Incidental Mutation 'R0419:Neo1'
ID 36929
Institutional Source Beutler Lab
Gene Symbol Neo1
Ensembl Gene ENSMUSG00000032340
Gene Name neogenin
Synonyms 2610028H22Rik, D930014N22Rik, Igdcc2
MMRRC Submission 038621-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R0419 (G1)
Quality Score 157
Status Validated
Chromosome 9
Chromosomal Location 58781970-58943724 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to G at 58897463 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000150600 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000068664] [ENSMUST00000214547]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000068664
SMART Domains Protein: ENSMUSP00000063656
Gene: ENSMUSG00000032340

DomainStartEndE-ValueType
signal peptide 1 41 N/A INTRINSIC
IGc2 76 147 9.49e-5 SMART
IGc2 175 239 4.43e-5 SMART
IGc2 272 338 6.15e-13 SMART
IGc2 364 428 7.76e-10 SMART
low complexity region 446 458 N/A INTRINSIC
FN3 470 553 8.23e-12 SMART
FN3 570 649 1.78e-16 SMART
FN3 665 749 1.54e-11 SMART
FN3 770 849 5.27e-10 SMART
FN3 885 970 7.63e-7 SMART
FN3 986 1072 2.78e-9 SMART
transmembrane domain 1136 1158 N/A INTRINSIC
Pfam:Neogenin_C 1189 1492 1.9e-122 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214547
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216941
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217545
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.8%
Validation Efficiency 98% (54/55)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may be involved in cell growth and differentiation and in cell-cell adhesion. Defects in this gene are associated with cell proliferation in certain cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
PHENOTYPE: Mice homozygous for a gene trap allele display perinatal lethality and abnormal trigeminal nerve development. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700029H14Rik T C 8: 13,601,842 (GRCm39) probably benign Het
5730507C01Rik A T 12: 18,583,424 (GRCm39) R161S possibly damaging Het
Adamts5 T C 16: 85,663,530 (GRCm39) I735V probably benign Het
Arid1a G T 4: 133,408,435 (GRCm39) P2024Q unknown Het
Ascc3 G T 10: 50,625,022 (GRCm39) V1637L probably benign Het
B3galt4 T C 17: 34,169,764 (GRCm39) Y158C probably damaging Het
BC049715 A G 6: 136,817,143 (GRCm39) T128A possibly damaging Het
Btaf1 T A 19: 36,922,629 (GRCm39) I11N probably damaging Het
Cfb T C 17: 35,077,485 (GRCm39) I496V probably damaging Het
Chd8 A T 14: 52,441,517 (GRCm39) H858Q probably benign Het
Chrne T C 11: 70,506,549 (GRCm39) I324V probably benign Het
Clec14a T C 12: 58,314,451 (GRCm39) I390M probably damaging Het
Cpsf3 A G 12: 21,347,800 (GRCm39) Y207C probably damaging Het
Cubn A C 2: 13,474,574 (GRCm39) I410S possibly damaging Het
Cubn T A 2: 13,474,575 (GRCm39) I410F possibly damaging Het
Dlc1 T C 8: 37,050,740 (GRCm39) E997G possibly damaging Het
Emilin1 G T 5: 31,072,366 (GRCm39) V71F probably damaging Het
Esrp2 T C 8: 106,861,307 (GRCm39) E164G probably damaging Het
Fars2 A G 13: 36,721,285 (GRCm39) T410A probably benign Het
Fat3 A G 9: 15,903,552 (GRCm39) V2981A probably damaging Het
Fkbp15 G A 4: 62,244,373 (GRCm39) T472I probably benign Het
Gm6871 A G 7: 41,222,869 (GRCm39) V73A probably benign Het
Gnl2 T G 4: 124,947,320 (GRCm39) S647R probably benign Het
Grb10 T C 11: 11,884,207 (GRCm39) I500V possibly damaging Het
Herc1 T C 9: 66,353,356 (GRCm39) probably benign Het
Iqgap2 A C 13: 95,826,207 (GRCm39) probably null Het
Kcnu1 A T 8: 26,427,646 (GRCm39) N321I probably benign Het
Kif23 G A 9: 61,833,687 (GRCm39) R519* probably null Het
Klhl1 C T 14: 96,619,225 (GRCm39) R224Q probably benign Het
Lama1 T C 17: 68,098,605 (GRCm39) probably null Het
Lamp3 T C 16: 19,492,302 (GRCm39) Y314C probably damaging Het
Lamtor5 C A 3: 107,189,227 (GRCm39) R88S probably damaging Het
Nbea G T 3: 55,726,715 (GRCm39) A2088E probably benign Het
Ntn4 A T 10: 93,518,291 (GRCm39) R199S probably benign Het
Or5ap2 A T 2: 85,680,311 (GRCm39) R172* probably null Het
Plekho2 A G 9: 65,464,334 (GRCm39) S172P possibly damaging Het
Pmp2 T C 3: 10,245,823 (GRCm39) Y129C probably damaging Het
Prss3b T C 6: 41,011,281 (GRCm39) N34D probably benign Het
Ralgapa2 A T 2: 146,270,592 (GRCm39) M578K possibly damaging Het
Ranbp3 C T 17: 57,015,219 (GRCm39) T307M possibly damaging Het
Serpinb11 G A 1: 107,304,590 (GRCm39) W185* probably null Het
Setdb2 A T 14: 59,644,193 (GRCm39) probably null Het
Sirpb1b A T 3: 15,613,656 (GRCm39) V75E probably damaging Het
Slc13a1 A T 6: 24,100,292 (GRCm39) L397Q probably damaging Het
Slc19a1 T A 10: 76,878,742 (GRCm39) I355N probably damaging Het
Slc51a T A 16: 32,295,254 (GRCm39) I275F possibly damaging Het
Spink14 T C 18: 44,164,934 (GRCm39) S84P probably damaging Het
Stx2 A G 5: 129,070,641 (GRCm39) probably benign Het
Tgfbi G T 13: 56,780,006 (GRCm39) probably benign Het
Tshr T A 12: 91,504,643 (GRCm39) M527K probably damaging Het
Upb1 T C 10: 75,248,717 (GRCm39) V79A probably damaging Het
Zdhhc5 A T 2: 84,521,587 (GRCm39) probably null Het
Zfp11 C T 5: 129,735,302 (GRCm39) G53E possibly damaging Het
Zfp280d T C 9: 72,219,519 (GRCm39) V32A probably benign Het
Other mutations in Neo1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00514:Neo1 APN 9 58,829,202 (GRCm39) splice site probably benign
IGL00885:Neo1 APN 9 58,795,746 (GRCm39) missense probably damaging 1.00
IGL01103:Neo1 APN 9 58,788,082 (GRCm39) missense possibly damaging 0.60
IGL01322:Neo1 APN 9 58,814,368 (GRCm39) missense possibly damaging 0.68
IGL02216:Neo1 APN 9 58,824,336 (GRCm39) missense probably damaging 0.96
IGL02327:Neo1 APN 9 58,810,371 (GRCm39) missense probably benign 0.08
IGL02392:Neo1 APN 9 58,833,094 (GRCm39) missense possibly damaging 0.49
IGL02458:Neo1 APN 9 58,801,150 (GRCm39) splice site probably benign
IGL03057:Neo1 APN 9 58,785,342 (GRCm39) missense probably damaging 1.00
IGL03091:Neo1 APN 9 58,885,951 (GRCm39) missense probably damaging 0.98
IGL03193:Neo1 APN 9 58,815,767 (GRCm39) missense probably damaging 1.00
R0097:Neo1 UTSW 9 58,882,021 (GRCm38) intron probably benign
R0571:Neo1 UTSW 9 58,893,069 (GRCm39) missense probably benign
R0646:Neo1 UTSW 9 58,838,317 (GRCm39) missense probably damaging 1.00
R0736:Neo1 UTSW 9 58,824,364 (GRCm39) missense possibly damaging 0.78
R0739:Neo1 UTSW 9 58,829,160 (GRCm39) missense probably benign 0.22
R1636:Neo1 UTSW 9 58,820,560 (GRCm39) missense probably damaging 1.00
R1694:Neo1 UTSW 9 58,787,886 (GRCm39) missense probably damaging 1.00
R1827:Neo1 UTSW 9 58,824,314 (GRCm39) nonsense probably null
R1927:Neo1 UTSW 9 58,897,668 (GRCm39) missense probably benign 0.12
R2354:Neo1 UTSW 9 58,892,917 (GRCm39) missense probably benign
R2365:Neo1 UTSW 9 58,863,286 (GRCm39) missense probably benign
R3156:Neo1 UTSW 9 58,796,262 (GRCm39) splice site probably null
R3552:Neo1 UTSW 9 58,801,161 (GRCm39) missense probably damaging 1.00
R3829:Neo1 UTSW 9 58,820,452 (GRCm39) missense possibly damaging 0.58
R4477:Neo1 UTSW 9 58,784,582 (GRCm39) missense probably damaging 0.99
R4613:Neo1 UTSW 9 58,796,324 (GRCm39) missense possibly damaging 0.94
R5023:Neo1 UTSW 9 58,897,554 (GRCm39) missense probably damaging 1.00
R5046:Neo1 UTSW 9 58,801,194 (GRCm39) missense possibly damaging 0.77
R5057:Neo1 UTSW 9 58,897,554 (GRCm39) missense probably damaging 1.00
R5323:Neo1 UTSW 9 58,813,931 (GRCm39) critical splice donor site probably null
R5394:Neo1 UTSW 9 58,897,517 (GRCm39) missense probably benign 0.10
R5470:Neo1 UTSW 9 58,838,350 (GRCm39) missense probably damaging 1.00
R5473:Neo1 UTSW 9 58,788,126 (GRCm39) missense possibly damaging 0.88
R5500:Neo1 UTSW 9 58,824,337 (GRCm39) missense possibly damaging 0.94
R5503:Neo1 UTSW 9 58,892,933 (GRCm39) missense possibly damaging 0.67
R6122:Neo1 UTSW 9 58,824,291 (GRCm39) missense probably benign
R6191:Neo1 UTSW 9 58,796,312 (GRCm39) missense probably damaging 1.00
R6431:Neo1 UTSW 9 58,814,354 (GRCm39) missense probably benign 0.27
R6560:Neo1 UTSW 9 58,787,884 (GRCm39) missense possibly damaging 0.95
R6658:Neo1 UTSW 9 58,829,132 (GRCm39) missense probably benign 0.14
R6772:Neo1 UTSW 9 58,810,259 (GRCm39) missense probably damaging 1.00
R6912:Neo1 UTSW 9 58,824,335 (GRCm39) missense probably benign 0.00
R7061:Neo1 UTSW 9 58,897,724 (GRCm39) missense possibly damaging 0.95
R7145:Neo1 UTSW 9 58,796,462 (GRCm39) missense probably damaging 1.00
R7156:Neo1 UTSW 9 58,810,206 (GRCm39) missense probably damaging 1.00
R7485:Neo1 UTSW 9 58,791,826 (GRCm39) missense probably benign 0.04
R7519:Neo1 UTSW 9 58,785,348 (GRCm39) missense probably benign 0.13
R7615:Neo1 UTSW 9 58,791,786 (GRCm39) missense probably benign 0.07
R7665:Neo1 UTSW 9 58,833,078 (GRCm39) missense probably damaging 1.00
R7695:Neo1 UTSW 9 58,810,212 (GRCm39) missense possibly damaging 0.81
R7753:Neo1 UTSW 9 58,863,288 (GRCm39) missense probably benign 0.00
R7807:Neo1 UTSW 9 58,897,777 (GRCm39) missense probably benign 0.01
R7915:Neo1 UTSW 9 58,838,264 (GRCm39) missense probably benign 0.42
R7973:Neo1 UTSW 9 58,897,476 (GRCm39) missense probably damaging 1.00
R8356:Neo1 UTSW 9 58,785,402 (GRCm39) missense probably damaging 1.00
R8505:Neo1 UTSW 9 58,820,566 (GRCm39) missense probably benign 0.02
R8700:Neo1 UTSW 9 58,825,913 (GRCm39) missense probably benign 0.28
R8798:Neo1 UTSW 9 58,820,449 (GRCm39) missense probably damaging 1.00
R8952:Neo1 UTSW 9 58,897,545 (GRCm39) missense probably benign 0.01
R9779:Neo1 UTSW 9 58,886,009 (GRCm39) nonsense probably null
R9784:Neo1 UTSW 9 58,889,503 (GRCm39) missense probably benign
R9789:Neo1 UTSW 9 58,801,307 (GRCm39) critical splice acceptor site probably null
X0063:Neo1 UTSW 9 58,897,581 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- TTTCAGACAGGCAAGACGCACG -3'
(R):5'- GAATCAGATGATCGACGCCAGCTAC -3'

Sequencing Primer
(F):5'- cacacacacacacacacac -3'
(R):5'- GCCAGCTACTCCCAGATG -3'
Posted On 2013-05-09