Incidental Mutation 'R4811:Erbb4'
| ID |
369400 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Erbb4
|
| Ensembl Gene |
ENSMUSG00000062209 |
| Gene Name |
erb-b2 receptor tyrosine kinase 4 |
| Synonyms |
Her4, ErbB4 |
| MMRRC Submission |
042430-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R4811 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
1 |
| Chromosomal Location |
68071345-69147218 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 68293703 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Leucine
at position 729
(F729L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000114123
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000119142]
[ENSMUST00000121473]
[ENSMUST00000153432]
|
| AlphaFold |
Q61527 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000119142
AA Change: F729L
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000112713
Gene: ENSMUSG00000062209
AA Change: F729L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Recep_L_domain
|
55 |
167 |
5e-34 |
PFAM |
|
FU
|
183 |
223 |
2.07e1 |
SMART |
|
FU
|
226 |
268 |
5.78e-10 |
SMART |
|
Pfam:Recep_L_domain
|
358 |
478 |
1e-29 |
PFAM |
|
FU
|
493 |
544 |
6.45e-8 |
SMART |
|
FU
|
549 |
599 |
3.51e-9 |
SMART |
|
FU
|
611 |
659 |
2.32e0 |
SMART |
|
TyrKc
|
718 |
974 |
7.53e-133 |
SMART |
|
low complexity region
|
1007 |
1023 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000121473
AA Change: F729L
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000114123
Gene: ENSMUSG00000062209
AA Change: F729L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Recep_L_domain
|
55 |
167 |
1.6e-34 |
PFAM |
|
FU
|
183 |
223 |
2.07e1 |
SMART |
|
FU
|
226 |
268 |
5.78e-10 |
SMART |
|
Pfam:Recep_L_domain
|
358 |
478 |
5.5e-29 |
PFAM |
|
FU
|
493 |
544 |
6.45e-8 |
SMART |
|
FU
|
549 |
599 |
3.51e-9 |
SMART |
|
FU
|
611 |
659 |
2.32e0 |
SMART |
|
TyrKc
|
718 |
974 |
7.53e-133 |
SMART |
|
low complexity region
|
1007 |
1023 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000153432
AA Change: F719L
PolyPhen 2
Score 0.969 (Sensitivity: 0.77; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000115373
Gene: ENSMUSG00000062209
AA Change: F719L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Recep_L_domain
|
55 |
167 |
1.7e-34 |
PFAM |
|
FU
|
183 |
223 |
2.07e1 |
SMART |
|
FU
|
226 |
268 |
5.78e-10 |
SMART |
|
Pfam:Recep_L_domain
|
358 |
478 |
5.7e-29 |
PFAM |
|
FU
|
493 |
544 |
6.45e-8 |
SMART |
|
FU
|
549 |
599 |
3.51e-9 |
SMART |
|
FU
|
611 |
649 |
2.98e0 |
SMART |
|
PDB:2R4B|B
|
680 |
732 |
1e-25 |
PDB |
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.5%
- 20x: 93.0%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for a targeted null mutation exhibit cardiac defects, alterations in hindbrain development, and midgestational lethality. Heterozygotes show schizophrenia-like behavior. Genetically rescued females show mammary defects. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(7) : Targeted(6) Gene trapped(1)
|
| Other mutations in this stock |
Total: 79 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930447A16Rik |
G |
A |
15: 37,425,952 (GRCm39) |
|
probably benign |
Het |
| Adam3 |
C |
T |
8: 25,201,740 (GRCm39) |
G208R |
probably benign |
Het |
| Arsg |
G |
T |
11: 109,424,898 (GRCm39) |
V290L |
probably benign |
Het |
| Cad |
A |
G |
5: 31,232,034 (GRCm39) |
T104A |
probably benign |
Het |
| Ccdc180 |
A |
G |
4: 45,928,020 (GRCm39) |
N1185S |
probably damaging |
Het |
| Cdh18 |
A |
G |
15: 23,226,877 (GRCm39) |
T113A |
probably benign |
Het |
| Crocc2 |
G |
A |
1: 93,133,618 (GRCm39) |
A967T |
probably damaging |
Het |
| Cyp4f16 |
A |
G |
17: 32,764,080 (GRCm39) |
T291A |
probably benign |
Het |
| Dcc |
T |
A |
18: 71,432,554 (GRCm39) |
H1300L |
probably benign |
Het |
| Ddx23 |
T |
A |
15: 98,545,352 (GRCm39) |
|
probably null |
Het |
| Dnhd1 |
T |
G |
7: 105,363,488 (GRCm39) |
S4017A |
probably damaging |
Het |
| Ercc6 |
G |
T |
14: 32,296,886 (GRCm39) |
R1292L |
probably benign |
Het |
| Fam186b |
C |
T |
15: 99,178,118 (GRCm39) |
V403M |
probably benign |
Het |
| Fam227a |
T |
C |
15: 79,499,628 (GRCm39) |
N576D |
possibly damaging |
Het |
| Fbln1 |
A |
G |
15: 85,111,167 (GRCm39) |
|
probably null |
Het |
| Fbxw17 |
T |
C |
13: 50,579,669 (GRCm39) |
V162A |
probably benign |
Het |
| Gas2l1 |
A |
C |
11: 5,014,436 (GRCm39) |
I8S |
probably damaging |
Het |
| Golgb1 |
T |
C |
16: 36,711,781 (GRCm39) |
L195P |
probably damaging |
Het |
| Gps2 |
A |
T |
11: 69,806,754 (GRCm39) |
H233L |
probably damaging |
Het |
| Guf1 |
T |
G |
5: 69,721,852 (GRCm39) |
|
probably null |
Het |
| H2-T9 |
A |
G |
17: 36,438,668 (GRCm39) |
L241S |
probably damaging |
Het |
| Il1rap |
T |
A |
16: 26,519,988 (GRCm39) |
|
probably null |
Het |
| Ints14 |
A |
G |
9: 64,871,800 (GRCm39) |
Y46C |
probably damaging |
Het |
| Kalrn |
T |
G |
16: 34,177,339 (GRCm39) |
Q293H |
probably damaging |
Het |
| Kank2 |
A |
G |
9: 21,687,043 (GRCm39) |
L593P |
probably damaging |
Het |
| Krt19 |
T |
C |
11: 100,032,174 (GRCm39) |
T297A |
possibly damaging |
Het |
| Lcp1 |
T |
C |
14: 75,437,848 (GRCm39) |
V86A |
probably damaging |
Het |
| Lins1 |
T |
A |
7: 66,357,898 (GRCm39) |
I11K |
probably benign |
Het |
| Lrba |
T |
C |
3: 86,683,448 (GRCm39) |
F2757L |
probably damaging |
Het |
| Lyst |
T |
C |
13: 13,951,685 (GRCm39) |
I3762T |
probably benign |
Het |
| Lyzl6 |
A |
G |
11: 103,525,851 (GRCm39) |
S90P |
possibly damaging |
Het |
| Mfsd2a |
T |
A |
4: 122,853,175 (GRCm39) |
Q38L |
probably benign |
Het |
| Mtss1 |
A |
G |
15: 58,815,922 (GRCm39) |
F546S |
probably damaging |
Het |
| Myo5a |
G |
A |
9: 75,048,825 (GRCm39) |
|
probably null |
Het |
| Naip6 |
C |
A |
13: 100,422,299 (GRCm39) |
G1245W |
probably damaging |
Het |
| Ndfip1 |
C |
T |
18: 38,584,645 (GRCm39) |
T107I |
probably benign |
Het |
| Nek8 |
C |
T |
11: 78,058,544 (GRCm39) |
|
probably null |
Het |
| Nphs1 |
T |
C |
7: 30,159,854 (GRCm39) |
V55A |
probably damaging |
Het |
| Nrp2 |
C |
A |
1: 62,758,240 (GRCm39) |
H75Q |
probably damaging |
Het |
| Oas1e |
C |
T |
5: 120,933,448 (GRCm39) |
S39N |
probably damaging |
Het |
| Or13g1 |
T |
C |
7: 85,956,166 (GRCm39) |
T52A |
probably benign |
Het |
| Or2y1e |
T |
G |
11: 49,218,575 (GRCm39) |
S112R |
possibly damaging |
Het |
| Or5d37 |
A |
G |
2: 87,923,876 (GRCm39) |
F135L |
probably benign |
Het |
| Or7h8 |
A |
T |
9: 20,124,049 (GRCm39) |
I135F |
probably damaging |
Het |
| Pan3 |
T |
A |
5: 147,466,868 (GRCm39) |
H632Q |
probably damaging |
Het |
| Paqr3 |
A |
C |
5: 97,243,842 (GRCm39) |
S291A |
probably benign |
Het |
| Pcdh17 |
A |
C |
14: 84,685,375 (GRCm39) |
D614A |
probably damaging |
Het |
| Pcyox1l |
T |
C |
18: 61,830,606 (GRCm39) |
E422G |
possibly damaging |
Het |
| Pgr |
G |
T |
9: 8,900,844 (GRCm39) |
E126* |
probably null |
Het |
| Pik3ap1 |
A |
G |
19: 41,290,936 (GRCm39) |
V532A |
possibly damaging |
Het |
| Pla2g4c |
T |
C |
7: 13,071,738 (GRCm39) |
I186T |
probably damaging |
Het |
| Pnkd |
G |
A |
1: 74,388,564 (GRCm39) |
|
probably null |
Het |
| Poc1a |
A |
G |
9: 106,226,908 (GRCm39) |
T334A |
probably damaging |
Het |
| Pou2f2 |
T |
A |
7: 24,797,111 (GRCm39) |
K211* |
probably null |
Het |
| Rdh13 |
T |
C |
7: 4,445,652 (GRCm39) |
E94G |
probably benign |
Het |
| Rnf186 |
A |
G |
4: 138,694,498 (GRCm39) |
S13G |
probably benign |
Het |
| Ryr2 |
T |
C |
13: 11,670,584 (GRCm39) |
R3471G |
probably damaging |
Het |
| Sbf2 |
T |
C |
7: 109,971,742 (GRCm39) |
T831A |
probably damaging |
Het |
| Sh3gl2 |
A |
G |
4: 85,316,403 (GRCm39) |
|
probably benign |
Het |
| Shoc1 |
T |
C |
4: 59,082,404 (GRCm39) |
N408S |
probably benign |
Het |
| Snn |
T |
C |
16: 10,890,397 (GRCm39) |
V72A |
probably benign |
Het |
| Sys1 |
T |
A |
2: 164,306,344 (GRCm39) |
H99Q |
possibly damaging |
Het |
| Syt7 |
A |
G |
19: 10,412,931 (GRCm39) |
K122R |
probably damaging |
Het |
| Tas1r2 |
T |
A |
4: 139,396,311 (GRCm39) |
L550Q |
probably damaging |
Het |
| Tent5b |
T |
C |
4: 133,213,681 (GRCm39) |
L184P |
probably benign |
Het |
| Thoc1 |
T |
C |
18: 9,993,438 (GRCm39) |
I599T |
probably damaging |
Het |
| Tle3 |
C |
T |
9: 61,281,279 (GRCm39) |
|
probably benign |
Het |
| Tll1 |
A |
C |
8: 64,538,507 (GRCm39) |
V379G |
possibly damaging |
Het |
| Tnfrsf21 |
G |
A |
17: 43,348,621 (GRCm39) |
E78K |
probably benign |
Het |
| Tpgs2 |
A |
G |
18: 25,262,897 (GRCm39) |
|
probably benign |
Het |
| Trpm1 |
T |
C |
7: 63,858,054 (GRCm39) |
L165P |
probably damaging |
Het |
| Trpm5 |
T |
C |
7: 142,633,956 (GRCm39) |
Y750C |
probably damaging |
Het |
| Ttbk2 |
A |
C |
2: 120,570,551 (GRCm39) |
S1201A |
possibly damaging |
Het |
| Ust |
T |
A |
10: 8,121,705 (GRCm39) |
H301L |
probably damaging |
Het |
| Vwa5a |
T |
C |
9: 38,647,249 (GRCm39) |
F543L |
probably benign |
Het |
| Yeats2 |
T |
A |
16: 19,971,645 (GRCm39) |
|
probably null |
Het |
| Zfp85 |
T |
C |
13: 67,897,745 (GRCm39) |
Y109C |
probably damaging |
Het |
| Zfr2 |
T |
A |
10: 81,079,547 (GRCm39) |
V362E |
probably benign |
Het |
| Znrf3 |
A |
T |
11: 5,237,420 (GRCm39) |
C134S |
probably benign |
Het |
|
| Other mutations in Erbb4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00965:Erbb4
|
APN |
1 |
68,110,789 (GRCm39) |
nonsense |
probably null |
|
|
IGL01020:Erbb4
|
APN |
1 |
68,337,608 (GRCm39) |
splice site |
probably benign |
|
|
IGL01349:Erbb4
|
APN |
1 |
68,385,752 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01386:Erbb4
|
APN |
1 |
68,383,090 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01516:Erbb4
|
APN |
1 |
68,367,404 (GRCm39) |
nonsense |
probably null |
|
|
IGL01536:Erbb4
|
APN |
1 |
68,329,441 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01721:Erbb4
|
APN |
1 |
68,293,722 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
IGL01832:Erbb4
|
APN |
1 |
68,293,725 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL02002:Erbb4
|
APN |
1 |
68,119,885 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02040:Erbb4
|
APN |
1 |
68,081,694 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02371:Erbb4
|
APN |
1 |
68,329,453 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02399:Erbb4
|
APN |
1 |
68,081,596 (GRCm39) |
splice site |
probably benign |
|
|
IGL02553:Erbb4
|
APN |
1 |
68,345,023 (GRCm39) |
missense |
probably benign |
0.17 |
|
IGL03118:Erbb4
|
APN |
1 |
68,081,878 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL03329:Erbb4
|
APN |
1 |
68,367,281 (GRCm39) |
missense |
probably benign |
0.30 |
|
IGL03405:Erbb4
|
APN |
1 |
68,369,397 (GRCm39) |
missense |
probably benign |
0.02 |
|
earthworm
|
UTSW |
1 |
68,289,739 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
excrescence
|
UTSW |
1 |
68,369,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Mole
|
UTSW |
1 |
68,599,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
P0018:Erbb4
|
UTSW |
1 |
68,110,835 (GRCm39) |
missense |
probably benign |
0.05 |
|
PIT4480001:Erbb4
|
UTSW |
1 |
68,114,702 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0193:Erbb4
|
UTSW |
1 |
68,083,119 (GRCm39) |
intron |
probably benign |
|
|
R0329:Erbb4
|
UTSW |
1 |
68,337,439 (GRCm39) |
splice site |
probably benign |
|
|
R0335:Erbb4
|
UTSW |
1 |
68,298,418 (GRCm39) |
missense |
probably benign |
|
|
R0362:Erbb4
|
UTSW |
1 |
68,369,429 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0579:Erbb4
|
UTSW |
1 |
68,081,621 (GRCm39) |
missense |
probably benign |
0.17 |
|
R0730:Erbb4
|
UTSW |
1 |
68,298,449 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1029:Erbb4
|
UTSW |
1 |
68,348,773 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1444:Erbb4
|
UTSW |
1 |
68,293,759 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1469:Erbb4
|
UTSW |
1 |
68,599,841 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1469:Erbb4
|
UTSW |
1 |
68,599,841 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1503:Erbb4
|
UTSW |
1 |
68,385,705 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1523:Erbb4
|
UTSW |
1 |
68,435,411 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1528:Erbb4
|
UTSW |
1 |
68,117,741 (GRCm39) |
nonsense |
probably null |
|
|
R1604:Erbb4
|
UTSW |
1 |
68,385,728 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R1611:Erbb4
|
UTSW |
1 |
68,079,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1642:Erbb4
|
UTSW |
1 |
68,370,393 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1905:Erbb4
|
UTSW |
1 |
68,114,569 (GRCm39) |
splice site |
probably benign |
|
|
R1929:Erbb4
|
UTSW |
1 |
68,238,047 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2046:Erbb4
|
UTSW |
1 |
68,337,482 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2139:Erbb4
|
UTSW |
1 |
68,385,788 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2271:Erbb4
|
UTSW |
1 |
68,238,047 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2298:Erbb4
|
UTSW |
1 |
68,081,690 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2356:Erbb4
|
UTSW |
1 |
68,117,755 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3821:Erbb4
|
UTSW |
1 |
68,345,072 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4007:Erbb4
|
UTSW |
1 |
68,779,560 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4012:Erbb4
|
UTSW |
1 |
68,599,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4077:Erbb4
|
UTSW |
1 |
68,079,496 (GRCm39) |
missense |
probably benign |
0.07 |
|
R4196:Erbb4
|
UTSW |
1 |
68,383,014 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R4536:Erbb4
|
UTSW |
1 |
68,385,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4561:Erbb4
|
UTSW |
1 |
68,383,080 (GRCm39) |
nonsense |
probably null |
|
|
R4642:Erbb4
|
UTSW |
1 |
68,289,791 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4737:Erbb4
|
UTSW |
1 |
68,383,059 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4739:Erbb4
|
UTSW |
1 |
68,383,059 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4780:Erbb4
|
UTSW |
1 |
68,337,473 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4801:Erbb4
|
UTSW |
1 |
68,369,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4802:Erbb4
|
UTSW |
1 |
68,369,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4832:Erbb4
|
UTSW |
1 |
68,369,397 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5068:Erbb4
|
UTSW |
1 |
68,083,061 (GRCm39) |
splice site |
probably null |
|
|
R5546:Erbb4
|
UTSW |
1 |
68,337,452 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5755:Erbb4
|
UTSW |
1 |
68,599,678 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R6189:Erbb4
|
UTSW |
1 |
68,083,075 (GRCm39) |
missense |
probably benign |
|
|
R6257:Erbb4
|
UTSW |
1 |
68,435,432 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6276:Erbb4
|
UTSW |
1 |
68,599,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6521:Erbb4
|
UTSW |
1 |
68,081,689 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6602:Erbb4
|
UTSW |
1 |
68,409,662 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6808:Erbb4
|
UTSW |
1 |
68,079,462 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7087:Erbb4
|
UTSW |
1 |
68,779,650 (GRCm39) |
missense |
probably null |
1.00 |
|
R7215:Erbb4
|
UTSW |
1 |
68,378,619 (GRCm39) |
missense |
probably benign |
|
|
R7356:Erbb4
|
UTSW |
1 |
68,378,514 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7509:Erbb4
|
UTSW |
1 |
68,289,739 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R7593:Erbb4
|
UTSW |
1 |
68,293,758 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7743:Erbb4
|
UTSW |
1 |
68,367,278 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7784:Erbb4
|
UTSW |
1 |
68,114,658 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7815:Erbb4
|
UTSW |
1 |
68,081,885 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7923:Erbb4
|
UTSW |
1 |
68,298,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8071:Erbb4
|
UTSW |
1 |
68,435,470 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8288:Erbb4
|
UTSW |
1 |
68,337,509 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8356:Erbb4
|
UTSW |
1 |
68,110,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8456:Erbb4
|
UTSW |
1 |
68,110,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8464:Erbb4
|
UTSW |
1 |
68,348,785 (GRCm39) |
missense |
probably benign |
|
|
R8783:Erbb4
|
UTSW |
1 |
68,079,331 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8830:Erbb4
|
UTSW |
1 |
68,114,627 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8881:Erbb4
|
UTSW |
1 |
68,382,997 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9053:Erbb4
|
UTSW |
1 |
68,289,779 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R9142:Erbb4
|
UTSW |
1 |
68,388,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9237:Erbb4
|
UTSW |
1 |
68,081,601 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R9350:Erbb4
|
UTSW |
1 |
68,329,638 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9374:Erbb4
|
UTSW |
1 |
68,779,642 (GRCm39) |
nonsense |
probably null |
|
|
R9434:Erbb4
|
UTSW |
1 |
68,081,773 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R9499:Erbb4
|
UTSW |
1 |
68,779,642 (GRCm39) |
nonsense |
probably null |
|
|
R9551:Erbb4
|
UTSW |
1 |
68,779,642 (GRCm39) |
nonsense |
probably null |
|
|
R9753:Erbb4
|
UTSW |
1 |
68,238,062 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0019:Erbb4
|
UTSW |
1 |
68,112,304 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Erbb4
|
UTSW |
1 |
68,367,418 (GRCm39) |
nonsense |
probably null |
|
|
Z1176:Erbb4
|
UTSW |
1 |
68,337,561 (GRCm39) |
frame shift |
probably null |
|
|
Z1177:Erbb4
|
UTSW |
1 |
68,348,802 (GRCm39) |
missense |
probably benign |
0.06 |
|
Z1177:Erbb4
|
UTSW |
1 |
68,329,635 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Erbb4
|
UTSW |
1 |
68,298,342 (GRCm39) |
frame shift |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AGCAACTTCTCAGCACTACTAAGG -3'
(R):5'- ATGTATGCTGGCGTACTCTTC -3'
Sequencing Primer
(F):5'- TTATGGAGCAGAGAACTACCTCGTC -3'
(R):5'- GTATGCTGGCGTACTCTTCTAAAAGC -3'
|
| Posted On |
2016-02-04 |
Incidental Mutation