Incidental Mutation 'R4258:Cyp3a25'
ID 371054
Institutional Source Beutler Lab
Gene Symbol Cyp3a25
Ensembl Gene ENSMUSG00000029630
Gene Name cytochrome P450, family 3, subfamily a, polypeptide 25
Synonyms
MMRRC Submission 041071-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.096) question?
Stock # R4258 (G1)
Quality Score 225
Status Validated
Chromosome 5
Chromosomal Location 145914004-145946428 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 145928248 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Glutamic Acid at position 266 (K266E)
Ref Sequence ENSEMBL: ENSMUSP00000065585 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000068317] [ENSMUST00000138870] [ENSMUST00000145062]
AlphaFold O09158
Predicted Effect probably damaging
Transcript: ENSMUST00000068317
AA Change: K266E

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000065585
Gene: ENSMUSG00000029630
AA Change: K266E

DomainStartEndE-ValueType
Pfam:p450 38 493 9.4e-129 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000138870
SMART Domains Protein: ENSMUSP00000116077
Gene: ENSMUSG00000029630

DomainStartEndE-ValueType
Pfam:p450 38 126 2e-13 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000145062
SMART Domains Protein: ENSMUSP00000123615
Gene: ENSMUSG00000029630

DomainStartEndE-ValueType
Pfam:p450 38 148 3.9e-21 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000153808
Meta Mutation Damage Score 0.1819 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.8%
Validation Efficiency 95% (60/63)
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932415M13Rik T A 17: 54,031,441 (GRCm39) noncoding transcript Het
Ank3 T C 10: 69,840,592 (GRCm39) I984T probably benign Het
Arnt2 T C 7: 83,960,163 (GRCm39) T204A probably damaging Het
Arsi T C 18: 61,050,388 (GRCm39) W424R probably damaging Het
Aspg A T 12: 112,087,687 (GRCm39) N346I probably benign Het
Brdt A G 5: 107,507,775 (GRCm39) S668G probably damaging Het
Ccdc178 C T 18: 22,150,392 (GRCm39) probably null Het
Cfap58 A T 19: 47,937,923 (GRCm39) probably null Het
Chaf1a C A 17: 56,363,474 (GRCm39) H319Q unknown Het
Colec12 T C 18: 9,720,950 (GRCm39) S13P probably damaging Het
Cpne9 C T 6: 113,259,984 (GRCm39) probably benign Het
Cyp2c65 A C 19: 39,081,872 (GRCm39) D466A probably benign Het
Dennd1b G T 1: 138,990,678 (GRCm39) R214L probably damaging Het
Dock9 T C 14: 121,818,854 (GRCm39) I1533V probably benign Het
Dynlt1a C T 17: 6,361,184 (GRCm39) M102I probably benign Het
Edil3 G T 13: 89,325,272 (GRCm39) L220F probably damaging Het
Eml5 A G 12: 98,831,693 (GRCm39) Y383H probably benign Het
Epc1 T A 18: 6,450,130 (GRCm39) T393S probably benign Het
Fbxo8 A T 8: 57,041,076 (GRCm39) D164V probably benign Het
Gbp4 T A 5: 105,284,841 (GRCm39) N16I probably damaging Het
Gdf6 G A 4: 9,844,877 (GRCm39) V134I probably damaging Het
Gm5475 A G 15: 100,322,117 (GRCm39) probably benign Het
Gm6430 T G 1: 96,952,561 (GRCm39) noncoding transcript Het
Ighv9-4 A T 12: 114,263,765 (GRCm39) V56E probably damaging Het
Il3ra A T 14: 14,347,961 (GRCm38) N36Y probably damaging Het
Kif7 G T 7: 79,360,261 (GRCm39) C325* probably null Het
Lipo2 A T 19: 33,708,328 (GRCm39) F229I possibly damaging Het
Lrba A G 3: 86,352,656 (GRCm39) K1935E probably damaging Het
Mki67 A T 7: 135,297,017 (GRCm39) D2672E possibly damaging Het
Mtf1 A G 4: 124,732,576 (GRCm39) T545A probably benign Het
Mup6 A T 4: 60,004,812 (GRCm39) probably null Het
Myo9b T C 8: 71,808,409 (GRCm39) V1672A probably damaging Het
Nudt16l2 T C 9: 105,020,767 (GRCm39) I165V probably damaging Het
Or10al6 C A 17: 38,082,949 (GRCm39) P135Q probably damaging Het
Or10j5 C T 1: 172,785,205 (GRCm39) T281I possibly damaging Het
Or4k36 A T 2: 111,145,983 (GRCm39) H53L probably benign Het
Or5d37 T A 2: 87,923,362 (GRCm39) N306I probably damaging Het
Pcdhgb2 A T 18: 37,825,102 (GRCm39) I698F probably damaging Het
Pkn3 C T 2: 29,978,572 (GRCm39) H665Y probably damaging Het
Ppil6 T A 10: 41,383,531 (GRCm39) L99* probably null Het
Psg22 T A 7: 18,458,554 (GRCm39) V376E probably damaging Het
Pum1 G A 4: 130,457,591 (GRCm39) R201H probably damaging Het
Rasa2 A T 9: 96,439,433 (GRCm39) probably benign Het
Schip1 T A 3: 68,525,963 (GRCm39) M379K possibly damaging Het
Scn9a A T 2: 66,395,398 (GRCm39) probably benign Het
Sh3tc1 C T 5: 35,864,322 (GRCm39) A622T probably benign Het
Smarcd2 A T 11: 106,156,076 (GRCm39) I292N probably damaging Het
Ssxb17 C T X: 21,041,167 (GRCm39) S45N probably damaging Het
Stab1 G A 14: 30,876,629 (GRCm39) R862C possibly damaging Het
Tdrd5 T A 1: 156,087,312 (GRCm39) H870L probably benign Het
Tnfaip8 A G 18: 50,223,443 (GRCm39) R60G possibly damaging Het
Traf3ip3 C T 1: 192,880,254 (GRCm39) R25Q probably damaging Het
Unc5b T C 10: 60,601,150 (GRCm39) Y892C probably damaging Het
Vmn2r2 T G 3: 64,042,118 (GRCm39) D199A probably damaging Het
Washc2 C A 6: 116,185,202 (GRCm39) P12Q probably damaging Het
Zfp286 T C 11: 62,671,896 (GRCm39) I121V probably benign Het
Zfp606 T A 7: 12,228,267 (GRCm39) probably null Het
Other mutations in Cyp3a25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00091:Cyp3a25 APN 5 145,938,273 (GRCm39) nonsense probably null
IGL00430:Cyp3a25 APN 5 145,930,170 (GRCm39) missense probably damaging 1.00
IGL00803:Cyp3a25 APN 5 145,938,253 (GRCm39) splice site probably benign
IGL00928:Cyp3a25 APN 5 145,923,764 (GRCm39) missense possibly damaging 0.94
IGL01557:Cyp3a25 APN 5 145,921,711 (GRCm39) missense probably damaging 1.00
IGL01997:Cyp3a25 APN 5 145,931,766 (GRCm39) missense possibly damaging 0.92
IGL02140:Cyp3a25 APN 5 145,946,273 (GRCm39) splice site probably benign
IGL02267:Cyp3a25 APN 5 145,935,362 (GRCm39) missense possibly damaging 0.48
IGL02272:Cyp3a25 APN 5 145,930,075 (GRCm39) intron probably benign
IGL02327:Cyp3a25 APN 5 145,923,731 (GRCm39) missense possibly damaging 0.50
IGL02411:Cyp3a25 APN 5 145,938,257 (GRCm39) critical splice donor site probably benign
IGL02504:Cyp3a25 APN 5 145,930,141 (GRCm39) missense probably benign 0.03
IGL02653:Cyp3a25 APN 5 145,939,920 (GRCm39) missense possibly damaging 0.95
R0378:Cyp3a25 UTSW 5 145,923,652 (GRCm39) missense probably damaging 1.00
R0403:Cyp3a25 UTSW 5 145,935,323 (GRCm39) missense probably damaging 1.00
R0685:Cyp3a25 UTSW 5 145,935,356 (GRCm39) missense probably damaging 1.00
R0725:Cyp3a25 UTSW 5 145,931,746 (GRCm39) missense probably damaging 1.00
R0798:Cyp3a25 UTSW 5 145,928,343 (GRCm39) missense probably damaging 0.98
R1061:Cyp3a25 UTSW 5 145,923,643 (GRCm39) missense probably benign
R1519:Cyp3a25 UTSW 5 145,938,257 (GRCm39) critical splice donor site probably null
R1628:Cyp3a25 UTSW 5 145,938,273 (GRCm39) nonsense probably null
R1822:Cyp3a25 UTSW 5 145,921,763 (GRCm39) missense probably damaging 1.00
R1824:Cyp3a25 UTSW 5 145,921,763 (GRCm39) missense probably damaging 1.00
R1864:Cyp3a25 UTSW 5 145,931,739 (GRCm39) missense probably damaging 0.98
R2062:Cyp3a25 UTSW 5 145,923,779 (GRCm39) splice site probably benign
R2401:Cyp3a25 UTSW 5 145,923,778 (GRCm39) critical splice acceptor site probably null
R2516:Cyp3a25 UTSW 5 145,939,837 (GRCm39) splice site probably null
R3080:Cyp3a25 UTSW 5 145,935,341 (GRCm39) missense probably benign 0.33
R3236:Cyp3a25 UTSW 5 145,939,938 (GRCm39) splice site probably benign
R3694:Cyp3a25 UTSW 5 145,926,786 (GRCm39) splice site probably null
R3730:Cyp3a25 UTSW 5 145,939,891 (GRCm39) missense probably damaging 1.00
R4112:Cyp3a25 UTSW 5 145,939,841 (GRCm39) missense probably benign 0.18
R4651:Cyp3a25 UTSW 5 145,931,701 (GRCm39) missense probably benign 0.01
R4788:Cyp3a25 UTSW 5 145,921,892 (GRCm39) nonsense probably null
R4899:Cyp3a25 UTSW 5 145,914,481 (GRCm39) missense possibly damaging 0.59
R4926:Cyp3a25 UTSW 5 145,928,266 (GRCm39) missense probably damaging 1.00
R4952:Cyp3a25 UTSW 5 145,928,334 (GRCm39) missense probably benign 0.01
R5270:Cyp3a25 UTSW 5 145,918,312 (GRCm39) missense probably benign 0.36
R5595:Cyp3a25 UTSW 5 145,931,673 (GRCm39) critical splice donor site probably null
R5659:Cyp3a25 UTSW 5 145,928,356 (GRCm39) missense possibly damaging 0.69
R5787:Cyp3a25 UTSW 5 145,935,313 (GRCm39) missense probably benign 0.14
R6307:Cyp3a25 UTSW 5 145,931,766 (GRCm39) missense possibly damaging 0.92
R6380:Cyp3a25 UTSW 5 145,935,357 (GRCm39) missense probably damaging 0.99
R7055:Cyp3a25 UTSW 5 145,929,801 (GRCm39) missense probably benign 0.00
R7140:Cyp3a25 UTSW 5 145,939,855 (GRCm39) missense probably benign
R7189:Cyp3a25 UTSW 5 145,939,870 (GRCm39) missense probably benign 0.37
R7201:Cyp3a25 UTSW 5 145,939,868 (GRCm39) missense probably benign 0.00
R7201:Cyp3a25 UTSW 5 145,928,257 (GRCm39) missense probably benign 0.22
R7332:Cyp3a25 UTSW 5 145,929,817 (GRCm39) missense probably damaging 1.00
R7404:Cyp3a25 UTSW 5 145,923,635 (GRCm39) missense probably damaging 1.00
R7548:Cyp3a25 UTSW 5 145,923,735 (GRCm39) missense probably damaging 0.98
R7607:Cyp3a25 UTSW 5 145,921,791 (GRCm39) missense possibly damaging 0.87
R8022:Cyp3a25 UTSW 5 145,914,478 (GRCm39) missense probably benign 0.33
R8266:Cyp3a25 UTSW 5 145,929,796 (GRCm39) missense probably damaging 1.00
R8894:Cyp3a25 UTSW 5 145,931,670 (GRCm39) splice site probably benign
R9249:Cyp3a25 UTSW 5 145,928,356 (GRCm39) missense possibly damaging 0.69
R9588:Cyp3a25 UTSW 5 145,921,699 (GRCm39) missense probably benign
R9691:Cyp3a25 UTSW 5 145,931,732 (GRCm39) missense probably benign 0.41
R9694:Cyp3a25 UTSW 5 145,923,685 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- TGTAATGACCAAACCTAGAGCAT -3'
(R):5'- GAGTCCAACATTGTGGGGAAT -3'

Sequencing Primer
(F):5'- TCATGACCACATCCTGGAAATCATG -3'
(R):5'- GGTAAGTGTCTGTGAAAACTCCCC -3'
Posted On 2016-02-10