Incidental Mutation 'R4823:Arhgef12'
| ID |
371303 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Arhgef12
|
| Ensembl Gene |
ENSMUSG00000059495 |
| Gene Name |
Rho guanine nucleotide exchange factor 12 |
| Synonyms |
2310014B11Rik, LARG |
| MMRRC Submission |
042439-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.936)
|
| Stock # |
R4823 (G1)
|
| Quality Score |
171 |
|
Status
|
Validated
|
| Chromosome |
9 |
| Chromosomal Location |
42875138-43017069 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 42931992 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 165
(V165A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126598
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000072767]
[ENSMUST00000165665]
|
| AlphaFold |
Q8R4H2 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000072767
AA Change: V165A
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000072547
Gene: ENSMUSG00000059495
AA Change: V165A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
49 |
64 |
N/A |
INTRINSIC |
|
PDZ
|
80 |
148 |
1.64e-19 |
SMART |
|
coiled coil region
|
196 |
259 |
N/A |
INTRINSIC |
|
low complexity region
|
293 |
313 |
N/A |
INTRINSIC |
|
Pfam:RGS-like
|
368 |
558 |
8.6e-87 |
PFAM |
|
low complexity region
|
583 |
596 |
N/A |
INTRINSIC |
|
low complexity region
|
663 |
676 |
N/A |
INTRINSIC |
|
low complexity region
|
721 |
733 |
N/A |
INTRINSIC |
|
RhoGEF
|
791 |
976 |
6.35e-66 |
SMART |
|
PH
|
1020 |
1134 |
6.26e-6 |
SMART |
|
low complexity region
|
1256 |
1269 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000165665
AA Change: V165A
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000126598
Gene: ENSMUSG00000059495
AA Change: V165A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
49 |
64 |
N/A |
INTRINSIC |
|
PDZ
|
80 |
148 |
1.64e-19 |
SMART |
|
coiled coil region
|
196 |
259 |
N/A |
INTRINSIC |
|
low complexity region
|
293 |
313 |
N/A |
INTRINSIC |
|
Pfam:RGS-like
|
369 |
559 |
1.6e-88 |
PFAM |
|
low complexity region
|
584 |
597 |
N/A |
INTRINSIC |
|
low complexity region
|
664 |
677 |
N/A |
INTRINSIC |
|
low complexity region
|
722 |
734 |
N/A |
INTRINSIC |
|
RhoGEF
|
792 |
977 |
6.35e-66 |
SMART |
|
PH
|
1021 |
1135 |
6.26e-6 |
SMART |
|
low complexity region
|
1257 |
1270 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000213566
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000215898
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000217502
|
| Meta Mutation Damage Score |
0.0870 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.5%
- 10x: 96.8%
- 20x: 94.1%
|
| Validation Efficiency |
98% (96/98) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
PHENOTYPE: Mice homozygous for a null allele exhibit decreased sensitivity to certain vasoconstrictors and resistance to salt-induced hypertension. Mice homozygous for a different knock-out allele exhibit partial prenatal lethality. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 88 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2310003L06Rik |
G |
A |
5: 88,120,457 (GRCm39) |
D405N |
probably benign |
Het |
| 4921517D22Rik |
T |
G |
13: 59,838,718 (GRCm39) |
E38A |
probably damaging |
Het |
| 4930433I11Rik |
A |
T |
7: 40,642,786 (GRCm39) |
I152F |
probably benign |
Het |
| Aass |
A |
T |
6: 23,107,690 (GRCm39) |
D364E |
probably benign |
Het |
| Adamts2 |
A |
G |
11: 50,628,014 (GRCm39) |
D238G |
probably benign |
Het |
| Albfm1 |
T |
A |
5: 90,714,362 (GRCm39) |
L124H |
probably benign |
Het |
| Aoc1l1 |
A |
G |
6: 48,952,195 (GRCm39) |
D40G |
probably damaging |
Het |
| Aplf |
G |
A |
6: 87,623,237 (GRCm39) |
L302F |
probably damaging |
Het |
| Apol7b |
G |
T |
15: 77,311,982 (GRCm39) |
|
probably benign |
Het |
| Ascc3 |
T |
C |
10: 50,589,329 (GRCm39) |
S1017P |
probably damaging |
Het |
| B230104I21Rik |
T |
A |
4: 154,434,204 (GRCm39) |
|
probably benign |
Het |
| Bfsp2 |
C |
A |
9: 103,357,082 (GRCm39) |
C115F |
probably damaging |
Het |
| Bhmt2 |
A |
T |
13: 93,799,798 (GRCm39) |
W213R |
probably benign |
Het |
| Capn5 |
A |
T |
7: 97,775,648 (GRCm39) |
V431E |
probably damaging |
Het |
| Ccdc88c |
A |
G |
12: 100,896,802 (GRCm39) |
Y1390H |
probably damaging |
Het |
| Ccr3 |
A |
G |
9: 123,828,718 (GRCm39) |
T18A |
probably damaging |
Het |
| Cdh5 |
T |
C |
8: 104,869,301 (GRCm39) |
S676P |
probably benign |
Het |
| Ceacam5 |
A |
G |
7: 17,491,669 (GRCm39) |
T680A |
possibly damaging |
Het |
| Cebpd |
G |
A |
16: 15,705,978 (GRCm39) |
G264S |
probably benign |
Het |
| Cfd |
T |
C |
10: 79,726,782 (GRCm39) |
V8A |
probably benign |
Het |
| Cops9 |
C |
T |
1: 92,569,588 (GRCm39) |
|
probably benign |
Het |
| Cpne6 |
T |
C |
14: 55,754,467 (GRCm39) |
Y533H |
probably damaging |
Het |
| Cyp2c67 |
T |
A |
19: 39,604,168 (GRCm39) |
H396L |
probably benign |
Het |
| Cyp2j9 |
G |
A |
4: 96,456,972 (GRCm39) |
P500S |
possibly damaging |
Het |
| Cyp4a12a |
A |
T |
4: 115,184,610 (GRCm39) |
|
probably null |
Het |
| Dbt |
G |
A |
3: 116,317,036 (GRCm39) |
D71N |
probably damaging |
Het |
| Ddx41 |
G |
T |
13: 55,679,868 (GRCm39) |
Q440K |
probably benign |
Het |
| Elovl4 |
A |
G |
9: 83,662,738 (GRCm39) |
F174S |
probably damaging |
Het |
| Emcn |
C |
G |
3: 137,129,187 (GRCm39) |
P193R |
probably damaging |
Het |
| Etnk1 |
T |
C |
6: 143,113,364 (GRCm39) |
|
probably null |
Het |
| Fads3 |
A |
C |
19: 10,019,252 (GRCm39) |
S53R |
probably damaging |
Het |
| Fam193a |
A |
G |
5: 34,616,372 (GRCm39) |
E849G |
probably damaging |
Het |
| Fat3 |
A |
G |
9: 15,907,803 (GRCm39) |
V2733A |
probably benign |
Het |
| Frem3 |
T |
A |
8: 81,340,587 (GRCm39) |
M960K |
probably benign |
Het |
| Frmd6 |
A |
T |
12: 70,919,349 (GRCm39) |
I62L |
probably benign |
Het |
| Glmp |
T |
C |
3: 88,232,530 (GRCm39) |
|
probably benign |
Het |
| Gm17421 |
T |
C |
12: 113,333,161 (GRCm39) |
|
noncoding transcript |
Het |
| Gm27013 |
T |
A |
6: 130,499,186 (GRCm39) |
|
noncoding transcript |
Het |
| Gtf2ird1 |
A |
G |
5: 134,424,576 (GRCm39) |
V390A |
probably damaging |
Het |
| Hps3 |
A |
G |
3: 20,066,890 (GRCm39) |
Y559H |
probably benign |
Het |
| Hsh2d |
G |
A |
8: 72,954,304 (GRCm39) |
D229N |
probably benign |
Het |
| Itpr3 |
A |
G |
17: 27,304,121 (GRCm39) |
D114G |
probably benign |
Het |
| Jmjd4 |
G |
A |
11: 59,346,406 (GRCm39) |
A408T |
probably benign |
Het |
| Kcnh4 |
G |
T |
11: 100,646,000 (GRCm39) |
A316D |
probably damaging |
Het |
| Klrg1 |
T |
A |
6: 122,250,492 (GRCm39) |
|
probably null |
Het |
| Lancl2 |
T |
A |
6: 57,709,262 (GRCm39) |
Y355N |
probably damaging |
Het |
| Ltb |
T |
C |
17: 35,414,206 (GRCm39) |
S115P |
probably benign |
Het |
| Mccc2 |
T |
G |
13: 100,136,762 (GRCm39) |
R64S |
probably benign |
Het |
| Mgam2-ps |
T |
A |
6: 40,809,596 (GRCm39) |
|
noncoding transcript |
Het |
| Mrrf |
T |
G |
2: 36,038,042 (GRCm39) |
N104K |
possibly damaging |
Het |
| Nipa1 |
C |
A |
7: 55,629,436 (GRCm39) |
V226L |
possibly damaging |
Het |
| Numa1 |
T |
A |
7: 101,645,244 (GRCm39) |
L290Q |
probably damaging |
Het |
| Ofcc1 |
T |
A |
13: 40,433,949 (GRCm39) |
H52L |
probably damaging |
Het |
| Ogfod3 |
G |
A |
11: 121,086,027 (GRCm39) |
A189V |
probably benign |
Het |
| Or14c39 |
T |
A |
7: 86,343,796 (GRCm39) |
I44N |
probably damaging |
Het |
| Or5b21 |
A |
T |
19: 12,839,180 (GRCm39) |
I14F |
probably benign |
Het |
| Or5d46 |
A |
G |
2: 88,170,179 (GRCm39) |
D90G |
probably damaging |
Het |
| Or9i1b |
G |
A |
19: 13,897,022 (GRCm39) |
V213I |
probably benign |
Het |
| P2ry12 |
G |
A |
3: 59,125,318 (GRCm39) |
S119L |
probably benign |
Het |
| Pde7b |
T |
A |
10: 20,314,531 (GRCm39) |
N192Y |
probably damaging |
Het |
| Pfkl |
T |
C |
10: 77,833,428 (GRCm39) |
N258S |
probably damaging |
Het |
| Phykpl |
G |
A |
11: 51,477,420 (GRCm39) |
A71T |
probably damaging |
Het |
| Ppp1r16a |
T |
C |
15: 76,577,393 (GRCm39) |
|
probably benign |
Het |
| Pramel15 |
T |
C |
4: 144,099,781 (GRCm39) |
N328S |
possibly damaging |
Het |
| Pramel32 |
T |
C |
4: 88,547,452 (GRCm39) |
K160R |
probably damaging |
Het |
| Prune2 |
C |
T |
19: 17,097,868 (GRCm39) |
T1124M |
probably damaging |
Het |
| Rapgef6 |
A |
G |
11: 54,585,326 (GRCm39) |
I1570V |
probably benign |
Het |
| Rbm34 |
T |
C |
8: 127,697,655 (GRCm39) |
S19G |
probably benign |
Het |
| Rnf10 |
T |
C |
5: 115,393,501 (GRCm39) |
|
probably null |
Het |
| Rnf34 |
A |
G |
5: 122,988,365 (GRCm39) |
|
probably null |
Het |
| Setd4 |
A |
G |
16: 93,386,838 (GRCm39) |
S287P |
probably benign |
Het |
| Shc3 |
C |
T |
13: 51,605,606 (GRCm39) |
V225I |
probably benign |
Het |
| Sipa1l3 |
C |
T |
7: 29,070,427 (GRCm39) |
V1030I |
probably damaging |
Het |
| Siva1 |
G |
T |
12: 112,611,498 (GRCm39) |
R33L |
probably damaging |
Het |
| Slc4a5 |
C |
T |
6: 83,249,115 (GRCm39) |
T573I |
probably damaging |
Het |
| Sorcs1 |
C |
T |
19: 50,666,578 (GRCm39) |
R110Q |
possibly damaging |
Het |
| Sorcs1 |
T |
C |
19: 50,218,740 (GRCm39) |
I581V |
possibly damaging |
Het |
| Sorl1 |
T |
C |
9: 41,903,617 (GRCm39) |
D1545G |
probably damaging |
Het |
| Tas2r124 |
T |
G |
6: 132,732,509 (GRCm39) |
S273A |
probably damaging |
Het |
| Tcf15 |
T |
C |
2: 151,985,813 (GRCm39) |
F90L |
probably damaging |
Het |
| Trim59 |
G |
A |
3: 68,944,453 (GRCm39) |
R296C |
probably benign |
Het |
| Tulp1 |
A |
T |
17: 28,572,546 (GRCm39) |
D229E |
probably benign |
Het |
| Ush1c |
T |
A |
7: 45,845,157 (GRCm39) |
N886I |
probably benign |
Het |
| Usp9y |
A |
T |
Y: 1,444,559 (GRCm39) |
S127T |
probably damaging |
Het |
| Vmn1r19 |
T |
A |
6: 57,382,219 (GRCm39) |
Y257* |
probably null |
Het |
| Vmn2r109 |
A |
T |
17: 20,774,153 (GRCm39) |
Y401N |
probably damaging |
Het |
| Vmn2r69 |
A |
C |
7: 85,060,508 (GRCm39) |
S359A |
probably benign |
Het |
| Zfp37 |
A |
T |
4: 62,109,740 (GRCm39) |
N479K |
probably benign |
Het |
|
| Other mutations in Arhgef12 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00923:Arhgef12
|
APN |
9 |
42,931,920 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00942:Arhgef12
|
APN |
9 |
42,893,296 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01529:Arhgef12
|
APN |
9 |
42,901,351 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01845:Arhgef12
|
APN |
9 |
42,934,137 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
IGL02039:Arhgef12
|
APN |
9 |
42,883,563 (GRCm39) |
missense |
probably benign |
|
|
IGL02135:Arhgef12
|
APN |
9 |
42,883,461 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
IGL02272:Arhgef12
|
APN |
9 |
42,912,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02498:Arhgef12
|
APN |
9 |
42,893,339 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL02507:Arhgef12
|
APN |
9 |
42,903,859 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02574:Arhgef12
|
APN |
9 |
42,916,919 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02586:Arhgef12
|
APN |
9 |
42,917,200 (GRCm39) |
nonsense |
probably null |
|
|
IGL02803:Arhgef12
|
APN |
9 |
42,883,324 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
IGL02892:Arhgef12
|
APN |
9 |
42,912,268 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL02937:Arhgef12
|
APN |
9 |
42,927,216 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02992:Arhgef12
|
APN |
9 |
42,910,373 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03028:Arhgef12
|
APN |
9 |
42,937,524 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL03146:Arhgef12
|
APN |
9 |
42,885,866 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL03193:Arhgef12
|
APN |
9 |
42,903,829 (GRCm39) |
splice site |
probably benign |
|
|
IGL03398:Arhgef12
|
APN |
9 |
42,889,522 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0019:Arhgef12
|
UTSW |
9 |
42,889,529 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0143:Arhgef12
|
UTSW |
9 |
42,916,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0211:Arhgef12
|
UTSW |
9 |
42,883,300 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0330:Arhgef12
|
UTSW |
9 |
42,931,982 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0364:Arhgef12
|
UTSW |
9 |
42,929,697 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0426:Arhgef12
|
UTSW |
9 |
42,882,286 (GRCm39) |
splice site |
probably null |
|
|
R0658:Arhgef12
|
UTSW |
9 |
42,893,281 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0686:Arhgef12
|
UTSW |
9 |
42,904,324 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0693:Arhgef12
|
UTSW |
9 |
42,929,697 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0990:Arhgef12
|
UTSW |
9 |
42,883,677 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1147:Arhgef12
|
UTSW |
9 |
42,955,552 (GRCm39) |
unclassified |
probably benign |
|
|
R1395:Arhgef12
|
UTSW |
9 |
42,917,166 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1419:Arhgef12
|
UTSW |
9 |
42,938,516 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1451:Arhgef12
|
UTSW |
9 |
42,903,874 (GRCm39) |
splice site |
probably benign |
|
|
R1458:Arhgef12
|
UTSW |
9 |
42,900,294 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1654:Arhgef12
|
UTSW |
9 |
42,908,956 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R1722:Arhgef12
|
UTSW |
9 |
42,932,013 (GRCm39) |
makesense |
probably null |
|
|
R1773:Arhgef12
|
UTSW |
9 |
42,916,838 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1895:Arhgef12
|
UTSW |
9 |
42,917,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2109:Arhgef12
|
UTSW |
9 |
42,890,768 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R2215:Arhgef12
|
UTSW |
9 |
42,917,167 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2421:Arhgef12
|
UTSW |
9 |
42,912,302 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3967:Arhgef12
|
UTSW |
9 |
42,916,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3968:Arhgef12
|
UTSW |
9 |
42,916,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3969:Arhgef12
|
UTSW |
9 |
42,916,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4077:Arhgef12
|
UTSW |
9 |
42,886,588 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4079:Arhgef12
|
UTSW |
9 |
42,886,588 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4111:Arhgef12
|
UTSW |
9 |
42,883,570 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4302:Arhgef12
|
UTSW |
9 |
42,929,645 (GRCm39) |
nonsense |
probably null |
|
|
R4327:Arhgef12
|
UTSW |
9 |
42,886,525 (GRCm39) |
nonsense |
probably null |
|
|
R4462:Arhgef12
|
UTSW |
9 |
42,893,278 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4583:Arhgef12
|
UTSW |
9 |
42,888,958 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4603:Arhgef12
|
UTSW |
9 |
42,921,489 (GRCm39) |
missense |
probably benign |
0.27 |
|
R4650:Arhgef12
|
UTSW |
9 |
42,893,266 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4741:Arhgef12
|
UTSW |
9 |
42,883,449 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R4840:Arhgef12
|
UTSW |
9 |
42,886,364 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4912:Arhgef12
|
UTSW |
9 |
42,904,361 (GRCm39) |
nonsense |
probably null |
|
|
R5176:Arhgef12
|
UTSW |
9 |
42,931,982 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5426:Arhgef12
|
UTSW |
9 |
42,897,880 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5579:Arhgef12
|
UTSW |
9 |
42,921,489 (GRCm39) |
missense |
probably benign |
0.27 |
|
R5838:Arhgef12
|
UTSW |
9 |
42,916,904 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6230:Arhgef12
|
UTSW |
9 |
42,900,261 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6741:Arhgef12
|
UTSW |
9 |
42,883,503 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6959:Arhgef12
|
UTSW |
9 |
42,927,249 (GRCm39) |
missense |
probably benign |
|
|
R7252:Arhgef12
|
UTSW |
9 |
42,927,205 (GRCm39) |
missense |
probably benign |
0.17 |
|
R7470:Arhgef12
|
UTSW |
9 |
42,951,848 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7658:Arhgef12
|
UTSW |
9 |
42,903,832 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7724:Arhgef12
|
UTSW |
9 |
42,938,567 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7980:Arhgef12
|
UTSW |
9 |
42,882,595 (GRCm39) |
nonsense |
probably null |
|
|
R8074:Arhgef12
|
UTSW |
9 |
42,882,399 (GRCm39) |
nonsense |
probably null |
|
|
R8155:Arhgef12
|
UTSW |
9 |
42,953,958 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8270:Arhgef12
|
UTSW |
9 |
42,882,354 (GRCm39) |
missense |
probably benign |
|
|
R8407:Arhgef12
|
UTSW |
9 |
42,937,475 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8527:Arhgef12
|
UTSW |
9 |
42,908,944 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9116:Arhgef12
|
UTSW |
9 |
42,893,241 (GRCm39) |
splice site |
probably benign |
|
|
R9127:Arhgef12
|
UTSW |
9 |
42,885,870 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9602:Arhgef12
|
UTSW |
9 |
42,895,676 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9665:Arhgef12
|
UTSW |
9 |
42,929,650 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9733:Arhgef12
|
UTSW |
9 |
42,901,294 (GRCm39) |
nonsense |
probably null |
|
|
R9735:Arhgef12
|
UTSW |
9 |
42,882,399 (GRCm39) |
nonsense |
probably null |
|
|
R9760:Arhgef12
|
UTSW |
9 |
42,903,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF020:Arhgef12
|
UTSW |
9 |
42,901,285 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
Z1176:Arhgef12
|
UTSW |
9 |
42,882,368 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1186:Arhgef12
|
UTSW |
9 |
42,911,311 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CTGTGGATTGGACACTGTTTTATAC -3'
(R):5'- TGGGTACAGTCCTCACTACC -3'
Sequencing Primer
(F):5'- GGACACTGTTTTATACATGACAGG -3'
(R):5'- GTCCTCACTACCACAGATAAAGAG -3'
|
| Posted On |
2016-03-01 |
Incidental Mutation