Incidental Mutation 'R4819:Ik'
ID 370085
Institutional Source Beutler Lab
Gene Symbol Ik
Ensembl Gene ENSMUSG00000024474
Gene Name IK cytokine
Synonyms MuRED
MMRRC Submission 042000-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.968) question?
Stock # R4819 (G1)
Quality Score 225
Status Not validated
Chromosome 18
Chromosomal Location 36877709-36890692 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to A at 36886310 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000007042 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000007042]
AlphaFold Q9Z1M8
Predicted Effect probably null
Transcript: ENSMUST00000007042
SMART Domains Protein: ENSMUSP00000007042
Gene: ENSMUSG00000024474

DomainStartEndE-ValueType
low complexity region 42 56 N/A INTRINSIC
Pfam:RED_N 76 302 1.6e-105 PFAM
low complexity region 334 380 N/A INTRINSIC
Pfam:RED_C 445 554 1.1e-52 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000224284
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.3%
  • 10x: 96.5%
  • 20x: 93.3%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene was identified by its RED repeat, a stretch of repeated arginine, glutamic acid and aspartic acid residues. The protein localizes to discrete dots within the nucleus, excluding the nucleolus. Its function is unknown. This gene maps to chromosome 5; however, a pseudogene may exist on chromosome 2. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 T A 11: 9,240,421 (GRCm39) N761K possibly damaging Het
Adgrf3 T A 5: 30,403,442 (GRCm39) L444F possibly damaging Het
Akap8 G A 17: 32,531,279 (GRCm39) R378W probably damaging Het
Amotl2 C T 9: 102,607,270 (GRCm39) R693W probably damaging Het
As3mt G T 19: 46,695,968 (GRCm39) probably benign Het
Atp6v1e2 A G 17: 87,251,966 (GRCm39) V144A probably benign Het
Bfar C T 16: 13,505,331 (GRCm39) Q114* probably null Het
Casd1 C T 6: 4,621,225 (GRCm39) A261V probably damaging Het
Cd177 A T 7: 24,451,696 (GRCm39) I440K probably damaging Het
Cfap54 G T 10: 92,672,339 (GRCm39) Y2910* probably null Het
Csl A G 10: 99,593,944 (GRCm39) F374L possibly damaging Het
Dctn1 G A 6: 83,167,501 (GRCm39) R275H probably damaging Het
Derl3 A G 10: 75,729,713 (GRCm39) probably null Het
Dst A G 1: 34,007,916 (GRCm39) I117V probably benign Het
Edc3 T A 9: 57,655,680 (GRCm39) C477S possibly damaging Het
Efs T C 14: 55,154,610 (GRCm39) E450G probably damaging Het
Fcrla T A 1: 170,748,508 (GRCm39) I212F probably damaging Het
Fsip2 A G 2: 82,818,786 (GRCm39) I4840V probably benign Het
Gpam T A 19: 55,066,773 (GRCm39) I581F probably benign Het
Greb1l A G 18: 10,458,358 (GRCm39) D45G probably damaging Het
Heca A G 10: 17,783,820 (GRCm39) Y478H probably damaging Het
Hspa9 C T 18: 35,072,441 (GRCm39) M561I probably damaging Het
Hyal6 T A 6: 24,734,965 (GRCm39) Y299* probably null Het
Iho1 A G 9: 108,283,877 (GRCm39) V189A probably benign Het
Khsrp A G 17: 57,330,360 (GRCm39) S582P possibly damaging Het
Kif18a A G 2: 109,122,471 (GRCm39) D182G probably damaging Het
Krt1c T C 15: 101,719,979 (GRCm39) T564A unknown Het
Lig4 A G 8: 10,021,885 (GRCm39) S632P probably benign Het
Med1 C T 11: 98,046,258 (GRCm39) probably benign Het
Mgat3 T A 15: 80,096,550 (GRCm39) I459N probably damaging Het
Mkln1 A T 6: 31,451,421 (GRCm39) Q454L probably benign Het
Mn1 A G 5: 111,567,803 (GRCm39) E591G possibly damaging Het
Myo5c T A 9: 75,199,484 (GRCm39) L1364Q probably damaging Het
Oas1d T C 5: 121,053,780 (GRCm39) V80A probably damaging Het
Obscn A T 11: 58,929,674 (GRCm39) D5180E probably damaging Het
Pax6 G A 2: 105,522,622 (GRCm39) probably null Het
Pcdh15 A C 10: 74,160,221 (GRCm39) N446T probably damaging Het
Pcnx2 A T 8: 126,581,969 (GRCm39) F922L probably benign Het
Ptpn4 G T 1: 119,587,580 (GRCm39) T921K probably benign Het
Selenov A G 7: 27,989,746 (GRCm39) probably null Het
Tmem100 A G 11: 89,926,271 (GRCm39) T33A probably benign Het
Tmem59 C T 4: 107,044,878 (GRCm39) Q66* probably null Het
Trav21-dv12 T A 14: 54,114,070 (GRCm39) Y63* probably null Het
Trim66 G T 7: 109,056,793 (GRCm39) H1121Q probably damaging Het
Trim80 A G 11: 115,338,769 (GRCm39) Y533C probably damaging Het
Ttc17 G A 2: 94,194,955 (GRCm39) P520L probably damaging Het
Ttn A T 2: 76,622,093 (GRCm39) V15483E probably damaging Het
Vinac1 G T 2: 128,882,721 (GRCm39) N98K probably damaging Het
Zdhhc1 CGGGGG CGGGGGG 8: 106,210,376 (GRCm39) probably null Het
Zfhx4 C A 3: 5,468,974 (GRCm39) T3069K probably benign Het
Zfp281 A G 1: 136,553,448 (GRCm39) H142R probably benign Het
Zfp462 G T 4: 55,060,044 (GRCm39) R1190L probably damaging Het
Zfp935 T A 13: 62,602,231 (GRCm39) H323L probably damaging Het
Other mutations in Ik
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00536:Ik APN 18 36,889,921 (GRCm39) nonsense probably null
IGL01409:Ik APN 18 36,889,974 (GRCm39) missense probably damaging 1.00
IGL01636:Ik APN 18 36,884,254 (GRCm39) missense possibly damaging 0.63
IGL02282:Ik APN 18 36,878,697 (GRCm39) missense probably damaging 0.99
IGL02422:Ik APN 18 36,886,313 (GRCm39) critical splice acceptor site probably null
IGL03263:Ik APN 18 36,881,699 (GRCm39) missense probably damaging 0.98
IGL03356:Ik APN 18 36,889,657 (GRCm39) missense probably damaging 1.00
R0675:Ik UTSW 18 36,880,386 (GRCm39) unclassified probably benign
R1778:Ik UTSW 18 36,889,871 (GRCm39) unclassified probably benign
R4060:Ik UTSW 18 36,881,943 (GRCm39) missense probably damaging 0.96
R4606:Ik UTSW 18 36,886,608 (GRCm39) missense possibly damaging 0.68
R4684:Ik UTSW 18 36,885,467 (GRCm39) missense probably damaging 1.00
R4978:Ik UTSW 18 36,880,468 (GRCm39) missense possibly damaging 0.54
R5256:Ik UTSW 18 36,881,926 (GRCm39) missense probably benign 0.00
R5751:Ik UTSW 18 36,886,566 (GRCm39) missense probably benign 0.07
R5966:Ik UTSW 18 36,888,531 (GRCm39) missense possibly damaging 0.50
R6378:Ik UTSW 18 36,890,341 (GRCm39) missense probably damaging 1.00
R6952:Ik UTSW 18 36,886,613 (GRCm39) missense probably damaging 1.00
R7068:Ik UTSW 18 36,888,518 (GRCm39) missense possibly damaging 0.57
R7143:Ik UTSW 18 36,884,230 (GRCm39) missense probably damaging 1.00
R7242:Ik UTSW 18 36,881,275 (GRCm39) missense probably null 1.00
R9251:Ik UTSW 18 36,880,495 (GRCm39) critical splice donor site probably null
R9483:Ik UTSW 18 36,886,635 (GRCm39) missense probably benign 0.20
R9565:Ik UTSW 18 36,886,959 (GRCm39) missense probably benign 0.00
R9694:Ik UTSW 18 36,877,840 (GRCm39) missense probably benign
R9715:Ik UTSW 18 36,886,566 (GRCm39) missense probably benign 0.07
Z1088:Ik UTSW 18 36,877,835 (GRCm39) nonsense probably null
Z1176:Ik UTSW 18 36,886,568 (GRCm39) missense possibly damaging 0.71
Predicted Primers PCR Primer
(F):5'- TTGGGTTTGAAGCATCAAGGAG -3'
(R):5'- TGGGAAAACCAGGTTCCAC -3'

Sequencing Primer
(F):5'- TACCAGGTACATATGTGGTGCAC -3'
(R):5'- TGGGAAAACCAGGTTCCACTAATTG -3'
Posted On 2016-02-04