Incidental Mutation 'R4818:Fdx2'
ID 370004
Institutional Source Beutler Lab
Gene Symbol Fdx2
Ensembl Gene ENSMUSG00000079677
Gene Name ferredoxin 2
Synonyms B230118G17Rik, Fdx1l
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4818 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 20978808-20984827 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 20979160 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 144 (I144V)
Ref Sequence ENSEMBL: ENSMUSP00000010348 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000010348] [ENSMUST00000115494] [ENSMUST00000213826] [ENSMUST00000217359]
AlphaFold Q9CPW2
Predicted Effect possibly damaging
Transcript: ENSMUST00000010348
AA Change: I144V

PolyPhen 2 Score 0.953 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000010348
Gene: ENSMUSG00000079677
AA Change: I144V

DomainStartEndE-ValueType
Pfam:Fer2 64 147 5.3e-12 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000115494
SMART Domains Protein: ENSMUSP00000111157
Gene: ENSMUSG00000079681

DomainStartEndE-ValueType
Pfam:GATA 197 231 7.8e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213826
AA Change: I58V

PolyPhen 2 Score 0.128 (Sensitivity: 0.93; Specificity: 0.86)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215338
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215631
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216484
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217150
Predicted Effect probably benign
Transcript: ENSMUST00000217359
Predicted Effect probably benign
Transcript: ENSMUST00000217282
Meta Mutation Damage Score 0.0684 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.8%
  • 20x: 94.1%
Validation Efficiency 100% (73/73)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the ferredoxin family. The encoded protein contains a 2Fe-2S ferredoxin-type domain and is essential for heme A and Fe/S protein biosynthesis. Mutation in FDX1L gene is associated with mitochondrial muscle myopathy. [provided by RefSeq, Sep 2014]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932414N04Rik A G 2: 68,571,810 (GRCm39) E562G probably benign Het
5730522E02Rik A G 11: 25,720,472 (GRCm39) probably null Het
A930033H14Rik A T 10: 69,048,190 (GRCm39) probably benign Het
Abca17 C T 17: 24,536,135 (GRCm39) E511K probably damaging Het
Abca9 C T 11: 110,045,980 (GRCm39) probably null Het
Abhd5 T A 9: 122,192,865 (GRCm39) probably null Het
Adra2b G A 2: 127,206,012 (GRCm39) W171* probably null Het
Ahcyl G A 16: 45,974,555 (GRCm39) T274I probably damaging Het
Aldh1l1 T C 6: 90,573,897 (GRCm39) Y799H probably benign Het
Arfgef1 A G 1: 10,286,772 (GRCm39) V46A probably benign Het
Arhgap40 A G 2: 158,381,639 (GRCm39) E374G probably damaging Het
Arhgef5 G A 6: 43,250,484 (GRCm39) V412I probably benign Het
Arid3c T C 4: 41,730,072 (GRCm39) E41G possibly damaging Het
Atp8b4 T A 2: 126,164,736 (GRCm39) K1193N probably benign Het
C4a C T 17: 35,035,975 (GRCm39) noncoding transcript Het
Chst2 C T 9: 95,287,417 (GRCm39) D310N probably damaging Het
Crtc3 T C 7: 80,327,170 (GRCm39) Q52R possibly damaging Het
Crybg1 T C 10: 43,874,583 (GRCm39) I842V probably benign Het
Dennd4c T C 4: 86,743,511 (GRCm39) S1167P probably benign Het
Edem3 T C 1: 151,668,136 (GRCm39) V305A possibly damaging Het
Epha10 T A 4: 124,780,007 (GRCm39) probably null Het
Epha6 C A 16: 59,474,426 (GRCm39) R1117L probably damaging Het
Gm10762 C T 2: 128,809,106 (GRCm39) W81* probably null Het
Hus1 A G 11: 8,946,808 (GRCm39) probably benign Het
Igbp1b C T 6: 138,634,803 (GRCm39) E214K probably benign Het
Inpp5f A G 7: 128,286,853 (GRCm39) I577M probably damaging Het
Kansl2 G A 15: 98,424,542 (GRCm39) T296I possibly damaging Het
Kcna6 A G 6: 126,715,387 (GRCm39) F501L probably benign Het
Kirrel2 A T 7: 30,149,293 (GRCm39) V579D probably benign Het
Larp1b T C 3: 40,925,005 (GRCm39) Y208H probably damaging Het
Lipf A T 19: 33,943,088 (GRCm39) D132V probably benign Het
Lsm12 T C 11: 102,057,989 (GRCm39) K40E probably damaging Het
Mastl A G 2: 23,027,038 (GRCm39) S275P probably benign Het
Mettl25b C A 3: 87,832,305 (GRCm39) R293L probably benign Het
Mrpl44 A G 1: 79,758,694 (GRCm39) I281V probably benign Het
Mtf1 T A 4: 124,698,505 (GRCm39) M1K probably null Het
Muc4 G C 16: 32,753,919 (GRCm38) R1265P probably benign Het
Myh2 G A 11: 67,067,081 (GRCm39) G179R probably damaging Het
Nfasc T C 1: 132,531,568 (GRCm39) T739A possibly damaging Het
Nfatc3 G A 8: 106,835,011 (GRCm39) V778I probably benign Het
Notch4 A G 17: 34,797,690 (GRCm39) probably benign Het
Npm2 T C 14: 70,889,842 (GRCm39) N24S probably benign Het
Obox7 T A 7: 14,398,410 (GRCm39) L108Q probably damaging Het
Or51ah3 T A 7: 103,209,968 (GRCm39) F95I probably benign Het
Pax3 A G 1: 78,108,869 (GRCm39) V263A probably damaging Het
Pdlim1 C T 19: 40,211,580 (GRCm39) V238I probably damaging Het
Pik3ip1 G A 11: 3,280,928 (GRCm39) probably benign Het
Ptprq A G 10: 107,546,442 (GRCm39) V284A possibly damaging Het
Rad9b G A 5: 122,477,839 (GRCm39) T179I probably damaging Het
Sirt4 G T 5: 115,617,785 (GRCm39) D290E possibly damaging Het
Skint6 T A 4: 112,812,589 (GRCm39) probably benign Het
Slc18a1 A C 8: 69,492,951 (GRCm39) I466S probably damaging Het
Slc35e4 C T 11: 3,862,889 (GRCm39) R100H probably benign Het
Sptbn5 T G 2: 119,898,449 (GRCm39) K470Q probably benign Het
Tas1r1 C G 4: 152,117,131 (GRCm39) V168L probably benign Het
Tmem233 T A 5: 116,221,222 (GRCm39) Q8L possibly damaging Het
Ttc17 G T 2: 94,163,236 (GRCm39) Q862K possibly damaging Het
Zdhhc1 CGGGGG CGGGGGG 8: 106,210,376 (GRCm39) probably null Het
Zfp1004 T A 2: 150,033,981 (GRCm39) C132S probably damaging Het
Zfp229 T C 17: 21,962,885 (GRCm39) I68T probably benign Het
Zfp423 A G 8: 88,631,128 (GRCm39) V30A probably benign Het
Other mutations in Fdx2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00952:Fdx2 APN 9 20,984,558 (GRCm39) critical splice donor site probably null
IGL02090:Fdx2 APN 9 20,984,766 (GRCm39) missense probably benign 0.00
IGL02207:Fdx2 APN 9 20,979,415 (GRCm39) critical splice acceptor site probably null
R1434:Fdx2 UTSW 9 20,984,694 (GRCm39) missense probably benign
R2093:Fdx2 UTSW 9 20,984,720 (GRCm39) missense probably benign 0.05
R5534:Fdx2 UTSW 9 20,984,562 (GRCm39) missense probably benign 0.01
R5776:Fdx2 UTSW 9 20,984,778 (GRCm39) missense possibly damaging 0.59
R7886:Fdx2 UTSW 9 20,984,623 (GRCm39) splice site probably null
R9593:Fdx2 UTSW 9 20,979,097 (GRCm39) missense probably damaging 1.00
R9663:Fdx2 UTSW 9 20,984,717 (GRCm39) missense probably benign
Z1176:Fdx2 UTSW 9 20,984,788 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- CACTGTGGGTCCAACTTCTC -3'
(R):5'- TGTATGTGAGTGAGGCCCAC -3'

Sequencing Primer
(F):5'- CTTTCCTGGGCAGTCCG -3'
(R):5'- GCCCACCTGGATCTCCTG -3'
Posted On 2016-02-04