Mutagenetix > Incidental Mutations

Incidental Mutation 'R4811:Yeats2'

369472

Institutional Source

Beutler Lab

Gene Symbol

Yeats2

Ensembl Gene

ENSMUSG00000041215

Gene Name

YEATS domain containing 2

Synonyms

MMRRC Submission

042430-MU

Accession Numbers

Ncbi RefSeq: NM_001145930.1, NM_001033237.2, NM_001145931.1; MGI:2447762

Is this an essential gene?

Probably essential (E-score: 0.964) question?

Stock #

R4811 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

20141063-20232573 bp(+) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

T to A at 20152895 bp

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000155892 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000090052] [ENSMUST00000115560] [ENSMUST00000231705] [ENSMUST00000232019] [ENSMUST00000232019] [ENSMUST00000232338]

Predicted Effect

probably null
Transcript: ENSMUST00000090052

SMART Domains

Protein: ENSMUSP00000087506
Gene: ENSMUSG00000041215

Domain	Start	End	E-Value	Type
Pfam:YEATS	179	262	2.6e-27	PFAM
low complexity region	299	309	N/A	INTRINSIC
low complexity region	312	333	N/A	INTRINSIC
low complexity region	409	429	N/A	INTRINSIC
low complexity region	458	467	N/A	INTRINSIC
internal_repeat_1	471	675	3.72e-6	PROSPERO
low complexity region	683	702	N/A	INTRINSIC
low complexity region	738	775	N/A	INTRINSIC
internal_repeat_1	785	978	3.72e-6	PROSPERO
low complexity region	1240	1249	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000115560

SMART Domains

Protein: ENSMUSP00000111222
Gene: ENSMUSG00000041215

Domain	Start	End	E-Value	Type
Pfam:YEATS	232	314	2.1e-28	PFAM
low complexity region	352	362	N/A	INTRINSIC
low complexity region	365	386	N/A	INTRINSIC
low complexity region	462	482	N/A	INTRINSIC
low complexity region	511	520	N/A	INTRINSIC
internal_repeat_1	524	728	4.68e-6	PROSPERO
low complexity region	736	755	N/A	INTRINSIC
low complexity region	791	828	N/A	INTRINSIC
internal_repeat_1	838	1031	4.68e-6	PROSPERO
low complexity region	1293	1302	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000231705

Predicted Effect

probably null
Transcript: ENSMUST00000232019

Predicted Effect

probably null
Transcript: ENSMUST00000232019

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000232172

Predicted Effect

probably benign
Transcript: ENSMUST00000232338

Coding Region Coverage

1x: 99.1%
3x: 98.4%
10x: 96.5%
20x: 93.0%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] YEATS2 is a scaffolding subunit of the ADA2A (TADA2A; MIM 602276)-containing (ATAC) histone acetyltransferase complex (Wang et al., 2008 [PubMed 18838386]).[supplied by OMIM, Apr 2010]

Allele List at MGI

All alleles(34) : Targeted(1) Gene trapped(33)

Other mutations in this stock

Total: 79 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930447A16Rik	G	A	15: 37,425,708		probably benign	Het
Adam3	C	T	8: 24,711,724	G208R	probably benign	Het
AI481877	T	C	4: 59,082,404	N408S	probably benign	Het
Arsg	G	T	11: 109,534,072	V290L	probably benign	Het
Cad	A	G	5: 31,074,690	T104A	probably benign	Het
Ccdc180	A	G	4: 45,928,020	N1185S	probably damaging	Het
Cdh18	A	G	15: 23,226,791	T113A	probably benign	Het
Crocc2	G	A	1: 93,205,896	A967T	probably damaging	Het
Cyp4f16	A	G	17: 32,545,106	T291A	probably benign	Het
Dcc	T	A	18: 71,299,483	H1300L	probably benign	Het
Ddx23	T	A	15: 98,647,471		probably null	Het
Dnhd1	T	G	7: 105,714,281	S4017A	probably damaging	Het
Erbb4	A	T	1: 68,254,544	F729L	probably damaging	Het
Ercc6	G	T	14: 32,574,929	R1292L	probably benign	Het
Fam186b	C	T	15: 99,280,237	V403M	probably benign	Het
Fam227a	T	C	15: 79,615,427	N576D	possibly damaging	Het
Fam46b	T	C	4: 133,486,370	L184P	probably benign	Het
Fbln1	A	G	15: 85,226,966		probably null	Het
Fbxw17	T	C	13: 50,425,633	V162A	probably benign	Het
Gas2l1	A	C	11: 5,064,436	I8S	probably damaging	Het
Gm7030	A	G	17: 36,127,776	L241S	probably damaging	Het
Golgb1	T	C	16: 36,891,419	L195P	probably damaging	Het
Gps2	A	T	11: 69,915,928	H233L	probably damaging	Het
Guf1	T	G	5: 69,564,509		probably null	Het
Il1rap	T	A	16: 26,701,238		probably null	Het
Ints14	A	G	9: 64,964,518	Y46C	probably damaging	Het
Kalrn	T	G	16: 34,356,969	Q293H	probably damaging	Het
Kank2	A	G	9: 21,775,747	L593P	probably damaging	Het
Krt19	T	C	11: 100,141,348	T297A	possibly damaging	Het
Lcp1	T	C	14: 75,200,408	V86A	probably damaging	Het
Lins1	T	A	7: 66,708,150	I11K	probably benign	Het
Lrba	T	C	3: 86,776,141	F2757L	probably damaging	Het
Lyst	T	C	13: 13,777,100	I3762T	probably benign	Het
Lyzl6	A	G	11: 103,635,025	S90P	possibly damaging	Het
Mfsd2a	T	A	4: 122,959,382	Q38L	probably benign	Het
Mtss1	A	G	15: 58,944,073	F546S	probably damaging	Het
Myo5a	G	A	9: 75,141,543		probably null	Het
Naip6	C	A	13: 100,285,791	G1245W	probably damaging	Het
Ndfip1	C	T	18: 38,451,592	T107I	probably benign	Het
Nek8	C	T	11: 78,167,718		probably null	Het
Nphs1	T	C	7: 30,460,429	V55A	probably damaging	Het
Nrp2	C	A	1: 62,719,081	H75Q	probably damaging	Het
Oas1e	C	T	5: 120,795,383	S39N	probably damaging	Het
Olfr1164	A	G	2: 88,093,532	F135L	probably benign	Het
Olfr1391	T	G	11: 49,327,748	S112R	possibly damaging	Het
Olfr309	T	C	7: 86,306,958	T52A	probably benign	Het
Olfr871	A	T	9: 20,212,753	I135F	probably damaging	Het
Pan3	T	A	5: 147,530,058	H632Q	probably damaging	Het
Paqr3	A	C	5: 97,095,983	S291A	probably benign	Het
Pcdh17	A	C	14: 84,447,935	D614A	probably damaging	Het
Pcyox1l	T	C	18: 61,697,535	E422G	possibly damaging	Het
Pgr	G	T	9: 8,900,843	E126*	probably null	Het
Pik3ap1	A	G	19: 41,302,497	V532A	possibly damaging	Het
Pla2g4c	T	C	7: 13,337,813	I186T	probably damaging	Het
Pnkd	G	A	1: 74,349,405		probably null	Het
Poc1a	A	G	9: 106,349,709	T334A	probably damaging	Het
Pou2f2	T	A	7: 25,097,686	K211*	probably null	Het
Rdh13	T	C	7: 4,442,653	E94G	probably benign	Het
Rnf186	A	G	4: 138,967,187	S13G	probably benign	Het
Ryr2	T	C	13: 11,655,698	R3471G	probably damaging	Het
Sbf2	T	C	7: 110,372,535	T831A	probably damaging	Het
Sh3gl2	A	G	4: 85,398,166		probably benign	Het
Snn	T	C	16: 11,072,533	V72A	probably benign	Het
Sys1	T	A	2: 164,464,424	H99Q	possibly damaging	Het
Syt7	A	G	19: 10,435,567	K122R	probably damaging	Het
Tas1r2	T	A	4: 139,669,000	L550Q	probably damaging	Het
Thoc1	T	C	18: 9,993,438	I599T	probably damaging	Het
Tle3	C	T	9: 61,373,997		probably benign	Het
Tll1	A	C	8: 64,085,473	V379G	possibly damaging	Het
Tnfrsf21	G	A	17: 43,037,730	E78K	probably benign	Het
Tpgs2	A	G	18: 25,129,840		probably benign	Het
Trpm1	T	C	7: 64,208,306	L165P	probably damaging	Het
Trpm5	T	C	7: 143,080,219	Y750C	probably damaging	Het
Ttbk2	A	C	2: 120,740,070	S1201A	possibly damaging	Het
Ust	T	A	10: 8,245,941	H301L	probably damaging	Het
Vwa5a	T	C	9: 38,735,953	F543L	probably benign	Het
Zfp85	T	C	13: 67,749,626	Y109C	probably damaging	Het
Zfr2	T	A	10: 81,243,713	V362E	probably benign	Het
Znrf3	A	T	11: 5,287,420	C134S	probably benign	Het

Other mutations in Yeats2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01118:Yeats2	APN	16	20186304	missense	probably damaging	0.99
IGL01128:Yeats2	APN	16	20161968	splice site	probably benign
IGL01139:Yeats2	APN	16	20214393	missense	probably damaging	1.00
IGL01394:Yeats2	APN	16	20162032	missense	probably damaging	0.99
IGL01482:Yeats2	APN	16	20222921	missense	probably damaging	1.00
IGL01924:Yeats2	APN	16	20206167	missense	probably damaging	1.00
IGL01925:Yeats2	APN	16	20179680	splice site	probably benign
IGL02106:Yeats2	APN	16	20193220	missense	possibly damaging	0.79
IGL02370:Yeats2	APN	16	20150471	missense	probably damaging	0.99
IGL02447:Yeats2	APN	16	20193679	missense	probably benign	0.00
IGL02669:Yeats2	APN	16	20186283	missense	probably benign	0.13
IGL03155:Yeats2	APN	16	20229573	critical splice donor site	probably null
tyrion	UTSW	16	20213401	splice site	probably benign
P0045:Yeats2	UTSW	16	20156945	missense	possibly damaging	0.47
R0051:Yeats2	UTSW	16	20193724	nonsense	probably null
R0051:Yeats2	UTSW	16	20193724	nonsense	probably null
R0118:Yeats2	UTSW	16	20156942	nonsense	probably null
R0157:Yeats2	UTSW	16	20221677	makesense	probably null
R0184:Yeats2	UTSW	16	20203685	missense	possibly damaging	0.79
R0194:Yeats2	UTSW	16	20152969	start codon destroyed	probably null	1.00
R0612:Yeats2	UTSW	16	20186425	missense	probably benign	0.00
R0655:Yeats2	UTSW	16	20193824	nonsense	probably null
R0826:Yeats2	UTSW	16	20193216	nonsense	probably null
R1526:Yeats2	UTSW	16	20206086	missense	probably damaging	1.00
R1535:Yeats2	UTSW	16	20189365	missense	probably damaging	0.99
R1749:Yeats2	UTSW	16	20186268	nonsense	probably null
R1842:Yeats2	UTSW	16	20171238	missense	probably damaging	1.00
R1843:Yeats2	UTSW	16	20229564	missense	probably benign	0.01
R1926:Yeats2	UTSW	16	20214426	missense	probably benign
R2000:Yeats2	UTSW	16	20186391	missense	probably benign	0.20
R2017:Yeats2	UTSW	16	20159181	missense	probably benign	0.01
R2076:Yeats2	UTSW	16	20186282	missense	possibly damaging	0.47
R2153:Yeats2	UTSW	16	20154166	missense	probably damaging	1.00
R2167:Yeats2	UTSW	16	20213401	splice site	probably benign
R2981:Yeats2	UTSW	16	20186301	missense	probably damaging	0.99
R3160:Yeats2	UTSW	16	20193645	missense	probably damaging	1.00
R3161:Yeats2	UTSW	16	20193645	missense	probably damaging	1.00
R3162:Yeats2	UTSW	16	20193645	missense	probably damaging	1.00
R3774:Yeats2	UTSW	16	20150495	missense	probably damaging	1.00
R4250:Yeats2	UTSW	16	20156935	missense	possibly damaging	0.90
R4305:Yeats2	UTSW	16	20208422	missense	probably damaging	1.00
R4455:Yeats2	UTSW	16	20161993	missense	possibly damaging	0.88
R4458:Yeats2	UTSW	16	20213321	missense	probably damaging	0.99
R4902:Yeats2	UTSW	16	20207668	missense	probably benign	0.00
R5043:Yeats2	UTSW	16	20208465	missense	probably damaging	1.00
R5047:Yeats2	UTSW	16	20208465	missense	probably damaging	1.00
R5319:Yeats2	UTSW	16	20186425	missense	probably benign	0.01
R5328:Yeats2	UTSW	16	20171205	missense	probably damaging	1.00
R5360:Yeats2	UTSW	16	20154162	missense	probably damaging	0.97
R5416:Yeats2	UTSW	16	20211569	missense	probably benign	0.01
R5672:Yeats2	UTSW	16	20162029	missense	probably damaging	1.00
R5684:Yeats2	UTSW	16	20193803	missense	possibly damaging	0.94
R5932:Yeats2	UTSW	16	20193163	missense	probably benign	0.06
R5946:Yeats2	UTSW	16	20207763	nonsense	probably null
R6168:Yeats2	UTSW	16	20179558	missense	probably benign	0.01
R6169:Yeats2	UTSW	16	20219667	missense	probably damaging	1.00
R6179:Yeats2	UTSW	16	20214475	missense	probably benign	0.16
R6371:Yeats2	UTSW	16	20221710	missense	possibly damaging	0.54
R6877:Yeats2	UTSW	16	20179594	missense	probably benign	0.00
R7149:Yeats2	UTSW	16	20154189	missense	probably damaging	1.00
R7405:Yeats2	UTSW	16	20222913	missense	probably damaging	1.00
R8353:Yeats2	UTSW	16	20222887	nonsense	probably null
R8367:Yeats2	UTSW	16	20222825	missense	probably damaging	1.00
R8453:Yeats2	UTSW	16	20222887	nonsense	probably null
R8506:Yeats2	UTSW	16	20152934	missense	probably damaging	0.98
R8535:Yeats2	UTSW	16	20159176	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- CCTATCTTACAGTTTCATGCAGATG -3'
(R):5'- TATCTGGGGATGGAAGTTCAAG -3'

Sequencing Primer
(F):5'- GGCTATTGTGTGATGAACTC -3'
(R):5'- AAGATTCATGTGCTCCAGGC -3'

Posted On

2016-02-04