Incidental Mutation 'R4818:Larp1b'
ID 369980
Institutional Source Beutler Lab
Gene Symbol Larp1b
Ensembl Gene ENSMUSG00000025762
Gene Name La ribonucleoprotein 1B
Synonyms 4933421B21Rik, Larp2, 1700108L22Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4818 (G1)
Quality Score 225
Status Validated
Chromosome 3
Chromosomal Location 40904263-40994669 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 40925005 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 208 (Y208H)
Ref Sequence ENSEMBL: ENSMUSP00000141487 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000048490] [ENSMUST00000191805] [ENSMUST00000191872]
AlphaFold F6U5V1
Predicted Effect probably damaging
Transcript: ENSMUST00000048490
AA Change: Y208H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000037127
Gene: ENSMUSG00000025762
AA Change: Y208H

DomainStartEndE-ValueType
low complexity region 28 49 N/A INTRINSIC
low complexity region 122 133 N/A INTRINSIC
low complexity region 138 164 N/A INTRINSIC
LA 213 291 4.35e-37 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000191805
AA Change: Y208H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000141487
Gene: ENSMUSG00000025762
AA Change: Y208H

DomainStartEndE-ValueType
low complexity region 28 49 N/A INTRINSIC
low complexity region 122 133 N/A INTRINSIC
low complexity region 138 164 N/A INTRINSIC
LA 213 291 4.35e-37 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000191872
AA Change: Y161H

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000142106
Gene: ENSMUSG00000025762
AA Change: Y161H

DomainStartEndE-ValueType
low complexity region 28 49 N/A INTRINSIC
low complexity region 70 86 N/A INTRINSIC
low complexity region 91 117 N/A INTRINSIC
LA 166 244 4.35e-37 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000191998
Predicted Effect unknown
Transcript: ENSMUST00000193795
AA Change: Y189H
Meta Mutation Damage Score 0.3870 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.8%
  • 20x: 94.1%
Validation Efficiency 100% (73/73)
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932414N04Rik A G 2: 68,571,810 (GRCm39) E562G probably benign Het
5730522E02Rik A G 11: 25,720,472 (GRCm39) probably null Het
A930033H14Rik A T 10: 69,048,190 (GRCm39) probably benign Het
Abca17 C T 17: 24,536,135 (GRCm39) E511K probably damaging Het
Abca9 C T 11: 110,045,980 (GRCm39) probably null Het
Abhd5 T A 9: 122,192,865 (GRCm39) probably null Het
Adra2b G A 2: 127,206,012 (GRCm39) W171* probably null Het
Ahcyl G A 16: 45,974,555 (GRCm39) T274I probably damaging Het
Aldh1l1 T C 6: 90,573,897 (GRCm39) Y799H probably benign Het
Arfgef1 A G 1: 10,286,772 (GRCm39) V46A probably benign Het
Arhgap40 A G 2: 158,381,639 (GRCm39) E374G probably damaging Het
Arhgef5 G A 6: 43,250,484 (GRCm39) V412I probably benign Het
Arid3c T C 4: 41,730,072 (GRCm39) E41G possibly damaging Het
Atp8b4 T A 2: 126,164,736 (GRCm39) K1193N probably benign Het
C4a C T 17: 35,035,975 (GRCm39) noncoding transcript Het
Chst2 C T 9: 95,287,417 (GRCm39) D310N probably damaging Het
Crtc3 T C 7: 80,327,170 (GRCm39) Q52R possibly damaging Het
Crybg1 T C 10: 43,874,583 (GRCm39) I842V probably benign Het
Dennd4c T C 4: 86,743,511 (GRCm39) S1167P probably benign Het
Edem3 T C 1: 151,668,136 (GRCm39) V305A possibly damaging Het
Epha10 T A 4: 124,780,007 (GRCm39) probably null Het
Epha6 C A 16: 59,474,426 (GRCm39) R1117L probably damaging Het
Fdx2 T C 9: 20,979,160 (GRCm39) I144V possibly damaging Het
Gm10762 C T 2: 128,809,106 (GRCm39) W81* probably null Het
Hus1 A G 11: 8,946,808 (GRCm39) probably benign Het
Igbp1b C T 6: 138,634,803 (GRCm39) E214K probably benign Het
Inpp5f A G 7: 128,286,853 (GRCm39) I577M probably damaging Het
Kansl2 G A 15: 98,424,542 (GRCm39) T296I possibly damaging Het
Kcna6 A G 6: 126,715,387 (GRCm39) F501L probably benign Het
Kirrel2 A T 7: 30,149,293 (GRCm39) V579D probably benign Het
Lipf A T 19: 33,943,088 (GRCm39) D132V probably benign Het
Lsm12 T C 11: 102,057,989 (GRCm39) K40E probably damaging Het
Mastl A G 2: 23,027,038 (GRCm39) S275P probably benign Het
Mettl25b C A 3: 87,832,305 (GRCm39) R293L probably benign Het
Mrpl44 A G 1: 79,758,694 (GRCm39) I281V probably benign Het
Mtf1 T A 4: 124,698,505 (GRCm39) M1K probably null Het
Muc4 G C 16: 32,753,919 (GRCm38) R1265P probably benign Het
Myh2 G A 11: 67,067,081 (GRCm39) G179R probably damaging Het
Nfasc T C 1: 132,531,568 (GRCm39) T739A possibly damaging Het
Nfatc3 G A 8: 106,835,011 (GRCm39) V778I probably benign Het
Notch4 A G 17: 34,797,690 (GRCm39) probably benign Het
Npm2 T C 14: 70,889,842 (GRCm39) N24S probably benign Het
Obox7 T A 7: 14,398,410 (GRCm39) L108Q probably damaging Het
Or51ah3 T A 7: 103,209,968 (GRCm39) F95I probably benign Het
Pax3 A G 1: 78,108,869 (GRCm39) V263A probably damaging Het
Pdlim1 C T 19: 40,211,580 (GRCm39) V238I probably damaging Het
Pik3ip1 G A 11: 3,280,928 (GRCm39) probably benign Het
Ptprq A G 10: 107,546,442 (GRCm39) V284A possibly damaging Het
Rad9b G A 5: 122,477,839 (GRCm39) T179I probably damaging Het
Sirt4 G T 5: 115,617,785 (GRCm39) D290E possibly damaging Het
Skint6 T A 4: 112,812,589 (GRCm39) probably benign Het
Slc18a1 A C 8: 69,492,951 (GRCm39) I466S probably damaging Het
Slc35e4 C T 11: 3,862,889 (GRCm39) R100H probably benign Het
Sptbn5 T G 2: 119,898,449 (GRCm39) K470Q probably benign Het
Tas1r1 C G 4: 152,117,131 (GRCm39) V168L probably benign Het
Tmem233 T A 5: 116,221,222 (GRCm39) Q8L possibly damaging Het
Ttc17 G T 2: 94,163,236 (GRCm39) Q862K possibly damaging Het
Zdhhc1 CGGGGG CGGGGGG 8: 106,210,376 (GRCm39) probably null Het
Zfp1004 T A 2: 150,033,981 (GRCm39) C132S probably damaging Het
Zfp229 T C 17: 21,962,885 (GRCm39) I68T probably benign Het
Zfp423 A G 8: 88,631,128 (GRCm39) V30A probably benign Het
Other mutations in Larp1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01506:Larp1b APN 3 40,987,875 (GRCm39) nonsense probably null
IGL01636:Larp1b APN 3 40,924,913 (GRCm39) missense probably benign 0.35
IGL01845:Larp1b APN 3 40,924,960 (GRCm39) missense probably benign 0.03
IGL02192:Larp1b APN 3 40,921,929 (GRCm39) missense probably benign 0.01
IGL03372:Larp1b APN 3 40,978,962 (GRCm39) missense possibly damaging 0.79
R0396:Larp1b UTSW 3 40,924,996 (GRCm39) missense probably damaging 1.00
R0512:Larp1b UTSW 3 40,924,469 (GRCm39) missense probably benign 0.00
R0975:Larp1b UTSW 3 40,924,925 (GRCm39) missense probably damaging 0.99
R1119:Larp1b UTSW 3 40,987,963 (GRCm39) missense possibly damaging 0.87
R1337:Larp1b UTSW 3 40,987,837 (GRCm39) missense probably damaging 1.00
R1460:Larp1b UTSW 3 40,916,653 (GRCm39) missense probably benign
R1565:Larp1b UTSW 3 40,926,819 (GRCm39) missense probably damaging 1.00
R1589:Larp1b UTSW 3 40,987,909 (GRCm39) missense probably damaging 1.00
R1640:Larp1b UTSW 3 40,988,507 (GRCm39) start codon destroyed probably null 0.04
R1899:Larp1b UTSW 3 40,918,519 (GRCm39) missense probably benign 0.04
R2133:Larp1b UTSW 3 40,924,970 (GRCm39) missense possibly damaging 0.69
R3054:Larp1b UTSW 3 40,918,535 (GRCm39) missense probably benign 0.10
R4621:Larp1b UTSW 3 40,918,424 (GRCm39) missense possibly damaging 0.71
R5023:Larp1b UTSW 3 40,988,420 (GRCm39) missense possibly damaging 0.88
R5166:Larp1b UTSW 3 40,918,487 (GRCm39) nonsense probably null
R5357:Larp1b UTSW 3 40,978,950 (GRCm39) missense probably benign 0.04
R5364:Larp1b UTSW 3 40,931,658 (GRCm39) missense probably damaging 0.99
R5492:Larp1b UTSW 3 40,924,334 (GRCm39) missense probably damaging 0.99
R5495:Larp1b UTSW 3 40,990,257 (GRCm39) missense probably damaging 1.00
R7070:Larp1b UTSW 3 40,931,086 (GRCm39) missense probably damaging 1.00
R7293:Larp1b UTSW 3 40,939,879 (GRCm39) missense
R7615:Larp1b UTSW 3 40,990,251 (GRCm39) missense probably benign 0.01
R7615:Larp1b UTSW 3 40,987,969 (GRCm39) missense possibly damaging 0.79
R7717:Larp1b UTSW 3 40,926,879 (GRCm39) missense probably damaging 0.97
R8060:Larp1b UTSW 3 40,939,837 (GRCm39) missense
R8282:Larp1b UTSW 3 40,991,245 (GRCm39) missense probably damaging 0.99
R8429:Larp1b UTSW 3 40,931,662 (GRCm39) makesense probably null
R8458:Larp1b UTSW 3 40,930,995 (GRCm39) missense probably benign 0.00
R9189:Larp1b UTSW 3 40,925,039 (GRCm39) missense probably damaging 1.00
R9468:Larp1b UTSW 3 40,930,990 (GRCm39) missense probably benign 0.00
R9628:Larp1b UTSW 3 40,916,103 (GRCm39) critical splice donor site probably null
X0021:Larp1b UTSW 3 40,921,929 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- AGTAGTCCTCTGACACGATGGG -3'
(R):5'- GGCAATGACATTTTAACTACTCTCTGG -3'

Sequencing Primer
(F):5'- TCTGACACGATGGGTCAGCTAATC -3'
(R):5'- TTCTCAATATCCTAGGGGGG -3'
Posted On 2016-02-04