Incidental Mutation 'R4825:Trpm2'
| ID |
371426 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Trpm2
|
| Ensembl Gene |
ENSMUSG00000009292 |
| Gene Name |
transient receptor potential cation channel, subfamily M, member 2 |
| Synonyms |
Trrp7, TRPC7, LTRPC2, 9830168K16Rik |
| MMRRC Submission |
042441-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.200)
|
| Stock # |
R4825 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
10 |
| Chromosomal Location |
77743556-77805746 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 77777007 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Glutamic Acid
at position 430
(V430E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000101040
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000105401]
|
| AlphaFold |
Q91YD4 |
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000105400
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000105401
AA Change: V430E
PolyPhen 2
Score 0.978 (Sensitivity: 0.76; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000101040
Gene: ENSMUSG00000009292
AA Change: V430E
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
654 |
672 |
N/A |
INTRINSIC |
|
transmembrane domain
|
750 |
772 |
N/A |
INTRINSIC |
|
Pfam:Ion_trans
|
794 |
1057 |
3.7e-21 |
PFAM |
|
low complexity region
|
1078 |
1090 |
N/A |
INTRINSIC |
|
low complexity region
|
1106 |
1115 |
N/A |
INTRINSIC |
|
low complexity region
|
1123 |
1146 |
N/A |
INTRINSIC |
|
PDB:1QVJ|A
|
1236 |
1506 |
3e-37 |
PDB |
|
SCOP:d1k2ea_
|
1369 |
1502 |
9e-10 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000126206
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.8%
- 20x: 93.8%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene forms a tetrameric cation channel that is permeable to calcium, sodium, and potassium and is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. Additional transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2016]
PHENOTYPE: Mice homozygous for a knock-out allele display impaired reactive oxygen species (ROS)-induced chemokine production in monocytes, and reduced neutrophil infiltration and ulceration in a dextran sulfate sodium-induced colitis inflammation model. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 130 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700012B07Rik |
C |
A |
11: 109,682,498 (GRCm39) |
L229F |
probably benign |
Het |
| A930002H24Rik |
A |
C |
17: 64,170,603 (GRCm39) |
S62A |
unknown |
Het |
| Abca12 |
T |
A |
1: 71,341,844 (GRCm39) |
Q1039L |
possibly damaging |
Het |
| Adgrg5 |
T |
A |
8: 95,668,362 (GRCm39) |
F476I |
possibly damaging |
Het |
| Alms1 |
A |
G |
6: 85,655,227 (GRCm39) |
K2789E |
probably damaging |
Het |
| Arrdc2 |
G |
A |
8: 71,291,921 (GRCm39) |
|
probably null |
Het |
| Atp2b1 |
T |
A |
10: 98,845,426 (GRCm39) |
I743K |
probably damaging |
Het |
| Atp6v1c2 |
C |
T |
12: 17,339,061 (GRCm39) |
G230D |
probably benign |
Het |
| AU040320 |
G |
A |
4: 126,685,586 (GRCm39) |
C54Y |
probably damaging |
Het |
| BC024139 |
C |
T |
15: 76,004,517 (GRCm39) |
V680I |
possibly damaging |
Het |
| Bckdhb |
A |
G |
9: 83,870,958 (GRCm39) |
D156G |
probably damaging |
Het |
| Bltp3a |
G |
A |
17: 28,096,368 (GRCm39) |
A107T |
probably damaging |
Het |
| Canx |
T |
A |
11: 50,199,636 (GRCm39) |
D143V |
probably benign |
Het |
| Ccdc180 |
T |
A |
4: 45,912,794 (GRCm39) |
V591E |
possibly damaging |
Het |
| Ccno |
T |
C |
13: 113,124,633 (GRCm39) |
S68P |
probably benign |
Het |
| Cdc45 |
C |
T |
16: 18,603,613 (GRCm39) |
E527K |
probably damaging |
Het |
| Cep290 |
T |
A |
10: 100,324,210 (GRCm39) |
D14E |
probably damaging |
Het |
| Cgnl1 |
A |
G |
9: 71,537,806 (GRCm39) |
V1238A |
probably benign |
Het |
| Ciz1 |
C |
T |
2: 32,261,753 (GRCm39) |
A455V |
probably damaging |
Het |
| Coro2b |
T |
A |
9: 62,361,905 (GRCm39) |
Y86F |
probably benign |
Het |
| Csf2ra |
C |
T |
19: 61,214,990 (GRCm39) |
R158Q |
probably benign |
Het |
| Cubn |
A |
T |
2: 13,330,036 (GRCm39) |
I2615N |
probably damaging |
Het |
| Dhx8 |
C |
T |
11: 101,628,996 (GRCm39) |
R129* |
probably null |
Het |
| Disc1 |
T |
A |
8: 125,862,041 (GRCm39) |
M471K |
possibly damaging |
Het |
| Dmxl2 |
G |
T |
9: 54,311,325 (GRCm39) |
L1799I |
probably benign |
Het |
| Dnah2 |
A |
G |
11: 69,314,031 (GRCm39) |
S4108P |
probably damaging |
Het |
| Ecpas |
G |
A |
4: 58,850,911 (GRCm39) |
L421F |
probably damaging |
Het |
| Ehmt2 |
C |
G |
17: 35,125,940 (GRCm39) |
P211R |
probably benign |
Het |
| Eif4g3 |
A |
G |
4: 137,921,392 (GRCm39) |
D1557G |
probably benign |
Het |
| Epha5 |
T |
C |
5: 84,381,699 (GRCm39) |
D384G |
probably damaging |
Het |
| Etl4 |
A |
G |
2: 20,811,738 (GRCm39) |
I1274V |
probably damaging |
Het |
| Fhip1a |
G |
A |
3: 85,580,739 (GRCm39) |
P489S |
possibly damaging |
Het |
| Fip1l1 |
G |
A |
5: 74,748,866 (GRCm39) |
|
probably null |
Het |
| Fubp1 |
T |
C |
3: 151,923,527 (GRCm39) |
|
probably null |
Het |
| Glul |
T |
C |
1: 153,778,790 (GRCm39) |
V33A |
probably benign |
Het |
| Gm4846 |
A |
G |
1: 166,319,237 (GRCm39) |
F167S |
probably damaging |
Het |
| Heatr6 |
T |
A |
11: 83,649,148 (GRCm39) |
L168M |
probably damaging |
Het |
| Hif1a |
T |
A |
12: 73,979,175 (GRCm39) |
I233N |
probably damaging |
Het |
| Hivep2 |
T |
A |
10: 14,007,063 (GRCm39) |
H1220Q |
possibly damaging |
Het |
| Igkv8-21 |
T |
C |
6: 70,292,410 (GRCm39) |
I9M |
probably benign |
Het |
| Izumo1 |
T |
A |
7: 45,274,411 (GRCm39) |
C62* |
probably null |
Het |
| Jakmip3 |
G |
A |
7: 138,628,495 (GRCm39) |
E424K |
probably damaging |
Het |
| Klhl2 |
A |
G |
8: 65,205,847 (GRCm39) |
V358A |
probably damaging |
Het |
| Klk10 |
C |
G |
7: 43,433,022 (GRCm39) |
D139E |
probably damaging |
Het |
| Klk14 |
T |
C |
7: 43,341,500 (GRCm39) |
C51R |
probably damaging |
Het |
| Klk1b5 |
T |
G |
7: 43,494,814 (GRCm39) |
I99S |
probably damaging |
Het |
| L3hypdh |
T |
C |
12: 72,124,167 (GRCm39) |
T258A |
probably benign |
Het |
| Lrp5 |
A |
G |
19: 3,664,292 (GRCm39) |
Y812H |
probably damaging |
Het |
| Lrrc40 |
T |
A |
3: 157,766,967 (GRCm39) |
L474* |
probably null |
Het |
| Mkks |
A |
T |
2: 136,722,575 (GRCm39) |
M194K |
probably benign |
Het |
| Mmp20 |
A |
G |
9: 7,654,121 (GRCm39) |
D347G |
probably damaging |
Het |
| Mmp27 |
A |
G |
9: 7,581,195 (GRCm39) |
E460G |
probably damaging |
Het |
| Mms22l |
T |
C |
4: 24,536,226 (GRCm39) |
F605S |
probably damaging |
Het |
| Mpzl3 |
A |
G |
9: 44,979,627 (GRCm39) |
S193G |
probably benign |
Het |
| Muc4 |
A |
T |
16: 32,570,565 (GRCm39) |
T542S |
probably benign |
Het |
| Muc5b |
T |
C |
7: 141,422,202 (GRCm39) |
L4446P |
possibly damaging |
Het |
| Mxi1 |
C |
A |
19: 53,358,769 (GRCm39) |
S131* |
probably null |
Het |
| Nanog |
G |
T |
6: 122,690,299 (GRCm39) |
A210S |
probably benign |
Het |
| Nrcam |
C |
T |
12: 44,622,769 (GRCm39) |
Q988* |
probably null |
Het |
| Nsg1 |
C |
A |
5: 38,316,391 (GRCm39) |
|
probably benign |
Het |
| Ogfod3 |
G |
A |
11: 121,086,027 (GRCm39) |
A189V |
probably benign |
Het |
| Or10g9b |
A |
T |
9: 39,918,038 (GRCm39) |
M69K |
possibly damaging |
Het |
| Or12e9 |
T |
A |
2: 87,202,432 (GRCm39) |
C185* |
probably null |
Het |
| Or4a68 |
A |
G |
2: 89,270,209 (GRCm39) |
V138A |
probably benign |
Het |
| Or4c122 |
T |
C |
2: 89,079,034 (GRCm39) |
|
probably null |
Het |
| Or4c35 |
G |
A |
2: 89,808,497 (GRCm39) |
C125Y |
probably damaging |
Het |
| Or51ai2 |
T |
C |
7: 103,586,710 (GRCm39) |
V41A |
probably benign |
Het |
| Or52b4i |
T |
A |
7: 102,191,587 (GRCm39) |
V148E |
possibly damaging |
Het |
| Or5b111 |
A |
T |
19: 13,291,684 (GRCm39) |
|
probably null |
Het |
| Or7e165 |
T |
G |
9: 19,694,872 (GRCm39) |
S148A |
possibly damaging |
Het |
| Or8b53 |
A |
T |
9: 38,667,703 (GRCm39) |
T240S |
probably damaging |
Het |
| Orc3 |
A |
T |
4: 34,571,774 (GRCm39) |
M665K |
possibly damaging |
Het |
| Pabpc1 |
A |
G |
15: 36,597,255 (GRCm39) |
S591P |
probably damaging |
Het |
| Pacc1 |
A |
T |
1: 191,073,040 (GRCm39) |
I154F |
probably damaging |
Het |
| Parp6 |
T |
A |
9: 59,531,645 (GRCm39) |
|
probably null |
Het |
| Pcdh1 |
T |
C |
18: 38,322,912 (GRCm39) |
M974V |
possibly damaging |
Het |
| Pcdhb22 |
T |
A |
18: 37,653,713 (GRCm39) |
V727E |
possibly damaging |
Het |
| Pex5l |
T |
C |
3: 33,047,134 (GRCm39) |
E272G |
probably damaging |
Het |
| Pglyrp2 |
G |
T |
17: 32,637,235 (GRCm39) |
N264K |
probably benign |
Het |
| Phxr4 |
T |
A |
9: 13,342,882 (GRCm39) |
|
probably benign |
Het |
| Piezo2 |
A |
G |
18: 63,278,025 (GRCm39) |
F293S |
probably damaging |
Het |
| Pkhd1 |
T |
C |
1: 20,607,625 (GRCm39) |
D1077G |
probably damaging |
Het |
| Plekhs1 |
A |
G |
19: 56,461,700 (GRCm39) |
|
probably null |
Het |
| Prex1 |
G |
T |
2: 166,427,777 (GRCm39) |
C788* |
probably null |
Het |
| Prrt3 |
A |
T |
6: 113,475,099 (GRCm39) |
M41K |
probably benign |
Het |
| Ptgir |
T |
C |
7: 16,642,768 (GRCm39) |
V326A |
probably damaging |
Het |
| Ptprg |
T |
A |
14: 12,220,654 (GRCm38) |
D455E |
probably damaging |
Het |
| Ptpru |
T |
A |
4: 131,526,914 (GRCm39) |
Q686L |
probably benign |
Het |
| Pxdc1 |
G |
T |
13: 34,814,343 (GRCm39) |
T190K |
probably benign |
Het |
| Rap1b |
A |
T |
10: 117,654,487 (GRCm39) |
C118S |
probably benign |
Het |
| Rapgef2 |
T |
C |
3: 78,990,534 (GRCm39) |
M915V |
probably benign |
Het |
| Rnd2 |
C |
T |
11: 101,359,825 (GRCm39) |
L57F |
probably damaging |
Het |
| Rpe65 |
C |
T |
3: 159,330,318 (GRCm39) |
A495V |
probably benign |
Het |
| Samd15 |
A |
G |
12: 87,247,608 (GRCm39) |
T98A |
possibly damaging |
Het |
| Sdk1 |
T |
G |
5: 141,568,049 (GRCm39) |
D82E |
probably benign |
Het |
| Slc26a7 |
T |
C |
4: 14,546,309 (GRCm39) |
D340G |
probably benign |
Het |
| Slc6a15 |
T |
A |
10: 103,253,921 (GRCm39) |
M619K |
probably benign |
Het |
| Slc7a4 |
C |
A |
16: 17,392,385 (GRCm39) |
D350Y |
probably damaging |
Het |
| Slk |
T |
G |
19: 47,608,395 (GRCm39) |
N449K |
probably benign |
Het |
| Spta1 |
A |
T |
1: 174,071,608 (GRCm39) |
|
probably null |
Het |
| Sptbn5 |
A |
T |
2: 119,886,374 (GRCm39) |
|
probably benign |
Het |
| Srd5a2 |
A |
T |
17: 74,354,800 (GRCm39) |
V8D |
probably benign |
Het |
| Srgap3 |
G |
A |
6: 112,704,271 (GRCm39) |
A906V |
probably benign |
Het |
| Stab2 |
A |
T |
10: 86,783,011 (GRCm39) |
M679K |
probably benign |
Het |
| Stk3 |
T |
C |
15: 35,000,054 (GRCm39) |
I291V |
probably benign |
Het |
| Supt6 |
T |
A |
11: 78,098,960 (GRCm39) |
Q1637L |
possibly damaging |
Het |
| Svil |
T |
C |
18: 5,114,564 (GRCm39) |
F2047S |
probably damaging |
Het |
| Swsap1 |
A |
G |
9: 21,867,284 (GRCm39) |
E76G |
probably benign |
Het |
| Syndig1 |
G |
T |
2: 149,741,473 (GRCm39) |
G20C |
probably damaging |
Het |
| Synj2bp |
A |
T |
12: 81,548,926 (GRCm39) |
N104K |
probably damaging |
Het |
| Synpo2 |
T |
A |
3: 122,908,068 (GRCm39) |
D416V |
probably damaging |
Het |
| Tacc3 |
G |
T |
5: 33,829,357 (GRCm39) |
C620F |
probably damaging |
Het |
| Tanc1 |
A |
G |
2: 59,529,766 (GRCm39) |
E19G |
probably damaging |
Het |
| Tars3 |
C |
T |
7: 65,297,302 (GRCm39) |
A139V |
probably benign |
Het |
| Tbc1d22a |
T |
A |
15: 86,235,935 (GRCm39) |
C365S |
probably damaging |
Het |
| Tdpoz2 |
T |
C |
3: 93,559,381 (GRCm39) |
H197R |
possibly damaging |
Het |
| Tha1 |
A |
T |
11: 117,760,205 (GRCm39) |
N300K |
probably damaging |
Het |
| Tm6sf1 |
T |
A |
7: 81,515,008 (GRCm39) |
F70L |
probably damaging |
Het |
| Tmem132b |
T |
A |
5: 125,860,497 (GRCm39) |
S581T |
probably benign |
Het |
| Tnfsf13 |
G |
T |
11: 69,576,075 (GRCm39) |
S4* |
probably null |
Het |
| Tonsl |
G |
A |
15: 76,517,448 (GRCm39) |
S757L |
probably benign |
Het |
| Trem2 |
G |
T |
17: 48,658,719 (GRCm39) |
R161S |
possibly damaging |
Het |
| Ttc14 |
T |
A |
3: 33,855,518 (GRCm39) |
D154E |
possibly damaging |
Het |
| Ugt2b37 |
T |
C |
5: 87,398,498 (GRCm39) |
M313V |
possibly damaging |
Het |
| Vmn2r24 |
A |
G |
6: 123,792,739 (GRCm39) |
I689V |
probably benign |
Het |
| Wdr76 |
A |
G |
2: 121,372,975 (GRCm39) |
T601A |
probably benign |
Het |
| Xirp1 |
T |
C |
9: 119,846,069 (GRCm39) |
D938G |
possibly damaging |
Het |
| Zfp608 |
A |
T |
18: 55,031,041 (GRCm39) |
D966E |
probably benign |
Het |
| Zfp957 |
A |
G |
14: 79,451,796 (GRCm39) |
M1T |
probably null |
Het |
| Zkscan16 |
A |
T |
4: 58,957,809 (GRCm39) |
H697L |
possibly damaging |
Het |
|
| Other mutations in Trpm2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00730:Trpm2
|
APN |
10 |
77,778,749 (GRCm39) |
splice site |
probably null |
|
|
IGL00773:Trpm2
|
APN |
10 |
77,785,048 (GRCm39) |
nonsense |
probably null |
|
|
IGL00962:Trpm2
|
APN |
10 |
77,779,750 (GRCm39) |
splice site |
probably benign |
|
|
IGL01093:Trpm2
|
APN |
10 |
77,768,114 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL01124:Trpm2
|
APN |
10 |
77,781,659 (GRCm39) |
splice site |
probably benign |
|
|
IGL01301:Trpm2
|
APN |
10 |
77,759,818 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02094:Trpm2
|
APN |
10 |
77,778,830 (GRCm39) |
nonsense |
probably null |
|
|
IGL02175:Trpm2
|
APN |
10 |
77,773,741 (GRCm39) |
missense |
probably benign |
0.07 |
|
IGL02653:Trpm2
|
APN |
10 |
77,748,503 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL02667:Trpm2
|
APN |
10 |
77,771,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02668:Trpm2
|
APN |
10 |
77,771,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02828:Trpm2
|
APN |
10 |
77,754,820 (GRCm39) |
missense |
probably benign |
0.16 |
|
IGL02951:Trpm2
|
APN |
10 |
77,765,112 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL03188:Trpm2
|
APN |
10 |
77,754,743 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL03242:Trpm2
|
APN |
10 |
77,753,568 (GRCm39) |
missense |
probably benign |
|
|
IGL03405:Trpm2
|
APN |
10 |
77,801,906 (GRCm39) |
splice site |
probably benign |
|
|
Fugit
|
UTSW |
10 |
77,774,202 (GRCm39) |
missense |
probably damaging |
1.00 |
|
scusate
|
UTSW |
10 |
77,802,828 (GRCm39) |
nonsense |
probably null |
|
|
temporal
|
UTSW |
10 |
77,761,516 (GRCm39) |
missense |
probably benign |
0.30 |
|
ANU18:Trpm2
|
UTSW |
10 |
77,759,818 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0147:Trpm2
|
UTSW |
10 |
77,761,659 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0148:Trpm2
|
UTSW |
10 |
77,761,659 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0302:Trpm2
|
UTSW |
10 |
77,779,824 (GRCm39) |
splice site |
probably benign |
|
|
R0332:Trpm2
|
UTSW |
10 |
77,783,822 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0586:Trpm2
|
UTSW |
10 |
77,759,350 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0847:Trpm2
|
UTSW |
10 |
77,765,122 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1183:Trpm2
|
UTSW |
10 |
77,759,398 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1472:Trpm2
|
UTSW |
10 |
77,801,841 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1510:Trpm2
|
UTSW |
10 |
77,802,828 (GRCm39) |
nonsense |
probably null |
|
|
R1518:Trpm2
|
UTSW |
10 |
77,778,839 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R1564:Trpm2
|
UTSW |
10 |
77,778,833 (GRCm39) |
missense |
probably benign |
0.14 |
|
R1593:Trpm2
|
UTSW |
10 |
77,778,910 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1617:Trpm2
|
UTSW |
10 |
77,771,709 (GRCm39) |
splice site |
probably null |
|
|
R1673:Trpm2
|
UTSW |
10 |
77,778,778 (GRCm39) |
missense |
probably benign |
|
|
R1912:Trpm2
|
UTSW |
10 |
77,781,710 (GRCm39) |
missense |
probably benign |
0.10 |
|
R1932:Trpm2
|
UTSW |
10 |
77,776,992 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1993:Trpm2
|
UTSW |
10 |
77,783,823 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2013:Trpm2
|
UTSW |
10 |
77,761,600 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2151:Trpm2
|
UTSW |
10 |
77,768,013 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2201:Trpm2
|
UTSW |
10 |
77,756,305 (GRCm39) |
nonsense |
probably null |
|
|
R2217:Trpm2
|
UTSW |
10 |
77,777,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2312:Trpm2
|
UTSW |
10 |
77,754,798 (GRCm39) |
missense |
probably benign |
0.04 |
|
R2339:Trpm2
|
UTSW |
10 |
77,750,640 (GRCm39) |
splice site |
probably benign |
|
|
R2395:Trpm2
|
UTSW |
10 |
77,783,714 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R2396:Trpm2
|
UTSW |
10 |
77,766,471 (GRCm39) |
missense |
probably benign |
0.14 |
|
R2405:Trpm2
|
UTSW |
10 |
77,770,558 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2567:Trpm2
|
UTSW |
10 |
77,777,008 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3001:Trpm2
|
UTSW |
10 |
77,766,368 (GRCm39) |
critical splice donor site |
probably null |
|
|
R3002:Trpm2
|
UTSW |
10 |
77,766,368 (GRCm39) |
critical splice donor site |
probably null |
|
|
R3125:Trpm2
|
UTSW |
10 |
77,747,208 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3500:Trpm2
|
UTSW |
10 |
77,768,136 (GRCm39) |
missense |
probably benign |
0.03 |
|
R3777:Trpm2
|
UTSW |
10 |
77,771,824 (GRCm39) |
missense |
probably benign |
0.13 |
|
R3778:Trpm2
|
UTSW |
10 |
77,771,824 (GRCm39) |
missense |
probably benign |
0.13 |
|
R4272:Trpm2
|
UTSW |
10 |
77,769,476 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4384:Trpm2
|
UTSW |
10 |
77,753,559 (GRCm39) |
missense |
probably benign |
0.44 |
|
R4395:Trpm2
|
UTSW |
10 |
77,765,053 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4423:Trpm2
|
UTSW |
10 |
77,770,902 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4452:Trpm2
|
UTSW |
10 |
77,759,427 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4612:Trpm2
|
UTSW |
10 |
77,781,750 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4662:Trpm2
|
UTSW |
10 |
77,773,972 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4906:Trpm2
|
UTSW |
10 |
77,768,023 (GRCm39) |
nonsense |
probably null |
|
|
R4943:Trpm2
|
UTSW |
10 |
77,801,841 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4948:Trpm2
|
UTSW |
10 |
77,753,626 (GRCm39) |
missense |
probably benign |
0.34 |
|
R5046:Trpm2
|
UTSW |
10 |
77,801,852 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5320:Trpm2
|
UTSW |
10 |
77,759,355 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5523:Trpm2
|
UTSW |
10 |
77,771,795 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5562:Trpm2
|
UTSW |
10 |
77,795,773 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R5623:Trpm2
|
UTSW |
10 |
77,767,973 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5628:Trpm2
|
UTSW |
10 |
77,748,470 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5633:Trpm2
|
UTSW |
10 |
77,774,187 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R5817:Trpm2
|
UTSW |
10 |
77,801,814 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5989:Trpm2
|
UTSW |
10 |
77,795,734 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6018:Trpm2
|
UTSW |
10 |
77,753,547 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6075:Trpm2
|
UTSW |
10 |
77,770,877 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6092:Trpm2
|
UTSW |
10 |
77,761,516 (GRCm39) |
missense |
probably benign |
0.30 |
|
R6309:Trpm2
|
UTSW |
10 |
77,774,202 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6327:Trpm2
|
UTSW |
10 |
77,768,061 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6568:Trpm2
|
UTSW |
10 |
77,773,660 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6579:Trpm2
|
UTSW |
10 |
77,773,660 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6640:Trpm2
|
UTSW |
10 |
77,773,660 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6642:Trpm2
|
UTSW |
10 |
77,773,660 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6798:Trpm2
|
UTSW |
10 |
77,750,574 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6999:Trpm2
|
UTSW |
10 |
77,771,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7034:Trpm2
|
UTSW |
10 |
77,748,426 (GRCm39) |
missense |
probably benign |
|
|
R7036:Trpm2
|
UTSW |
10 |
77,748,426 (GRCm39) |
missense |
probably benign |
|
|
R7113:Trpm2
|
UTSW |
10 |
77,783,765 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7171:Trpm2
|
UTSW |
10 |
77,759,848 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7240:Trpm2
|
UTSW |
10 |
77,771,710 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7274:Trpm2
|
UTSW |
10 |
77,759,389 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7379:Trpm2
|
UTSW |
10 |
77,750,568 (GRCm39) |
missense |
probably benign |
|
|
R7527:Trpm2
|
UTSW |
10 |
77,801,894 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7571:Trpm2
|
UTSW |
10 |
77,773,784 (GRCm39) |
missense |
probably benign |
0.21 |
|
R7600:Trpm2
|
UTSW |
10 |
77,773,885 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7727:Trpm2
|
UTSW |
10 |
77,761,623 (GRCm39) |
missense |
probably benign |
0.34 |
|
R7771:Trpm2
|
UTSW |
10 |
77,768,013 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7844:Trpm2
|
UTSW |
10 |
77,759,340 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8158:Trpm2
|
UTSW |
10 |
77,783,731 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8225:Trpm2
|
UTSW |
10 |
77,783,807 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8226:Trpm2
|
UTSW |
10 |
77,783,807 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8239:Trpm2
|
UTSW |
10 |
77,771,836 (GRCm39) |
missense |
probably benign |
0.06 |
|
R8275:Trpm2
|
UTSW |
10 |
77,801,859 (GRCm39) |
nonsense |
probably null |
|
|
R8340:Trpm2
|
UTSW |
10 |
77,759,458 (GRCm39) |
nonsense |
probably null |
|
|
R8354:Trpm2
|
UTSW |
10 |
77,769,483 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8427:Trpm2
|
UTSW |
10 |
77,747,236 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8445:Trpm2
|
UTSW |
10 |
77,746,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8769:Trpm2
|
UTSW |
10 |
77,768,128 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9144:Trpm2
|
UTSW |
10 |
77,765,122 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9286:Trpm2
|
UTSW |
10 |
77,777,014 (GRCm39) |
missense |
probably benign |
0.06 |
|
R9319:Trpm2
|
UTSW |
10 |
77,785,032 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9319:Trpm2
|
UTSW |
10 |
77,778,776 (GRCm39) |
nonsense |
probably null |
|
|
R9381:Trpm2
|
UTSW |
10 |
77,747,191 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R9457:Trpm2
|
UTSW |
10 |
77,747,226 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R9477:Trpm2
|
UTSW |
10 |
77,747,224 (GRCm39) |
missense |
probably benign |
0.12 |
|
R9547:Trpm2
|
UTSW |
10 |
77,748,467 (GRCm39) |
missense |
probably benign |
0.33 |
|
R9660:Trpm2
|
UTSW |
10 |
77,766,389 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9663:Trpm2
|
UTSW |
10 |
77,756,320 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1177:Trpm2
|
UTSW |
10 |
77,773,702 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGTTACACTGACTCAAACGTTTT -3'
(R):5'- AGAGTATCACTCCTTGTTGGGGC -3'
Sequencing Primer
(F):5'- GGGATAACAGTCATCTCACGTTGC -3'
(R):5'- GGGGCCTTGATTCTCTTTGACC -3'
|
| Posted On |
2016-03-01 |
Incidental Mutation