Incidental Mutation 'R4809:Epha5'
| ID |
370892 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Epha5
|
| Ensembl Gene |
ENSMUSG00000029245 |
| Gene Name |
Eph receptor A5 |
| Synonyms |
Rek7, Cek7, Els1, Ehk1, Hek7, bsk |
| MMRRC Submission |
042428-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R4809 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
84202620-84565241 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 84253750 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Asparagine
at position 548
(D548N)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000109028
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000053733]
[ENSMUST00000113398]
[ENSMUST00000113399]
[ENSMUST00000113401]
[ENSMUST00000113403]
[ENSMUST00000113406]
|
| AlphaFold |
Q60629 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000053733
AA Change: D571N
PolyPhen 2
Score 0.227 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000060646
Gene: ENSMUSG00000029245
AA Change: D571N
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
7 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
42 |
57 |
N/A |
INTRINSIC |
|
EPH_lbd
|
62 |
235 |
7e-122 |
SMART |
|
FN3
|
307 |
387 |
1.92e-12 |
SMART |
|
Pfam:EphA2_TM
|
413 |
511 |
2.1e-22 |
PFAM |
|
TyrKc
|
514 |
771 |
9.33e-138 |
SMART |
|
SAM
|
801 |
868 |
6.65e-23 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000113398
AA Change: D623N
PolyPhen 2
Score 0.142 (Sensitivity: 0.92; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000109025
Gene: ENSMUSG00000029245
AA Change: D623N
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
7 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
42 |
57 |
N/A |
INTRINSIC |
|
EPH_lbd
|
62 |
235 |
7e-122 |
SMART |
|
FN3
|
359 |
439 |
1.92e-12 |
SMART |
|
Pfam:EphA2_TM
|
465 |
563 |
8.4e-23 |
PFAM |
|
TyrKc
|
566 |
823 |
9.33e-138 |
SMART |
|
Pfam:SAM_1
|
854 |
894 |
7.2e-11 |
PFAM |
|
Pfam:SAM_2
|
856 |
894 |
1.6e-9 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000113399
AA Change: D735N
PolyPhen 2
Score 0.016 (Sensitivity: 0.95; Specificity: 0.79)
|
| SMART Domains |
Protein: ENSMUSP00000109026
Gene: ENSMUSG00000029245
AA Change: D735N
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
7 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
42 |
57 |
N/A |
INTRINSIC |
|
EPH_lbd
|
62 |
235 |
7e-122 |
SMART |
|
FN3
|
360 |
450 |
1.53e-6 |
SMART |
|
FN3
|
471 |
551 |
1.92e-12 |
SMART |
|
Pfam:EphA2_TM
|
577 |
675 |
3.4e-22 |
PFAM |
|
TyrKc
|
678 |
935 |
9.33e-138 |
SMART |
|
Pfam:SAM_1
|
966 |
1006 |
2.9e-10 |
PFAM |
|
Pfam:SAM_2
|
968 |
1006 |
5.9e-9 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000113401
AA Change: D548N
PolyPhen 2
Score 0.878 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000109028
Gene: ENSMUSG00000029245
AA Change: D548N
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
7 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
42 |
57 |
N/A |
INTRINSIC |
|
EPH_lbd
|
62 |
235 |
7e-122 |
SMART |
|
FN3
|
307 |
387 |
1.92e-12 |
SMART |
|
Pfam:EphA2_TM
|
411 |
488 |
3.1e-30 |
PFAM |
|
TyrKc
|
491 |
748 |
9.33e-138 |
SMART |
|
Pfam:SAM_1
|
779 |
819 |
1.7e-10 |
PFAM |
|
Pfam:SAM_2
|
781 |
819 |
3.5e-9 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000113403
AA Change: D735N
PolyPhen 2
Score 0.016 (Sensitivity: 0.95; Specificity: 0.79)
|
| SMART Domains |
Protein: ENSMUSP00000109030
Gene: ENSMUSG00000029245
AA Change: D735N
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
7 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
42 |
57 |
N/A |
INTRINSIC |
|
EPH_lbd
|
62 |
235 |
7e-122 |
SMART |
|
FN3
|
360 |
450 |
1.53e-6 |
SMART |
|
FN3
|
471 |
551 |
1.92e-12 |
SMART |
|
Pfam:EphA2_TM
|
577 |
675 |
1.2e-25 |
PFAM |
|
TyrKc
|
678 |
935 |
9.33e-138 |
SMART |
|
SAM
|
965 |
1032 |
6.65e-23 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000113406
AA Change: D712N
PolyPhen 2
Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
|
| SMART Domains |
Protein: ENSMUSP00000109033
Gene: ENSMUSG00000029245
AA Change: D712N
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
7 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
42 |
57 |
N/A |
INTRINSIC |
|
EPH_lbd
|
62 |
235 |
7e-122 |
SMART |
|
FN3
|
360 |
450 |
1.53e-6 |
SMART |
|
FN3
|
471 |
551 |
1.92e-12 |
SMART |
|
Pfam:EphA2_TM
|
575 |
652 |
1.9e-30 |
PFAM |
|
TyrKc
|
655 |
912 |
9.33e-138 |
SMART |
|
SAM
|
942 |
1009 |
6.65e-23 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000154804
|
| Meta Mutation Damage Score |
0.0726 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.8%
- 20x: 94.0%
|
| Validation Efficiency |
96% (96/100) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Aug 2013]
PHENOTYPE: Homozygous mutant mice are overtly normal but show abnormal retinal axon mapping. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 87 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 3425401B19Rik |
A |
G |
14: 32,384,588 (GRCm39) |
V459A |
probably benign |
Het |
| Abca12 |
C |
T |
1: 71,318,015 (GRCm39) |
A1840T |
probably benign |
Het |
| Abhd6 |
T |
G |
14: 8,039,771 (GRCm38) |
M1R |
probably null |
Het |
| Abl1 |
T |
C |
2: 31,690,254 (GRCm39) |
L572P |
probably damaging |
Het |
| Adamts2 |
C |
A |
11: 50,694,517 (GRCm39) |
S1101R |
probably benign |
Het |
| Adgra2 |
G |
A |
8: 27,600,507 (GRCm39) |
W200* |
probably null |
Het |
| AI661453 |
C |
A |
17: 47,778,112 (GRCm39) |
|
probably benign |
Het |
| Aldh1l2 |
A |
G |
10: 83,342,496 (GRCm39) |
F438S |
probably damaging |
Het |
| Ankrd49 |
G |
A |
9: 14,692,510 (GRCm39) |
T218I |
possibly damaging |
Het |
| Ano7 |
T |
C |
1: 93,322,288 (GRCm39) |
F410L |
probably benign |
Het |
| Aox4 |
T |
A |
1: 58,305,808 (GRCm39) |
F1271I |
probably damaging |
Het |
| Aqr |
T |
C |
2: 114,005,695 (GRCm39) |
|
probably benign |
Het |
| Arhgap42 |
A |
G |
9: 9,180,118 (GRCm39) |
S54P |
probably damaging |
Het |
| Aunip |
C |
A |
4: 134,238,450 (GRCm39) |
D16E |
possibly damaging |
Het |
| Btbd7 |
A |
G |
12: 102,760,003 (GRCm39) |
|
probably null |
Het |
| Cabp4 |
T |
C |
19: 4,189,290 (GRCm39) |
H89R |
probably benign |
Het |
| Ccni |
AAA |
AAACTAA |
5: 93,335,429 (GRCm39) |
|
probably benign |
Het |
| Chfr |
C |
T |
5: 110,306,700 (GRCm39) |
H410Y |
probably damaging |
Het |
| Churc1 |
C |
A |
12: 76,829,671 (GRCm39) |
L111M |
probably damaging |
Het |
| Clasp1 |
C |
T |
1: 118,388,980 (GRCm39) |
T113I |
probably benign |
Het |
| Col12a1 |
T |
A |
9: 79,600,849 (GRCm39) |
Q745L |
probably benign |
Het |
| Col20a1 |
T |
C |
2: 180,640,454 (GRCm39) |
L537P |
probably damaging |
Het |
| Creb5 |
A |
T |
6: 53,587,411 (GRCm39) |
E47V |
probably null |
Het |
| Csnk1d |
A |
T |
11: 120,854,668 (GRCm39) |
|
probably benign |
Het |
| Cts6 |
A |
T |
13: 61,349,995 (GRCm39) |
W29R |
probably damaging |
Het |
| Dbt |
T |
A |
3: 116,339,992 (GRCm39) |
I420N |
probably damaging |
Het |
| Det1 |
C |
A |
7: 78,493,555 (GRCm39) |
D150Y |
probably damaging |
Het |
| Dlk2 |
A |
G |
17: 46,609,940 (GRCm39) |
|
probably null |
Het |
| Dnmt3a |
A |
T |
12: 3,950,352 (GRCm39) |
I639F |
probably damaging |
Het |
| Dock9 |
A |
T |
14: 121,784,008 (GRCm39) |
Y1989N |
probably benign |
Het |
| Dsg4 |
A |
T |
18: 20,599,678 (GRCm39) |
T765S |
possibly damaging |
Het |
| Entrep2 |
G |
A |
7: 64,426,488 (GRCm39) |
T159I |
probably damaging |
Het |
| Fam227b |
T |
A |
2: 125,958,045 (GRCm39) |
Y240F |
possibly damaging |
Het |
| Fbxw21 |
C |
T |
9: 108,972,458 (GRCm39) |
V395I |
probably damaging |
Het |
| Fn1 |
C |
A |
1: 71,691,959 (GRCm39) |
|
probably benign |
Het |
| Fpr-rs3 |
A |
T |
17: 20,844,683 (GRCm39) |
S153T |
probably benign |
Het |
| Frem2 |
A |
G |
3: 53,561,316 (GRCm39) |
F1064L |
probably benign |
Het |
| Gas2l3 |
CACTCGTCATACT |
CACT |
10: 89,266,820 (GRCm39) |
|
probably benign |
Het |
| Gjd2 |
C |
T |
2: 113,842,022 (GRCm39) |
G152R |
probably damaging |
Het |
| Gpr75 |
T |
C |
11: 30,842,154 (GRCm39) |
I353T |
possibly damaging |
Het |
| Grb7 |
T |
C |
11: 98,342,262 (GRCm39) |
V145A |
possibly damaging |
Het |
| Igkv4-73 |
G |
A |
6: 69,174,807 (GRCm39) |
R40W |
unknown |
Het |
| Kif1c |
C |
T |
11: 70,617,183 (GRCm39) |
A839V |
probably benign |
Het |
| Krt31 |
G |
A |
11: 99,940,748 (GRCm39) |
A125V |
possibly damaging |
Het |
| Lamb1 |
A |
G |
12: 31,328,525 (GRCm39) |
Y163C |
probably damaging |
Het |
| Mars1 |
G |
T |
10: 127,136,084 (GRCm39) |
T535K |
probably damaging |
Het |
| Mdc1 |
T |
C |
17: 36,159,993 (GRCm39) |
|
probably null |
Het |
| Micos10 |
C |
G |
4: 138,858,268 (GRCm39) |
W10S |
probably damaging |
Het |
| Micu1 |
C |
T |
10: 59,576,644 (GRCm39) |
H167Y |
probably benign |
Het |
| Mrgprb1 |
C |
T |
7: 48,097,739 (GRCm39) |
V58I |
possibly damaging |
Het |
| Ncoa7 |
T |
A |
10: 30,647,758 (GRCm39) |
E6V |
possibly damaging |
Het |
| Nectin3 |
A |
C |
16: 46,268,523 (GRCm39) |
|
probably benign |
Het |
| Or13a18 |
A |
G |
7: 140,190,987 (GRCm39) |
K295E |
probably damaging |
Het |
| Or4k44 |
C |
T |
2: 111,367,956 (GRCm39) |
C226Y |
probably benign |
Het |
| Or52ab7 |
T |
A |
7: 102,977,730 (GRCm39) |
Y12* |
probably null |
Het |
| Or8k38 |
T |
A |
2: 86,488,029 (GRCm39) |
M258L |
possibly damaging |
Het |
| Pex16 |
T |
C |
2: 92,206,983 (GRCm39) |
S54P |
probably damaging |
Het |
| Pik3cg |
A |
T |
12: 32,254,080 (GRCm39) |
S636T |
possibly damaging |
Het |
| Plin5 |
A |
G |
17: 56,423,855 (GRCm39) |
S27P |
probably benign |
Het |
| Ptch1 |
A |
T |
13: 63,661,522 (GRCm39) |
D1068E |
probably damaging |
Het |
| Ptprq |
T |
C |
10: 107,399,036 (GRCm39) |
T1960A |
probably damaging |
Het |
| Rap1gap2 |
T |
C |
11: 74,298,800 (GRCm39) |
|
probably benign |
Het |
| Rcc2 |
G |
A |
4: 140,444,353 (GRCm39) |
R348Q |
probably damaging |
Het |
| Rhbdd3 |
C |
A |
11: 5,055,949 (GRCm39) |
A377D |
probably damaging |
Het |
| Rpl7 |
T |
G |
1: 16,172,189 (GRCm39) |
|
probably benign |
Het |
| Scn11a |
G |
T |
9: 119,648,936 (GRCm39) |
D42E |
probably benign |
Het |
| Scube3 |
C |
T |
17: 28,384,147 (GRCm39) |
R549W |
probably damaging |
Het |
| Sil1 |
A |
T |
18: 35,458,428 (GRCm39) |
M189K |
probably damaging |
Het |
| Slc39a6 |
G |
A |
18: 24,718,531 (GRCm39) |
Q225* |
probably null |
Het |
| Slc7a15 |
A |
T |
12: 8,589,002 (GRCm39) |
C182S |
probably benign |
Het |
| Spata21 |
G |
A |
4: 140,824,431 (GRCm39) |
|
probably null |
Het |
| Stim2 |
T |
C |
5: 54,267,955 (GRCm39) |
V417A |
probably damaging |
Het |
| Szt2 |
T |
C |
4: 118,246,182 (GRCm39) |
D993G |
probably damaging |
Het |
| Tet3 |
A |
G |
6: 83,379,928 (GRCm39) |
S747P |
probably benign |
Het |
| Tmem86a |
C |
G |
7: 46,702,678 (GRCm39) |
S34R |
possibly damaging |
Het |
| Top2b |
T |
A |
14: 16,383,125 (GRCm38) |
S38T |
probably benign |
Het |
| Trim33 |
A |
T |
3: 103,236,572 (GRCm39) |
T561S |
possibly damaging |
Het |
| Ttc39a |
C |
T |
4: 109,273,218 (GRCm39) |
Q25* |
probably null |
Het |
| Urb1 |
A |
G |
16: 90,556,730 (GRCm39) |
I1816T |
possibly damaging |
Het |
| Usp24 |
T |
C |
4: 106,270,873 (GRCm39) |
|
probably null |
Het |
| Usp36 |
A |
C |
11: 118,153,896 (GRCm39) |
L840R |
probably damaging |
Het |
| Usp50 |
C |
A |
2: 126,619,773 (GRCm39) |
|
probably benign |
Het |
| Vangl2 |
A |
G |
1: 171,837,230 (GRCm39) |
V193A |
possibly damaging |
Het |
| Vmn1r62 |
T |
A |
7: 5,678,866 (GRCm39) |
H182Q |
probably benign |
Het |
| Vmn2r124 |
A |
T |
17: 18,294,007 (GRCm39) |
Y698F |
probably benign |
Het |
| Wls |
C |
T |
3: 159,603,082 (GRCm39) |
T165I |
probably benign |
Het |
| Zfp808 |
G |
T |
13: 62,319,106 (GRCm39) |
E112* |
probably null |
Het |
|
| Other mutations in Epha5 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00808:Epha5
|
APN |
5 |
84,254,559 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01084:Epha5
|
APN |
5 |
84,218,946 (GRCm39) |
nonsense |
probably null |
|
|
IGL01462:Epha5
|
APN |
5 |
84,219,092 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01516:Epha5
|
APN |
5 |
84,534,135 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01998:Epha5
|
APN |
5 |
84,232,593 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02744:Epha5
|
APN |
5 |
84,255,848 (GRCm39) |
missense |
probably benign |
0.22 |
|
IGL03076:Epha5
|
APN |
5 |
84,479,549 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03123:Epha5
|
APN |
5 |
84,479,085 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03381:Epha5
|
APN |
5 |
84,479,191 (GRCm39) |
missense |
probably damaging |
0.98 |
|
BB001:Epha5
|
UTSW |
5 |
84,232,705 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
BB011:Epha5
|
UTSW |
5 |
84,232,705 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
PIT4544001:Epha5
|
UTSW |
5 |
84,479,471 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R0004:Epha5
|
UTSW |
5 |
84,479,701 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0490:Epha5
|
UTSW |
5 |
84,255,833 (GRCm39) |
splice site |
probably benign |
|
|
R0545:Epha5
|
UTSW |
5 |
84,215,217 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0835:Epha5
|
UTSW |
5 |
84,534,101 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1074:Epha5
|
UTSW |
5 |
84,298,255 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1074:Epha5
|
UTSW |
5 |
84,298,254 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1075:Epha5
|
UTSW |
5 |
84,298,255 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1075:Epha5
|
UTSW |
5 |
84,298,254 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1102:Epha5
|
UTSW |
5 |
84,381,434 (GRCm39) |
splice site |
probably benign |
|
|
R1184:Epha5
|
UTSW |
5 |
84,219,134 (GRCm39) |
splice site |
probably null |
|
|
R1255:Epha5
|
UTSW |
5 |
84,298,255 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1255:Epha5
|
UTSW |
5 |
84,298,254 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1327:Epha5
|
UTSW |
5 |
84,254,644 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1437:Epha5
|
UTSW |
5 |
84,381,555 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1804:Epha5
|
UTSW |
5 |
84,479,674 (GRCm39) |
missense |
probably benign |
0.21 |
|
R1967:Epha5
|
UTSW |
5 |
84,564,288 (GRCm39) |
missense |
probably benign |
0.23 |
|
R2187:Epha5
|
UTSW |
5 |
84,234,223 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2282:Epha5
|
UTSW |
5 |
84,298,269 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2899:Epha5
|
UTSW |
5 |
84,381,667 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3746:Epha5
|
UTSW |
5 |
84,206,963 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4454:Epha5
|
UTSW |
5 |
84,304,303 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4771:Epha5
|
UTSW |
5 |
84,298,278 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4810:Epha5
|
UTSW |
5 |
84,253,750 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R4825:Epha5
|
UTSW |
5 |
84,381,699 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4833:Epha5
|
UTSW |
5 |
84,253,750 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R4961:Epha5
|
UTSW |
5 |
84,381,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4976:Epha5
|
UTSW |
5 |
84,232,683 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4981:Epha5
|
UTSW |
5 |
84,298,342 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5149:Epha5
|
UTSW |
5 |
84,298,217 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5422:Epha5
|
UTSW |
5 |
84,479,349 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5575:Epha5
|
UTSW |
5 |
84,564,361 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5664:Epha5
|
UTSW |
5 |
84,479,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5801:Epha5
|
UTSW |
5 |
84,479,085 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5821:Epha5
|
UTSW |
5 |
84,232,587 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5924:Epha5
|
UTSW |
5 |
84,381,533 (GRCm39) |
nonsense |
probably null |
|
|
R5951:Epha5
|
UTSW |
5 |
84,479,051 (GRCm39) |
intron |
probably benign |
|
|
R5956:Epha5
|
UTSW |
5 |
84,298,228 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6127:Epha5
|
UTSW |
5 |
84,218,953 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6189:Epha5
|
UTSW |
5 |
84,385,399 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6240:Epha5
|
UTSW |
5 |
84,265,438 (GRCm39) |
missense |
probably benign |
0.27 |
|
R6343:Epha5
|
UTSW |
5 |
84,254,606 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6463:Epha5
|
UTSW |
5 |
84,254,569 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6517:Epha5
|
UTSW |
5 |
84,304,360 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R6622:Epha5
|
UTSW |
5 |
84,385,387 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R6667:Epha5
|
UTSW |
5 |
84,219,050 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6741:Epha5
|
UTSW |
5 |
84,254,557 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R6757:Epha5
|
UTSW |
5 |
84,253,737 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6762:Epha5
|
UTSW |
5 |
84,479,585 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6819:Epha5
|
UTSW |
5 |
84,254,649 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7019:Epha5
|
UTSW |
5 |
84,564,321 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R7031:Epha5
|
UTSW |
5 |
84,290,159 (GRCm39) |
missense |
probably benign |
0.12 |
|
R7213:Epha5
|
UTSW |
5 |
84,381,782 (GRCm39) |
splice site |
probably null |
|
|
R7728:Epha5
|
UTSW |
5 |
84,215,267 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7924:Epha5
|
UTSW |
5 |
84,232,705 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R7953:Epha5
|
UTSW |
5 |
84,381,513 (GRCm39) |
missense |
probably benign |
0.19 |
|
R8043:Epha5
|
UTSW |
5 |
84,381,513 (GRCm39) |
missense |
probably benign |
0.19 |
|
R8468:Epha5
|
UTSW |
5 |
84,290,275 (GRCm39) |
splice site |
probably null |
|
|
R8558:Epha5
|
UTSW |
5 |
84,206,975 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8796:Epha5
|
UTSW |
5 |
84,255,850 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9035:Epha5
|
UTSW |
5 |
84,255,886 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9060:Epha5
|
UTSW |
5 |
84,218,977 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9244:Epha5
|
UTSW |
5 |
84,265,441 (GRCm39) |
missense |
probably benign |
0.28 |
|
R9347:Epha5
|
UTSW |
5 |
84,479,731 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R9355:Epha5
|
UTSW |
5 |
84,253,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9434:Epha5
|
UTSW |
5 |
84,479,227 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
Z1088:Epha5
|
UTSW |
5 |
84,385,381 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1176:Epha5
|
UTSW |
5 |
84,218,979 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGCCCTGATCATAATGGTGG -3'
(R):5'- TACTGTGGACGTTTGGTCTCAC -3'
Sequencing Primer
(F):5'- CCTGATCATAATGGTGGGCATTTAAG -3'
(R):5'- CTGAACCTTAATCCTTCAGAAGTTTG -3'
|
| Posted On |
2016-02-04 |
Incidental Mutation