16a10 G T 10: 39,916,627 (GRCm39) S138* probably null Het
Slc36a4 A T 9: 15,645,562 (GRCm39) I330F probably damaging Het
Slc5a8 A G 10: 88,722,420 (GRCm39) I84M probably benign Het
Spag9 T C 11: 93,982,579 (GRCm39) probably benign Het
Suco C T 1: 161,662,419 (GRCm39) V671I probably benign Het
Suox G A 10: 128,506,754 (GRCm39) P425S probably damaging Het
Tmem266 T A 9: 55,344,697 (GRCm39) V443E probably benign Het
Tmprss11f A T 5: 86,704,870 (GRCm39) I16N probably benign Het
Tnik T A 3: 28,625,029 (GRCm39) Y321* probably null Het
Tnrc6b T C 15: 80,797,524 (GRCm39) M1357T probably benign Het
Tpbg C A 9: 85,726,803 (GRCm39) Y257* probably null Het
Usp37 A T 1: 74,529,266 (GRCm39) S138T probably benign Het
Veph1 T A 3: 66,162,449 (GRCm39) R70* probably null Het
Vmn2r17 C T 5: 109,600,747 (GRCm39) P682S probably damaging Het
Vmn2r79 A C 7: 86,651,611 (GRCm39) N337H probably benign Het
Vstm2b A G 7: 40,551,876 (GRCm39) D68G probably damaging Het
Vwa7 G T 17: 35,236,933 (GRCm39) A167S possibly damaging Het
Zfp647 A T 15: 76,795,586 (GRCm39) I358N probably damaging Het
Zic2 CCCACCACCACCATCACCACCACCACC CCCACCATCACCACCACCACC 14: 122,713,776 (GRCm39) probably benign Het
Other mutations in Dpp9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00895:Dpp9 APN 17 56,512,240 (GRCm39) missense probably damaging 0.99
IGL00920:Dpp9 APN 17 56,507,599 (GRCm39) missense probably benign 0.01
IGL01568:Dpp9 APN 17 56,498,159 (GRCm39) missense probably benign
IGL01583:Dpp9 APN 17 56,518,666 (GRCm39) missense probably benign 0.00
IGL01613:Dpp9 APN 17 56,497,713 (GRCm39) missense probably benign
IGL03371:Dpp9 APN 17 56,494,377 (GRCm39) missense probably benign 0.00
R0100:Dpp9 UTSW 17 56,512,854 (GRCm39) missense possibly damaging 0.75
R0100:Dpp9 UTSW 17 56,512,854 (GRCm39) missense possibly damaging 0.75
R1163:Dpp9 UTSW 17 56,506,426 (GRCm39) missense possibly damaging 0.90
R1680:Dpp9 UTSW 17 56,497,103 (GRCm39) missense probably benign 0.00
R1709:Dpp9 UTSW 17 56,501,431 (GRCm39) missense probably benign
R1762:Dpp9 UTSW 17 56,495,362 (GRCm39) missense probably damaging 1.00
R1809:Dpp9 UTSW 17 56,506,038 (GRCm39) missense probably damaging 1.00
R1853:Dpp9 UTSW 17 56,509,885 (GRCm39) missense probably benign 0.00
R1854:Dpp9 UTSW 17 56,509,885 (GRCm39) missense probably benign 0.00
R2162:Dpp9 UTSW 17 56,506,113 (GRCm39) missense possibly damaging 0.81
R2205:Dpp9 UTSW 17 56,506,287 (GRCm39) missense possibly damaging 0.87
R2301:Dpp9 UTSW 17 56,501,973 (GRCm39) missense probably benign 0.00
R2520:Dpp9 UTSW 17 56,513,868 (GRCm39) missense probably damaging 1.00
R3831:Dpp9 UTSW 17 56,506,113 (GRCm39) missense possibly damaging 0.81
R3833:Dpp9 UTSW 17 56,506,113 (GRCm39) missense possibly damaging 0.81
R4364:Dpp9 UTSW 17 56,494,391 (GRCm39) missense possibly damaging 0.79
R4737:Dpp9 UTSW 17 56,505,970 (GRCm39) critical splice donor site probably null
R4740:Dpp9 UTSW 17 56,505,970 (GRCm39) critical splice donor site probably null
R4741:Dpp9 UTSW 17 56,512,286 (GRCm39) missense probably benign
R4798:Dpp9 UTSW 17 56,498,016 (GRCm39) missense probably damaging 0.96
R4806:Dpp9 UTSW 17 56,497,030 (GRCm39) missense probably damaging 1.00
R5375:Dpp9 UTSW 17 56,496,424 (GRCm39) nonsense probably null
R5709:Dpp9 UTSW 17 56,496,393 (GRCm39) missense probably benign
R5783:Dpp9 UTSW 17 56,518,655 (GRCm39) missense probably damaging 0.98
R6454:Dpp9 UTSW 17 56,513,808 (GRCm39) missense probably damaging 1.00
R6532:Dpp9 UTSW 17 56,512,854 (GRCm39) missense possibly damaging 0.75
R6894:Dpp9 UTSW 17 56,495,321 (GRCm39) missense probably damaging 1.00
R7398:Dpp9 UTSW 17 56,496,405 (GRCm39) nonsense probably null
R7494:Dpp9 UTSW 17 56,507,619 (GRCm39) missense probably damaging 1.00
R7495:Dpp9 UTSW 17 56,502,044 (GRCm39) missense probably benign
R7511:Dpp9 UTSW 17 56,512,611 (GRCm39) missense possibly damaging 0.52
R7556:Dpp9 UTSW 17 56,497,012 (GRCm39) missense possibly damaging 0.66
R8228:Dpp9 UTSW 17 56,498,129 (GRCm39) missense probably damaging 1.00
R8481:Dpp9 UTSW 17 56,501,467 (GRCm39) missense possibly damaging 0.75
R8724:Dpp9 UTSW 17 56,512,867 (GRCm39) missense probably benign 0.03
R8798:Dpp9 UTSW 17 56,506,037 (GRCm39) missense probably damaging 1.00
R9209:Dpp9 UTSW 17 56,512,765 (GRCm39) missense probably damaging 1.00
R9660:Dpp9 UTSW 17 56,494,458 (GRCm39) missense probably damaging 1.00
R9666:Dpp9 UTSW 17 56,501,946 (GRCm39) missense probably damaging 0.99
X0065:Dpp9 UTSW 17 56,502,006 (GRCm39) missense possibly damaging 0.92
Predicted Primers PCR Primer
(F):5'- TGCTCAGAGGCACTGTCACAAC -3'
(R):5'- GATGCCTGTCCATTGAGGACGAAG -3'

Sequencing Primer
(F):5'- ACCATTACCCCAGGGTGC -3'
(R):5'- AGGTTCGTCACCTGCAAAG -3'
Posted On 2013-05-09