Incidental Mutation 'R4805:Or5b101'
ID 370655
Institutional Source Beutler Lab
Gene Symbol Or5b101
Ensembl Gene ENSMUSG00000094755
Gene Name olfactory receptor family 5 subfamily B member 101
Synonyms Olfr1453, GA_x6K02T2RE5P-3357666-3356743, MOR202-6
MMRRC Submission 041999-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.074) question?
Stock # R4805 (G1)
Quality Score 225
Status Validated
Chromosome 19
Chromosomal Location 13004768-13005691 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 13005661 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 11 (I11F)
Ref Sequence ENSEMBL: ENSMUSP00000085071 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087773]
AlphaFold Q8VFX0
Predicted Effect probably benign
Transcript: ENSMUST00000087773
AA Change: I11F

PolyPhen 2 Score 0.041 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000085071
Gene: ENSMUSG00000094755
AA Change: I11F

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 6.6e-50 PFAM
Pfam:7tm_1 39 288 2.6e-20 PFAM
Meta Mutation Damage Score 0.2140 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.4%
  • 20x: 92.7%
Validation Efficiency 99% (69/70)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930407I10Rik T A 15: 81,950,628 (GRCm39) Y1508* probably null Het
4931414P19Rik T C 14: 54,832,911 (GRCm39) E88G probably benign Het
Acaa1b A G 9: 118,986,014 (GRCm39) S17P probably benign Het
Arhgef7 G A 8: 11,881,552 (GRCm39) E565K probably damaging Het
Arl6ip1 AAAATAAATAAATAAATAAATAAATA AAAATAAATAAATAAATAAATAAATAAATA 7: 117,721,122 (GRCm39) probably benign Het
Bpnt1 T A 1: 185,077,504 (GRCm39) probably null Het
Ccnt1 C T 15: 98,442,189 (GRCm39) V360I probably benign Het
Chd4 T C 6: 125,105,908 (GRCm39) S1829P possibly damaging Het
Dennd1b A T 1: 138,981,122 (GRCm39) N112I probably damaging Het
Fat2 A T 11: 55,174,805 (GRCm39) D1969E probably benign Het
Flywch1 A C 17: 23,979,591 (GRCm39) D394E probably benign Het
Gal3st4 T A 5: 138,263,733 (GRCm39) probably null Het
Gm14403 T C 2: 177,200,492 (GRCm39) L146P probably damaging Het
Gm5283 G T 3: 17,285,123 (GRCm39) noncoding transcript Het
Gpr161 T A 1: 165,134,029 (GRCm39) L97Q probably damaging Het
Gstm2 A T 3: 107,892,411 (GRCm39) M105K possibly damaging Het
Hecw2 A G 1: 53,880,018 (GRCm39) Y1264H probably damaging Het
Ifi206 T A 1: 173,308,952 (GRCm39) Q348L possibly damaging Het
Ighv1-83 A T 12: 115,927,489 (GRCm39) M87K possibly damaging Het
Ighv2-7 A T 12: 113,771,154 (GRCm39) S44T probably damaging Het
Ipo7 T A 7: 109,650,691 (GRCm39) N884K probably benign Het
Itga2b T C 11: 102,358,692 (GRCm39) N75S probably benign Het
Krt20 A G 11: 99,319,811 (GRCm39) V431A unknown Het
Krt24 A T 11: 99,174,452 (GRCm39) I205N possibly damaging Het
Lmo2 T C 2: 103,811,407 (GRCm39) Y147H probably damaging Het
Lrrc31 A T 3: 30,745,446 (GRCm39) L67* probably null Het
Lrrc37a A G 11: 103,395,135 (GRCm39) F97L probably benign Het
Mapkap1 G A 2: 34,487,434 (GRCm39) probably null Het
Mgat4d T G 8: 84,084,787 (GRCm39) probably null Het
Mrgprb3 C T 7: 48,293,054 (GRCm39) V166I probably benign Het
Myh11 T A 16: 14,052,329 (GRCm39) Q379L possibly damaging Het
Myh7 T C 14: 55,222,590 (GRCm39) S782G probably benign Het
Nobox T C 6: 43,282,053 (GRCm39) D340G probably damaging Het
Ntn4 C T 10: 93,480,362 (GRCm39) R29C probably damaging Het
Or2t29 G A 11: 58,433,396 (GRCm39) T315I probably benign Het
Pikfyve T A 1: 65,307,959 (GRCm39) I1845N probably damaging Het
Pramel15 A G 4: 144,103,590 (GRCm39) Y179H probably benign Het
Rad21l T G 2: 151,509,927 (GRCm39) H58P probably damaging Het
Scnn1g T C 7: 121,345,825 (GRCm39) L316S probably damaging Het
Serpina5 G A 12: 104,068,460 (GRCm39) V174I probably damaging Het
Shank1 T C 7: 43,993,135 (GRCm39) S788P unknown Het
Shisal1 T A 15: 84,301,397 (GRCm39) H82L probably damaging Het
Snap47 A G 11: 59,319,343 (GRCm39) V265A possibly damaging Het
Steap3 T A 1: 120,171,616 (GRCm39) H163L probably benign Het
Sycp2 T C 2: 178,035,754 (GRCm39) probably benign Het
Tet2 A G 3: 133,173,076 (GRCm39) F1729L probably benign Het
Thsd7b T C 1: 130,116,276 (GRCm39) V1343A probably benign Het
Thumpd2 G A 17: 81,334,130 (GRCm39) T486I probably damaging Het
Ttc41 G T 10: 86,565,662 (GRCm39) M405I possibly damaging Het
Ttn T C 2: 76,577,873 (GRCm39) D24340G probably damaging Het
Vmn1r10 T G 6: 57,090,602 (GRCm39) F65V possibly damaging Het
Vmn2r118 G T 17: 55,899,581 (GRCm39) D774E probably damaging Het
Vmn2r13 C T 5: 109,304,331 (GRCm39) C700Y probably damaging Het
Wsb1 A C 11: 79,131,217 (GRCm39) M393R possibly damaging Het
Zmat3 A G 3: 32,397,504 (GRCm39) Y214H probably benign Het
Zswim3 C T 2: 164,662,099 (GRCm39) T193I possibly damaging Het
Other mutations in Or5b101
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00914:Or5b101 APN 19 13,004,955 (GRCm39) missense probably damaging 0.98
IGL01137:Or5b101 APN 19 13,005,394 (GRCm39) missense possibly damaging 0.52
IGL01894:Or5b101 APN 19 13,005,649 (GRCm39) missense probably damaging 1.00
IGL02579:Or5b101 APN 19 13,004,892 (GRCm39) missense probably damaging 0.99
PIT4418001:Or5b101 UTSW 19 13,005,095 (GRCm39) nonsense probably null
R0099:Or5b101 UTSW 19 13,005,165 (GRCm39) missense probably damaging 1.00
R0211:Or5b101 UTSW 19 13,005,646 (GRCm39) missense possibly damaging 0.95
R0211:Or5b101 UTSW 19 13,005,646 (GRCm39) missense possibly damaging 0.95
R0395:Or5b101 UTSW 19 13,005,663 (GRCm39) missense probably damaging 1.00
R0453:Or5b101 UTSW 19 13,005,295 (GRCm39) missense probably damaging 0.97
R0847:Or5b101 UTSW 19 13,005,095 (GRCm39) nonsense probably null
R1227:Or5b101 UTSW 19 13,005,217 (GRCm39) missense probably benign
R1823:Or5b101 UTSW 19 13,005,181 (GRCm39) missense probably benign 0.06
R2509:Or5b101 UTSW 19 13,005,058 (GRCm39) missense probably damaging 1.00
R2899:Or5b101 UTSW 19 13,005,058 (GRCm39) missense probably damaging 1.00
R2964:Or5b101 UTSW 19 13,005,412 (GRCm39) missense probably benign 0.38
R2965:Or5b101 UTSW 19 13,005,412 (GRCm39) missense probably benign 0.38
R3157:Or5b101 UTSW 19 13,005,411 (GRCm39) missense probably benign 0.03
R3158:Or5b101 UTSW 19 13,005,411 (GRCm39) missense probably benign 0.03
R3409:Or5b101 UTSW 19 13,005,411 (GRCm39) missense probably benign 0.03
R3410:Or5b101 UTSW 19 13,005,411 (GRCm39) missense probably benign 0.03
R3411:Or5b101 UTSW 19 13,005,411 (GRCm39) missense probably benign 0.03
R3425:Or5b101 UTSW 19 13,005,411 (GRCm39) missense probably benign 0.03
R4018:Or5b101 UTSW 19 13,005,189 (GRCm39) missense probably benign
R4668:Or5b101 UTSW 19 13,005,445 (GRCm39) missense probably benign 0.00
R5180:Or5b101 UTSW 19 13,004,776 (GRCm39) missense probably benign 0.01
R5391:Or5b101 UTSW 19 13,005,150 (GRCm39) missense probably damaging 1.00
R5557:Or5b101 UTSW 19 13,005,004 (GRCm39) missense probably benign 0.01
R5740:Or5b101 UTSW 19 13,004,926 (GRCm39) missense probably benign 0.24
R7472:Or5b101 UTSW 19 13,005,439 (GRCm39) missense probably benign
R7832:Or5b101 UTSW 19 13,005,360 (GRCm39) missense probably benign 0.02
R7970:Or5b101 UTSW 19 13,005,058 (GRCm39) missense probably damaging 1.00
R8044:Or5b101 UTSW 19 13,004,829 (GRCm39) missense probably damaging 1.00
R8229:Or5b101 UTSW 19 13,005,561 (GRCm39) missense possibly damaging 0.55
R8474:Or5b101 UTSW 19 13,005,357 (GRCm39) missense probably damaging 1.00
R8951:Or5b101 UTSW 19 13,004,827 (GRCm39) missense
R8957:Or5b101 UTSW 19 13,004,881 (GRCm39) missense probably benign 0.03
R9046:Or5b101 UTSW 19 13,005,115 (GRCm39) missense probably benign 0.01
R9059:Or5b101 UTSW 19 13,005,277 (GRCm39) missense probably damaging 1.00
R9131:Or5b101 UTSW 19 13,005,360 (GRCm39) missense probably benign 0.02
R9266:Or5b101 UTSW 19 13,005,648 (GRCm39) missense probably damaging 1.00
R9269:Or5b101 UTSW 19 13,004,994 (GRCm39) missense probably benign
Z1088:Or5b101 UTSW 19 13,005,391 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- AGTCCACTAAAGACAGGTTACCTAGG -3'
(R):5'- GCACAGGTTGTTTCTATACTGTCC -3'

Sequencing Primer
(F):5'- CAGGTTACCTAGGAAAATGTACATG -3'
(R):5'- TGTGCATCATGCTTGAAAAGGCC -3'
Posted On 2016-02-04