Mutagenetix > Incidental Mutation

Incidental Mutation 'R0422:Taar7a'

37133

Institutional Source

Beutler Lab

Gene Symbol

Taar7a

Ensembl Gene

ENSMUSG00000095647

Gene Name

trace amine-associated receptor 7A

Synonyms

Taar7a, LOC215856

MMRRC Submission

038624-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.096) question?

Stock #

R0422 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

23992405-23993481 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 23993274 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 70 (T70A)

Ref Sequence

ENSEMBL: ENSMUSP00000077616 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000078532]

AlphaFold

Q5QD12

Predicted Effect

probably benign
Transcript: ENSMUST00000078532
AA Change: T70A

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)

SMART Domains

Protein: ENSMUSP00000077616
Gene: ENSMUSG00000095647
AA Change: T70A

Domain	Start	End	E-Value	Type
Pfam:7tm_4	54	344	9.2e-10	PFAM
Pfam:7TM_GPCR_Srx	56	261	5.2e-9	PFAM
Pfam:7tm_1	64	326	3.2e-58	PFAM

Coding Region Coverage

1x: 99.3%
3x: 98.7%
10x: 97.3%
20x: 95.6%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700022I11Rik	T	C	4: 42,972,199	S511P	possibly damaging	Het
Acsm3	T	A	7: 119,773,740	Y155*	probably null	Het
Adamts16	A	G	13: 70,738,955	C937R	probably damaging	Het
Akna	T	C	4: 63,392,154	D451G	probably damaging	Het
Alox12	A	T	11: 70,254,558	V63E	probably damaging	Het
Ap3b1	T	C	13: 94,462,460	I514T	probably damaging	Het
Arhgap23	T	C	11: 97,463,652	M286T	probably damaging	Het
Cdkl2	T	C	5: 92,020,312	D341G	probably benign	Het
Clip2	T	C	5: 134,498,113	D813G	probably benign	Het
Cntnap3	A	G	13: 64,757,285	V894A	probably damaging	Het
Coro2b	T	A	9: 62,427,977	Y304F	probably benign	Het
Dclre1a	T	A	19: 56,544,135	K676*	probably null	Het
Dmxl2	A	G	9: 54,399,940		probably null	Het
Dpep3	A	G	8: 105,976,118		probably null	Het
Efna5	C	T	17: 62,607,419	A177T	probably benign	Het
Fabp1	G	A	6: 71,203,093	V83I	possibly damaging	Het
H2-DMa	G	T	17: 34,137,947	G140C	probably damaging	Het
Hectd4	T	A	5: 121,343,082		probably null	Het
Hyou1	T	A	9: 44,389,242	N869K	probably damaging	Het
Ing1	G	A	8: 11,561,933	V124I	probably damaging	Het
Kalrn	T	A	16: 34,314,273	I380F	probably damaging	Het
Kcnh1	A	G	1: 192,337,580	I378V	probably benign	Het
Kmt2c	A	G	5: 25,315,664	V1816A	probably benign	Het
Matn2	G	A	15: 34,435,771		probably null	Het
Naip2	C	T	13: 100,161,113	S805N	probably benign	Het
Napsa	A	C	7: 44,585,106	Q254P	probably damaging	Het
Nat10	G	T	2: 103,726,729	S860*	probably null	Het
Nipbl	T	C	15: 8,351,628	D560G	probably benign	Het
Nr3c2	A	G	8: 77,185,967	M736V	probably benign	Het
Olfr1294	A	T	2: 111,537,983	F102Y	probably damaging	Het
Olfr52	A	T	2: 86,181,222	D296E	probably benign	Het
Olfr868	A	T	9: 20,101,448	R230*	probably null	Het
Palm3	A	G	8: 84,028,863	S335G	possibly damaging	Het
Panx1	G	T	9: 15,007,816	S249*	probably null	Het
Parvb	A	G	15: 84,295,611	T231A	probably benign	Het
Pcdhb11	G	T	18: 37,421,870	L84F	probably damaging	Het
Pi4k2b	T	C	5: 52,767,754	*447Q	probably null	Het
Ppp1r1a	A	G	15: 103,532,356	S125P	probably benign	Het
Prss1	T	A	6: 41,463,312	D194E	probably damaging	Het
Rnf216	A	T	5: 143,015,654	C772*	probably null	Het
Rnf216	A	T	5: 143,090,370	F253Y	probably benign	Het
Rsf1	A	T	7: 97,680,817	E1183D	probably benign	Het
Rusc1	T	C	3: 89,086,825	T958A	probably benign	Het
Rxfp1	A	G	3: 79,650,731	M480T	probably benign	Het
Slc22a16	T	A	10: 40,591,890	V473E	probably damaging	Het
Slc26a3	A	G	12: 31,465,849	T583A	possibly damaging	Het
Slc7a15	T	C	12: 8,534,400	T117A	probably benign	Het
Slitrk6	A	T	14: 110,749,932	L781H	probably damaging	Het
Slitrk6	T	A	14: 110,752,293		probably benign	Het
Spata7	A	G	12: 98,658,265	Y110C	probably damaging	Het
Supt16	T	A	14: 52,183,996	I31F	probably benign	Het
Top2a	A	G	11: 99,009,853	F594L	probably damaging	Het
Unc13d	C	T	11: 116,070,020		probably null	Het
Unc80	T	G	1: 66,483,338	V233G	probably damaging	Het
Wdr91	A	T	6: 34,880,846	D735E	probably damaging	Het
Zzef1	A	G	11: 72,866,091	T1141A	possibly damaging	Het

Other mutations in Taar7a

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00476:Taar7a	APN	10	23992396	unclassified	probably benign
IGL02408:Taar7a	APN	10	23992602	missense	probably benign
PIT4434001:Taar7a	UTSW	10	23993421	missense	probably benign
R1029:Taar7a	UTSW	10	23992541	missense	possibly damaging	0.65
R1742:Taar7a	UTSW	10	23993219	missense	probably damaging	0.98
R2104:Taar7a	UTSW	10	23993061	missense	probably damaging	0.99
R2421:Taar7a	UTSW	10	23992517	missense	probably damaging	1.00
R3907:Taar7a	UTSW	10	23992559	missense	probably benign	0.25
R4021:Taar7a	UTSW	10	23993386	missense	probably benign	0.00
R5180:Taar7a	UTSW	10	23993148	missense	probably damaging	1.00
R5486:Taar7a	UTSW	10	23992458	missense	probably benign	0.00
R5507:Taar7a	UTSW	10	23992631	missense	probably damaging	0.98
R5587:Taar7a	UTSW	10	23992828	missense	probably benign	0.00
R5766:Taar7a	UTSW	10	23993362	missense	probably benign	0.01
R5861:Taar7a	UTSW	10	23992439	missense	probably benign
R7201:Taar7a	UTSW	10	23992460	missense	probably benign	0.04
R7506:Taar7a	UTSW	10	23992994	missense	possibly damaging	0.50
R8810:Taar7a	UTSW	10	23993381	missense	probably benign	0.20
R9015:Taar7a	UTSW	10	23992835	missense	probably damaging	0.97
R9172:Taar7a	UTSW	10	23992779	missense	probably benign	0.16
R9686:Taar7a	UTSW	10	23993411	missense	probably benign	0.01
R9717:Taar7a	UTSW	10	23992901	missense	probably benign	0.01
R9720:Taar7a	UTSW	10	23992835	missense	probably benign	0.10
X0064:Taar7a	UTSW	10	23992617	missense	probably damaging	1.00
Z1177:Taar7a	UTSW	10	23992892	missense	probably benign	0.01

Predicted Primers

PCR Primer
(F):5'- CTTGCCAGAAACAGAAGCAGTGAAC -3'
(R):5'- ACAATGGGAACTGACGACTTAAGCC -3'

Sequencing Primer
(F):5'- GGGGTCACTGACTGCAATATATC -3'
(R):5'- ACTGACGACTTAAGCCTTAGAG -3'

Posted On

2013-05-09