Incidental Mutation 'R4821:Rgs6'
ID 370242
Institutional Source Beutler Lab
Gene Symbol Rgs6
Ensembl Gene ENSMUSG00000021219
Gene Name regulator of G-protein signaling 6
Synonyms
MMRRC Submission 042437-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.147) question?
Stock # R4821 (G1)
Quality Score 225
Status Validated
Chromosome 12
Chromosomal Location 82663325-83208835 bp(+) (GRCm39)
Type of Mutation critical splice acceptor site
DNA Base Change (assembly) A to T at 83114185 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000143961 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000101234] [ENSMUST00000101234] [ENSMUST00000161801] [ENSMUST00000185665] [ENSMUST00000185674] [ENSMUST00000185674] [ENSMUST00000186081] [ENSMUST00000186309] [ENSMUST00000186309] [ENSMUST00000186848] [ENSMUST00000186323] [ENSMUST00000186323] [ENSMUST00000186458] [ENSMUST00000191107] [ENSMUST00000191311] [ENSMUST00000191311] [ENSMUST00000191352] [ENSMUST00000191352] [ENSMUST00000200911] [ENSMUST00000202210] [ENSMUST00000201271]
AlphaFold Q9Z2H2
Predicted Effect probably null
Transcript: ENSMUST00000101234
SMART Domains Protein: ENSMUSP00000098793
Gene: ENSMUSG00000021219

DomainStartEndE-ValueType
DEP 40 115 3.28e-24 SMART
G_gamma 255 319 2.23e-23 SMART
GGL 258 319 1.38e-27 SMART
RGS 336 451 2.05e-47 SMART
Predicted Effect probably null
Transcript: ENSMUST00000101234
SMART Domains Protein: ENSMUSP00000098793
Gene: ENSMUSG00000021219

DomainStartEndE-ValueType
DEP 40 115 3.28e-24 SMART
G_gamma 255 319 2.23e-23 SMART
GGL 258 319 1.38e-27 SMART
RGS 336 451 2.05e-47 SMART
Predicted Effect probably null
Transcript: ENSMUST00000161801
SMART Domains Protein: ENSMUSP00000125256
Gene: ENSMUSG00000021219

DomainStartEndE-ValueType
DEP 40 115 3.28e-24 SMART
G_gamma 255 319 2.23e-23 SMART
GGL 258 319 1.38e-27 SMART
Predicted Effect probably null
Transcript: ENSMUST00000185665
SMART Domains Protein: ENSMUSP00000139566
Gene: ENSMUSG00000021219

DomainStartEndE-ValueType
DEP 40 115 1.5e-26 SMART
G_gamma 255 319 1e-27 SMART
GGL 258 319 8.7e-30 SMART
RGS 336 451 7.5e-50 SMART
Predicted Effect probably null
Transcript: ENSMUST00000185674
SMART Domains Protein: ENSMUSP00000139940
Gene: ENSMUSG00000021219

DomainStartEndE-ValueType
DEP 40 115 1.5e-26 SMART
RGS 299 414 7.5e-50 SMART
Predicted Effect probably null
Transcript: ENSMUST00000185674
SMART Domains Protein: ENSMUSP00000139940
Gene: ENSMUSG00000021219

DomainStartEndE-ValueType
DEP 40 115 1.5e-26 SMART
RGS 299 414 7.5e-50 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000186081
SMART Domains Protein: ENSMUSP00000140188
Gene: ENSMUSG00000021219

DomainStartEndE-ValueType
DEP 40 115 1.5e-26 SMART
RGS 299 414 7.5e-50 SMART
low complexity region 417 425 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000186309
SMART Domains Protein: ENSMUSP00000140701
Gene: ENSMUSG00000021219

DomainStartEndE-ValueType
DEP 40 115 1.5e-26 SMART
G_gamma 255 319 1e-27 SMART
GGL 258 319 8.7e-30 SMART
RGS 336 451 7.5e-50 SMART
low complexity region 494 499 N/A INTRINSIC
low complexity region 511 523 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000186309
SMART Domains Protein: ENSMUSP00000140701
Gene: ENSMUSG00000021219

DomainStartEndE-ValueType
DEP 40 115 1.5e-26 SMART
G_gamma 255 319 1e-27 SMART
GGL 258 319 8.7e-30 SMART
RGS 336 451 7.5e-50 SMART
low complexity region 494 499 N/A INTRINSIC
low complexity region 511 523 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000186848
SMART Domains Protein: ENSMUSP00000141044
Gene: ENSMUSG00000021219

DomainStartEndE-ValueType
DEP 5 80 1.6e-26 SMART
G_gamma 220 284 1.1e-27 SMART
GGL 223 284 8.8e-30 SMART
RGS 301 416 7.6e-50 SMART
Predicted Effect probably null
Transcript: ENSMUST00000186323
SMART Domains Protein: ENSMUSP00000141079
Gene: ENSMUSG00000021219

DomainStartEndE-ValueType
DEP 40 115 1.5e-26 SMART
RGS 299 414 7.5e-50 SMART
Predicted Effect probably null
Transcript: ENSMUST00000186323
SMART Domains Protein: ENSMUSP00000141079
Gene: ENSMUSG00000021219

DomainStartEndE-ValueType
DEP 40 115 1.5e-26 SMART
RGS 299 414 7.5e-50 SMART
Predicted Effect probably null
Transcript: ENSMUST00000186458
SMART Domains Protein: ENSMUSP00000139735
Gene: ENSMUSG00000021219

DomainStartEndE-ValueType
DEP 40 115 3.28e-24 SMART
G_gamma 255 319 2.23e-23 SMART
GGL 258 319 1.38e-27 SMART
RGS 336 451 2.05e-47 SMART
Predicted Effect probably null
Transcript: ENSMUST00000191107
SMART Domains Protein: ENSMUSP00000139725
Gene: ENSMUSG00000021219

DomainStartEndE-ValueType
DEP 40 115 1.5e-26 SMART
G_gamma 255 319 1e-27 SMART
GGL 258 319 8.7e-30 SMART
RGS 336 451 7.5e-50 SMART
Predicted Effect probably null
Transcript: ENSMUST00000191311
SMART Domains Protein: ENSMUSP00000140723
Gene: ENSMUSG00000021219

DomainStartEndE-ValueType
DEP 40 115 1.5e-26 SMART
G_gamma 255 319 1e-27 SMART
GGL 258 319 8.7e-30 SMART
RGS 336 451 7.5e-50 SMART
Predicted Effect probably null
Transcript: ENSMUST00000191311
SMART Domains Protein: ENSMUSP00000140723
Gene: ENSMUSG00000021219

DomainStartEndE-ValueType
DEP 40 115 1.5e-26 SMART
G_gamma 255 319 1e-27 SMART
GGL 258 319 8.7e-30 SMART
RGS 336 451 7.5e-50 SMART
Predicted Effect probably null
Transcript: ENSMUST00000191352
SMART Domains Protein: ENSMUSP00000139718
Gene: ENSMUSG00000021219

DomainStartEndE-ValueType
DEP 40 115 1.5e-26 SMART
G_gamma 255 319 1e-27 SMART
GGL 258 319 8.7e-30 SMART
RGS 336 451 7.5e-50 SMART
Predicted Effect probably null
Transcript: ENSMUST00000191352
SMART Domains Protein: ENSMUSP00000139718
Gene: ENSMUSG00000021219

DomainStartEndE-ValueType
DEP 40 115 1.5e-26 SMART
G_gamma 255 319 1e-27 SMART
GGL 258 319 8.7e-30 SMART
RGS 336 451 7.5e-50 SMART
Predicted Effect probably null
Transcript: ENSMUST00000200911
SMART Domains Protein: ENSMUSP00000143801
Gene: ENSMUSG00000021219

DomainStartEndE-ValueType
DEP 40 115 3.28e-24 SMART
G_gamma 255 319 2.23e-23 SMART
GGL 258 319 1.38e-27 SMART
RGS 336 451 2.05e-47 SMART
Predicted Effect probably null
Transcript: ENSMUST00000202210
SMART Domains Protein: ENSMUSP00000143961
Gene: ENSMUSG00000021219

DomainStartEndE-ValueType
DEP 40 115 3.28e-24 SMART
G_gamma 255 319 2.23e-23 SMART
GGL 258 319 1.38e-27 SMART
RGS 336 451 2.05e-47 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000187556
Predicted Effect probably benign
Transcript: ENSMUST00000201271
SMART Domains Protein: ENSMUSP00000144139
Gene: ENSMUSG00000021219

DomainStartEndE-ValueType
DEP 40 115 1.6e-26 SMART
Meta Mutation Damage Score 0.9489 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.3%
  • 20x: 92.5%
Validation Efficiency 100% (79/79)
MGI Phenotype FUNCTION: This gene encodes a member of the RGS (regulator of G protein signaling) family of proteins, which are defined by the presence of a RGS domain that confers the GTPase-activating activity of these proteins toward certain G alpha subunits. This protein also belongs to a subfamily of RGS proteins characterized by the presence of DEP (Dishevelled, Egl-10, and Pleckstrin) and GGL (G-protein gamma like)domains, the latter a G beta 5-interacting domain. The RGS proteins negatively regulate G protein signaling, and may modulate neuronal, cardiovascular, lymphocytic activities, and cancer risk. Mice lacking this gene exhibit decreased heart rate. Alternative splicing results in multiple transcript variants, however, the full-length nature of some of these variants is not known. [provided by RefSeq, Sep 2015]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased heart rate and abnormal impulse conducting system conduction. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 70 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921539E11Rik T C 4: 103,092,871 (GRCm39) K150R probably damaging Het
Aak1 T C 6: 86,827,171 (GRCm39) V46A probably damaging Het
Abcb9 T C 5: 124,228,212 (GRCm39) T10A probably benign Het
Acaca A G 11: 84,185,813 (GRCm39) D116G possibly damaging Het
Adam33 G A 2: 130,903,115 (GRCm39) P43L probably benign Het
Adamtsl2 T A 2: 26,988,604 (GRCm39) probably null Het
Akap13 A G 7: 75,327,255 (GRCm39) probably benign Het
Art1 T A 7: 101,756,385 (GRCm39) L192Q probably damaging Het
Baalc A G 15: 38,796,575 (GRCm39) probably benign Het
Baz2a A G 10: 127,946,978 (GRCm39) E164G probably damaging Het
Bcs1l A G 1: 74,631,144 (GRCm39) I391V probably benign Het
Cacna1c T C 6: 118,673,386 (GRCm39) T497A probably damaging Het
Cap2 C A 13: 46,763,586 (GRCm39) T164N probably damaging Het
Ccdc57 A G 11: 120,751,225 (GRCm39) probably null Het
Ccdc88c T C 12: 100,904,338 (GRCm39) N1120S probably benign Het
Cfap210 T C 2: 69,612,452 (GRCm39) E96G possibly damaging Het
Chd7 T A 4: 8,844,706 (GRCm39) V1605D probably damaging Het
Col12a1 A T 9: 79,622,622 (GRCm39) probably benign Het
Commd3 T C 2: 18,677,339 (GRCm39) S22P probably benign Het
Cpd T C 11: 76,737,063 (GRCm39) I244V probably benign Het
Cpeb2 C A 5: 43,390,817 (GRCm39) probably benign Het
Cyp2c65 A G 19: 39,060,635 (GRCm39) D165G probably damaging Het
Ddx1 T C 12: 13,289,148 (GRCm39) Y152C probably damaging Het
Dennd4a G A 9: 64,804,531 (GRCm39) C1290Y possibly damaging Het
Ebf4 G A 2: 130,148,965 (GRCm39) M232I probably benign Het
Farp2 A G 1: 93,502,192 (GRCm39) probably null Het
Frk T C 10: 34,360,233 (GRCm39) V78A probably benign Het
Gm5799 A G 14: 43,782,098 (GRCm39) D90G probably damaging Het
Gpr45 C G 1: 43,069,613 (GRCm39) probably benign Het
Hfm1 C T 5: 107,002,606 (GRCm39) probably null Het
Igkv4-57-1 T A 6: 69,521,387 (GRCm39) D105V probably damaging Het
Impdh2-ps A G 8: 100,757,995 (GRCm39) noncoding transcript Het
Kctd4 G A 14: 76,200,217 (GRCm39) V63I probably benign Het
Lcn6 T A 2: 25,570,822 (GRCm39) L137M probably damaging Het
Lonrf1 T C 8: 36,687,126 (GRCm39) N737D probably benign Het
Mcu C T 10: 59,303,511 (GRCm39) V109M probably damaging Het
Mecom C A 3: 30,039,500 (GRCm39) K186N probably damaging Het
Muc4 T C 16: 32,753,802 (GRCm38) I1226T probably benign Het
Mybpc1 T C 10: 88,384,727 (GRCm39) D533G probably damaging Het
Nae1 A C 8: 105,246,416 (GRCm39) C294G probably damaging Het
Ncapg2 T G 12: 116,379,077 (GRCm39) H190Q probably damaging Het
Nkx2-2 A T 2: 147,027,763 (GRCm39) L59Q possibly damaging Het
Nrxn3 C T 12: 90,171,483 (GRCm39) T295I probably damaging Het
Obscn C T 11: 58,897,652 (GRCm39) probably benign Het
Obscn A T 11: 58,931,293 (GRCm39) M5781K probably damaging Het
Or11g24 A G 14: 50,662,206 (GRCm39) T77A possibly damaging Het
Or4k39 T C 2: 111,239,570 (GRCm39) noncoding transcript Het
Or4z4 T A 19: 12,076,110 (GRCm39) M298L probably benign Het
Pcdhb6 C A 18: 37,467,381 (GRCm39) P101T probably damaging Het
Pot1b A G 17: 55,979,885 (GRCm39) S324P possibly damaging Het
Potefam1 T C 2: 111,034,490 (GRCm39) probably null Het
Ppcdc C T 9: 57,342,194 (GRCm39) V43I probably benign Het
Prr13 A T 15: 102,369,120 (GRCm39) probably benign Het
Rab10os T A 12: 3,287,322 (GRCm39) noncoding transcript Het
Rabgap1 T C 2: 37,422,531 (GRCm39) S595P probably damaging Het
Rap1gap T C 4: 137,439,440 (GRCm39) S126P probably damaging Het
Slc5a6 T A 5: 31,194,228 (GRCm39) K610* probably null Het
Sun5 C T 2: 153,711,386 (GRCm39) V27I probably benign Het
Tmco5b T C 2: 113,120,102 (GRCm39) I126T probably benign Het
Tmed7 G A 18: 46,726,480 (GRCm39) Q92* probably null Het
Trav7d-2 A G 14: 52,921,885 (GRCm39) D98G probably benign Het
Trbv16 T A 6: 41,128,936 (GRCm39) L40Q probably damaging Het
Ush2a T C 1: 188,485,848 (GRCm39) V2986A probably benign Het
Usp33 T C 3: 152,064,310 (GRCm39) V58A probably benign Het
Vmn2r94 T A 17: 18,477,293 (GRCm39) M373L probably benign Het
Ywhaq T C 12: 21,467,512 (GRCm39) probably benign Het
Zbbx G A 3: 74,989,054 (GRCm39) H345Y possibly damaging Het
Zfp346 G T 13: 55,261,626 (GRCm39) probably benign Het
Zfp616 C T 11: 73,975,033 (GRCm39) A434V probably benign Het
Zfp992 C T 4: 146,551,976 (GRCm39) H566Y probably damaging Het
Other mutations in Rgs6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00502:Rgs6 APN 12 83,098,097 (GRCm39) missense probably benign 0.01
IGL02131:Rgs6 APN 12 83,116,269 (GRCm39) missense probably damaging 1.00
IGL02354:Rgs6 APN 12 82,665,393 (GRCm39) intron probably benign
IGL02361:Rgs6 APN 12 82,665,393 (GRCm39) intron probably benign
IGL02568:Rgs6 APN 12 83,117,376 (GRCm39) missense probably benign 0.25
IGL02598:Rgs6 APN 12 83,138,571 (GRCm39) missense probably benign 0.02
IGL03146:Rgs6 APN 12 83,099,312 (GRCm39) missense probably damaging 1.00
IGL03248:Rgs6 APN 12 83,099,324 (GRCm39) splice site probably benign
IGL03098:Rgs6 UTSW 12 83,032,150 (GRCm39) missense probably damaging 1.00
IGL03147:Rgs6 UTSW 12 83,138,620 (GRCm39) missense probably damaging 0.99
PIT4453001:Rgs6 UTSW 12 83,138,553 (GRCm39) missense probably damaging 1.00
R0270:Rgs6 UTSW 12 83,180,463 (GRCm39) missense probably damaging 1.00
R0390:Rgs6 UTSW 12 83,180,451 (GRCm39) missense probably damaging 1.00
R0540:Rgs6 UTSW 12 83,106,578 (GRCm39) nonsense probably null
R0630:Rgs6 UTSW 12 83,094,324 (GRCm39) splice site probably benign
R1479:Rgs6 UTSW 12 83,163,018 (GRCm39) missense probably damaging 1.00
R1533:Rgs6 UTSW 12 83,138,547 (GRCm39) missense probably benign 0.00
R1545:Rgs6 UTSW 12 83,162,951 (GRCm39) missense probably damaging 0.99
R2161:Rgs6 UTSW 12 83,138,578 (GRCm39) missense probably damaging 1.00
R2421:Rgs6 UTSW 12 83,163,057 (GRCm39) missense possibly damaging 0.93
R4089:Rgs6 UTSW 12 83,110,261 (GRCm39) missense probably damaging 1.00
R4573:Rgs6 UTSW 12 83,112,789 (GRCm39) missense probably damaging 1.00
R6228:Rgs6 UTSW 12 83,112,738 (GRCm39) missense probably damaging 0.99
R7023:Rgs6 UTSW 12 83,138,878 (GRCm39) intron probably benign
R7585:Rgs6 UTSW 12 83,153,644 (GRCm39) missense probably damaging 1.00
R7610:Rgs6 UTSW 12 83,138,553 (GRCm39) missense probably damaging 1.00
R7798:Rgs6 UTSW 12 83,116,293 (GRCm39) missense probably benign 0.02
R8003:Rgs6 UTSW 12 83,032,144 (GRCm39) missense probably damaging 0.99
R8011:Rgs6 UTSW 12 83,163,066 (GRCm39) missense probably null 0.32
R8081:Rgs6 UTSW 12 83,094,347 (GRCm39) nonsense probably null
R8248:Rgs6 UTSW 12 83,184,478 (GRCm39) intron probably benign
R8267:Rgs6 UTSW 12 82,698,669 (GRCm39) missense probably benign
R8285:Rgs6 UTSW 12 83,162,949 (GRCm39) missense probably benign 0.14
R8932:Rgs6 UTSW 12 83,112,733 (GRCm39) missense probably damaging 1.00
R9398:Rgs6 UTSW 12 82,698,615 (GRCm39) missense probably benign 0.09
R9415:Rgs6 UTSW 12 83,184,166 (GRCm39) missense probably benign 0.06
RF008:Rgs6 UTSW 12 83,110,223 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGGTGCCCTGATTATAAGGTC -3'
(R):5'- TGCCTAGAACATACCAGCCG -3'

Sequencing Primer
(F):5'- AAGGTCAGGCTTTATATTTCCAGTG -3'
(R):5'- GCCACCCAACGAATATTTCTAG -3'
Posted On 2016-02-04