Incidental Mutation 'R4804:Or10w1'
ID 370592
Institutional Source Beutler Lab
Gene Symbol Or10w1
Ensembl Gene ENSMUSG00000061387
Gene Name olfactory receptor family 10 subfamily W member 1
Synonyms Olfr1490, GA_x6K02T2RE5P-3987000-3987950, MOR266-6P
MMRRC Submission 041998-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.128) question?
Stock # R4804 (G1)
Quality Score 225
Status Validated
Chromosome 19
Chromosomal Location 13631810-13632760 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 13631882 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Valine at position 30 (M30V)
Ref Sequence ENSEMBL: ENSMUSP00000151186 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080162] [ENSMUST00000208667] [ENSMUST00000213900]
AlphaFold A0A1L1SVH0
Predicted Effect probably benign
Transcript: ENSMUST00000080162
AA Change: M25V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000079057
Gene: ENSMUSG00000061387
AA Change: M25V

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 5.3e-48 PFAM
Pfam:7tm_1 41 290 2e-22 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000208667
AA Change: M30V
Predicted Effect probably benign
Transcript: ENSMUST00000213900
AA Change: M30V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216631
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.2%
Validation Efficiency 99% (78/79)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930527J03Rik T C 1: 178,103,675 (GRCm39) noncoding transcript Het
Ap4e1 T C 2: 126,885,678 (GRCm39) probably null Het
Apbb1ip T C 2: 22,713,610 (GRCm39) probably null Het
Apol11b T A 15: 77,519,466 (GRCm39) I205F probably damaging Het
Arl6ip1 A T 7: 117,728,775 (GRCm39) probably null Het
Barx2 A G 9: 31,758,108 (GRCm39) S277P unknown Het
BC035947 T G 1: 78,474,513 (GRCm39) D673A probably damaging Het
Cacna2d1 A T 5: 16,564,206 (GRCm39) I930F probably damaging Het
Cd226 T C 18: 89,225,292 (GRCm39) V63A possibly damaging Het
Cdk8 A G 5: 146,233,209 (GRCm39) K236E probably damaging Het
Cds1 T C 5: 101,969,389 (GRCm39) L449P probably damaging Het
Celsr1 T C 15: 85,822,154 (GRCm39) D1721G possibly damaging Het
Chtf18 T C 17: 25,938,231 (GRCm39) D934G probably benign Het
Clk4 T A 11: 51,172,150 (GRCm39) L271Q probably damaging Het
Cnnm1 C A 19: 43,480,014 (GRCm39) T853N probably benign Het
Col26a1 A G 5: 136,865,579 (GRCm39) V103A probably damaging Het
D5Ertd579e C T 5: 36,786,996 (GRCm39) probably null Het
Ddx39a A G 8: 84,447,724 (GRCm39) K190E probably damaging Het
Dgkg G A 16: 22,393,943 (GRCm39) probably benign Het
Dnajc14 A T 10: 128,649,926 (GRCm39) H477L probably benign Het
Dytn A G 1: 63,682,525 (GRCm39) V374A probably benign Het
Gfra2 T C 14: 71,163,361 (GRCm39) Y215H possibly damaging Het
Grik1 A G 16: 87,754,457 (GRCm39) I376T probably damaging Het
Gzmm A T 10: 79,530,890 (GRCm39) T231S probably benign Het
Hecw1 A G 13: 14,480,570 (GRCm39) S499P probably benign Het
Hhla1 T C 15: 65,794,948 (GRCm39) I511V probably benign Het
Ifnlr1 A G 4: 135,432,647 (GRCm39) D361G possibly damaging Het
Ikzf3 A G 11: 98,381,400 (GRCm39) V60A probably benign Het
Ipo4 G C 14: 55,868,313 (GRCm39) R495G possibly damaging Het
Kat2b-ps A T 5: 93,540,392 (GRCm39) noncoding transcript Het
Kdm1b C T 13: 47,216,553 (GRCm39) R308W probably damaging Het
Mblac2 T A 13: 81,898,428 (GRCm39) L268* probably null Het
Mipep C T 14: 61,040,401 (GRCm39) T307I probably damaging Het
Ms4a14 A G 19: 11,281,404 (GRCm39) S385P possibly damaging Het
Myh2 T A 11: 67,077,328 (GRCm39) I821N possibly damaging Het
Myo5c A T 9: 75,152,306 (GRCm39) I65F probably damaging Het
Neurog1 A G 13: 56,399,579 (GRCm39) L56P probably benign Het
Nrsn1 C A 13: 25,437,580 (GRCm39) C116F probably benign Het
Nscme3l A T 19: 5,553,028 (GRCm39) M251K possibly damaging Het
Nynrin T C 14: 56,102,326 (GRCm39) V665A probably benign Het
Or2w1b T A 13: 21,300,175 (GRCm39) Y104* probably null Het
Or5ak20 T C 2: 85,183,425 (GRCm39) I282V probably benign Het
Pakap T C 4: 57,854,688 (GRCm39) S67P probably benign Het
Pcdhac1 C T 18: 37,224,231 (GRCm39) S348L possibly damaging Het
Pcnx4 T C 12: 72,620,976 (GRCm39) I932T probably benign Het
Pfkl G A 10: 77,827,228 (GRCm39) T486I probably benign Het
Pi4ka A T 16: 17,126,025 (GRCm39) M1115K possibly damaging Het
Rilpl1 A G 5: 124,631,828 (GRCm39) W173R probably damaging Het
Rnf111 A T 9: 70,338,239 (GRCm39) C900S possibly damaging Het
Ryr2 A G 13: 11,731,983 (GRCm39) V2319A probably damaging Het
Scnn1g AATCCTGCAGGTGA AA 7: 121,362,303 (GRCm39) probably null Het
Slc25a13 A T 6: 6,109,213 (GRCm39) L383H probably damaging Het
Slco2a1 C T 9: 102,950,383 (GRCm39) P325L probably damaging Het
Stoml2 T C 4: 43,029,882 (GRCm39) N162S probably benign Het
Syne1 G T 10: 5,299,310 (GRCm39) Q982K possibly damaging Het
Tbc1d31 C T 15: 57,814,502 (GRCm39) Q568* probably null Het
Tbc1d9 G A 8: 83,982,554 (GRCm39) probably null Het
Tbx3 A G 5: 119,818,577 (GRCm39) D384G possibly damaging Het
Tecta T C 9: 42,309,533 (GRCm39) I14V probably benign Het
Tgm1 A T 14: 55,943,076 (GRCm39) V588E probably benign Het
Tpk1 A C 6: 43,570,012 (GRCm39) probably benign Het
Tspear A T 10: 77,612,791 (GRCm39) probably null Het
Ubxn10 G T 4: 138,448,515 (GRCm39) Q54K possibly damaging Het
Ubxn4 C T 1: 128,194,141 (GRCm39) R312* probably null Het
Vmn1r230 A T 17: 21,067,345 (GRCm39) K178M probably damaging Het
Zfp143 G A 7: 109,687,976 (GRCm39) V445I probably damaging Het
Zfp688 C A 7: 127,021,057 (GRCm39) W40C probably damaging Het
Other mutations in Or10w1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01324:Or10w1 APN 19 13,632,297 (GRCm39) missense probably damaging 0.96
IGL01335:Or10w1 APN 19 13,632,540 (GRCm39) missense probably damaging 1.00
IGL01561:Or10w1 APN 19 13,632,269 (GRCm39) missense probably benign
IGL01644:Or10w1 APN 19 13,632,768 (GRCm39) utr 3 prime probably benign
IGL02257:Or10w1 APN 19 13,632,629 (GRCm39) missense probably benign
IGL02282:Or10w1 APN 19 13,632,622 (GRCm39) missense probably damaging 1.00
IGL02355:Or10w1 APN 19 13,632,597 (GRCm39) missense probably benign 0.02
IGL02362:Or10w1 APN 19 13,632,597 (GRCm39) missense probably benign 0.02
IGL02639:Or10w1 APN 19 13,631,960 (GRCm39) missense possibly damaging 0.73
R0078:Or10w1 UTSW 19 13,632,179 (GRCm39) missense probably benign 0.00
R0278:Or10w1 UTSW 19 13,632,129 (GRCm39) missense probably damaging 1.00
R0278:Or10w1 UTSW 19 13,632,128 (GRCm39) missense probably damaging 1.00
R0506:Or10w1 UTSW 19 13,632,261 (GRCm39) missense possibly damaging 0.62
R0927:Or10w1 UTSW 19 13,631,816 (GRCm39) missense probably damaging 0.99
R1087:Or10w1 UTSW 19 13,632,376 (GRCm39) nonsense probably null
R1762:Or10w1 UTSW 19 13,631,868 (GRCm39) missense probably benign
R2901:Or10w1 UTSW 19 13,632,309 (GRCm39) missense probably damaging 1.00
R2907:Or10w1 UTSW 19 13,632,611 (GRCm39) missense possibly damaging 0.84
R3625:Or10w1 UTSW 19 13,632,346 (GRCm39) nonsense probably null
R3838:Or10w1 UTSW 19 13,632,321 (GRCm39) missense probably benign 0.00
R4745:Or10w1 UTSW 19 13,632,750 (GRCm39) missense probably benign
R5026:Or10w1 UTSW 19 13,632,296 (GRCm39) missense probably benign 0.03
R5314:Or10w1 UTSW 19 13,632,630 (GRCm39) missense probably benign 0.08
R6052:Or10w1 UTSW 19 13,631,871 (GRCm39) missense possibly damaging 0.95
R6235:Or10w1 UTSW 19 13,632,145 (GRCm39) nonsense probably null
R7405:Or10w1 UTSW 19 13,632,246 (GRCm39) missense probably benign 0.14
R7557:Or10w1 UTSW 19 13,632,390 (GRCm39) missense possibly damaging 0.71
R8038:Or10w1 UTSW 19 13,632,719 (GRCm39) missense possibly damaging 0.91
R8338:Or10w1 UTSW 19 13,632,216 (GRCm39) missense possibly damaging 0.92
R8366:Or10w1 UTSW 19 13,631,903 (GRCm39) missense probably damaging 1.00
R8496:Or10w1 UTSW 19 13,632,388 (GRCm39) missense probably damaging 0.96
R8783:Or10w1 UTSW 19 13,632,323 (GRCm39) missense probably damaging 1.00
R8838:Or10w1 UTSW 19 13,632,371 (GRCm39) missense probably damaging 0.98
R8859:Or10w1 UTSW 19 13,632,246 (GRCm39) missense probably damaging 0.99
R9064:Or10w1 UTSW 19 13,632,719 (GRCm39) missense possibly damaging 0.91
R9161:Or10w1 UTSW 19 13,632,038 (GRCm39) missense probably damaging 1.00
R9466:Or10w1 UTSW 19 13,631,796 (GRCm39) start codon destroyed probably null
R9596:Or10w1 UTSW 19 13,632,002 (GRCm39) missense probably damaging 1.00
R9623:Or10w1 UTSW 19 13,632,414 (GRCm39) missense probably damaging 1.00
Z1176:Or10w1 UTSW 19 13,631,827 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TCACTGCCAAACTATTTGCAG -3'
(R):5'- GCCAAAATGTGTGGTACCAC -3'

Sequencing Primer
(F):5'- GTCCAGTACAGGGGAACACC -3'
(R):5'- TGGTACCACCACTGCAGTGTAAC -3'
Posted On 2016-02-04