Incidental Mutation 'R0421:Niban1'
ID 37030
Institutional Source Beutler Lab
Gene Symbol Niban1
Ensembl Gene ENSMUSG00000026483
Gene Name niban apoptosis regulator 1
Synonyms Fam129a, Niban
MMRRC Submission 038623-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0421 (G1)
Quality Score 207
Status Validated
Chromosome 1
Chromosomal Location 151447124-151596791 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to A at 151584833 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000115822 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000097541] [ENSMUST00000148810]
AlphaFold Q3UW53
Predicted Effect noncoding transcript
Transcript: ENSMUST00000086267
Predicted Effect probably benign
Transcript: ENSMUST00000097541
SMART Domains Protein: ENSMUSP00000095148
Gene: ENSMUSG00000026483

DomainStartEndE-ValueType
Blast:PH 70 197 2e-83 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000148810
SMART Domains Protein: ENSMUSP00000115822
Gene: ENSMUSG00000026483

DomainStartEndE-ValueType
SCOP:d1faoa_ 67 118 1e-2 SMART
Blast:PH 70 197 1e-80 BLAST
low complexity region 540 549 N/A INTRINSIC
low complexity region 699 714 N/A INTRINSIC
low complexity region 784 797 N/A INTRINSIC
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.3%
  • 10x: 96.4%
  • 20x: 92.7%
Validation Efficiency 97% (67/69)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the family with sequence similarity 129 protein family. This gene is highly expressed in several cancer cells and may serve as a prognostic marker for certain cancers. The encoded protein may play a role in regulating p53-mediated apoptosis. [provided by RefSeq, Sep 2016]
PHENOTYPE: Mice homozygous for a knock-out allele are viable with no overt phenotypic abnormalities. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 69 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abi1 G A 2: 22,850,839 (GRCm39) T195I probably damaging Het
Afap1l1 T C 18: 61,884,945 (GRCm39) N180S probably damaging Het
Arsg A G 11: 109,418,592 (GRCm39) Y196C probably damaging Het
Ascc3 G T 10: 50,625,022 (GRCm39) V1637L probably benign Het
Atp2b2 C A 6: 113,790,849 (GRCm39) R185L probably damaging Het
Ccr9 A T 9: 123,608,671 (GRCm39) M118L probably benign Het
Cdh12 A T 15: 21,480,310 (GRCm39) probably null Het
Cdk13 T C 13: 17,937,755 (GRCm39) S763G probably damaging Het
Cenpk C A 13: 104,378,911 (GRCm39) N177K probably benign Het
Cfap43 T G 19: 47,824,014 (GRCm39) N119T probably benign Het
Chrna6 T C 8: 27,898,415 (GRCm39) E101G probably null Het
Clasp2 G A 9: 113,683,370 (GRCm39) R400H probably benign Het
Col6a6 T C 9: 105,661,405 (GRCm39) M235V probably benign Het
Ddx49 A T 8: 70,748,282 (GRCm39) L291Q probably damaging Het
Dhrs7 A T 12: 72,699,860 (GRCm39) probably benign Het
Dnah5 A T 15: 28,229,687 (GRCm39) K107M possibly damaging Het
Dsg2 C T 18: 20,712,448 (GRCm39) R151C probably damaging Het
Dsn1 T C 2: 156,847,789 (GRCm39) T2A possibly damaging Het
Edem3 A G 1: 151,668,189 (GRCm39) probably benign Het
Eif3c T C 7: 126,162,884 (GRCm39) N133S possibly damaging Het
F10 A G 8: 13,095,097 (GRCm39) K85E probably benign Het
Fbn2 T A 18: 58,160,876 (GRCm39) probably benign Het
Gtpbp10 A T 5: 5,607,290 (GRCm39) H50Q probably benign Het
Hephl1 A G 9: 14,970,456 (GRCm39) F1013L probably benign Het
Hps3 C A 3: 20,083,480 (GRCm39) V238F probably benign Het
Kcna10 A C 3: 107,101,820 (GRCm39) K150N probably damaging Het
Kirrel1 C T 3: 86,990,914 (GRCm39) G636D probably damaging Het
Kndc1 G A 7: 139,488,912 (GRCm39) R189H probably damaging Het
Knop1 C T 7: 118,454,852 (GRCm39) E50K possibly damaging Het
Kplce T C 3: 92,776,291 (GRCm39) T131A probably damaging Het
Kpna7 T A 5: 144,926,551 (GRCm39) H467L possibly damaging Het
Lcn4 T C 2: 26,558,661 (GRCm39) N142D possibly damaging Het
Map3k3 T C 11: 106,039,741 (GRCm39) probably benign Het
Mdn1 A G 4: 32,684,707 (GRCm39) T806A probably benign Het
Nbeal1 T A 1: 60,307,598 (GRCm39) N1703K probably benign Het
Neurl4 T C 11: 69,799,360 (GRCm39) V914A probably damaging Het
Nop56 T C 2: 130,118,692 (GRCm39) S275P possibly damaging Het
Or1j20 A G 2: 36,759,653 (GRCm39) E25G possibly damaging Het
Or52ac1 A G 7: 104,245,929 (GRCm39) V153A probably benign Het
Or7e174 A G 9: 20,012,771 (GRCm39) K239E probably damaging Het
Otof A C 5: 30,528,912 (GRCm39) I1827S possibly damaging Het
Pappa2 A T 1: 158,675,650 (GRCm39) I1032N probably damaging Het
Pcdh7 A G 5: 57,877,402 (GRCm39) E319G probably damaging Het
Pcdhb11 T A 18: 37,555,533 (GRCm39) S288T probably benign Het
Phip A T 9: 82,808,510 (GRCm39) D488E probably damaging Het
Pla2g7 A T 17: 43,922,303 (GRCm39) H394L probably damaging Het
Plk3 A G 4: 116,990,641 (GRCm39) V69A probably damaging Het
Prob1 C A 18: 35,786,083 (GRCm39) A724S possibly damaging Het
Prune2 T C 19: 17,100,675 (GRCm39) F2060L probably benign Het
Rgl3 G A 9: 21,887,328 (GRCm39) R498C probably benign Het
Rnf213 A C 11: 119,338,083 (GRCm39) N3362H probably damaging Het
Sbds A G 5: 130,282,774 (GRCm39) probably benign Het
Scn9a T C 2: 66,373,621 (GRCm39) S453G probably benign Het
Sh3rf3 T C 10: 58,819,897 (GRCm39) L236P probably damaging Het
Skint1 A G 4: 111,876,211 (GRCm39) N44S possibly damaging Het
Slc5a1 T A 5: 33,291,996 (GRCm39) I141N probably damaging Het
Tlcd3b G A 7: 126,424,187 (GRCm39) V44M probably damaging Het
Trank1 T A 9: 111,220,907 (GRCm39) I2548N probably damaging Het
Tsc22d2 G A 3: 58,324,749 (GRCm39) probably benign Het
Unc13c T A 9: 73,840,492 (GRCm39) I120F possibly damaging Het
Vmn2r11 T G 5: 109,207,294 (GRCm39) I9L probably benign Het
Vmn2r58 T G 7: 41,514,628 (GRCm39) N114H probably benign Het
Vps53 A G 11: 75,973,496 (GRCm39) L166P probably damaging Het
Zfp119a T A 17: 56,172,248 (GRCm39) K532* probably null Het
Zfp472 A G 17: 33,194,897 (GRCm39) T11A possibly damaging Het
Zfp512b T A 2: 181,230,051 (GRCm39) K87* probably null Het
Zfp518b G A 5: 38,831,918 (GRCm39) P29L probably damaging Het
Zfp599 A G 9: 22,161,843 (GRCm39) probably benign Het
Zic2 CCCACCACCACCATCACCACCACCACC CCCACCATCACCACCACCACC 14: 122,713,776 (GRCm39) probably benign Het
Other mutations in Niban1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01150:Niban1 APN 1 151,593,472 (GRCm39) missense probably benign 0.06
IGL01690:Niban1 APN 1 151,579,555 (GRCm39) missense probably damaging 1.00
IGL01762:Niban1 APN 1 151,512,242 (GRCm39) missense probably damaging 1.00
IGL01784:Niban1 APN 1 151,525,116 (GRCm39) missense probably damaging 1.00
IGL01938:Niban1 APN 1 151,565,365 (GRCm39) missense probably benign 0.22
IGL02427:Niban1 APN 1 151,593,025 (GRCm39) missense probably damaging 1.00
IGL02617:Niban1 APN 1 151,447,296 (GRCm39) missense probably benign 0.11
IGL02946:Niban1 APN 1 151,525,176 (GRCm39) missense probably damaging 0.99
R0242:Niban1 UTSW 1 151,593,967 (GRCm39) missense probably benign 0.00
R0242:Niban1 UTSW 1 151,593,967 (GRCm39) missense probably benign 0.00
R0279:Niban1 UTSW 1 151,584,957 (GRCm39) critical splice donor site probably null
R0531:Niban1 UTSW 1 151,593,835 (GRCm39) missense probably benign 0.11
R0725:Niban1 UTSW 1 151,581,766 (GRCm39) missense probably benign 0.04
R1493:Niban1 UTSW 1 151,581,841 (GRCm39) missense probably damaging 1.00
R1563:Niban1 UTSW 1 151,591,424 (GRCm39) missense possibly damaging 0.69
R1868:Niban1 UTSW 1 151,517,302 (GRCm39) missense possibly damaging 0.71
R1944:Niban1 UTSW 1 151,571,979 (GRCm39) missense probably damaging 0.99
R1945:Niban1 UTSW 1 151,571,979 (GRCm39) missense probably damaging 0.99
R2071:Niban1 UTSW 1 151,512,181 (GRCm39) missense probably damaging 1.00
R2126:Niban1 UTSW 1 151,584,884 (GRCm39) missense possibly damaging 0.94
R2126:Niban1 UTSW 1 151,571,886 (GRCm39) missense probably damaging 1.00
R2138:Niban1 UTSW 1 151,572,002 (GRCm39) missense probably damaging 0.98
R2180:Niban1 UTSW 1 151,593,829 (GRCm39) missense probably benign 0.02
R2402:Niban1 UTSW 1 151,565,365 (GRCm39) missense probably benign 0.22
R3689:Niban1 UTSW 1 151,579,447 (GRCm39) splice site probably null
R3783:Niban1 UTSW 1 151,565,399 (GRCm39) missense possibly damaging 0.66
R3975:Niban1 UTSW 1 151,525,086 (GRCm39) missense probably damaging 1.00
R4029:Niban1 UTSW 1 151,571,441 (GRCm39) missense probably benign 0.00
R4328:Niban1 UTSW 1 151,512,169 (GRCm39) missense possibly damaging 0.86
R4447:Niban1 UTSW 1 151,512,153 (GRCm39) critical splice acceptor site probably null
R4573:Niban1 UTSW 1 151,579,517 (GRCm39) missense possibly damaging 0.85
R4774:Niban1 UTSW 1 151,591,445 (GRCm39) missense probably damaging 1.00
R5064:Niban1 UTSW 1 151,565,410 (GRCm39) missense probably benign 0.05
R5077:Niban1 UTSW 1 151,590,274 (GRCm39) missense probably benign 0.00
R5187:Niban1 UTSW 1 151,579,580 (GRCm39) missense possibly damaging 0.50
R5484:Niban1 UTSW 1 151,593,837 (GRCm39) missense probably benign 0.08
R5553:Niban1 UTSW 1 151,592,986 (GRCm39) missense probably damaging 0.99
R5572:Niban1 UTSW 1 151,584,941 (GRCm39) missense probably benign 0.05
R5575:Niban1 UTSW 1 151,593,991 (GRCm39) missense probably benign 0.31
R5586:Niban1 UTSW 1 151,593,307 (GRCm39) missense probably benign 0.00
R5697:Niban1 UTSW 1 151,576,012 (GRCm39) missense probably damaging 1.00
R6305:Niban1 UTSW 1 151,571,469 (GRCm39) missense probably damaging 1.00
R7065:Niban1 UTSW 1 151,575,858 (GRCm39) critical splice acceptor site probably null
R7126:Niban1 UTSW 1 151,590,318 (GRCm39) nonsense probably null
R7392:Niban1 UTSW 1 151,571,975 (GRCm39) missense probably damaging 1.00
R7571:Niban1 UTSW 1 151,594,048 (GRCm39) missense probably benign 0.01
R7577:Niban1 UTSW 1 151,594,063 (GRCm39) missense probably benign
R7939:Niban1 UTSW 1 151,581,775 (GRCm39) missense probably damaging 1.00
R8018:Niban1 UTSW 1 151,593,006 (GRCm39) nonsense probably null
R8164:Niban1 UTSW 1 151,593,339 (GRCm39) missense probably benign 0.02
R8356:Niban1 UTSW 1 151,571,901 (GRCm39) missense probably damaging 1.00
R8478:Niban1 UTSW 1 151,512,263 (GRCm39) missense possibly damaging 0.77
R8833:Niban1 UTSW 1 151,520,681 (GRCm39) missense probably damaging 1.00
R8847:Niban1 UTSW 1 151,575,929 (GRCm39) missense probably damaging 1.00
R8854:Niban1 UTSW 1 151,584,950 (GRCm39) missense probably damaging 1.00
R8960:Niban1 UTSW 1 151,591,463 (GRCm39) missense possibly damaging 0.92
R9616:Niban1 UTSW 1 151,512,193 (GRCm39) missense probably damaging 1.00
R9684:Niban1 UTSW 1 151,593,538 (GRCm39) missense possibly damaging 0.87
Predicted Primers PCR Primer
(F):5'- GCCTGTTTGTAAAAGAGGTGCATGG -3'
(R):5'- TCAGGGTACACGCTCTCTCAGTAAG -3'

Sequencing Primer
(F):5'- aaagaggtgcatggactagg -3'
(R):5'- ctctctctctctctctctctctc -3'
Posted On 2013-05-09