Mutagenetix > Incidental Mutation

Incidental Mutation 'R4801:Cr2'

370359

Institutional Source

Beutler Lab

Gene Symbol

Cr2

Ensembl Gene

ENSMUSG00000026616

Gene Name

complement receptor 2

Synonyms

C3DR, CD21, Cr-1, Cr1, CD35, Cr-2

MMRRC Submission

042423-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.140) question?

Stock #

R4801 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

195136811-195176716 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 195163311 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glycine to Aspartic acid at position 112 (G112D)

Ref Sequence

ENSEMBL: ENSMUSP00000141538 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000043104] [ENSMUST00000082321] [ENSMUST00000193356] [ENSMUST00000193801] [ENSMUST00000195120] [ENSMUST00000210219]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000043104

SMART Domains

Protein: ENSMUSP00000044261
Gene: ENSMUSG00000026616

Domain	Start	End	E-Value	Type
CCP	2	58	5.04e-7	SMART
CCP	63	120	3.58e-12	SMART
CCP	125	191	1.2e-13	SMART
CCP	197	252	2.73e-17	SMART
CCP	256	311	1.01e-15	SMART
Blast:CCP	316	347	2e-13	BLAST

Predicted Effect

probably damaging
Transcript: ENSMUST00000082321
AA Change: G112D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000080938
Gene: ENSMUSG00000026616
AA Change: G112D

Domain	Start	End	E-Value	Type
CCP	23	82	1.01e-11	SMART
CCP	91	147	9.1e-14	SMART
CCP	155	211	1.9e-16	SMART
CCP	216	272	1.6e-9	SMART
CCP	277	343	1.01e-11	SMART
CCP	352	407	1.2e-13	SMART
CCP	411	467	2.34e-16	SMART
CCP	472	523	1.24e0	SMART
CCP	528	594	4.48e-13	SMART
CCP	603	658	1.95e-13	SMART
CCP	718	778	1.75e-15	SMART
CCP	787	842	2.06e-12	SMART
CCP	850	906	7.92e-14	SMART
CCP	911	967	1.29e-13	SMART
transmembrane domain	975	997	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000193356

SMART Domains

Protein: ENSMUSP00000141706
Gene: ENSMUSG00000026616

Domain	Start	End	E-Value	Type
CCP	1	46	1.2e-1	SMART
CCP	55	110	5.9e-16	SMART
CCP	114	170	1.1e-18	SMART
CCP	175	226	6.1e-3	SMART
CCP	231	297	2.2e-15	SMART
CCP	306	361	9.4e-16	SMART
CCP	421	481	8.3e-18	SMART
CCP	490	545	1e-14	SMART
CCP	553	609	4e-16	SMART
CCP	614	670	6.2e-16	SMART
transmembrane domain	678	700	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000193801

SMART Domains

Protein: ENSMUSP00000141276
Gene: ENSMUSG00000026616

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000194149

Predicted Effect

probably damaging
Transcript: ENSMUST00000195120
AA Change: G112D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000141538
Gene: ENSMUSG00000026616
AA Change: G112D

Domain	Start	End	E-Value	Type
CCP	23	82	4.9e-14	SMART
CCP	91	147	4.5e-16	SMART
CCP	155	211	9.1e-19	SMART
CCP	216	272	8e-12	SMART
CCP	277	343	5e-14	SMART
CCP	352	407	5.9e-16	SMART
CCP	411	467	1.1e-18	SMART
CCP	472	523	6.1e-3	SMART
CCP	528	594	2.2e-15	SMART
CCP	603	658	9.4e-16	SMART
CCP	718	778	8.3e-18	SMART
CCP	787	842	1e-14	SMART
CCP	850	906	4e-16	SMART
CCP	911	967	6.2e-16	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000195347

Predicted Effect

possibly damaging
Transcript: ENSMUST00000210219
AA Change: G488D

PolyPhen 2 Score 0.466 (Sensitivity: 0.89; Specificity: 0.90)

Meta Mutation Damage Score

0.6891

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.1%
20x: 94.8%

Validation Efficiency

99% (88/89)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a membrane protein, which functions as a receptor for Epstein-Barr virus (EBV) binding on B and T lymphocytes. Genetic variations in this gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
PHENOTYPE: Homozygotes for targeted null mutations exhibit impaired humoral immune responses to T cell-dependent antigens, with limited affinity maturation, and reduced memory B cell and germinal center formation. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 164 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2310057J18Rik	A	G	10: 28,983,926 (GRCm38)		probably null	Het
Aadacl3	A	G	4: 144,456,232 (GRCm38)	I222T	probably damaging	Het
Abca13	G	T	11: 9,522,341 (GRCm38)	G4249V	possibly damaging	Het
Abcb10	A	G	8: 123,966,527 (GRCm38)	V346A	probably benign	Het
Abcc2	A	T	19: 43,819,361 (GRCm38)	I814F	probably damaging	Het
AF366264	T	A	8: 13,836,970 (GRCm38)	I374F	possibly damaging	Het
Alkbh2	C	T	5: 114,124,226 (GRCm38)	E148K	probably damaging	Het
Ankrd28	A	C	14: 31,736,830 (GRCm38)	D335E	probably damaging	Het
Ankrd44	T	C	1: 54,762,316 (GRCm38)	H284R	probably damaging	Het
Arfgef3	G	T	10: 18,591,906 (GRCm38)	Q1849K	probably benign	Het
Atp2c2	T	C	8: 119,747,687 (GRCm38)	M490T	probably damaging	Het
Bach1	T	A	16: 87,722,452 (GRCm38)	D543E	probably damaging	Het
Bahcc1	G	A	11: 120,282,225 (GRCm38)	V1558I	probably benign	Het
Bbs5	T	A	2: 69,655,614 (GRCm38)	W168R	probably damaging	Het
Bcar3	A	T	3: 122,529,594 (GRCm38)	D766V	probably benign	Het
C1ra	A	G	6: 124,513,768 (GRCm38)	D40G	probably benign	Het
Ccdc138	G	A	10: 58,573,643 (GRCm38)	C598Y	probably damaging	Het
Cd200r3	T	A	16: 44,957,825 (GRCm38)	N197K	possibly damaging	Het
Cenpf	T	A	1: 189,651,220 (GRCm38)	E2634D	probably damaging	Het
Cisd2	T	C	3: 135,411,141 (GRCm38)	K63R	probably damaging	Het
Clca3a2	A	T	3: 144,807,351 (GRCm38)	S478T	possibly damaging	Het
Clptm1l	T	C	13: 73,607,862 (GRCm38)	M199T	possibly damaging	Het
Cntnap4	T	A	8: 112,773,590 (GRCm38)	S505T	possibly damaging	Het
Crb2	T	A	2: 37,793,756 (GRCm38)	I1090N	probably benign	Het
Csmd3	G	T	15: 47,621,292 (GRCm38)	P3057Q	probably damaging	Het
Ctso	G	A	3: 81,954,240 (GRCm38)	V307I	probably damaging	Het
Cyp3a41b	T	A	5: 145,573,651 (GRCm38)	T138S	probably benign	Het
Dctn3	G	T	4: 41,719,904 (GRCm38)	Y67*	probably null	Het
Dennd4c	C	A	4: 86,819,884 (GRCm38)	Y918*	probably null	Het
Dlg5	C	T	14: 24,154,689 (GRCm38)	G1262D	probably damaging	Het
Dnaaf1	G	A	8: 119,577,361 (GRCm38)	G46D	probably benign	Het
Dnah6	A	G	6: 73,089,698 (GRCm38)	V2563A	probably damaging	Het
Dnajc13	A	G	9: 104,175,727 (GRCm38)	Y1679H	probably benign	Het
Eif2ak3	T	C	6: 70,887,893 (GRCm38)	Y578H	probably benign	Het
Endod1	C	T	9: 14,357,023 (GRCm38)	V389M	probably benign	Het
Ephb4	T	C	5: 137,365,506 (GRCm38)	L582P	probably damaging	Het
Eps15	T	C	4: 109,324,217 (GRCm38)	L316S	possibly damaging	Het
Erbb4	G	T	1: 68,330,246 (GRCm38)	T412K	probably damaging	Het
Fam117a	T	A	11: 95,364,070 (GRCm38)	F90I	probably damaging	Het
Fam187b	T	G	7: 30,977,090 (GRCm38)	V8G	possibly damaging	Het
Fam84b	C	A	15: 60,823,944 (GRCm38)		probably benign	Het
Far1	T	A	7: 113,539,453 (GRCm38)	I59N	possibly damaging	Het
Fbxo34	T	A	14: 47,530,869 (GRCm38)	L562Q	probably damaging	Het
Frem1	T	A	4: 82,916,628 (GRCm38)		probably benign	Het
Gfra3	G	T	18: 34,720,192 (GRCm38)	P10Q	probably damaging	Het
Gm10698	A	G	9: 33,728,772 (GRCm38)		noncoding transcript	Het
Gm11487	C	T	4: 73,401,267 (GRCm38)	W80*	probably null	Het
Gm19965	T	A	1: 116,821,896 (GRCm38)	Y436N	probably benign	Het
Gm21818	T	A	13: 120,173,222 (GRCm38)	S13R	probably benign	Het
Gm5767	A	G	16: 8,683,345 (GRCm38)	T22A	unknown	Het
Gm5799	A	T	14: 43,544,548 (GRCm38)	H59L	probably damaging	Het
Gmppb	T	A	9: 108,050,217 (GRCm38)	V121E	probably benign	Het
Ighv7-4	G	C	12: 114,223,279 (GRCm38)		probably benign	Het
Ipo4	A	G	14: 55,631,214 (GRCm38)	S446P	probably damaging	Het
Itpr2	T	C	6: 146,371,331 (GRCm38)	T855A	probably damaging	Het
Jaml	T	C	9: 45,101,064 (GRCm38)	I283T	possibly damaging	Het
Kcnn2	T	C	18: 45,685,267 (GRCm38)		probably benign	Het
Klhl32	T	C	4: 24,649,698 (GRCm38)	Y399C	possibly damaging	Het
Lrriq1	G	A	10: 103,221,318 (GRCm38)	T207I	probably benign	Het
Lrriq3	A	T	3: 155,187,970 (GRCm38)	H436L	probably benign	Het
Mad2l1bp	T	C	17: 46,148,263 (GRCm38)	K114E	possibly damaging	Het
Mamstr	T	C	7: 45,642,418 (GRCm38)	V64A	possibly damaging	Het
Map4	T	A	9: 110,035,257 (GRCm38)	S517T	probably benign	Het
Matn1	A	T	4: 130,950,025 (GRCm38)	I182F	possibly damaging	Het
Mcm3	A	G	1: 20,810,156 (GRCm38)	I484T	probably damaging	Het
Med13	T	A	11: 86,278,773 (GRCm38)	I1922F	probably damaging	Het
Metap2	A	G	10: 93,868,895 (GRCm38)	V137A	probably damaging	Het
Mex3d	A	G	10: 80,386,954 (GRCm38)	V156A	possibly damaging	Het
Mfsd6	G	A	1: 52,709,596 (GRCm38)	P37S	probably benign	Het
Mkl1	T	C	15: 81,104,799 (GRCm38)	E7G	probably benign	Het
Mrgprx1	A	C	7: 48,021,211 (GRCm38)	S263A	possibly damaging	Het
Msl1	C	T	11: 98,803,969 (GRCm38)	R505*	probably null	Het
Mta2	T	C	19: 8,945,851 (GRCm38)	S96P	probably damaging	Het
Mtr	A	T	13: 12,195,251 (GRCm38)	N986K	probably benign	Het
Mut	A	G	17: 40,937,351 (GRCm38)	T90A	probably benign	Het
Mutyh	C	T	4: 116,817,029 (GRCm38)	T259I	probably benign	Het
Myof	T	C	19: 37,945,738 (GRCm38)	T908A	probably benign	Het
Nav2	A	T	7: 49,545,852 (GRCm38)	D992V	possibly damaging	Het
Neb	T	C	2: 52,200,703 (GRCm38)	T1352A	possibly damaging	Het
Nfix	CAAAAA	CAAAA	8: 84,716,247 (GRCm38)		probably null	Het
Nudt6	G	A	3: 37,405,354 (GRCm38)	R161C	probably benign	Het
Olfr1122	T	A	2: 87,388,209 (GRCm38)	V168E	probably benign	Het
Olfr1173	T	A	2: 88,274,879 (GRCm38)	M57L	probably damaging	Het
Olfr125	T	C	17: 37,835,349 (GRCm38)	Y117H	probably damaging	Het
Olfr1276	T	A	2: 111,257,152 (GRCm38)	F12L	probably damaging	Het
Olfr1411	T	A	1: 92,596,998 (GRCm38)	C160S	probably benign	Het
Olfr154	T	A	2: 85,664,278 (GRCm38)	D52V	probably damaging	Het
Olfr23	T	A	11: 73,940,870 (GRCm38)	I208K	possibly damaging	Het
Olfr319	T	C	11: 58,701,791 (GRCm38)	V30A	probably benign	Het
Olfr456	A	T	6: 42,486,679 (GRCm38)	N171K	probably benign	Het
Olfr744	A	G	14: 50,619,022 (GRCm38)	T267A	probably benign	Het
Olfr959	T	G	9: 39,572,858 (GRCm38)	M134L	probably benign	Het
Olr1	A	G	6: 129,488,090 (GRCm38)	F141S	possibly damaging	Het
Oprl1	G	T	2: 181,719,253 (GRCm38)	M340I	probably benign	Het
Otogl	A	C	10: 107,901,336 (GRCm38)	C72W	probably damaging	Het
Pcdha11	T	A	18: 37,005,465 (GRCm38)	I49N	probably damaging	Het
Pcdha4	T	A	18: 36,953,955 (GRCm38)	L397*	probably null	Het
Pcdhb14	A	G	18: 37,448,278 (GRCm38)	S146G	probably benign	Het
Pclo	T	A	5: 14,675,815 (GRCm38)	H1562Q	unknown	Het
Pcsk9	T	C	4: 106,447,569 (GRCm38)	E434G	probably benign	Het
Phc2	A	G	4: 128,751,598 (GRCm38)	K833E	probably damaging	Het
Pja2	A	T	17: 64,292,862 (GRCm38)	S480R	probably damaging	Het
Pkd1	G	A	17: 24,578,096 (GRCm38)	G2493D	probably damaging	Het
Plk5	G	A	10: 80,359,304 (GRCm38)	V179M	possibly damaging	Het
Polr1a	G	A	6: 71,976,070 (GRCm38)	V1541I	probably benign	Het
Ppard	C	G	17: 28,286,374 (GRCm38)	R12G	unknown	Het
Ppp1r14a	A	G	7: 29,291,526 (GRCm38)	D73G	probably damaging	Het
Psd3	C	T	8: 68,121,148 (GRCm38)	R127H	probably benign	Het
Pten	G	T	19: 32,758,503 (GRCm38)	G20V	possibly damaging	Het
Ptprg	T	C	14: 11,554,233 (GRCm38)		probably benign	Het
Rad54l	T	C	4: 116,122,924 (GRCm38)	D21G	probably null	Het
Rgs14	T	C	13: 55,380,957 (GRCm38)	Y304H	probably damaging	Het
Rgs9	T	C	11: 109,240,868 (GRCm38)	K346R	probably damaging	Het
Rnf169	C	G	7: 99,926,446 (GRCm38)	G314A	probably damaging	Het
Rpgrip1l	T	A	8: 91,270,177 (GRCm38)	T692S	probably damaging	Het
Rtf1	T	C	2: 119,675,228 (GRCm38)	V54A	possibly damaging	Het
Rtn4	T	C	11: 29,708,660 (GRCm38)	V938A	probably benign	Het
Ryr2	T	C	13: 11,708,227 (GRCm38)	T2509A	probably damaging	Het
Ryr2	T	A	13: 11,687,932 (GRCm38)	D2890V	probably damaging	Het
Scel	A	C	14: 103,583,100 (GRCm38)	T348P	probably benign	Het
Scgb1b2	G	T	7: 31,291,573 (GRCm38)	L37I	possibly damaging	Het
Sdf4	A	G	4: 156,000,721 (GRCm38)	H171R	possibly damaging	Het
Sec31a	A	G	5: 100,393,363 (GRCm38)	V295A	probably damaging	Het
Setx	T	A	2: 29,146,373 (GRCm38)	S957T	probably benign	Het
Shroom3	G	T	5: 92,943,086 (GRCm38)	V1151F	probably damaging	Het
Six5	A	G	7: 19,096,969 (GRCm38)	N507S	probably benign	Het
Slc12a7	T	C	13: 73,763,892 (GRCm38)		probably null	Het
Slc1a7	T	A	4: 107,993,040 (GRCm38)	V116E	probably damaging	Het
Slc22a1	A	G	17: 12,675,535 (GRCm38)	L42P	probably damaging	Het
Slc25a31	A	T	3: 40,721,545 (GRCm38)	I174F	probably damaging	Het
Slc31a2	A	T	4: 62,292,632 (GRCm38)	M3L	probably damaging	Het
Slco1a4	T	A	6: 141,845,497 (GRCm38)		probably benign	Het
Smcr8	C	T	11: 60,778,610 (GRCm38)		probably null	Het
Smg5	G	T	3: 88,355,692 (GRCm38)	E801*	probably null	Het
Smgc	C	A	15: 91,854,616 (GRCm38)	H492Q	probably benign	Het
Smyd4	G	T	11: 75,403,184 (GRCm38)	G694V	probably damaging	Het
Sorcs3	A	G	19: 48,398,744 (GRCm38)	T223A	possibly damaging	Het
Stab1	G	T	14: 31,141,371 (GRCm38)	C2119*	probably null	Het
Taar9	A	G	10: 24,108,843 (GRCm38)	I231T	probably damaging	Het
Tacr2	A	G	10: 62,261,548 (GRCm38)	Y269C	probably damaging	Het
Taf3	T	G	2: 9,951,123 (GRCm38)	K744N	possibly damaging	Het
Tenm4	T	A	7: 96,906,245 (GRCm38)	V2682E	probably damaging	Het
Tet1	A	C	10: 62,822,663 (GRCm38)	L1468R	probably damaging	Het
Tgds	T	C	14: 118,117,033 (GRCm38)		probably benign	Het
Tgfb2	A	T	1: 186,628,913 (GRCm38)	Y380*	probably null	Het
Tgm5	T	G	2: 121,052,472 (GRCm38)	K435Q	probably damaging	Het
Themis	A	G	10: 28,761,511 (GRCm38)	T204A	probably benign	Het
Tm4sf1	T	C	3: 57,294,679 (GRCm38)	Y37C	probably damaging	Het
Tnn	T	C	1: 160,145,033 (GRCm38)	N333S	possibly damaging	Het
Tppp2	A	G	14: 51,919,348 (GRCm38)	N61D	probably benign	Het
Treml2	A	G	17: 48,309,159 (GRCm38)	T276A	probably benign	Het
Trit1	T	C	4: 123,016,638 (GRCm38)	V10A	probably benign	Het
Uba1y	T	G	Y: 825,890 (GRCm38)		probably null	Het
Uqcc1	T	C	2: 155,858,106 (GRCm38)		probably benign	Het
Vcam1	C	G	3: 116,115,935 (GRCm38)	G581A	probably damaging	Het
Vmn1r16	G	A	6: 57,323,190 (GRCm38)	T149I	probably benign	Het
Vmn1r209	T	C	13: 22,805,656 (GRCm38)	D288G	probably damaging	Het
Vmn1r78	T	A	7: 12,152,964 (GRCm38)	Y167*	probably null	Het
Vmn2r103	T	A	17: 19,795,076 (GRCm38)	S493T	probably benign	Het
Vmn2r105	T	A	17: 20,227,294 (GRCm38)	M423L	probably benign	Het
Vps13c	T	C	9: 67,964,282 (GRCm38)	F3244L	probably damaging	Het
Zfp119b	A	T	17: 55,939,642 (GRCm38)	D149E	probably damaging	Het
Zfp345	T	C	2: 150,473,308 (GRCm38)	Y103C	possibly damaging	Het
Zmym6	C	T	4: 127,123,216 (GRCm38)	T930I	probably benign	Het

Other mutations in Cr2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00587:Cr2	APN	1	195,154,251 (GRCm38)	missense	possibly damaging	0.76
IGL01326:Cr2	APN	1	195,141,221 (GRCm38)	missense	probably null	1.00
IGL01358:Cr2	APN	1	195,159,820 (GRCm38)	missense	probably damaging	1.00
IGL01410:Cr2	APN	1	195,163,234 (GRCm38)	missense	possibly damaging	0.49
IGL01468:Cr2	APN	1	195,168,535 (GRCm38)	missense	probably damaging	1.00
IGL01608:Cr2	APN	1	195,155,220 (GRCm38)	missense	possibly damaging	0.50
IGL01810:Cr2	APN	1	195,159,595 (GRCm38)	missense	possibly damaging	0.49
IGL01843:Cr2	APN	1	195,150,914 (GRCm38)	splice site	probably benign
IGL02332:Cr2	APN	1	195,160,322 (GRCm38)	missense	probably benign	0.19
IGL02934:Cr2	APN	1	195,154,325 (GRCm38)	splice site	probably benign
IGL02938:Cr2	APN	1	195,166,388 (GRCm38)	missense	probably damaging	1.00
IGL03149:Cr2	APN	1	195,166,366 (GRCm38)	missense	probably damaging	1.00
IGL03327:Cr2	APN	1	195,169,759 (GRCm38)	missense	probably damaging	1.00
IGL03346:Cr2	APN	1	195,169,759 (GRCm38)	missense	probably damaging	1.00
Pillar	UTSW	1	195,155,888 (GRCm38)	nonsense	probably null
PIT4354001:Cr2	UTSW	1	195,166,309 (GRCm38)	missense	probably damaging	1.00
PIT4418001:Cr2	UTSW	1	195,157,452 (GRCm38)	missense	probably benign	0.08
R0128:Cr2	UTSW	1	195,166,231 (GRCm38)	missense	probably damaging	0.99
R0130:Cr2	UTSW	1	195,166,231 (GRCm38)	missense	probably damaging	0.99
R0380:Cr2	UTSW	1	195,157,407 (GRCm38)	missense	probably damaging	1.00
R0538:Cr2	UTSW	1	195,160,359 (GRCm38)	splice site	probably benign
R0605:Cr2	UTSW	1	195,163,596 (GRCm38)	splice site	probably benign
R0626:Cr2	UTSW	1	195,171,111 (GRCm38)	missense	possibly damaging	0.95
R1135:Cr2	UTSW	1	195,157,190 (GRCm38)	missense	probably damaging	1.00
R1396:Cr2	UTSW	1	195,169,253 (GRCm38)	splice site	probably null
R1422:Cr2	UTSW	1	195,171,125 (GRCm38)	missense	probably benign	0.01
R1467:Cr2	UTSW	1	195,157,509 (GRCm38)	missense	probably damaging	1.00
R1467:Cr2	UTSW	1	195,157,509 (GRCm38)	missense	probably damaging	1.00
R1511:Cr2	UTSW	1	195,155,272 (GRCm38)	missense	possibly damaging	0.92
R1572:Cr2	UTSW	1	195,163,314 (GRCm38)	missense	probably damaging	1.00
R1714:Cr2	UTSW	1	195,151,686 (GRCm38)	missense	possibly damaging	0.46
R1748:Cr2	UTSW	1	195,155,905 (GRCm38)	nonsense	probably null
R1761:Cr2	UTSW	1	195,155,123 (GRCm38)	critical splice donor site	probably null
R1824:Cr2	UTSW	1	195,157,316 (GRCm38)	missense	probably damaging	1.00
R1893:Cr2	UTSW	1	195,155,187 (GRCm38)	missense	probably benign	0.03
R1990:Cr2	UTSW	1	195,154,150 (GRCm38)	missense	possibly damaging	0.63
R1991:Cr2	UTSW	1	195,154,150 (GRCm38)	missense	possibly damaging	0.63
R1992:Cr2	UTSW	1	195,154,150 (GRCm38)	missense	possibly damaging	0.63
R2191:Cr2	UTSW	1	195,163,381 (GRCm38)	missense	possibly damaging	0.94
R2276:Cr2	UTSW	1	195,157,368 (GRCm38)	missense	possibly damaging	0.94
R2277:Cr2	UTSW	1	195,157,368 (GRCm38)	missense	possibly damaging	0.94
R3548:Cr2	UTSW	1	195,155,888 (GRCm38)	nonsense	probably null
R3743:Cr2	UTSW	1	195,149,966 (GRCm38)	splice site	probably benign
R3941:Cr2	UTSW	1	195,165,814 (GRCm38)	missense	probably damaging	0.97
R3963:Cr2	UTSW	1	195,159,739 (GRCm38)	missense	probably damaging	1.00
R4211:Cr2	UTSW	1	195,156,328 (GRCm38)	missense	probably damaging	0.96
R4484:Cr2	UTSW	1	195,154,174 (GRCm38)	missense	probably damaging	1.00
R4546:Cr2	UTSW	1	195,171,041 (GRCm38)	missense	possibly damaging	0.94
R4791:Cr2	UTSW	1	195,155,935 (GRCm38)	missense	probably damaging	1.00
R4802:Cr2	UTSW	1	195,163,311 (GRCm38)	missense	probably damaging	1.00
R4874:Cr2	UTSW	1	195,176,570 (GRCm38)	missense	possibly damaging	0.82
R4885:Cr2	UTSW	1	195,158,731 (GRCm38)	missense	possibly damaging	0.92
R4889:Cr2	UTSW	1	195,176,585 (GRCm38)	missense	possibly damaging	0.70
R5154:Cr2	UTSW	1	195,159,446 (GRCm38)	missense	probably damaging	1.00
R5574:Cr2	UTSW	1	195,141,236 (GRCm38)	missense	probably damaging	1.00
R5594:Cr2	UTSW	1	195,157,190 (GRCm38)	missense	probably damaging	1.00
R5645:Cr2	UTSW	1	195,154,273 (GRCm38)	missense	probably damaging	1.00
R5700:Cr2	UTSW	1	195,159,757 (GRCm38)	missense	probably damaging	0.96
R5929:Cr2	UTSW	1	195,171,111 (GRCm38)	missense	possibly damaging	0.91
R6237:Cr2	UTSW	1	195,157,502 (GRCm38)	missense	probably damaging	1.00
R6299:Cr2	UTSW	1	195,168,646 (GRCm38)	missense	probably damaging	1.00
R6368:Cr2	UTSW	1	195,168,472 (GRCm38)	missense	probably damaging	1.00
R6406:Cr2	UTSW	1	195,169,771 (GRCm38)	missense	probably damaging	1.00
R6618:Cr2	UTSW	1	195,157,379 (GRCm38)	missense	probably damaging	0.98
R6684:Cr2	UTSW	1	195,171,021 (GRCm38)	nonsense	probably null
R6720:Cr2	UTSW	1	195,155,200 (GRCm38)	missense	probably damaging	0.97
R6866:Cr2	UTSW	1	195,151,691 (GRCm38)	missense	probably damaging	1.00
R6915:Cr2	UTSW	1	195,171,146 (GRCm38)	missense	probably benign	0.06
R7057:Cr2	UTSW	1	195,151,610 (GRCm38)	missense	possibly damaging	0.83
R7117:Cr2	UTSW	1	195,160,601 (GRCm38)	missense	possibly damaging	0.79
R7200:Cr2	UTSW	1	195,163,249 (GRCm38)	missense	probably damaging	1.00
R7209:Cr2	UTSW	1	195,168,724 (GRCm38)	missense	probably damaging	1.00
R7350:Cr2	UTSW	1	195,155,286 (GRCm38)	missense	probably benign	0.21
R7414:Cr2	UTSW	1	195,150,036 (GRCm38)	missense	probably benign
R7453:Cr2	UTSW	1	195,165,257 (GRCm38)	splice site	probably null
R7479:Cr2	UTSW	1	195,158,410 (GRCm38)	critical splice donor site	probably null
R7480:Cr2	UTSW	1	195,154,176 (GRCm38)	missense	probably damaging	1.00
R7570:Cr2	UTSW	1	195,169,340 (GRCm38)	nonsense	probably null
R7666:Cr2	UTSW	1	195,154,225 (GRCm38)	missense	probably damaging	1.00
R7921:Cr2	UTSW	1	195,151,667 (GRCm38)	missense	possibly damaging	0.94
R7923:Cr2	UTSW	1	195,168,687 (GRCm38)	missense	probably benign	0.03
R8396:Cr2	UTSW	1	195,158,068 (GRCm38)	missense	probably damaging	1.00
R8503:Cr2	UTSW	1	195,163,542 (GRCm38)	missense	probably benign
R8517:Cr2	UTSW	1	195,155,899 (GRCm38)	missense	probably benign	0.03
R8773:Cr2	UTSW	1	195,158,605 (GRCm38)	missense	probably damaging	1.00
R8849:Cr2	UTSW	1	195,157,239 (GRCm38)	missense	probably damaging	1.00
R8896:Cr2	UTSW	1	195,169,273 (GRCm38)	missense	possibly damaging	0.58
R8938:Cr2	UTSW	1	195,171,116 (GRCm38)	missense	probably damaging	0.99
R9027:Cr2	UTSW	1	195,151,721 (GRCm38)	missense	probably benign	0.08
R9045:Cr2	UTSW	1	195,155,372 (GRCm38)	missense	possibly damaging	0.61
R9116:Cr2	UTSW	1	195,158,669 (GRCm38)	nonsense	probably null
R9137:Cr2	UTSW	1	195,168,332 (GRCm38)	critical splice donor site	probably null
R9476:Cr2	UTSW	1	195,158,108 (GRCm38)	missense	probably damaging	0.97
R9497:Cr2	UTSW	1	195,168,435 (GRCm38)	missense	probably damaging	0.99
R9510:Cr2	UTSW	1	195,158,108 (GRCm38)	missense	probably damaging	0.97
R9752:Cr2	UTSW	1	195,141,267 (GRCm38)	missense	probably benign	0.37
R9799:Cr2	UTSW	1	195,160,680 (GRCm38)	missense	probably benign	0.02
X0028:Cr2	UTSW	1	195,149,982 (GRCm38)	missense	probably benign	0.09
X0066:Cr2	UTSW	1	195,166,321 (GRCm38)	missense	probably damaging	0.99
Z1176:Cr2	UTSW	1	195,154,153 (GRCm38)	missense	probably benign	0.23

Predicted Primers

PCR Primer
(F):5'- TGATGTAGCTTTGCTTCCACAC -3'
(R):5'- CCTGGAACTGTTCTGAGGTACAC -3'

Sequencing Primer
(F):5'- ACACTCAATGTTCTCACAGCTGG -3'
(R):5'- GAGGTACACTTGTTCACCTAGC -3'

Posted On

2016-02-04