Incidental Mutation 'R4811:Erbb4'
| ID |
369400 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Erbb4
|
| Ensembl Gene |
ENSMUSG00000062209 |
| Gene Name |
erb-b2 receptor tyrosine kinase 4 |
| Synonyms |
Her4, ErbB4 |
| MMRRC Submission |
042430-MU
|
| Accession Numbers |
Ncbi RefSeq: NM_010154.1; MGI:104771
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R4811 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
1 |
| Chromosomal Location |
68032186-69108059 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 68254544 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Leucine
at position 729
(F729L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000114123
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000119142]
[ENSMUST00000121473]
[ENSMUST00000153432]
|
| AlphaFold |
Q61527 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000119142
AA Change: F729L
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000112713
Gene: ENSMUSG00000062209
AA Change: F729L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Recep_L_domain
|
55 |
167 |
5e-34 |
PFAM |
|
FU
|
183 |
223 |
2.07e1 |
SMART |
|
FU
|
226 |
268 |
5.78e-10 |
SMART |
|
Pfam:Recep_L_domain
|
358 |
478 |
1e-29 |
PFAM |
|
FU
|
493 |
544 |
6.45e-8 |
SMART |
|
FU
|
549 |
599 |
3.51e-9 |
SMART |
|
FU
|
611 |
659 |
2.32e0 |
SMART |
|
TyrKc
|
718 |
974 |
7.53e-133 |
SMART |
|
low complexity region
|
1007 |
1023 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000121473
AA Change: F729L
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000114123
Gene: ENSMUSG00000062209
AA Change: F729L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Recep_L_domain
|
55 |
167 |
1.6e-34 |
PFAM |
|
FU
|
183 |
223 |
2.07e1 |
SMART |
|
FU
|
226 |
268 |
5.78e-10 |
SMART |
|
Pfam:Recep_L_domain
|
358 |
478 |
5.5e-29 |
PFAM |
|
FU
|
493 |
544 |
6.45e-8 |
SMART |
|
FU
|
549 |
599 |
3.51e-9 |
SMART |
|
FU
|
611 |
659 |
2.32e0 |
SMART |
|
TyrKc
|
718 |
974 |
7.53e-133 |
SMART |
|
low complexity region
|
1007 |
1023 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000153432
AA Change: F719L
PolyPhen 2
Score 0.969 (Sensitivity: 0.77; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000115373
Gene: ENSMUSG00000062209
AA Change: F719L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Recep_L_domain
|
55 |
167 |
1.7e-34 |
PFAM |
|
FU
|
183 |
223 |
2.07e1 |
SMART |
|
FU
|
226 |
268 |
5.78e-10 |
SMART |
|
Pfam:Recep_L_domain
|
358 |
478 |
5.7e-29 |
PFAM |
|
FU
|
493 |
544 |
6.45e-8 |
SMART |
|
FU
|
549 |
599 |
3.51e-9 |
SMART |
|
FU
|
611 |
649 |
2.98e0 |
SMART |
|
PDB:2R4B|B
|
680 |
732 |
1e-25 |
PDB |
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.5%
- 20x: 93.0%
|
| Validation Efficiency |
|
| MGI Phenotype |
Strain: 1929607
Lethality: E10-E11
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for a targeted null mutation exhibit cardiac defects, alterations in hindbrain development, and midgestational lethality. Heterozygotes show schizophrenia-like behavior. Genetically rescued females show mammary defects. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(7) : Targeted(6) Gene trapped(1)
|
| Other mutations in this stock |
Total: 79 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930447A16Rik |
G |
A |
15: 37,425,708 (GRCm38) |
|
probably benign |
Het |
| Adam3 |
C |
T |
8: 24,711,724 (GRCm38) |
G208R |
probably benign |
Het |
| AI481877 |
T |
C |
4: 59,082,404 (GRCm38) |
N408S |
probably benign |
Het |
| Arsg |
G |
T |
11: 109,534,072 (GRCm38) |
V290L |
probably benign |
Het |
| Cad |
A |
G |
5: 31,074,690 (GRCm38) |
T104A |
probably benign |
Het |
| Ccdc180 |
A |
G |
4: 45,928,020 (GRCm38) |
N1185S |
probably damaging |
Het |
| Cdh18 |
A |
G |
15: 23,226,791 (GRCm38) |
T113A |
probably benign |
Het |
| Crocc2 |
G |
A |
1: 93,205,896 (GRCm38) |
A967T |
probably damaging |
Het |
| Cyp4f16 |
A |
G |
17: 32,545,106 (GRCm38) |
T291A |
probably benign |
Het |
| Dcc |
T |
A |
18: 71,299,483 (GRCm38) |
H1300L |
probably benign |
Het |
| Ddx23 |
T |
A |
15: 98,647,471 (GRCm38) |
|
probably null |
Het |
| Dnhd1 |
T |
G |
7: 105,714,281 (GRCm38) |
S4017A |
probably damaging |
Het |
| Ercc6 |
G |
T |
14: 32,574,929 (GRCm38) |
R1292L |
probably benign |
Het |
| Fam186b |
C |
T |
15: 99,280,237 (GRCm38) |
V403M |
probably benign |
Het |
| Fam227a |
T |
C |
15: 79,615,427 (GRCm38) |
N576D |
possibly damaging |
Het |
| Fam46b |
T |
C |
4: 133,486,370 (GRCm38) |
L184P |
probably benign |
Het |
| Fbln1 |
A |
G |
15: 85,226,966 (GRCm38) |
|
probably null |
Het |
| Fbxw17 |
T |
C |
13: 50,425,633 (GRCm38) |
V162A |
probably benign |
Het |
| Gas2l1 |
A |
C |
11: 5,064,436 (GRCm38) |
I8S |
probably damaging |
Het |
| Gm7030 |
A |
G |
17: 36,127,776 (GRCm38) |
L241S |
probably damaging |
Het |
| Golgb1 |
T |
C |
16: 36,891,419 (GRCm38) |
L195P |
probably damaging |
Het |
| Gps2 |
A |
T |
11: 69,915,928 (GRCm38) |
H233L |
probably damaging |
Het |
| Guf1 |
T |
G |
5: 69,564,509 (GRCm38) |
|
probably null |
Het |
| Il1rap |
T |
A |
16: 26,701,238 (GRCm38) |
|
probably null |
Het |
| Ints14 |
A |
G |
9: 64,964,518 (GRCm38) |
Y46C |
probably damaging |
Het |
| Kalrn |
T |
G |
16: 34,356,969 (GRCm38) |
Q293H |
probably damaging |
Het |
| Kank2 |
A |
G |
9: 21,775,747 (GRCm38) |
L593P |
probably damaging |
Het |
| Krt19 |
T |
C |
11: 100,141,348 (GRCm38) |
T297A |
possibly damaging |
Het |
| Lcp1 |
T |
C |
14: 75,200,408 (GRCm38) |
V86A |
probably damaging |
Het |
| Lins1 |
T |
A |
7: 66,708,150 (GRCm38) |
I11K |
probably benign |
Het |
| Lrba |
T |
C |
3: 86,776,141 (GRCm38) |
F2757L |
probably damaging |
Het |
| Lyst |
T |
C |
13: 13,777,100 (GRCm38) |
I3762T |
probably benign |
Het |
| Lyzl6 |
A |
G |
11: 103,635,025 (GRCm38) |
S90P |
possibly damaging |
Het |
| Mfsd2a |
T |
A |
4: 122,959,382 (GRCm38) |
Q38L |
probably benign |
Het |
| Mtss1 |
A |
G |
15: 58,944,073 (GRCm38) |
F546S |
probably damaging |
Het |
| Myo5a |
G |
A |
9: 75,141,543 (GRCm38) |
|
probably null |
Het |
| Naip6 |
C |
A |
13: 100,285,791 (GRCm38) |
G1245W |
probably damaging |
Het |
| Ndfip1 |
C |
T |
18: 38,451,592 (GRCm38) |
T107I |
probably benign |
Het |
| Nek8 |
C |
T |
11: 78,167,718 (GRCm38) |
|
probably null |
Het |
| Nphs1 |
T |
C |
7: 30,460,429 (GRCm38) |
V55A |
probably damaging |
Het |
| Nrp2 |
C |
A |
1: 62,719,081 (GRCm38) |
H75Q |
probably damaging |
Het |
| Oas1e |
C |
T |
5: 120,795,383 (GRCm38) |
S39N |
probably damaging |
Het |
| Olfr1164 |
A |
G |
2: 88,093,532 (GRCm38) |
F135L |
probably benign |
Het |
| Olfr1391 |
T |
G |
11: 49,327,748 (GRCm38) |
S112R |
possibly damaging |
Het |
| Olfr309 |
T |
C |
7: 86,306,958 (GRCm38) |
T52A |
probably benign |
Het |
| Olfr871 |
A |
T |
9: 20,212,753 (GRCm38) |
I135F |
probably damaging |
Het |
| Pan3 |
T |
A |
5: 147,530,058 (GRCm38) |
H632Q |
probably damaging |
Het |
| Paqr3 |
A |
C |
5: 97,095,983 (GRCm38) |
S291A |
probably benign |
Het |
| Pcdh17 |
A |
C |
14: 84,447,935 (GRCm38) |
D614A |
probably damaging |
Het |
| Pcyox1l |
T |
C |
18: 61,697,535 (GRCm38) |
E422G |
possibly damaging |
Het |
| Pgr |
G |
T |
9: 8,900,843 (GRCm38) |
E126* |
probably null |
Het |
| Pik3ap1 |
A |
G |
19: 41,302,497 (GRCm38) |
V532A |
possibly damaging |
Het |
| Pla2g4c |
T |
C |
7: 13,337,813 (GRCm38) |
I186T |
probably damaging |
Het |
| Pnkd |
G |
A |
1: 74,349,405 (GRCm38) |
|
probably null |
Het |
| Poc1a |
A |
G |
9: 106,349,709 (GRCm38) |
T334A |
probably damaging |
Het |
| Pou2f2 |
T |
A |
7: 25,097,686 (GRCm38) |
K211* |
probably null |
Het |
| Rdh13 |
T |
C |
7: 4,442,653 (GRCm38) |
E94G |
probably benign |
Het |
| Rnf186 |
A |
G |
4: 138,967,187 (GRCm38) |
S13G |
probably benign |
Het |
| Ryr2 |
T |
C |
13: 11,655,698 (GRCm38) |
R3471G |
probably damaging |
Het |
| Sbf2 |
T |
C |
7: 110,372,535 (GRCm38) |
T831A |
probably damaging |
Het |
| Sh3gl2 |
A |
G |
4: 85,398,166 (GRCm38) |
|
probably benign |
Het |
| Snn |
T |
C |
16: 11,072,533 (GRCm38) |
V72A |
probably benign |
Het |
| Sys1 |
T |
A |
2: 164,464,424 (GRCm38) |
H99Q |
possibly damaging |
Het |
| Syt7 |
A |
G |
19: 10,435,567 (GRCm38) |
K122R |
probably damaging |
Het |
| Tas1r2 |
T |
A |
4: 139,669,000 (GRCm38) |
L550Q |
probably damaging |
Het |
| Thoc1 |
T |
C |
18: 9,993,438 (GRCm38) |
I599T |
probably damaging |
Het |
| Tle3 |
C |
T |
9: 61,373,997 (GRCm38) |
|
probably benign |
Het |
| Tll1 |
A |
C |
8: 64,085,473 (GRCm38) |
V379G |
possibly damaging |
Het |
| Tnfrsf21 |
G |
A |
17: 43,037,730 (GRCm38) |
E78K |
probably benign |
Het |
| Tpgs2 |
A |
G |
18: 25,129,840 (GRCm38) |
|
probably benign |
Het |
| Trpm1 |
T |
C |
7: 64,208,306 (GRCm38) |
L165P |
probably damaging |
Het |
| Trpm5 |
T |
C |
7: 143,080,219 (GRCm38) |
Y750C |
probably damaging |
Het |
| Ttbk2 |
A |
C |
2: 120,740,070 (GRCm38) |
S1201A |
possibly damaging |
Het |
| Ust |
T |
A |
10: 8,245,941 (GRCm38) |
H301L |
probably damaging |
Het |
| Vwa5a |
T |
C |
9: 38,735,953 (GRCm38) |
F543L |
probably benign |
Het |
| Yeats2 |
T |
A |
16: 20,152,895 (GRCm38) |
|
probably null |
Het |
| Zfp85 |
T |
C |
13: 67,749,626 (GRCm38) |
Y109C |
probably damaging |
Het |
| Zfr2 |
T |
A |
10: 81,243,713 (GRCm38) |
V362E |
probably benign |
Het |
| Znrf3 |
A |
T |
11: 5,287,420 (GRCm38) |
C134S |
probably benign |
Het |
|
| Other mutations in Erbb4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00965:Erbb4
|
APN |
1 |
68,071,630 (GRCm38) |
nonsense |
probably null |
|
|
IGL01020:Erbb4
|
APN |
1 |
68,298,449 (GRCm38) |
splice site |
probably benign |
|
|
IGL01349:Erbb4
|
APN |
1 |
68,346,593 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL01386:Erbb4
|
APN |
1 |
68,343,931 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01516:Erbb4
|
APN |
1 |
68,328,245 (GRCm38) |
nonsense |
probably null |
|
|
IGL01536:Erbb4
|
APN |
1 |
68,290,282 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL01721:Erbb4
|
APN |
1 |
68,254,563 (GRCm38) |
missense |
possibly damaging |
0.46 |
|
IGL01832:Erbb4
|
APN |
1 |
68,254,566 (GRCm38) |
missense |
possibly damaging |
0.84 |
|
IGL02002:Erbb4
|
APN |
1 |
68,080,726 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02040:Erbb4
|
APN |
1 |
68,042,535 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02371:Erbb4
|
APN |
1 |
68,290,294 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL02399:Erbb4
|
APN |
1 |
68,042,437 (GRCm38) |
splice site |
probably benign |
|
|
IGL02553:Erbb4
|
APN |
1 |
68,305,864 (GRCm38) |
missense |
probably benign |
0.17 |
|
IGL03118:Erbb4
|
APN |
1 |
68,042,719 (GRCm38) |
missense |
probably benign |
0.11 |
|
IGL03329:Erbb4
|
APN |
1 |
68,328,122 (GRCm38) |
missense |
probably benign |
0.30 |
|
IGL03405:Erbb4
|
APN |
1 |
68,330,238 (GRCm38) |
missense |
probably benign |
0.02 |
|
earthworm
|
UTSW |
1 |
68,250,580 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
excrescence
|
UTSW |
1 |
68,330,246 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Mole
|
UTSW |
1 |
68,560,576 (GRCm38) |
missense |
probably damaging |
1.00 |
|
P0018:Erbb4
|
UTSW |
1 |
68,071,676 (GRCm38) |
missense |
probably benign |
0.05 |
|
PIT4480001:Erbb4
|
UTSW |
1 |
68,075,543 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0193:Erbb4
|
UTSW |
1 |
68,043,960 (GRCm38) |
intron |
probably benign |
|
|
R0329:Erbb4
|
UTSW |
1 |
68,298,280 (GRCm38) |
splice site |
probably benign |
|
|
R0335:Erbb4
|
UTSW |
1 |
68,259,259 (GRCm38) |
missense |
probably benign |
|
|
R0362:Erbb4
|
UTSW |
1 |
68,330,270 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R0579:Erbb4
|
UTSW |
1 |
68,042,462 (GRCm38) |
missense |
probably benign |
0.17 |
|
R0730:Erbb4
|
UTSW |
1 |
68,259,290 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R1029:Erbb4
|
UTSW |
1 |
68,309,614 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R1444:Erbb4
|
UTSW |
1 |
68,254,600 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1469:Erbb4
|
UTSW |
1 |
68,560,682 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1469:Erbb4
|
UTSW |
1 |
68,560,682 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1503:Erbb4
|
UTSW |
1 |
68,346,546 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1523:Erbb4
|
UTSW |
1 |
68,396,252 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R1528:Erbb4
|
UTSW |
1 |
68,078,582 (GRCm38) |
nonsense |
probably null |
|
|
R1604:Erbb4
|
UTSW |
1 |
68,346,569 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R1611:Erbb4
|
UTSW |
1 |
68,040,388 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1642:Erbb4
|
UTSW |
1 |
68,331,234 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1905:Erbb4
|
UTSW |
1 |
68,075,410 (GRCm38) |
splice site |
probably benign |
|
|
R1929:Erbb4
|
UTSW |
1 |
68,198,888 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R2046:Erbb4
|
UTSW |
1 |
68,298,323 (GRCm38) |
missense |
probably benign |
0.02 |
|
R2139:Erbb4
|
UTSW |
1 |
68,346,629 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R2271:Erbb4
|
UTSW |
1 |
68,198,888 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R2298:Erbb4
|
UTSW |
1 |
68,042,531 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2356:Erbb4
|
UTSW |
1 |
68,078,596 (GRCm38) |
missense |
probably benign |
0.00 |
|
R3821:Erbb4
|
UTSW |
1 |
68,305,913 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R4007:Erbb4
|
UTSW |
1 |
68,740,401 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4012:Erbb4
|
UTSW |
1 |
68,560,576 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4077:Erbb4
|
UTSW |
1 |
68,040,337 (GRCm38) |
missense |
probably benign |
0.07 |
|
R4196:Erbb4
|
UTSW |
1 |
68,343,855 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R4536:Erbb4
|
UTSW |
1 |
68,346,622 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4561:Erbb4
|
UTSW |
1 |
68,343,921 (GRCm38) |
nonsense |
probably null |
|
|
R4642:Erbb4
|
UTSW |
1 |
68,250,632 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4737:Erbb4
|
UTSW |
1 |
68,343,900 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R4739:Erbb4
|
UTSW |
1 |
68,343,900 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R4780:Erbb4
|
UTSW |
1 |
68,298,314 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4801:Erbb4
|
UTSW |
1 |
68,330,246 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4802:Erbb4
|
UTSW |
1 |
68,330,246 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4832:Erbb4
|
UTSW |
1 |
68,330,238 (GRCm38) |
missense |
probably benign |
0.02 |
|
R5068:Erbb4
|
UTSW |
1 |
68,043,902 (GRCm38) |
splice site |
probably null |
|
|
R5546:Erbb4
|
UTSW |
1 |
68,298,293 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5755:Erbb4
|
UTSW |
1 |
68,560,519 (GRCm38) |
missense |
possibly damaging |
0.96 |
|
R6189:Erbb4
|
UTSW |
1 |
68,043,916 (GRCm38) |
missense |
probably benign |
|
|
R6257:Erbb4
|
UTSW |
1 |
68,396,273 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6276:Erbb4
|
UTSW |
1 |
68,560,576 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6521:Erbb4
|
UTSW |
1 |
68,042,530 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6602:Erbb4
|
UTSW |
1 |
68,370,503 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6808:Erbb4
|
UTSW |
1 |
68,040,303 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7087:Erbb4
|
UTSW |
1 |
68,740,491 (GRCm38) |
missense |
probably null |
1.00 |
|
R7215:Erbb4
|
UTSW |
1 |
68,339,460 (GRCm38) |
missense |
probably benign |
|
|
R7356:Erbb4
|
UTSW |
1 |
68,339,355 (GRCm38) |
critical splice donor site |
probably null |
|
|
R7509:Erbb4
|
UTSW |
1 |
68,250,580 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
R7593:Erbb4
|
UTSW |
1 |
68,254,599 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R7743:Erbb4
|
UTSW |
1 |
68,328,119 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7784:Erbb4
|
UTSW |
1 |
68,075,499 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7815:Erbb4
|
UTSW |
1 |
68,042,726 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7923:Erbb4
|
UTSW |
1 |
68,259,209 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8071:Erbb4
|
UTSW |
1 |
68,396,311 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8288:Erbb4
|
UTSW |
1 |
68,298,350 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8356:Erbb4
|
UTSW |
1 |
68,071,630 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8456:Erbb4
|
UTSW |
1 |
68,071,630 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8464:Erbb4
|
UTSW |
1 |
68,309,626 (GRCm38) |
missense |
probably benign |
|
|
R8783:Erbb4
|
UTSW |
1 |
68,040,172 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R8830:Erbb4
|
UTSW |
1 |
68,075,468 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8881:Erbb4
|
UTSW |
1 |
68,343,838 (GRCm38) |
critical splice donor site |
probably null |
|
|
R9053:Erbb4
|
UTSW |
1 |
68,250,620 (GRCm38) |
missense |
possibly damaging |
0.63 |
|
R9142:Erbb4
|
UTSW |
1 |
68,349,393 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9237:Erbb4
|
UTSW |
1 |
68,042,442 (GRCm38) |
missense |
possibly damaging |
0.72 |
|
R9350:Erbb4
|
UTSW |
1 |
68,290,479 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9374:Erbb4
|
UTSW |
1 |
68,740,483 (GRCm38) |
nonsense |
probably null |
|
|
R9434:Erbb4
|
UTSW |
1 |
68,042,614 (GRCm38) |
missense |
possibly damaging |
0.84 |
|
R9499:Erbb4
|
UTSW |
1 |
68,740,483 (GRCm38) |
nonsense |
probably null |
|
|
R9551:Erbb4
|
UTSW |
1 |
68,740,483 (GRCm38) |
nonsense |
probably null |
|
|
R9753:Erbb4
|
UTSW |
1 |
68,198,903 (GRCm38) |
missense |
probably benign |
0.00 |
|
X0019:Erbb4
|
UTSW |
1 |
68,073,145 (GRCm38) |
missense |
probably benign |
0.00 |
|
Z1176:Erbb4
|
UTSW |
1 |
68,328,259 (GRCm38) |
nonsense |
probably null |
|
|
Z1176:Erbb4
|
UTSW |
1 |
68,298,402 (GRCm38) |
frame shift |
probably null |
|
|
Z1177:Erbb4
|
UTSW |
1 |
68,309,643 (GRCm38) |
missense |
probably benign |
0.06 |
|
Z1177:Erbb4
|
UTSW |
1 |
68,290,476 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1177:Erbb4
|
UTSW |
1 |
68,259,183 (GRCm38) |
frame shift |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AGCAACTTCTCAGCACTACTAAGG -3'
(R):5'- ATGTATGCTGGCGTACTCTTC -3'
Sequencing Primer
(F):5'- TTATGGAGCAGAGAACTACCTCGTC -3'
(R):5'- GTATGCTGGCGTACTCTTCTAAAAGC -3'
|
| Posted On |
2016-02-04 |
Incidental Mutation