Incidental Mutation 'R4805:Zswim3'
ID370607
Institutional Source Beutler Lab
Gene Symbol Zswim3
Ensembl Gene ENSMUSG00000045822
Gene Namezinc finger SWIM-type containing 3
Synonyms4921517A06Rik
MMRRC Submission 041999-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.088) question?
Stock #R4805 (G1)
Quality Score225
Status Validated
Chromosome2
Chromosomal Location164805098-164822130 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to T at 164820179 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Isoleucine at position 193 (T193I)
Ref Sequence ENSEMBL: ENSMUSP00000050970 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000017908] [ENSMUST00000052107] [ENSMUST00000132282]
Predicted Effect probably benign
Transcript: ENSMUST00000017908
SMART Domains Protein: ENSMUSP00000017908
Gene: ENSMUSG00000017764

DomainStartEndE-ValueType
Pfam:SWIM 342 375 2e-9 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000052107
AA Change: T193I

PolyPhen 2 Score 0.524 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000050970
Gene: ENSMUSG00000045822
AA Change: T193I

DomainStartEndE-ValueType
low complexity region 436 453 N/A INTRINSIC
low complexity region 474 489 N/A INTRINSIC
ZnF_PMZ 546 573 2.09e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000132282
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.4%
  • 20x: 92.7%
Validation Efficiency 99% (69/70)
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1810041L15Rik T A 15: 84,417,196 H82L probably damaging Het
4930407I10Rik T A 15: 82,066,427 Y1508* probably null Het
4931414P19Rik T C 14: 54,595,454 E88G probably benign Het
Acaa1b A G 9: 119,156,946 S17P probably benign Het
Arhgef7 G A 8: 11,831,552 E565K probably damaging Het
Arl6ip1 AAAATAAATAAATAAATAAATAAATA AAAATAAATAAATAAATAAATAAATAAATA 7: 118,121,899 probably benign Het
Bpnt1 T A 1: 185,345,307 probably null Het
Ccnt1 C T 15: 98,544,308 V360I probably benign Het
Chd4 T C 6: 125,128,945 S1829P possibly damaging Het
Dennd1b A T 1: 139,053,384 N112I probably damaging Het
Fat2 A T 11: 55,283,979 D1969E probably benign Het
Flywch1 A C 17: 23,760,617 D394E probably benign Het
Gal3st4 T A 5: 138,265,471 probably null Het
Gm14403 T C 2: 177,508,699 L146P probably damaging Het
Gm5283 G T 3: 17,230,959 noncoding transcript Het
Gpr161 T A 1: 165,306,460 L97Q probably damaging Het
Gstm2 A T 3: 107,985,095 M105K possibly damaging Het
Hecw2 A G 1: 53,840,859 Y1264H probably damaging Het
Ifi206 T A 1: 173,481,386 Q348L possibly damaging Het
Ighv1-83 A T 12: 115,963,869 M87K possibly damaging Het
Ighv2-7 A T 12: 113,807,534 S44T probably damaging Het
Ipo7 T A 7: 110,051,484 N884K probably benign Het
Itga2b T C 11: 102,467,866 N75S probably benign Het
Krt20 A G 11: 99,428,985 V431A unknown Het
Krt24 A T 11: 99,283,626 I205N possibly damaging Het
Lmo2 T C 2: 103,981,062 Y147H probably damaging Het
Lrrc31 A T 3: 30,691,297 L67* probably null Het
Lrrc37a A G 11: 103,504,309 F97L probably benign Het
Mapkap1 G A 2: 34,597,422 probably null Het
Mgat4d T G 8: 83,358,158 probably null Het
Mrgprb3 C T 7: 48,643,306 V166I probably benign Het
Myh11 T A 16: 14,234,465 Q379L possibly damaging Het
Myh7 T C 14: 54,985,133 S782G probably benign Het
Nobox T C 6: 43,305,119 D340G probably damaging Het
Ntn4 C T 10: 93,644,500 R29C probably damaging Het
Olfr1453 T A 19: 13,028,297 I11F probably benign Het
Olfr329-ps G A 11: 58,542,570 T315I probably benign Het
Pikfyve T A 1: 65,268,800 I1845N probably damaging Het
Pramef20 A G 4: 144,377,020 Y179H probably benign Het
Rad21l T G 2: 151,668,007 H58P probably damaging Het
Scnn1g T C 7: 121,746,602 L316S probably damaging Het
Serpina5 G A 12: 104,102,201 V174I probably damaging Het
Shank1 T C 7: 44,343,711 S788P unknown Het
Snap47 A G 11: 59,428,517 V265A possibly damaging Het
Steap3 T A 1: 120,243,886 H163L probably benign Het
Sycp2 T C 2: 178,393,961 probably benign Het
Tet2 A G 3: 133,467,315 F1729L probably benign Het
Thsd7b T C 1: 130,188,539 V1343A probably benign Het
Thumpd2 G A 17: 81,026,701 T486I probably damaging Het
Ttc41 G T 10: 86,729,798 M405I possibly damaging Het
Ttn T C 2: 76,747,529 D24340G probably damaging Het
Vmn1r10 T G 6: 57,113,617 F65V possibly damaging Het
Vmn2r118 G T 17: 55,592,581 D774E probably damaging Het
Vmn2r13 C T 5: 109,156,465 C700Y probably damaging Het
Wsb1 A C 11: 79,240,391 M393R possibly damaging Het
Zmat3 A G 3: 32,343,355 Y214H probably benign Het
Other mutations in Zswim3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00517:Zswim3 APN 2 164821091 missense probably damaging 1.00
IGL01345:Zswim3 APN 2 164820137 missense probably damaging 1.00
IGL01608:Zswim3 APN 2 164821520 missense probably damaging 1.00
IGL01621:Zswim3 APN 2 164821520 missense probably damaging 1.00
IGL01634:Zswim3 APN 2 164820002 missense probably damaging 0.99
IGL02165:Zswim3 APN 2 164821115 missense possibly damaging 0.94
IGL02173:Zswim3 APN 2 164820839 missense probably damaging 1.00
IGL02336:Zswim3 APN 2 164820377 missense probably damaging 0.98
IGL02379:Zswim3 APN 2 164820682 unclassified probably null
R0321:Zswim3 UTSW 2 164820359 missense possibly damaging 0.83
R1489:Zswim3 UTSW 2 164819981 missense probably benign 0.00
R2126:Zswim3 UTSW 2 164819993 missense probably benign 0.31
R2176:Zswim3 UTSW 2 164820694 missense probably benign 0.08
R2859:Zswim3 UTSW 2 164820389 missense probably damaging 1.00
R3853:Zswim3 UTSW 2 164820857 missense possibly damaging 0.61
R4434:Zswim3 UTSW 2 164820643 missense probably benign 0.00
R4435:Zswim3 UTSW 2 164820643 missense probably benign 0.00
R4436:Zswim3 UTSW 2 164820643 missense probably benign 0.00
R4438:Zswim3 UTSW 2 164820643 missense probably benign 0.00
R5874:Zswim3 UTSW 2 164820112 missense probably benign 0.06
R6417:Zswim3 UTSW 2 164820733 missense probably damaging 0.97
R6420:Zswim3 UTSW 2 164820733 missense probably damaging 0.97
R6722:Zswim3 UTSW 2 164820624 unclassified probably null
R6786:Zswim3 UTSW 2 164820851 missense probably damaging 1.00
R7266:Zswim3 UTSW 2 164820482 missense probably benign 0.41
R7467:Zswim3 UTSW 2 164819875 missense possibly damaging 0.59
R7487:Zswim3 UTSW 2 164820215 missense probably damaging 0.99
R7788:Zswim3 UTSW 2 164819779 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGCTCAGCATCAGGAAAGAC -3'
(R):5'- TTGAGCATCTTGGCCACAGAAG -3'

Sequencing Primer
(F):5'- GACCTTGATACAGCAGAGAAGCC -3'
(R):5'- ACAGAAGGCGCTGTCTCAG -3'
Posted On2016-02-04