Incidental Mutation 'R0421:Vmn2r11'
ID |
37053 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r11
|
Ensembl Gene |
ENSMUSG00000091450 |
Gene Name |
vomeronasal 2, receptor 11 |
Synonyms |
EG384219 |
MMRRC Submission |
038623-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.073)
|
Stock # |
R0421 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
5 |
Chromosomal Location |
109194739-109207318 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to G
at 109207294 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Isoleucine to Leucine
at position 9
(I9L)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000133218
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000164875]
|
AlphaFold |
E9Q4X4 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000164875
AA Change: I9L
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
SMART Domains |
Protein: ENSMUSP00000133218 Gene: ENSMUSG00000091450 AA Change: I9L
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
167 |
475 |
1.6e-29 |
PFAM |
Pfam:NCD3G
|
520 |
574 |
9.1e-19 |
PFAM |
Pfam:7tm_3
|
607 |
842 |
4.6e-55 |
PFAM |
|
Meta Mutation Damage Score |
0.0898 |
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.3%
- 10x: 96.4%
- 20x: 92.7%
|
Validation Efficiency |
97% (67/69) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 69 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Abi1 |
G |
A |
2: 22,850,839 (GRCm39) |
T195I |
probably damaging |
Het |
Afap1l1 |
T |
C |
18: 61,884,945 (GRCm39) |
N180S |
probably damaging |
Het |
Arsg |
A |
G |
11: 109,418,592 (GRCm39) |
Y196C |
probably damaging |
Het |
Ascc3 |
G |
T |
10: 50,625,022 (GRCm39) |
V1637L |
probably benign |
Het |
Atp2b2 |
C |
A |
6: 113,790,849 (GRCm39) |
R185L |
probably damaging |
Het |
Ccr9 |
A |
T |
9: 123,608,671 (GRCm39) |
M118L |
probably benign |
Het |
Cdh12 |
A |
T |
15: 21,480,310 (GRCm39) |
|
probably null |
Het |
Cdk13 |
T |
C |
13: 17,937,755 (GRCm39) |
S763G |
probably damaging |
Het |
Cenpk |
C |
A |
13: 104,378,911 (GRCm39) |
N177K |
probably benign |
Het |
Cfap43 |
T |
G |
19: 47,824,014 (GRCm39) |
N119T |
probably benign |
Het |
Chrna6 |
T |
C |
8: 27,898,415 (GRCm39) |
E101G |
probably null |
Het |
Clasp2 |
G |
A |
9: 113,683,370 (GRCm39) |
R400H |
probably benign |
Het |
Col6a6 |
T |
C |
9: 105,661,405 (GRCm39) |
M235V |
probably benign |
Het |
Ddx49 |
A |
T |
8: 70,748,282 (GRCm39) |
L291Q |
probably damaging |
Het |
Dhrs7 |
A |
T |
12: 72,699,860 (GRCm39) |
|
probably benign |
Het |
Dnah5 |
A |
T |
15: 28,229,687 (GRCm39) |
K107M |
possibly damaging |
Het |
Dsg2 |
C |
T |
18: 20,712,448 (GRCm39) |
R151C |
probably damaging |
Het |
Dsn1 |
T |
C |
2: 156,847,789 (GRCm39) |
T2A |
possibly damaging |
Het |
Edem3 |
A |
G |
1: 151,668,189 (GRCm39) |
|
probably benign |
Het |
Eif3c |
T |
C |
7: 126,162,884 (GRCm39) |
N133S |
possibly damaging |
Het |
F10 |
A |
G |
8: 13,095,097 (GRCm39) |
K85E |
probably benign |
Het |
Fbn2 |
T |
A |
18: 58,160,876 (GRCm39) |
|
probably benign |
Het |
Gtpbp10 |
A |
T |
5: 5,607,290 (GRCm39) |
H50Q |
probably benign |
Het |
Hephl1 |
A |
G |
9: 14,970,456 (GRCm39) |
F1013L |
probably benign |
Het |
Hps3 |
C |
A |
3: 20,083,480 (GRCm39) |
V238F |
probably benign |
Het |
Kcna10 |
A |
C |
3: 107,101,820 (GRCm39) |
K150N |
probably damaging |
Het |
Kirrel1 |
C |
T |
3: 86,990,914 (GRCm39) |
G636D |
probably damaging |
Het |
Kndc1 |
G |
A |
7: 139,488,912 (GRCm39) |
R189H |
probably damaging |
Het |
Knop1 |
C |
T |
7: 118,454,852 (GRCm39) |
E50K |
possibly damaging |
Het |
Kplce |
T |
C |
3: 92,776,291 (GRCm39) |
T131A |
probably damaging |
Het |
Kpna7 |
T |
A |
5: 144,926,551 (GRCm39) |
H467L |
possibly damaging |
Het |
Lcn4 |
T |
C |
2: 26,558,661 (GRCm39) |
N142D |
possibly damaging |
Het |
Map3k3 |
T |
C |
11: 106,039,741 (GRCm39) |
|
probably benign |
Het |
Mdn1 |
A |
G |
4: 32,684,707 (GRCm39) |
T806A |
probably benign |
Het |
Nbeal1 |
T |
A |
1: 60,307,598 (GRCm39) |
N1703K |
probably benign |
Het |
Neurl4 |
T |
C |
11: 69,799,360 (GRCm39) |
V914A |
probably damaging |
Het |
Niban1 |
T |
A |
1: 151,584,833 (GRCm39) |
|
probably benign |
Het |
Nop56 |
T |
C |
2: 130,118,692 (GRCm39) |
S275P |
possibly damaging |
Het |
Or1j20 |
A |
G |
2: 36,759,653 (GRCm39) |
E25G |
possibly damaging |
Het |
Or52ac1 |
A |
G |
7: 104,245,929 (GRCm39) |
V153A |
probably benign |
Het |
Or7e174 |
A |
G |
9: 20,012,771 (GRCm39) |
K239E |
probably damaging |
Het |
Otof |
A |
C |
5: 30,528,912 (GRCm39) |
I1827S |
possibly damaging |
Het |
Pappa2 |
A |
T |
1: 158,675,650 (GRCm39) |
I1032N |
probably damaging |
Het |
Pcdh7 |
A |
G |
5: 57,877,402 (GRCm39) |
E319G |
probably damaging |
Het |
Pcdhb11 |
T |
A |
18: 37,555,533 (GRCm39) |
S288T |
probably benign |
Het |
Phip |
A |
T |
9: 82,808,510 (GRCm39) |
D488E |
probably damaging |
Het |
Pla2g7 |
A |
T |
17: 43,922,303 (GRCm39) |
H394L |
probably damaging |
Het |
Plk3 |
A |
G |
4: 116,990,641 (GRCm39) |
V69A |
probably damaging |
Het |
Prob1 |
C |
A |
18: 35,786,083 (GRCm39) |
A724S |
possibly damaging |
Het |
Prune2 |
T |
C |
19: 17,100,675 (GRCm39) |
F2060L |
probably benign |
Het |
Rgl3 |
G |
A |
9: 21,887,328 (GRCm39) |
R498C |
probably benign |
Het |
Rnf213 |
A |
C |
11: 119,338,083 (GRCm39) |
N3362H |
probably damaging |
Het |
Sbds |
A |
G |
5: 130,282,774 (GRCm39) |
|
probably benign |
Het |
Scn9a |
T |
C |
2: 66,373,621 (GRCm39) |
S453G |
probably benign |
Het |
Sh3rf3 |
T |
C |
10: 58,819,897 (GRCm39) |
L236P |
probably damaging |
Het |
Skint1 |
A |
G |
4: 111,876,211 (GRCm39) |
N44S |
possibly damaging |
Het |
Slc5a1 |
T |
A |
5: 33,291,996 (GRCm39) |
I141N |
probably damaging |
Het |
Tlcd3b |
G |
A |
7: 126,424,187 (GRCm39) |
V44M |
probably damaging |
Het |
Trank1 |
T |
A |
9: 111,220,907 (GRCm39) |
I2548N |
probably damaging |
Het |
Tsc22d2 |
G |
A |
3: 58,324,749 (GRCm39) |
|
probably benign |
Het |
Unc13c |
T |
A |
9: 73,840,492 (GRCm39) |
I120F |
possibly damaging |
Het |
Vmn2r58 |
T |
G |
7: 41,514,628 (GRCm39) |
N114H |
probably benign |
Het |
Vps53 |
A |
G |
11: 75,973,496 (GRCm39) |
L166P |
probably damaging |
Het |
Zfp119a |
T |
A |
17: 56,172,248 (GRCm39) |
K532* |
probably null |
Het |
Zfp472 |
A |
G |
17: 33,194,897 (GRCm39) |
T11A |
possibly damaging |
Het |
Zfp512b |
T |
A |
2: 181,230,051 (GRCm39) |
K87* |
probably null |
Het |
Zfp518b |
G |
A |
5: 38,831,918 (GRCm39) |
P29L |
probably damaging |
Het |
Zfp599 |
A |
G |
9: 22,161,843 (GRCm39) |
|
probably benign |
Het |
Zic2 |
CCCACCACCACCATCACCACCACCACC |
CCCACCATCACCACCACCACC |
14: 122,713,776 (GRCm39) |
|
probably benign |
Het |
|
Other mutations in Vmn2r11 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00925:Vmn2r11
|
APN |
5 |
109,194,885 (GRCm39) |
missense |
probably benign |
0.00 |
IGL01677:Vmn2r11
|
APN |
5 |
109,201,823 (GRCm39) |
missense |
possibly damaging |
0.50 |
IGL02048:Vmn2r11
|
APN |
5 |
109,202,658 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02559:Vmn2r11
|
APN |
5 |
109,200,046 (GRCm39) |
missense |
probably damaging |
0.98 |
IGL02879:Vmn2r11
|
APN |
5 |
109,201,704 (GRCm39) |
missense |
possibly damaging |
0.95 |
IGL03084:Vmn2r11
|
APN |
5 |
109,207,209 (GRCm39) |
missense |
probably benign |
0.00 |
IGL03163:Vmn2r11
|
APN |
5 |
109,201,692 (GRCm39) |
missense |
probably benign |
0.41 |
IGL03289:Vmn2r11
|
APN |
5 |
109,196,788 (GRCm39) |
splice site |
probably benign |
|
IGL03294:Vmn2r11
|
APN |
5 |
109,201,935 (GRCm39) |
missense |
probably benign |
0.22 |
R0233:Vmn2r11
|
UTSW |
5 |
109,201,968 (GRCm39) |
missense |
probably benign |
0.16 |
R0233:Vmn2r11
|
UTSW |
5 |
109,201,968 (GRCm39) |
missense |
probably benign |
0.16 |
R0549:Vmn2r11
|
UTSW |
5 |
109,199,963 (GRCm39) |
missense |
possibly damaging |
0.80 |
R0628:Vmn2r11
|
UTSW |
5 |
109,195,597 (GRCm39) |
missense |
possibly damaging |
0.88 |
R1523:Vmn2r11
|
UTSW |
5 |
109,201,707 (GRCm39) |
missense |
probably benign |
0.25 |
R1660:Vmn2r11
|
UTSW |
5 |
109,201,724 (GRCm39) |
missense |
possibly damaging |
0.79 |
R1827:Vmn2r11
|
UTSW |
5 |
109,199,938 (GRCm39) |
missense |
probably benign |
0.01 |
R1913:Vmn2r11
|
UTSW |
5 |
109,202,654 (GRCm39) |
missense |
probably benign |
|
R2260:Vmn2r11
|
UTSW |
5 |
109,201,657 (GRCm39) |
nonsense |
probably null |
|
R2400:Vmn2r11
|
UTSW |
5 |
109,199,928 (GRCm39) |
missense |
probably benign |
0.03 |
R3933:Vmn2r11
|
UTSW |
5 |
109,201,260 (GRCm39) |
missense |
probably damaging |
0.97 |
R4091:Vmn2r11
|
UTSW |
5 |
109,202,616 (GRCm39) |
critical splice donor site |
probably null |
|
R4624:Vmn2r11
|
UTSW |
5 |
109,200,101 (GRCm39) |
missense |
probably damaging |
0.99 |
R4762:Vmn2r11
|
UTSW |
5 |
109,195,436 (GRCm39) |
missense |
probably damaging |
1.00 |
R5256:Vmn2r11
|
UTSW |
5 |
109,202,658 (GRCm39) |
missense |
probably benign |
0.26 |
R5370:Vmn2r11
|
UTSW |
5 |
109,195,421 (GRCm39) |
missense |
probably damaging |
1.00 |
R5419:Vmn2r11
|
UTSW |
5 |
109,207,224 (GRCm39) |
missense |
possibly damaging |
0.55 |
R5516:Vmn2r11
|
UTSW |
5 |
109,195,032 (GRCm39) |
missense |
probably damaging |
0.98 |
R5643:Vmn2r11
|
UTSW |
5 |
109,194,869 (GRCm39) |
missense |
probably damaging |
1.00 |
R5671:Vmn2r11
|
UTSW |
5 |
109,202,772 (GRCm39) |
missense |
probably benign |
0.03 |
R5679:Vmn2r11
|
UTSW |
5 |
109,202,708 (GRCm39) |
missense |
probably benign |
0.00 |
R5739:Vmn2r11
|
UTSW |
5 |
109,207,114 (GRCm39) |
critical splice donor site |
probably null |
|
R5746:Vmn2r11
|
UTSW |
5 |
109,201,560 (GRCm39) |
missense |
probably benign |
0.41 |
R5995:Vmn2r11
|
UTSW |
5 |
109,194,921 (GRCm39) |
missense |
probably damaging |
1.00 |
R6147:Vmn2r11
|
UTSW |
5 |
109,202,700 (GRCm39) |
missense |
probably benign |
0.04 |
R6220:Vmn2r11
|
UTSW |
5 |
109,201,434 (GRCm39) |
missense |
probably benign |
0.09 |
R6374:Vmn2r11
|
UTSW |
5 |
109,201,679 (GRCm39) |
missense |
possibly damaging |
0.65 |
R6491:Vmn2r11
|
UTSW |
5 |
109,196,800 (GRCm39) |
missense |
possibly damaging |
0.95 |
R6804:Vmn2r11
|
UTSW |
5 |
109,201,350 (GRCm39) |
missense |
probably damaging |
1.00 |
R6814:Vmn2r11
|
UTSW |
5 |
109,194,976 (GRCm39) |
missense |
possibly damaging |
0.81 |
R6872:Vmn2r11
|
UTSW |
5 |
109,194,976 (GRCm39) |
missense |
possibly damaging |
0.81 |
R7014:Vmn2r11
|
UTSW |
5 |
109,201,289 (GRCm39) |
missense |
probably damaging |
1.00 |
R7041:Vmn2r11
|
UTSW |
5 |
109,202,816 (GRCm39) |
missense |
probably damaging |
1.00 |
R7043:Vmn2r11
|
UTSW |
5 |
109,200,098 (GRCm39) |
missense |
probably benign |
0.00 |
R7050:Vmn2r11
|
UTSW |
5 |
109,202,657 (GRCm39) |
missense |
probably benign |
0.05 |
R7184:Vmn2r11
|
UTSW |
5 |
109,201,281 (GRCm39) |
missense |
probably damaging |
1.00 |
R7388:Vmn2r11
|
UTSW |
5 |
109,202,742 (GRCm39) |
missense |
probably benign |
0.05 |
R7477:Vmn2r11
|
UTSW |
5 |
109,207,214 (GRCm39) |
missense |
possibly damaging |
0.67 |
R7524:Vmn2r11
|
UTSW |
5 |
109,201,848 (GRCm39) |
missense |
probably benign |
0.01 |
R7682:Vmn2r11
|
UTSW |
5 |
109,195,481 (GRCm39) |
missense |
probably benign |
0.02 |
R7715:Vmn2r11
|
UTSW |
5 |
109,195,307 (GRCm39) |
missense |
probably damaging |
0.99 |
R7869:Vmn2r11
|
UTSW |
5 |
109,199,986 (GRCm39) |
missense |
probably damaging |
1.00 |
R8094:Vmn2r11
|
UTSW |
5 |
109,201,626 (GRCm39) |
missense |
probably damaging |
1.00 |
R8277:Vmn2r11
|
UTSW |
5 |
109,202,833 (GRCm39) |
missense |
probably benign |
0.00 |
R8506:Vmn2r11
|
UTSW |
5 |
109,207,270 (GRCm39) |
missense |
probably benign |
0.00 |
R8676:Vmn2r11
|
UTSW |
5 |
109,201,626 (GRCm39) |
missense |
probably damaging |
1.00 |
R8701:Vmn2r11
|
UTSW |
5 |
109,195,556 (GRCm39) |
missense |
probably damaging |
1.00 |
R8749:Vmn2r11
|
UTSW |
5 |
109,195,319 (GRCm39) |
missense |
probably damaging |
0.97 |
R9046:Vmn2r11
|
UTSW |
5 |
109,202,850 (GRCm39) |
missense |
probably benign |
0.00 |
R9138:Vmn2r11
|
UTSW |
5 |
109,201,904 (GRCm39) |
missense |
probably damaging |
1.00 |
R9267:Vmn2r11
|
UTSW |
5 |
109,199,929 (GRCm39) |
missense |
possibly damaging |
0.93 |
R9306:Vmn2r11
|
UTSW |
5 |
109,196,831 (GRCm39) |
missense |
probably damaging |
1.00 |
R9384:Vmn2r11
|
UTSW |
5 |
109,201,266 (GRCm39) |
missense |
probably damaging |
1.00 |
R9443:Vmn2r11
|
UTSW |
5 |
109,195,159 (GRCm39) |
nonsense |
probably null |
|
R9520:Vmn2r11
|
UTSW |
5 |
109,201,455 (GRCm39) |
missense |
probably benign |
0.35 |
R9596:Vmn2r11
|
UTSW |
5 |
109,201,563 (GRCm39) |
missense |
possibly damaging |
0.67 |
R9677:Vmn2r11
|
UTSW |
5 |
109,201,332 (GRCm39) |
missense |
|
|
|
Predicted Primers |
PCR Primer
(F):5'- TAGGACAGACCCTCACAGTTGGTG -3'
(R):5'- GCTTGAGGCCAGAATTTTCCCGATG -3'
Sequencing Primer
(F):5'- GTTTCCTCGAATGTCCAAAGG -3'
(R):5'- TGTATCCAGGGAGCATGATATAAATG -3'
|
Posted On |
2013-05-09 |