Mutagenetix > Incidental Mutations

Incidental Mutation 'R4804:Olfr1369-ps1'

370567

Institutional Source

Beutler Lab

Gene Symbol

Olfr1369-ps1

Ensembl Gene

ENSMUSG00000060404

Gene Name

olfactory receptor 1369, pseudogene 1

Synonyms

GA_x6K02T2QHY8-12126170-12125935, MOR256-31

MMRRC Submission

041998-MU

Accession Numbers

Is this an essential gene?

Possibly non essential (E-score: 0.397) question?

Stock #

R4804 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

21111483-21119095 bp(+) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

T to A at 21116005 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 104 (Y104*)

Ref Sequence

ENSEMBL: ENSMUSP00000151041 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000079050] [ENSMUST00000213326] [ENSMUST00000213922] [ENSMUST00000215207] [ENSMUST00000215941]

AlphaFold

A0A140T8K7

Predicted Effect

probably null
Transcript: ENSMUST00000079050
AA Change: Y104*

SMART Domains

Protein: ENSMUSP00000078059
Gene: ENSMUSG00000060404
AA Change: Y104*

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	6.2e-47	PFAM
Pfam:7tm_1	41	290	1.1e-30	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000213326
AA Change: Y104*

Predicted Effect

probably null
Transcript: ENSMUST00000213922
AA Change: Y104*

Predicted Effect

probably null
Transcript: ENSMUST00000215207
AA Change: Y104*

Predicted Effect

probably null
Transcript: ENSMUST00000215941
AA Change: Y104*

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 96.9%
20x: 94.2%

Validation Efficiency

99% (78/79)

Allele List at MGI

Other mutations in this stock

Total: 67 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700020D05Rik	A	T	19: 5,503,000	M251K	possibly damaging	Het
4930527J03Rik	T	C	1: 178,276,109		noncoding transcript	Het
Akap2	T	C	4: 57,854,688	S67P	probably benign	Het
Ap4e1	T	C	2: 127,043,758		probably null	Het
Apbb1ip	T	C	2: 22,823,598		probably null	Het
Apol11b	T	A	15: 77,635,266	I205F	probably damaging	Het
Arl6ip1	A	T	7: 118,129,552		probably null	Het
Barx2	A	G	9: 31,846,812	S277P	unknown	Het
BC035947	T	G	1: 78,497,876	D673A	probably damaging	Het
Cacna2d1	A	T	5: 16,359,208	I930F	probably damaging	Het
Cd226	T	C	18: 89,207,168	V63A	possibly damaging	Het
Cdk8	A	G	5: 146,296,399	K236E	probably damaging	Het
Cds1	T	C	5: 101,821,523	L449P	probably damaging	Het
Celsr1	T	C	15: 85,937,953	D1721G	possibly damaging	Het
Chtf18	T	C	17: 25,719,257	D934G	probably benign	Het
Clk4	T	A	11: 51,281,323	L271Q	probably damaging	Het
Cnnm1	C	A	19: 43,491,575	T853N	probably benign	Het
Col26a1	A	G	5: 136,836,725	V103A	probably damaging	Het
D5Ertd579e	C	T	5: 36,629,652		probably null	Het
Ddx39	A	G	8: 83,721,095	K190E	probably damaging	Het
Dgkg	G	A	16: 22,575,193		probably benign	Het
Dnajc14	A	T	10: 128,814,057	H477L	probably benign	Het
Dytn	A	G	1: 63,643,366	V374A	probably benign	Het
Gfra2	T	C	14: 70,925,921	Y215H	possibly damaging	Het
Grik1	A	G	16: 87,957,569	I376T	probably damaging	Het
Gzmm	A	T	10: 79,695,056	T231S	probably benign	Het
Hecw1	A	G	13: 14,305,985	S499P	probably benign	Het
Hhla1	T	C	15: 65,923,099	I511V	probably benign	Het
Ifnlr1	A	G	4: 135,705,336	D361G	possibly damaging	Het
Ikzf3	A	G	11: 98,490,574	V60A	probably benign	Het
Ipo4	G	C	14: 55,630,856	R495G	possibly damaging	Het
Kat2b-ps	A	T	5: 93,392,533		noncoding transcript	Het
Kdm1b	C	T	13: 47,063,077	R308W	probably damaging	Het
Mblac2	T	A	13: 81,750,309	L268*	probably null	Het
Mipep	C	T	14: 60,802,952	T307I	probably damaging	Het
Ms4a14	A	G	19: 11,304,040	S385P	possibly damaging	Het
Myh2	T	A	11: 67,186,502	I821N	possibly damaging	Het
Myo5c	A	T	9: 75,245,024	I65F	probably damaging	Het
Neurog1	A	G	13: 56,251,766	L56P	probably benign	Het
Nrsn1	C	A	13: 25,253,597	C116F	probably benign	Het
Nynrin	T	C	14: 55,864,869	V665A	probably benign	Het
Olfr1490	A	G	19: 13,654,518	M30V	probably benign	Het
Olfr988	T	C	2: 85,353,081	I282V	probably benign	Het
Pcdhac1	C	T	18: 37,091,178	S348L	possibly damaging	Het
Pcnx4	T	C	12: 72,574,202	I932T	probably benign	Het
Pfkl	G	A	10: 77,991,394	T486I	probably benign	Het
Pi4ka	A	T	16: 17,308,161	M1115K	possibly damaging	Het
Rilpl1	A	G	5: 124,493,765	W173R	probably damaging	Het
Rnf111	A	T	9: 70,430,957	C900S	possibly damaging	Het
Ryr2	A	G	13: 11,717,097	V2319A	probably damaging	Het
Scnn1g	AATCCTGCAGGTGA	AA	7: 121,763,080		probably null	Het
Slc25a13	A	T	6: 6,109,213	L383H	probably damaging	Het
Slco2a1	C	T	9: 103,073,184	P325L	probably damaging	Het
Stoml2	T	C	4: 43,029,882	N162S	probably benign	Het
Syne1	G	T	10: 5,349,310	Q982K	possibly damaging	Het
Tbc1d31	C	T	15: 57,951,106	Q568*	probably null	Het
Tbc1d9	G	A	8: 83,255,925		probably null	Het
Tbx3	A	G	5: 119,680,512	D384G	possibly damaging	Het
Tecta	T	C	9: 42,398,237	I14V	probably benign	Het
Tgm1	A	T	14: 55,705,619	V588E	probably benign	Het
Tpk1	A	C	6: 43,593,078		probably benign	Het
Tspear	A	T	10: 77,776,957		probably null	Het
Ubxn10	G	T	4: 138,721,204	Q54K	possibly damaging	Het
Ubxn4	C	T	1: 128,266,404	R312*	probably null	Het
Vmn1r230	A	T	17: 20,847,083	K178M	probably damaging	Het
Zfp143	G	A	7: 110,088,769	V445I	probably damaging	Het
Zfp688	C	A	7: 127,421,885	W40C	probably damaging	Het

Other mutations in Olfr1369-ps1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01689:Olfr1369-ps1	APN	13	21116073	missense	probably damaging	0.97
R0631:Olfr1369-ps1	UTSW	13	21115908	missense	probably damaging	1.00
R0960:Olfr1369-ps1	UTSW	13	21116265	missense	possibly damaging	0.94
R1499:Olfr1369-ps1	UTSW	13	21116133	missense	probably benign	0.32
R1549:Olfr1369-ps1	UTSW	13	21116118	missense	probably benign	0.01
R1698:Olfr1369-ps1	UTSW	13	21116565	missense	probably benign	0.11
R1711:Olfr1369-ps1	UTSW	13	21116306	missense	probably benign	0.01
R2404:Olfr1369-ps1	UTSW	13	21115842	missense	probably damaging	1.00
R2471:Olfr1369-ps1	UTSW	13	21116429	missense	probably damaging	1.00
R3844:Olfr1369-ps1	UTSW	13	21116063	missense	possibly damaging	0.91
R3977:Olfr1369-ps1	UTSW	13	21115861	missense	probably benign	0.03
R3979:Olfr1369-ps1	UTSW	13	21115861	missense	probably benign	0.03
R4914:Olfr1369-ps1	UTSW	13	21116397	missense	probably benign	0.12
R5210:Olfr1369-ps1	UTSW	13	21116052	missense	probably damaging	0.99
R5359:Olfr1369-ps1	UTSW	13	21116267	missense	probably damaging	1.00
R5700:Olfr1369-ps1	UTSW	13	21116001	missense	probably damaging	1.00
R6218:Olfr1369-ps1	UTSW	13	21116231	missense	probably damaging	1.00
R6767:Olfr1369-ps1	UTSW	13	21116057	missense	probably benign	0.02
R7396:Olfr1369-ps1	UTSW	13	21116307	missense	probably benign	0.02
R7476:Olfr1369-ps1	UTSW	13	21116021	missense	probably benign	0.04
R7612:Olfr1369-ps1	UTSW	13	21116047	missense	probably damaging	0.99
R8257:Olfr1369-ps1	UTSW	13	21116373	missense	probably benign	0.11
R9388:Olfr1369-ps1	UTSW	13	21116604	missense	probably damaging	0.96
V8831:Olfr1369-ps1	UTSW	13	21116003	missense	possibly damaging	0.93
Z1176:Olfr1369-ps1	UTSW	13	21116601	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- AACACTGCTATAATTCTTGCATCCC -3'
(R):5'- CTGGCAACTCACACAGGAAG -3'

Sequencing Primer
(F):5'- GCTATAATTCTTGCATCCCTCCTGG -3'
(R):5'- ATGTTATGTCCACATCGAGGC -3'

Posted On

2016-02-04