Mutagenetix > Incidental Mutation

Incidental Mutation 'R4799:Ugt1a10'

369285

Institutional Source

Beutler Lab

Gene Symbol

Ugt1a10

Ensembl Gene

ENSMUSG00000090165

Gene Name

UDP glycosyltransferase 1 family, polypeptide A10

Synonyms

A13

MMRRC Submission

041997-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.147) question?

Stock #

R4799 (G1)

Quality Score

134

Status

Validated

Chromosome

Chromosomal Location

88055388-88219004 bp(+) (GRCm38)

Type of Mutation

intron

DNA Base Change (assembly)

TAAAAAAAAA to TAAAAAAA at 88215928 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000134443 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000014263] [ENSMUST00000049289] [ENSMUST00000058237] [ENSMUST00000073049] [ENSMUST00000073772] [ENSMUST00000097659] [ENSMUST00000113134] [ENSMUST00000113135] [ENSMUST00000113137] [ENSMUST00000113138] [ENSMUST00000113139] [ENSMUST00000140092] [ENSMUST00000138182] [ENSMUST00000173325] [ENSMUST00000126203] [ENSMUST00000150634] [ENSMUST00000113142]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000014263

SMART Domains

Protein: ENSMUSP00000014263
Gene: ENSMUSG00000054545

Domain	Start	End	E-Value	Type
signal peptide	1	26	N/A	INTRINSIC
Pfam:UDPGT	27	522	1.2e-229	PFAM
Pfam:Glyco_tran_28_C	363	448	1e-8	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000049289

SMART Domains

Protein: ENSMUSP00000037258
Gene: ENSMUSG00000090171

Domain	Start	End	E-Value	Type
signal peptide	1	27	N/A	INTRINSIC
Pfam:UDPGT	28	524	2.2e-247	PFAM
Pfam:Glyco_tran_28_C	363	452	4.5e-9	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000058237

SMART Domains

Protein: ENSMUSP00000058683
Gene: ENSMUSG00000090124

Domain	Start	End	E-Value	Type
signal peptide	1	25	N/A	INTRINSIC
Pfam:UDPGT	26	522	1.5e-234	PFAM
Pfam:Glyco_tran_28_C	361	450	4.5e-9	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000073049

SMART Domains

Protein: ENSMUSP00000072803
Gene: ENSMUSG00000089960

Domain	Start	End	E-Value	Type
signal peptide	1	29	N/A	INTRINSIC
Pfam:UDPGT	30	526	5.8e-241	PFAM
Pfam:Glyco_tran_28_C	365	454	4.5e-9	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000073772

SMART Domains

Protein: ENSMUSP00000073444
Gene: ENSMUSG00000090175

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
Pfam:UDPGT	24	519	2.3e-232	PFAM
Pfam:Glyco_tran_28_C	358	447	4.5e-9	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000097659

SMART Domains

Protein: ENSMUSP00000095263
Gene: ENSMUSG00000089943

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
Pfam:UDPGT	25	520	6.7e-246	PFAM
Pfam:Glyco_tran_28_C	359	448	1.3e-9	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000113134

SMART Domains

Protein: ENSMUSP00000108759
Gene: ENSMUSG00000054545

Domain	Start	End	E-Value	Type
signal peptide	1	26	N/A	INTRINSIC
Pfam:UDPGT	27	522	2.7e-232	PFAM
Pfam:Glyco_tran_28_C	361	450	4.5e-9	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000113135

SMART Domains

Protein: ENSMUSP00000108760
Gene: ENSMUSG00000090124

Domain	Start	End	E-Value	Type
signal peptide	1	26	N/A	INTRINSIC
Pfam:UDPGT	27	522	1.2e-229	PFAM
Pfam:Glyco_tran_28_C	363	448	1e-8	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000113137

SMART Domains

Protein: ENSMUSP00000108762
Gene: ENSMUSG00000090145

Domain	Start	End	E-Value	Type
signal peptide	1	26	N/A	INTRINSIC
Pfam:UDPGT	27	522	1.3e-231	PFAM
Pfam:Glyco_tran_28_C	361	450	2.8e-9	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000113138

SMART Domains

Protein: ENSMUSP00000108763
Gene: ENSMUSG00000090145

Domain	Start	End	E-Value	Type
signal peptide	1	26	N/A	INTRINSIC
Pfam:UDPGT	27	522	7.3e-229	PFAM
Pfam:Glyco_tran_28_C	363	448	6.6e-9	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000124852

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000173165

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000174821

Predicted Effect

probably benign
Transcript: ENSMUST00000113139

SMART Domains

Protein: ENSMUSP00000108764
Gene: ENSMUSG00000089675

Domain	Start	End	E-Value	Type
signal peptide	1	25	N/A	INTRINSIC
Pfam:UDPGT	26	521	3.6e-237	PFAM
Pfam:Glyco_tran_28_C	360	449	1.3e-9	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000140092

SMART Domains

Protein: ENSMUSP00000115642
Gene: ENSMUSG00000054545

Domain	Start	End	E-Value	Type
Pfam:UDPGT	1	166	9.3e-98	PFAM
Pfam:Glyco_tran_28_C	96	166	4.9e-9	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000138182

SMART Domains

Protein: ENSMUSP00000119985
Gene: ENSMUSG00000090165

Domain	Start	End	E-Value	Type
signal peptide	1	25	N/A	INTRINSIC
Pfam:UDPGT	26	62	7e-11	PFAM
Pfam:UDPGT	58	207	1.9e-90	PFAM
Pfam:Glyco_tran_28_C	137	207	4.8e-9	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000173325

SMART Domains

Protein: ENSMUSP00000134443
Gene: ENSMUSG00000090165

Domain	Start	End	E-Value	Type
signal peptide	1	25	N/A	INTRINSIC
Pfam:UDPGT	26	61	3.4e-10	PFAM
Pfam:UDPGT	59	210	8.9e-92	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000126203

SMART Domains

Protein: ENSMUSP00000116653
Gene: ENSMUSG00000090124

Domain	Start	End	E-Value	Type
signal peptide	1	25	N/A	INTRINSIC
Pfam:UDPGT	26	62	4.6e-11	PFAM
Pfam:UDPGT	59	127	8.9e-24	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000150634

SMART Domains

Protein: ENSMUSP00000123452
Gene: ENSMUSG00000090124

Domain	Start	End	E-Value	Type
signal peptide	1	25	N/A	INTRINSIC
Pfam:UDPGT	26	62	9.5e-11	PFAM
Pfam:UDPGT	58	207	2e-90	PFAM
Pfam:Glyco_tran_28_C	137	207	4.8e-9	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000113142

SMART Domains

Protein: ENSMUSP00000108767
Gene: ENSMUSG00000090165

Domain	Start	End	E-Value	Type
signal peptide	1	25	N/A	INTRINSIC
Pfam:UDPGT	26	521	7.3e-231	PFAM
Pfam:Glyco_tran_28_C	360	449	1.3e-9	PFAM

Coding Region Coverage

1x: 99.1%
3x: 98.3%
10x: 96.4%
20x: 92.6%

Validation Efficiency

97% (122/126)

Allele List at MGI

Other mutations in this stock

Total: 119 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abhd12b	C	G	12: 70,169,064	S170C	probably damaging	Het
Acads	T	A	5: 115,113,090	T112S	probably benign	Het
Adgrl1	A	G	8: 83,935,573	H1021R	probably benign	Het
Ago3	A	T	4: 126,347,872		probably null	Het
Ap5m1	A	G	14: 49,081,070	K412E	probably benign	Het
Arid1b	C	T	17: 5,339,221	P1681S	probably damaging	Het
Atxn10	T	C	15: 85,376,708		probably null	Het
AU040320	A	G	4: 126,839,669	T661A	probably benign	Het
Capn7	T	C	14: 31,360,557	I455M	probably benign	Het
Capzb	A	G	4: 139,192,999		probably benign	Het
Car10	G	A	11: 93,578,666	V156I	possibly damaging	Het
Cbs	T	A	17: 31,632,852	D59V	probably damaging	Het
Ccar2	T	C	14: 70,139,554	E819G	probably damaging	Het
Cdc73	T	A	1: 143,627,875	Q346L	probably benign	Het
Cdhr4	T	C	9: 107,998,699		probably benign	Het
Chd2	A	T	7: 73,484,436	M721K	possibly damaging	Het
Cntnap5b	G	A	1: 100,358,725	G402R	probably benign	Het
Cps1	T	C	1: 67,142,986	Y120H	probably damaging	Het
Csf2	T	C	11: 54,249,480	D44G	probably benign	Het
Cubn	T	A	2: 13,287,024	Q3330L	possibly damaging	Het
Cubn	A	G	2: 13,351,058	S1788P	probably damaging	Het
Cul9	T	C	17: 46,500,844	D2486G	possibly damaging	Het
Cyp2c40	A	T	19: 39,773,849	S451R	probably damaging	Het
Cyp51	T	A	5: 4,083,256	T461S	probably damaging	Het
Cyth1	T	C	11: 118,183,942	M164V	probably damaging	Het
D130043K22Rik	T	C	13: 24,878,040	I664T	probably damaging	Het
Ddc	T	C	11: 11,846,632		probably null	Het
Ddx21	A	T	10: 62,588,121	D589E	probably damaging	Het
Dgkb	C	T	12: 38,114,568	R113C	possibly damaging	Het
Dglucy	A	T	12: 100,850,343	M415L	probably benign	Het
Efnb2	A	T	8: 8,623,104		probably null	Het
Elp4	T	A	2: 105,809,267	Q189L	probably damaging	Het
Enpp2	T	C	15: 54,910,094	N77S	probably damaging	Het
Eps15	G	A	4: 109,366,530		probably benign	Het
F2rl1	G	A	13: 95,513,969	S135F	possibly damaging	Het
Fam133b	T	C	5: 3,557,815	M65T	probably damaging	Het
Fanca	A	G	8: 123,288,202	V689A	probably damaging	Het
Fbxo18	C	T	2: 11,755,747	C79Y	probably damaging	Het
Fbxw7	C	T	3: 84,903,861	Q98*	probably null	Het
Flrt3	T	C	2: 140,660,166	N514S	probably damaging	Het
Foxj3	A	T	4: 119,621,660	S438C	unknown	Het
Gcm2	T	C	13: 41,103,494	K260E	possibly damaging	Het
Gm12863	C	T	4: 118,954,488		noncoding transcript	Het
Gm5096	C	A	18: 87,756,449	A32E	probably damaging	Het
Gpnmb	G	T	6: 49,045,483		probably null	Het
Gsap	C	A	5: 21,250,943	N379K	probably benign	Het
Hsd3b1	T	A	3: 98,852,865	Y270F	probably benign	Het
Il22	C	A	10: 118,205,153	R55S	probably damaging	Het
Kcnd3	C	T	3: 105,658,766	A421V	probably damaging	Het
Klhdc3	T	C	17: 46,677,300	R180G	possibly damaging	Het
Lmbrd1	G	A	1: 24,744,975		probably null	Het
Lrrcc1	C	T	3: 14,536,096	R63*	probably null	Het
Lyar	A	G	5: 38,224,779	D35G	probably damaging	Het
Mbd4	C	T	6: 115,845,322	R442Q	probably benign	Het
Mib2	G	T	4: 155,659,772	S144R	probably benign	Het
Mms22l	A	T	4: 24,580,052		probably null	Het
Mtmr3	G	A	11: 4,487,764	H897Y	probably benign	Het
Muc5b	T	A	7: 141,847,716	C566*	probably null	Het
Nap1l4	A	T	7: 143,534,463		probably null	Het
Ncor2	A	T	5: 125,037,060		probably null	Het
Ndufa7	T	C	17: 33,838,213		probably benign	Het
Ndufs1	C	A	1: 63,160,949	G268V	probably damaging	Het
Nfs1	A	G	2: 156,134,449	V175A	possibly damaging	Het
Obsl1	C	A	1: 75,489,501	A1528S	possibly damaging	Het
Olfr1089	C	T	2: 86,732,674		probably null	Het
Olfr1252	C	T	2: 89,721,362	V250I	probably benign	Het
Olfr372	A	G	8: 72,058,094	N138S	probably benign	Het
Olfr67	A	T	7: 103,787,481	F265L	possibly damaging	Het
Olfr8	T	G	10: 78,956,097	D297E	probably null	Het
Pcdhb8	A	G	18: 37,355,653	D128G	probably damaging	Het
Pkp4	A	T	2: 59,342,105	I522F	probably damaging	Het
Plod3	G	A	5: 136,990,800	A398T	probably benign	Het
Pou4f3	A	G	18: 42,395,987	M332V	possibly damaging	Het
Prox1	A	G	1: 190,153,472	F593L	probably damaging	Het
Prrc2a	G	A	17: 35,150,042	P2006L	probably damaging	Het
Prss50	A	G	9: 110,863,796	D328G	probably damaging	Het
Psmd6	C	T	14: 14,120,126	S71N	probably benign	Het
Ptprd	A	G	4: 76,091,532	I764T	probably benign	Het
Ptprr	C	T	10: 116,048,218	A60V	probably benign	Het
Raet1e	T	A	10: 22,181,300	D174E	probably damaging	Het
Rbfox2	T	C	15: 77,091,818	I308M	probably benign	Het
Rnf20	G	C	4: 49,649,962		probably null	Het
Rpap2	A	T	5: 107,620,247	H317L	probably benign	Het
Rsph6a	T	A	7: 19,065,858	Y471*	probably null	Het
Sdhb	A	G	4: 140,977,466	H246R	possibly damaging	Het
Sh3bp5	C	A	14: 31,377,495	R265L	probably benign	Het
Sin3b	A	C	8: 72,725,643	I126L	probably benign	Het
Skint2	G	A	4: 112,652,108	A363T	probably benign	Het
Slc22a30	A	G	19: 8,344,404	I432T	probably benign	Het
Slc2a2	G	A	3: 28,717,532		probably null	Het
Slco1a5	T	C	6: 142,248,807	Y370C	possibly damaging	Het
Sltm	A	G	9: 70,589,057	H958R	probably damaging	Het
Smpdl3a	C	T	10: 57,808,015	H290Y	probably damaging	Het
Snrnp40	A	G	4: 130,362,756	I91M	probably damaging	Het
Spag9	A	T	11: 94,048,516	K90N	possibly damaging	Het
Spag9	T	A	11: 94,048,517	F91I	probably damaging	Het
Stox1	A	C	10: 62,665,737	I348S	probably damaging	Het
Sult1e1	A	G	5: 87,590,168	V18A	possibly damaging	Het
Syne2	A	G	12: 75,899,167	M338V	probably benign	Het
Tbc1d23	T	A	16: 57,192,628	Q327L	probably benign	Het
Terf2	G	T	8: 107,076,675	H425Q	probably benign	Het
Timd2	A	T	11: 46,677,267	Y233*	probably null	Het
Tmem39a	A	G	16: 38,591,162		probably benign	Het
Trappc10	T	C	10: 78,201,590	D793G	possibly damaging	Het
Ttc30a2	T	A	2: 75,977,385	Y261F	probably benign	Het
Unc93a	T	C	17: 13,120,895		probably null	Het
Utrn	T	C	10: 12,750,069	T123A	probably damaging	Het
Vmn1r171	T	C	7: 23,632,944	I198T	probably benign	Het
Vmn1r213	T	A	13: 23,011,846	S200T	probably damaging	Het
Vmn2r108	T	A	17: 20,462,629	D771V	probably damaging	Het
Wdr66	C	T	5: 123,302,772	H1131Y	probably benign	Het
Wls	C	T	3: 159,897,445	T165I	probably benign	Het
Zc3h13	G	A	14: 75,339,423	C1657Y	probably damaging	Het
Zdhhc5	T	C	2: 84,693,431	K224E	probably damaging	Het
Zfp54	T	A	17: 21,434,140	Y299N	probably damaging	Het
Zfp820	A	T	17: 21,818,985	L454Q	probably benign	Het
Zfp960	T	A	17: 17,088,436	F471I	probably damaging	Het
Zswim5	A	G	4: 116,972,972	I515V	probably benign	Het
Zzef1	G	T	11: 72,859,623	S919I	probably benign	Het

Other mutations in Ugt1a10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01126:Ugt1a10	APN	1	88055987	missense	possibly damaging	0.72
IGL02219:Ugt1a10	APN	1	88056058	missense	probably benign	0.00
IGL02511:Ugt1a10	APN	1	88055863	missense	probably damaging	1.00
IGL02990:Ugt1a10	APN	1	88055879	missense	probably damaging	1.00
PIT4142001:Ugt1a10	UTSW	1	88216158	small deletion	probably benign
R0201:Ugt1a10	UTSW	1	88215123	missense	probably damaging	1.00
R0201:Ugt1a10	UTSW	1	88218249	missense	probably damaging	1.00
R0522:Ugt1a10	UTSW	1	88218249	missense	probably damaging	1.00
R0525:Ugt1a10	UTSW	1	88218249	missense	probably damaging	1.00
R0554:Ugt1a10	UTSW	1	88056095	missense	probably damaging	1.00
R0748:Ugt1a10	UTSW	1	88215123	missense	probably damaging	1.00
R0811:Ugt1a10	UTSW	1	88056182	missense	probably benign	0.33
R0812:Ugt1a10	UTSW	1	88056182	missense	probably benign	0.33
R1129:Ugt1a10	UTSW	1	88055609	missense	probably benign
R1207:Ugt1a10	UTSW	1	88216254	missense	probably damaging	1.00
R1432:Ugt1a10	UTSW	1	88216260	missense	probably damaging	1.00
R1457:Ugt1a10	UTSW	1	88055711	missense	probably damaging	1.00
R1469:Ugt1a10	UTSW	1	88216254	missense	probably damaging	1.00
R1972:Ugt1a10	UTSW	1	88056047	missense	probably damaging	1.00
R1973:Ugt1a10	UTSW	1	88056047	missense	probably damaging	1.00
R2039:Ugt1a10	UTSW	1	88055981	missense	probably benign	0.32
R2307:Ugt1a10	UTSW	1	88055947	missense	probably benign	0.01
R3952:Ugt1a10	UTSW	1	88216140	missense	probably damaging	1.00
R3973:Ugt1a10	UTSW	1	88216140	missense	probably damaging	1.00
R4232:Ugt1a10	UTSW	1	88056210	missense	probably benign	0.39
R4392:Ugt1a10	UTSW	1	88215123	missense	probably damaging	1.00
R4393:Ugt1a10	UTSW	1	88215123	missense	probably damaging	1.00
R4402:Ugt1a10	UTSW	1	88215123	missense	probably damaging	1.00
R4417:Ugt1a10	UTSW	1	88055995	missense	probably benign
R4474:Ugt1a10	UTSW	1	88215928	intron	probably benign
R4476:Ugt1a10	UTSW	1	88215928	intron	probably benign
R4515:Ugt1a10	UTSW	1	88056197	missense	probably damaging	1.00
R4579:Ugt1a10	UTSW	1	88056116	missense	probably benign
R4582:Ugt1a10	UTSW	1	88055741	missense	possibly damaging	0.90
R4609:Ugt1a10	UTSW	1	88055482	start codon destroyed	possibly damaging	0.92
R4627:Ugt1a10	UTSW	1	88218390	missense	probably damaging	1.00
R4790:Ugt1a10	UTSW	1	88056287	missense	probably damaging	0.98
R4910:Ugt1a10	UTSW	1	88215123	missense	probably damaging	1.00
R4915:Ugt1a10	UTSW	1	88055924	missense	probably damaging	1.00
R5110:Ugt1a10	UTSW	1	88056252	splice site	probably null
R5168:Ugt1a10	UTSW	1	88055809	missense	probably benign	0.01
R5329:Ugt1a10	UTSW	1	88216254	missense	probably damaging	1.00
R5373:Ugt1a10	UTSW	1	88055910	missense	probably damaging	0.98
R5374:Ugt1a10	UTSW	1	88055910	missense	probably damaging	0.98
R5615:Ugt1a10	UTSW	1	88216158	small deletion	probably benign
R6498:Ugt1a10	UTSW	1	88216140	missense	probably damaging	1.00
R6727:Ugt1a10	UTSW	1	88056257	splice site	probably null
R6809:Ugt1a10	UTSW	1	88055925	missense	probably damaging	0.98
R6924:Ugt1a10	UTSW	1	88055657	missense	probably damaging	0.99
R6967:Ugt1a10	UTSW	1	88215123	missense	probably damaging	1.00
R7913:Ugt1a10	UTSW	1	88055755	missense	probably benign	0.00
R9165:Ugt1a10	UTSW	1	88055787	missense	probably benign	0.00
R9264:Ugt1a10	UTSW	1	88055671	missense	possibly damaging	0.62
R9475:Ugt1a10	UTSW	1	88216260	missense	probably damaging	1.00
S24628:Ugt1a10	UTSW	1	88216158	small deletion	probably benign
X0013:Ugt1a10	UTSW	1	88216254	missense	probably damaging	1.00
Z1088:Ugt1a10	UTSW	1	88055842	missense	probably benign	0.20
Z1190:Ugt1a10	UTSW	1	88216158	small deletion	probably benign

Predicted Primers

PCR Primer
(F):5'- TGGCCTTTCTAGCTAGTATTGC -3'
(R):5'- ACAGACAAGGATGCTGAGCTC -3'

Sequencing Primer
(F):5'- CGGAACTAGACCATCGAATC -3'
(R):5'- TCGCCAGTCTCACAGAGTCTG -3'

Posted On

2016-02-04