Mutagenetix > Incidental Mutations

Incidental Mutation 'R0421:Zfp119a'

37090

Institutional Source

Beutler Lab

Gene Symbol

Zfp119a

Ensembl Gene

ENSMUSG00000057835

Gene Name

zinc finger protein 119a

Synonyms

Mzf13, Zfp119

MMRRC Submission

038623-MU

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

R0421 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

55864892-55878930 bp(-) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

T to A at 55865248 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Stop codon at position 532 (K532*)

Ref Sequence

ENSEMBL: ENSMUSP00000078587 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000079642]

AlphaFold

Q9JIC0

Predicted Effect

probably null
Transcript: ENSMUST00000079642
AA Change: K532*

SMART Domains

Protein: ENSMUSP00000078587
Gene: ENSMUSG00000057835
AA Change: K532*

Domain	Start	End	E-Value	Type
KRAB	4	66	6.16e-15	SMART
ZnF_C2H2	155	177	1.57e2	SMART
ZnF_C2H2	261	283	2.14e2	SMART
ZnF_C2H2	289	311	6.78e-3	SMART
ZnF_C2H2	317	339	1.98e-4	SMART
ZnF_C2H2	345	367	4.17e-3	SMART
ZnF_C2H2	373	395	3.39e-3	SMART
ZnF_C2H2	401	423	1.64e-1	SMART
ZnF_C2H2	429	451	5.5e-3	SMART
ZnF_C2H2	457	479	1.51e0	SMART
ZnF_C2H2	485	507	6.32e-3	SMART
ZnF_C2H2	513	535	1.69e-3	SMART

Coding Region Coverage

1x: 99.2%
3x: 98.3%
10x: 96.4%
20x: 92.7%

Validation Efficiency

97% (67/69)

Allele List at MGI

Other mutations in this stock

Total: 69 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2310050C09Rik	T	C	3: 92,868,984	T131A	probably damaging	Het
Abi1	G	A	2: 22,960,827	T195I	probably damaging	Het
Afap1l1	T	C	18: 61,751,874	N180S	probably damaging	Het
Arsg	A	G	11: 109,527,766	Y196C	probably damaging	Het
Ascc3	G	T	10: 50,748,926	V1637L	probably benign	Het
Atp2b2	C	A	6: 113,813,888	R185L	probably damaging	Het
Ccr9	A	T	9: 123,779,606	M118L	probably benign	Het
Cdh12	A	T	15: 21,480,224		probably null	Het
Cdk13	T	C	13: 17,763,170	S763G	probably damaging	Het
Cenpk	C	A	13: 104,242,403	N177K	probably benign	Het
Cfap43	T	G	19: 47,835,575	N119T	probably benign	Het
Chrna6	T	C	8: 27,408,387	E101G	probably null	Het
Clasp2	G	A	9: 113,854,302	R400H	probably benign	Het
Col6a6	T	C	9: 105,784,206	M235V	probably benign	Het
Ddx49	A	T	8: 70,295,632	L291Q	probably damaging	Het
Dhrs7	A	T	12: 72,653,086		probably benign	Het
Dnah5	A	T	15: 28,229,541	K107M	possibly damaging	Het
Dsg2	C	T	18: 20,579,391	R151C	probably damaging	Het
Dsn1	T	C	2: 157,005,869	T2A	possibly damaging	Het
Edem3	A	G	1: 151,792,438		probably benign	Het
Eif3c	T	C	7: 126,563,712	N133S	possibly damaging	Het
F10	A	G	8: 13,045,097	K85E	probably benign	Het
Fam129a	T	A	1: 151,709,082		probably benign	Het
Fam57b	G	A	7: 126,825,015	V44M	probably damaging	Het
Fbn2	T	A	18: 58,027,804		probably benign	Het
Gtpbp10	A	T	5: 5,557,290	H50Q	probably benign	Het
Hephl1	A	G	9: 15,059,160	F1013L	probably benign	Het
Hps3	C	A	3: 20,029,316	V238F	probably benign	Het
Kcna10	A	C	3: 107,194,504	K150N	probably damaging	Het
Kirrel	C	T	3: 87,083,607	G636D	probably damaging	Het
Kndc1	G	A	7: 139,908,996	R189H	probably damaging	Het
Knop1	C	T	7: 118,855,629	E50K	possibly damaging	Het
Kpna7	T	A	5: 144,989,741	H467L	possibly damaging	Het
Lcn4	T	C	2: 26,668,649	N142D	possibly damaging	Het
Map3k3	T	C	11: 106,148,915		probably benign	Het
Mdn1	A	G	4: 32,684,707	T806A	probably benign	Het
Nbeal1	T	A	1: 60,268,439	N1703K	probably benign	Het
Neurl4	T	C	11: 69,908,534	V914A	probably damaging	Het
Nop56	T	C	2: 130,276,772	S275P	possibly damaging	Het
Olfr352	A	G	2: 36,869,641	E25G	possibly damaging	Het
Olfr655	A	G	7: 104,596,722	V153A	probably benign	Het
Olfr868	A	G	9: 20,101,475	K239E	probably damaging	Het
Otof	A	C	5: 30,371,568	I1827S	possibly damaging	Het
Pappa2	A	T	1: 158,848,080	I1032N	probably damaging	Het
Pcdh7	A	G	5: 57,720,060	E319G	probably damaging	Het
Pcdhb11	T	A	18: 37,422,480	S288T	probably benign	Het
Phip	A	T	9: 82,926,457	D488E	probably damaging	Het
Pla2g7	A	T	17: 43,611,412	H394L	probably damaging	Het
Plk3	A	G	4: 117,133,444	V69A	probably damaging	Het
Prob1	C	A	18: 35,653,030	A724S	possibly damaging	Het
Prune2	T	C	19: 17,123,311	F2060L	probably benign	Het
Rgl3	G	A	9: 21,976,032	R498C	probably benign	Het
Rnf213	A	C	11: 119,447,257	N3362H	probably damaging	Het
Sbds	A	G	5: 130,253,933		probably benign	Het
Scn9a	T	C	2: 66,543,277	S453G	probably benign	Het
Sh3rf3	T	C	10: 58,984,075	L236P	probably damaging	Het
Skint1	A	G	4: 112,019,014	N44S	possibly damaging	Het
Slc5a1	T	A	5: 33,134,652	I141N	probably damaging	Het
Trank1	T	A	9: 111,391,839	I2548N	probably damaging	Het
Tsc22d2	G	A	3: 58,417,328		probably benign	Het
Unc13c	T	A	9: 73,933,210	I120F	possibly damaging	Het
Vmn2r11	T	G	5: 109,059,428	I9L	probably benign	Het
Vmn2r58	T	G	7: 41,865,204	N114H	probably benign	Het
Vps53	A	G	11: 76,082,670	L166P	probably damaging	Het
Zfp472	A	G	17: 32,975,923	T11A	possibly damaging	Het
Zfp512b	T	A	2: 181,588,258	K87*	probably null	Het
Zfp518b	G	A	5: 38,674,575	P29L	probably damaging	Het
Zfp599	A	G	9: 22,250,547		probably benign	Het
Zic2	CCCACCACCACCATCACCACCACCACC	CCCACCATCACCACCACCACC	14: 122,476,364		probably benign	Het

Other mutations in Zfp119a

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00420:Zfp119a	APN	17	55865792	nonsense	probably null
R1385:Zfp119a	UTSW	17	55865826	missense	probably damaging	1.00
R1600:Zfp119a	UTSW	17	55868355	missense	possibly damaging	0.93
R2310:Zfp119a	UTSW	17	55865440	missense	probably benign	0.00
R2924:Zfp119a	UTSW	17	55868343	missense	possibly damaging	0.96
R3910:Zfp119a	UTSW	17	55866520	missense	probably benign
R4594:Zfp119a	UTSW	17	55866325	missense	probably benign
R5217:Zfp119a	UTSW	17	55865425	nonsense	probably null
R5321:Zfp119a	UTSW	17	55865595	missense	probably damaging	1.00
R5392:Zfp119a	UTSW	17	55866328	missense	probably benign	0.03
R5678:Zfp119a	UTSW	17	55868336	missense	probably benign	0.03
R7033:Zfp119a	UTSW	17	55866009	missense	probably benign	0.04
R7355:Zfp119a	UTSW	17	55866287	nonsense	probably null
R7489:Zfp119a	UTSW	17	55866158	missense	probably damaging	1.00
R8130:Zfp119a	UTSW	17	55865971	missense	probably damaging	1.00
R8940:Zfp119a	UTSW	17	55865551	missense	probably damaging	1.00
Z1176:Zfp119a	UTSW	17	55866011	missense	possibly damaging	0.61

Predicted Primers

PCR Primer
(F):5'- TGACAATATGCCTACAATTTGAAAAGGAGACA -3'
(R):5'- ACACCGAAGAACTCATTTGGAAATGAAATACT -3'

Sequencing Primer
(F):5'- GGGGAAATGAGTGTGTTACCCA -3'
(R):5'- tgtggtaaacatttttcatgtaacag -3'

Posted On

2013-05-09