Incidental Mutation 'R4822:Oprm1'
| ID |
371222 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Oprm1
|
| Ensembl Gene |
ENSMUSG00000000766 |
| Gene Name |
opioid receptor, mu 1 |
| Synonyms |
MOP-R, MOR-1, MOP receptor, mor, Oprm, muOR |
| MMRRC Submission |
042438-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.110)
|
| Stock # |
R4822 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
10 |
| Chromosomal Location |
6708593-6988209 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 6779036 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Valine
at position 146
(I146V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000101229
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000000783]
[ENSMUST00000052751]
[ENSMUST00000056385]
[ENSMUST00000063036]
[ENSMUST00000078634]
[ENSMUST00000092729]
[ENSMUST00000092731]
[ENSMUST00000105604]
[ENSMUST00000105607]
[ENSMUST00000092734]
[ENSMUST00000129954]
[ENSMUST00000105615]
[ENSMUST00000105602]
[ENSMUST00000105603]
[ENSMUST00000105605]
[ENSMUST00000129221]
[ENSMUST00000105611]
[ENSMUST00000123861]
[ENSMUST00000105597]
[ENSMUST00000105601]
[ENSMUST00000154941]
[ENSMUST00000135502]
[ENSMUST00000154906]
[ENSMUST00000147171]
[ENSMUST00000144264]
[ENSMUST00000150374]
[ENSMUST00000143875]
[ENSMUST00000152674]
|
| AlphaFold |
P42866 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000000783
AA Change: I146V
PolyPhen 2
Score 0.804 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000000783
Gene: ENSMUSG00000000766
AA Change: I146V
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7TM_GPCR_Srx
|
76 |
339 |
1.6e-7 |
PFAM |
|
Pfam:7TM_GPCR_Srsx
|
79 |
351 |
1.3e-10 |
PFAM |
|
Pfam:7tm_1
|
85 |
336 |
4e-67 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000052751
AA Change: I146V
PolyPhen 2
Score 0.804 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000060329
Gene: ENSMUSG00000000766
AA Change: I146V
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7TM_GPCR_Srx
|
76 |
325 |
1.1e-7 |
PFAM |
|
Pfam:7TM_GPCR_Srsx
|
79 |
351 |
1e-10 |
PFAM |
|
Pfam:7tm_1
|
85 |
336 |
3.2e-67 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000056385
AA Change: I146V
PolyPhen 2
Score 0.804 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000060590
Gene: ENSMUSG00000000766
AA Change: I146V
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7TM_GPCR_Srx
|
76 |
325 |
1.7e-7 |
PFAM |
|
Pfam:7TM_GPCR_Srsx
|
79 |
351 |
1e-10 |
PFAM |
|
Pfam:7tm_1
|
85 |
336 |
3.3e-67 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000063036
AA Change: I78V
PolyPhen 2
Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)
|
| SMART Domains |
Protein: ENSMUSP00000053498
Gene: ENSMUSG00000000766
AA Change: I78V
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_1
|
24 |
268 |
8.7e-64 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000078634
AA Change: I146V
PolyPhen 2
Score 0.330 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000077704
Gene: ENSMUSG00000000766
AA Change: I146V
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7TM_GPCR_Srx
|
76 |
339 |
2.1e-7 |
PFAM |
|
Pfam:7TM_GPCR_Srsx
|
79 |
351 |
2.4e-10 |
PFAM |
|
Pfam:7tm_1
|
85 |
336 |
9e-60 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000092729
AA Change: I146V
PolyPhen 2
Score 0.804 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000090405
Gene: ENSMUSG00000000766
AA Change: I146V
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7TM_GPCR_Srx
|
76 |
325 |
1.7e-7 |
PFAM |
|
Pfam:7TM_GPCR_Srsx
|
79 |
351 |
9.6e-11 |
PFAM |
|
Pfam:7tm_1
|
85 |
336 |
3.1e-67 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000092731
AA Change: I146V
PolyPhen 2
Score 0.804 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000090407
Gene: ENSMUSG00000000766
AA Change: I146V
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7TM_GPCR_Srx
|
76 |
325 |
1e-7 |
PFAM |
|
Pfam:7TM_GPCR_Srsx
|
79 |
351 |
9.9e-11 |
PFAM |
|
Pfam:7tm_1
|
85 |
336 |
3.2e-67 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000105604
AA Change: I146V
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000101229
Gene: ENSMUSG00000000766
AA Change: I146V
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7TM_GPCR_Srx
|
76 |
332 |
5.1e-8 |
PFAM |
|
Pfam:7TM_GPCR_Srsx
|
79 |
351 |
9.9e-11 |
PFAM |
|
Pfam:7tm_1
|
85 |
336 |
3.8e-67 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000105607
AA Change: I146V
PolyPhen 2
Score 0.804 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000101232
Gene: ENSMUSG00000000766
AA Change: I146V
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7TM_GPCR_Srx
|
76 |
325 |
1.7e-7 |
PFAM |
|
Pfam:7TM_GPCR_Srsx
|
79 |
351 |
1e-10 |
PFAM |
|
Pfam:7tm_1
|
85 |
336 |
3.3e-67 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000092734
AA Change: I146V
PolyPhen 2
Score 0.804 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000090410
Gene: ENSMUSG00000000766
AA Change: I146V
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7TM_GPCR_Srx
|
76 |
325 |
1.7e-7 |
PFAM |
|
Pfam:7TM_GPCR_Srsx
|
79 |
351 |
1e-10 |
PFAM |
|
Pfam:7tm_1
|
85 |
336 |
3.3e-67 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000129954
AA Change: I146V
PolyPhen 2
Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000122385
Gene: ENSMUSG00000000766
AA Change: I146V
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7TM_GPCR_Srx
|
76 |
338 |
6.9e-8 |
PFAM |
|
Pfam:7TM_GPCR_Srsx
|
79 |
351 |
1.5e-10 |
PFAM |
|
Pfam:7tm_1
|
85 |
336 |
5.4e-67 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000105615
AA Change: I78V
PolyPhen 2
Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)
|
| SMART Domains |
Protein: ENSMUSP00000101240
Gene: ENSMUSG00000000766
AA Change: I78V
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_1
|
24 |
268 |
1.3e-63 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000105602
AA Change: I146V
PolyPhen 2
Score 0.804 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000101227
Gene: ENSMUSG00000000766
AA Change: I146V
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7TM_GPCR_Srx
|
76 |
325 |
1.8e-7 |
PFAM |
|
Pfam:7TM_GPCR_Srsx
|
79 |
351 |
9.8e-11 |
PFAM |
|
Pfam:7tm_1
|
85 |
336 |
3.1e-67 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000105603
AA Change: I146V
PolyPhen 2
Score 0.923 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000101228
Gene: ENSMUSG00000000766
AA Change: I146V
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7TM_GPCR_Srx
|
76 |
325 |
6.7e-8 |
PFAM |
|
Pfam:7TM_GPCR_Srsx
|
79 |
351 |
9.6e-11 |
PFAM |
|
Pfam:7tm_1
|
85 |
336 |
3.6e-67 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000105605
AA Change: I146V
PolyPhen 2
Score 0.804 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000101230
Gene: ENSMUSG00000000766
AA Change: I146V
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7TM_GPCR_Srx
|
76 |
325 |
1e-7 |
PFAM |
|
Pfam:7TM_GPCR_Srsx
|
79 |
351 |
9.8e-11 |
PFAM |
|
Pfam:7tm_1
|
85 |
336 |
3.2e-67 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000129221
AA Change: I82V
PolyPhen 2
Score 0.507 (Sensitivity: 0.88; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000123117
Gene: ENSMUSG00000000766
AA Change: I82V
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7TM_GPCR_Srx
|
12 |
261 |
1.1e-7 |
PFAM |
|
Pfam:7TM_GPCR_Srsx
|
15 |
287 |
7.3e-11 |
PFAM |
|
Pfam:7tm_1
|
21 |
272 |
2.4e-67 |
PFAM |
|
low complexity region
|
340 |
351 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000105611
AA Change: I146V
PolyPhen 2
Score 0.804 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000101236
Gene: ENSMUSG00000000766
AA Change: I146V
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7TM_GPCR_Srx
|
76 |
338 |
1.7e-7 |
PFAM |
|
Pfam:7TM_GPCR_Srsx
|
79 |
351 |
1.4e-10 |
PFAM |
|
Pfam:7tm_1
|
85 |
336 |
4.4e-67 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000133486
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000123861
|
| SMART Domains |
Protein: ENSMUSP00000120187
Gene: ENSMUSG00000000766
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1l9ha_
|
46 |
100 |
3e-9 |
SMART |
|
PDB:4DKL|A
|
52 |
100 |
3e-21 |
PDB |
|
low complexity region
|
119 |
131 |
N/A |
INTRINSIC |
|
low complexity region
|
173 |
184 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000105597
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000105601
|
| SMART Domains |
Protein: ENSMUSP00000101226
Gene: ENSMUSG00000000766
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1l9ha_
|
46 |
100 |
3e-9 |
SMART |
|
PDB:4DKL|A
|
52 |
100 |
3e-21 |
PDB |
|
low complexity region
|
119 |
131 |
N/A |
INTRINSIC |
|
low complexity region
|
173 |
184 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000154941
AA Change: I82V
PolyPhen 2
Score 0.171 (Sensitivity: 0.92; Specificity: 0.87)
|
| SMART Domains |
Protein: ENSMUSP00000115413
Gene: ENSMUSG00000000766
AA Change: I82V
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7TM_GPCR_Srx
|
12 |
261 |
9.6e-8 |
PFAM |
|
Pfam:7TM_GPCR_Srsx
|
15 |
287 |
6.1e-11 |
PFAM |
|
Pfam:7tm_1
|
21 |
272 |
2e-67 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000135502
AA Change: I146V
PolyPhen 2
Score 0.804 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000135143
Gene: ENSMUSG00000000766
AA Change: I146V
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7TM_GPCR_Srx
|
76 |
339 |
2.2e-7 |
PFAM |
|
Pfam:7TM_GPCR_Srsx
|
79 |
351 |
1.9e-10 |
PFAM |
|
Pfam:7tm_1
|
85 |
336 |
7.5e-67 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000154906
AA Change: I146V
PolyPhen 2
Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000114342
Gene: ENSMUSG00000000766
AA Change: I146V
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7TM_GPCR_Srx
|
76 |
332 |
1.5e-7 |
PFAM |
|
Pfam:7TM_GPCR_Srsx
|
79 |
351 |
1.1e-10 |
PFAM |
|
Pfam:7tm_1
|
85 |
336 |
3.6e-67 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000147171
AA Change: I78V
PolyPhen 2
Score 0.568 (Sensitivity: 0.88; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000117950
Gene: ENSMUSG00000000766
AA Change: I78V
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_1
|
24 |
268 |
9.2e-64 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000144264
AA Change: I146V
PolyPhen 2
Score 0.804 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000115836
Gene: ENSMUSG00000000766
AA Change: I146V
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7TM_GPCR_Srx
|
76 |
325 |
1.7e-7 |
PFAM |
|
Pfam:7TM_GPCR_Srsx
|
79 |
351 |
1e-10 |
PFAM |
|
Pfam:7tm_1
|
85 |
336 |
3.4e-67 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000148625
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000141897
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000150374
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000143875
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000152674
|
| SMART Domains |
Protein: ENSMUSP00000115552
Gene: ENSMUSG00000000766
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1l9ha_
|
46 |
94 |
8e-8 |
SMART |
|
PDB:4DKL|A
|
52 |
94 |
7e-23 |
PDB |
|
| Meta Mutation Damage Score |
0.0905 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.7%
- 20x: 93.7%
|
| Validation Efficiency |
98% (101/103) |
| MGI Phenotype |
FUNCTION: This gene encodes the mu opioid receptor which is where drugs such as morphine and other opioids have pharmacological effects. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
PHENOTYPE: Homozygotes for null mutations exhibit isoform dependent loss of behavioral and gastrointestinal opioid responses and may also show impaired spatial memory, heightened nociception, reduced locomotor activity, increased hematopoietic proliferation, and decreased male fertility. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 92 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 9930012K11Rik |
C |
T |
14: 70,393,907 (GRCm39) |
V243I |
probably benign |
Het |
| Acadvl |
C |
T |
11: 69,902,010 (GRCm39) |
G485S |
probably benign |
Het |
| Acap3 |
T |
A |
4: 155,986,908 (GRCm39) |
|
probably benign |
Het |
| Adamts19 |
A |
G |
18: 59,023,356 (GRCm39) |
I250M |
probably damaging |
Het |
| Amacr |
T |
A |
15: 10,983,496 (GRCm39) |
I102N |
probably damaging |
Het |
| Apob |
A |
G |
12: 8,065,741 (GRCm39) |
T4237A |
probably benign |
Het |
| Bbs10 |
A |
G |
10: 111,136,995 (GRCm39) |
K703E |
probably benign |
Het |
| Bicd1 |
A |
T |
6: 149,420,752 (GRCm39) |
|
probably benign |
Het |
| Caskin2 |
T |
A |
11: 115,698,125 (GRCm39) |
E49V |
probably damaging |
Het |
| Cemip |
T |
A |
7: 83,622,449 (GRCm39) |
I577F |
probably benign |
Het |
| Chrnb1 |
T |
C |
11: 69,686,501 (GRCm39) |
S40G |
possibly damaging |
Het |
| Ctif |
C |
T |
18: 75,654,632 (GRCm39) |
C298Y |
probably benign |
Het |
| Cul9 |
A |
C |
17: 46,840,977 (GRCm39) |
H764Q |
probably benign |
Het |
| Cwf19l2 |
T |
A |
9: 3,458,839 (GRCm39) |
C763S |
probably damaging |
Het |
| Dhx57 |
A |
T |
17: 80,549,596 (GRCm39) |
|
probably null |
Het |
| Dnaaf10 |
T |
A |
11: 17,177,165 (GRCm39) |
N174K |
probably damaging |
Het |
| Dnhd1 |
G |
A |
7: 105,353,171 (GRCm39) |
D2775N |
probably benign |
Het |
| Enpp1 |
A |
T |
10: 24,537,833 (GRCm39) |
M384K |
possibly damaging |
Het |
| Fat2 |
T |
C |
11: 55,202,144 (GRCm39) |
N310S |
probably benign |
Het |
| Fbxw7 |
A |
T |
3: 84,874,814 (GRCm39) |
Y232F |
possibly damaging |
Het |
| Fcamr |
T |
A |
1: 130,740,423 (GRCm39) |
S281T |
possibly damaging |
Het |
| Gm10762 |
C |
T |
2: 128,809,106 (GRCm39) |
W81* |
probably null |
Het |
| Gm5592 |
A |
G |
7: 40,805,314 (GRCm39) |
|
probably benign |
Het |
| Gm5745 |
T |
C |
9: 73,082,980 (GRCm39) |
|
noncoding transcript |
Het |
| Gm6185 |
G |
C |
1: 161,040,824 (GRCm39) |
|
noncoding transcript |
Het |
| Hid1 |
T |
A |
11: 115,246,125 (GRCm39) |
N382Y |
probably damaging |
Het |
| Hoxa10 |
A |
T |
6: 52,209,569 (GRCm39) |
F68I |
probably damaging |
Het |
| Ift88 |
T |
A |
14: 57,679,326 (GRCm39) |
|
probably null |
Het |
| Ighg2b |
A |
T |
12: 113,270,011 (GRCm39) |
*336R |
probably null |
Het |
| Ighv7-2 |
A |
C |
12: 113,875,892 (GRCm39) |
L37R |
probably damaging |
Het |
| Kcnd3 |
C |
T |
3: 105,566,082 (GRCm39) |
A421V |
probably damaging |
Het |
| Kcnn3 |
G |
C |
3: 89,574,596 (GRCm39) |
V703L |
possibly damaging |
Het |
| Kiz |
C |
A |
2: 146,732,989 (GRCm39) |
S388R |
probably damaging |
Het |
| Klhl20 |
G |
A |
1: 160,921,333 (GRCm39) |
Q41* |
probably null |
Het |
| Krt31 |
T |
C |
11: 99,938,610 (GRCm39) |
I328V |
possibly damaging |
Het |
| Lama4 |
A |
T |
10: 38,909,049 (GRCm39) |
I330L |
probably benign |
Het |
| Lipo2 |
A |
T |
19: 33,723,151 (GRCm39) |
S213T |
probably benign |
Het |
| Lrsam1 |
A |
T |
2: 32,816,804 (GRCm39) |
I723N |
probably damaging |
Het |
| Man2b2 |
G |
A |
5: 36,972,865 (GRCm39) |
R550W |
probably damaging |
Het |
| Map4k5 |
A |
T |
12: 69,888,758 (GRCm39) |
L224* |
probably null |
Het |
| Mast3 |
A |
G |
8: 71,233,010 (GRCm39) |
S1101P |
probably damaging |
Het |
| Mertk |
A |
G |
2: 128,643,225 (GRCm39) |
S875G |
probably benign |
Het |
| Mmel1 |
A |
G |
4: 154,972,354 (GRCm39) |
M302V |
probably benign |
Het |
| Mrgpra3 |
T |
A |
7: 47,239,716 (GRCm39) |
H70L |
possibly damaging |
Het |
| Myh3 |
T |
A |
11: 66,979,836 (GRCm39) |
S592T |
probably benign |
Het |
| Nbeal2 |
T |
C |
9: 110,465,383 (GRCm39) |
I451V |
possibly damaging |
Het |
| Nup155 |
T |
A |
15: 8,158,010 (GRCm39) |
V489D |
possibly damaging |
Het |
| Obscn |
T |
A |
11: 58,913,159 (GRCm39) |
T6300S |
probably benign |
Het |
| Or1ad1 |
T |
A |
11: 50,875,910 (GRCm39) |
C127* |
probably null |
Het |
| Or1j4 |
A |
G |
2: 36,740,888 (GRCm39) |
M277V |
probably benign |
Het |
| Or4k44 |
G |
T |
2: 111,367,797 (GRCm39) |
T279K |
probably damaging |
Het |
| Or5ae1 |
A |
C |
7: 84,565,634 (GRCm39) |
I216L |
possibly damaging |
Het |
| Otub1 |
A |
T |
19: 7,181,794 (GRCm39) |
D27E |
probably damaging |
Het |
| Pik3ca |
T |
C |
3: 32,492,131 (GRCm39) |
V243A |
probably benign |
Het |
| Pla2g12b |
G |
A |
10: 59,252,336 (GRCm39) |
|
probably null |
Het |
| Plekha8 |
A |
G |
6: 54,601,546 (GRCm39) |
D321G |
probably damaging |
Het |
| Pprc1 |
T |
C |
19: 46,059,795 (GRCm39) |
|
probably benign |
Het |
| Prkdc |
A |
G |
16: 15,468,576 (GRCm39) |
D129G |
possibly damaging |
Het |
| Rbms3 |
C |
T |
9: 116,773,441 (GRCm39) |
|
probably benign |
Het |
| Rictor |
T |
A |
15: 6,821,161 (GRCm39) |
V1495D |
probably benign |
Het |
| Rpl31-ps21 |
T |
C |
5: 21,324,507 (GRCm39) |
|
noncoding transcript |
Het |
| Ryr3 |
A |
T |
2: 112,483,090 (GRCm39) |
I4219N |
probably damaging |
Het |
| Sbf2 |
G |
A |
7: 109,977,146 (GRCm39) |
|
probably benign |
Het |
| Scn10a |
C |
T |
9: 119,467,738 (GRCm39) |
A801T |
probably damaging |
Het |
| Scn9a |
T |
A |
2: 66,314,093 (GRCm39) |
Y1866F |
possibly damaging |
Het |
| Sec1 |
A |
C |
7: 45,328,727 (GRCm39) |
Y107D |
probably damaging |
Het |
| Sema6d |
C |
T |
2: 124,504,214 (GRCm39) |
T619M |
possibly damaging |
Het |
| Sh2b3 |
C |
A |
5: 121,966,618 (GRCm39) |
|
probably benign |
Het |
| Slc2a4 |
A |
G |
11: 69,837,413 (GRCm39) |
V44A |
probably damaging |
Het |
| Slc5a12 |
T |
C |
2: 110,452,085 (GRCm39) |
I326T |
possibly damaging |
Het |
| Smarca5 |
T |
C |
8: 81,435,309 (GRCm39) |
|
probably null |
Het |
| Smarcd2 |
A |
G |
11: 106,157,357 (GRCm39) |
|
probably null |
Het |
| Snrpa1 |
A |
T |
7: 65,719,321 (GRCm39) |
|
probably benign |
Het |
| Sptbn5 |
T |
G |
2: 119,898,449 (GRCm39) |
K470Q |
probably benign |
Het |
| Stard9 |
T |
G |
2: 120,526,422 (GRCm39) |
V893G |
possibly damaging |
Het |
| Stx8 |
T |
G |
11: 67,864,099 (GRCm39) |
V53G |
possibly damaging |
Het |
| Sv2c |
A |
T |
13: 96,122,457 (GRCm39) |
W440R |
probably damaging |
Het |
| Tcstv2a |
A |
T |
13: 120,725,686 (GRCm39) |
T117S |
probably damaging |
Het |
| Tmem181a |
A |
T |
17: 6,330,940 (GRCm39) |
I67F |
probably benign |
Het |
| Tmprss7 |
C |
T |
16: 45,483,679 (GRCm39) |
C565Y |
probably damaging |
Het |
| Trafd1 |
A |
T |
5: 121,516,561 (GRCm39) |
L109H |
probably damaging |
Het |
| Trpv4 |
A |
G |
5: 114,768,083 (GRCm39) |
I422T |
possibly damaging |
Het |
| Usp24 |
T |
A |
4: 106,273,244 (GRCm39) |
Y2210N |
probably damaging |
Het |
| Vmn1r236 |
A |
T |
17: 21,507,202 (GRCm39) |
N107Y |
probably damaging |
Het |
| Vmn2r13 |
A |
T |
5: 109,321,938 (GRCm39) |
I253K |
probably damaging |
Het |
| Vmn2r2 |
T |
A |
3: 64,041,960 (GRCm39) |
I252F |
probably damaging |
Het |
| Vsig8 |
A |
G |
1: 172,387,205 (GRCm39) |
D27G |
probably damaging |
Het |
| Wiz |
A |
T |
17: 32,575,411 (GRCm39) |
Y908* |
probably null |
Het |
| Wnk1 |
A |
T |
6: 119,939,399 (GRCm39) |
S1113T |
probably benign |
Het |
| Zdhhc1 |
CGGGGG |
CGGGGGG |
8: 106,210,376 (GRCm39) |
|
probably null |
Het |
| Zfp691 |
G |
T |
4: 119,027,764 (GRCm39) |
T156K |
probably damaging |
Het |
| Zfp791 |
A |
T |
8: 85,837,035 (GRCm39) |
D276E |
probably benign |
Het |
|
| Other mutations in Oprm1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01018:Oprm1
|
APN |
10 |
6,987,170 (GRCm39) |
utr 3 prime |
probably benign |
|
|
IGL01768:Oprm1
|
APN |
10 |
6,779,186 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02455:Oprm1
|
APN |
10 |
6,780,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03391:Oprm1
|
APN |
10 |
6,964,077 (GRCm39) |
intron |
probably benign |
|
|
IGL03410:Oprm1
|
APN |
10 |
6,780,051 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03048:Oprm1
|
UTSW |
10 |
6,779,064 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0189:Oprm1
|
UTSW |
10 |
6,739,071 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0321:Oprm1
|
UTSW |
10 |
6,779,183 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0629:Oprm1
|
UTSW |
10 |
6,782,604 (GRCm39) |
splice site |
probably null |
|
|
R0730:Oprm1
|
UTSW |
10 |
6,782,652 (GRCm39) |
intron |
probably benign |
|
|
R1542:Oprm1
|
UTSW |
10 |
6,738,960 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1743:Oprm1
|
UTSW |
10 |
6,780,105 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1874:Oprm1
|
UTSW |
10 |
6,739,035 (GRCm39) |
missense |
probably benign |
0.17 |
|
R2864:Oprm1
|
UTSW |
10 |
6,744,226 (GRCm39) |
splice site |
probably null |
|
|
R2964:Oprm1
|
UTSW |
10 |
6,738,914 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3792:Oprm1
|
UTSW |
10 |
6,789,544 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4008:Oprm1
|
UTSW |
10 |
6,782,520 (GRCm39) |
missense |
probably benign |
|
|
R4049:Oprm1
|
UTSW |
10 |
6,779,087 (GRCm39) |
missense |
probably benign |
0.36 |
|
R4088:Oprm1
|
UTSW |
10 |
6,780,234 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4724:Oprm1
|
UTSW |
10 |
6,708,656 (GRCm39) |
nonsense |
probably null |
|
|
R4812:Oprm1
|
UTSW |
10 |
6,782,698 (GRCm39) |
intron |
probably benign |
|
|
R4855:Oprm1
|
UTSW |
10 |
6,788,468 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5072:Oprm1
|
UTSW |
10 |
6,782,550 (GRCm39) |
missense |
probably benign |
0.15 |
|
R5768:Oprm1
|
UTSW |
10 |
6,739,026 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5770:Oprm1
|
UTSW |
10 |
6,739,026 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5995:Oprm1
|
UTSW |
10 |
6,782,520 (GRCm39) |
missense |
probably benign |
|
|
R6327:Oprm1
|
UTSW |
10 |
6,780,063 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7135:Oprm1
|
UTSW |
10 |
6,780,203 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R7413:Oprm1
|
UTSW |
10 |
6,778,919 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7455:Oprm1
|
UTSW |
10 |
6,780,204 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8192:Oprm1
|
UTSW |
10 |
6,788,417 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8210:Oprm1
|
UTSW |
10 |
6,780,442 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8945:Oprm1
|
UTSW |
10 |
6,782,644 (GRCm39) |
intron |
probably benign |
|
|
R9054:Oprm1
|
UTSW |
10 |
6,773,914 (GRCm39) |
intron |
probably benign |
|
|
R9723:Oprm1
|
UTSW |
10 |
6,788,514 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R9726:Oprm1
|
UTSW |
10 |
6,929,694 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0066:Oprm1
|
UTSW |
10 |
6,780,462 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- GTCAGGGTCTTCCATTAACCAC -3'
(R):5'- ATTACGGGCAGACCAATGGC -3'
Sequencing Primer
(F):5'- CTAAGAGAATACTAGGTGGTGTCTCC -3'
(R):5'- CAGAAGAGAGGATCCAGTTGC -3'
|
| Posted On |
2016-03-01 |
Incidental Mutation