Incidental Mutation 'R4839:Tnik'
| ID |
371609 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tnik
|
| Ensembl Gene |
ENSMUSG00000027692 |
| Gene Name |
TRAF2 and NCK interacting kinase |
| Synonyms |
C530008O15Rik, 4831440I19Rik, 1500031A17Rik, C630040K21Rik |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R4839 (G1)
|
| Quality Score |
214 |
|
Status
|
Not validated
|
| Chromosome |
3 |
| Chromosomal Location |
28317362-28724734 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 28650224 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Asparagine
at position 446
(Y446N)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000124681
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000159236]
[ENSMUST00000159308]
[ENSMUST00000159680]
[ENSMUST00000160307]
[ENSMUST00000160518]
[ENSMUST00000160934]
[ENSMUST00000161964]
[ENSMUST00000162777]
[ENSMUST00000162485]
|
| AlphaFold |
P83510 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000159236
AA Change: Y446N
PolyPhen 2
Score 0.861 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000124681
Gene: ENSMUSG00000027692
AA Change: Y446N
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
|
low complexity region
|
691 |
726 |
N/A |
INTRINSIC |
|
low complexity region
|
793 |
812 |
N/A |
INTRINSIC |
|
low complexity region
|
951 |
958 |
N/A |
INTRINSIC |
|
CNH
|
1005 |
1303 |
1.92e-117 |
SMART |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000159308
AA Change: Y446N
|
| SMART Domains |
Protein: ENSMUSP00000125466
Gene: ENSMUSG00000027692
AA Change: Y446N
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
|
low complexity region
|
636 |
671 |
N/A |
INTRINSIC |
|
low complexity region
|
746 |
765 |
N/A |
INTRINSIC |
|
low complexity region
|
904 |
911 |
N/A |
INTRINSIC |
|
CNH
|
958 |
1256 |
1.92e-117 |
SMART |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000159680
AA Change: Y475N
|
| SMART Domains |
Protein: ENSMUSP00000124876
Gene: ENSMUSG00000027692
AA Change: Y475N
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
|
low complexity region
|
720 |
755 |
N/A |
INTRINSIC |
|
low complexity region
|
822 |
841 |
N/A |
INTRINSIC |
|
low complexity region
|
980 |
987 |
N/A |
INTRINSIC |
|
CNH
|
1034 |
1332 |
1.92e-117 |
SMART |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000160307
AA Change: Y475N
|
| SMART Domains |
Protein: ENSMUSP00000125081
Gene: ENSMUSG00000027692
AA Change: Y475N
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
|
low complexity region
|
720 |
755 |
N/A |
INTRINSIC |
|
low complexity region
|
830 |
849 |
N/A |
INTRINSIC |
|
low complexity region
|
988 |
995 |
N/A |
INTRINSIC |
|
CNH
|
1042 |
1340 |
1.92e-117 |
SMART |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000160518
AA Change: Y446N
|
| SMART Domains |
Protein: ENSMUSP00000124011
Gene: ENSMUSG00000027692
AA Change: Y446N
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
5.9e-99 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
|
low complexity region
|
691 |
726 |
N/A |
INTRINSIC |
|
low complexity region
|
801 |
820 |
N/A |
INTRINSIC |
|
low complexity region
|
959 |
966 |
N/A |
INTRINSIC |
|
CNH
|
1013 |
1311 |
9.3e-120 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000160934
|
| SMART Domains |
Protein: ENSMUSP00000123859
Gene: ENSMUSG00000027692
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Pkinase_Tyr
|
25 |
212 |
2.2e-37 |
PFAM |
|
Pfam:Pkinase
|
25 |
219 |
5.9e-52 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000161423
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000161964
AA Change: Y446N
|
| SMART Domains |
Protein: ENSMUSP00000125411
Gene: ENSMUSG00000027692
AA Change: Y446N
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
|
low complexity region
|
636 |
671 |
N/A |
INTRINSIC |
|
low complexity region
|
738 |
757 |
N/A |
INTRINSIC |
|
low complexity region
|
896 |
903 |
N/A |
INTRINSIC |
|
CNH
|
950 |
1248 |
1.92e-117 |
SMART |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000162777
AA Change: Y475N
|
| SMART Domains |
Protein: ENSMUSP00000124726
Gene: ENSMUSG00000027692
AA Change: Y475N
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
|
low complexity region
|
665 |
700 |
N/A |
INTRINSIC |
|
low complexity region
|
767 |
786 |
N/A |
INTRINSIC |
|
low complexity region
|
925 |
932 |
N/A |
INTRINSIC |
|
CNH
|
979 |
1277 |
1.92e-117 |
SMART |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000162485
AA Change: Y475N
|
| SMART Domains |
Protein: ENSMUSP00000124387
Gene: ENSMUSG00000027692
AA Change: Y475N
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
|
low complexity region
|
665 |
700 |
N/A |
INTRINSIC |
|
low complexity region
|
775 |
794 |
N/A |
INTRINSIC |
|
low complexity region
|
933 |
940 |
N/A |
INTRINSIC |
|
CNH
|
987 |
1285 |
1.92e-117 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000162037
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.8%
- 20x: 93.8%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function (Fu et al., 1999 [PubMed 10521462]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired postsynaptic signaling and cognitive function. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 93 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700010I14Rik |
T |
A |
17: 9,226,845 (GRCm39) |
S467T |
probably benign |
Het |
| 2310030G06Rik |
A |
T |
9: 50,652,023 (GRCm39) |
Y68* |
probably null |
Het |
| Abat |
T |
G |
16: 8,401,512 (GRCm39) |
|
probably benign |
Het |
| Abca2 |
C |
T |
2: 25,330,921 (GRCm39) |
S1203F |
probably damaging |
Het |
| Adam22 |
G |
A |
5: 8,186,813 (GRCm39) |
P436L |
probably damaging |
Het |
| Ak3 |
A |
C |
19: 29,025,132 (GRCm39) |
L33R |
probably damaging |
Het |
| Arhgap11a |
A |
T |
2: 113,672,374 (GRCm39) |
I198K |
probably damaging |
Het |
| Arl14epl |
A |
T |
18: 47,065,544 (GRCm39) |
K103M |
possibly damaging |
Het |
| Atg16l1 |
T |
A |
1: 87,693,896 (GRCm39) |
N65K |
probably damaging |
Het |
| Btnl2 |
G |
A |
17: 34,584,260 (GRCm39) |
W394* |
probably null |
Het |
| Cacna1e |
C |
A |
1: 154,296,804 (GRCm39) |
R1687L |
probably damaging |
Het |
| Cacna1g |
G |
T |
11: 94,350,433 (GRCm39) |
R471S |
probably benign |
Het |
| Cdh13 |
A |
T |
8: 119,578,587 (GRCm39) |
R205* |
probably null |
Het |
| Cdkl3 |
A |
T |
11: 51,895,861 (GRCm39) |
Y36F |
probably damaging |
Het |
| Cep290 |
T |
A |
10: 100,344,648 (GRCm39) |
N488K |
probably damaging |
Het |
| Cep350 |
A |
T |
1: 155,804,240 (GRCm39) |
C948S |
probably benign |
Het |
| Cep70 |
A |
G |
9: 99,178,138 (GRCm39) |
K446R |
probably benign |
Het |
| Cfap70 |
T |
C |
14: 20,475,597 (GRCm39) |
T375A |
probably damaging |
Het |
| Cfhr1 |
A |
G |
1: 139,487,871 (GRCm39) |
L9S |
probably damaging |
Het |
| Chrm4 |
T |
A |
2: 91,757,952 (GRCm39) |
M120K |
probably damaging |
Het |
| Col1a1 |
A |
G |
11: 94,840,921 (GRCm39) |
|
probably null |
Het |
| Col3a1 |
T |
C |
1: 45,362,963 (GRCm39) |
|
probably null |
Het |
| Csrnp3 |
A |
T |
2: 65,852,375 (GRCm39) |
R256* |
probably null |
Het |
| Dbf4 |
T |
A |
5: 8,458,263 (GRCm39) |
K190* |
probably null |
Het |
| Dnah10 |
A |
T |
5: 124,850,196 (GRCm39) |
I1573F |
probably damaging |
Het |
| Dock8 |
A |
G |
19: 25,146,858 (GRCm39) |
I1446V |
probably benign |
Het |
| Dst |
G |
T |
1: 34,229,943 (GRCm39) |
R2187M |
probably damaging |
Het |
| Ece2 |
C |
T |
16: 20,449,918 (GRCm39) |
R257C |
probably damaging |
Het |
| Espn |
A |
G |
4: 152,222,961 (GRCm39) |
Y306H |
probably damaging |
Het |
| Fkbpl |
G |
A |
17: 34,864,839 (GRCm39) |
M202I |
probably benign |
Het |
| Fn1 |
A |
G |
1: 71,681,242 (GRCm39) |
L362P |
probably damaging |
Het |
| Ganc |
A |
C |
2: 120,290,304 (GRCm39) |
R880S |
probably benign |
Het |
| Gucy1b2 |
A |
T |
14: 62,685,695 (GRCm39) |
L90Q |
probably damaging |
Het |
| Hcn1 |
T |
A |
13: 118,062,246 (GRCm39) |
I504N |
unknown |
Het |
| Hdac2 |
C |
A |
10: 36,873,462 (GRCm39) |
T352K |
probably benign |
Het |
| Hip1 |
T |
C |
5: 135,455,172 (GRCm39) |
|
probably null |
Het |
| Hspa13 |
G |
A |
16: 75,562,169 (GRCm39) |
S10L |
probably damaging |
Het |
| Ipo5 |
T |
C |
14: 121,157,450 (GRCm39) |
I96T |
probably benign |
Het |
| Isl1 |
T |
C |
13: 116,438,220 (GRCm39) |
Y264C |
probably damaging |
Het |
| Izumo1 |
T |
C |
7: 45,275,657 (GRCm39) |
I322T |
probably benign |
Het |
| Kars1 |
A |
C |
8: 112,729,158 (GRCm39) |
V183G |
possibly damaging |
Het |
| Lrrc15 |
C |
A |
16: 30,093,086 (GRCm39) |
M84I |
probably benign |
Het |
| Magi1 |
A |
T |
6: 93,671,177 (GRCm39) |
V796E |
probably damaging |
Het |
| Matn4 |
G |
T |
2: 164,242,896 (GRCm39) |
D67E |
probably benign |
Het |
| Mertk |
A |
G |
2: 128,624,496 (GRCm39) |
M636V |
probably damaging |
Het |
| Mettl27 |
C |
A |
5: 134,963,266 (GRCm39) |
P126T |
probably damaging |
Het |
| Mfrp |
T |
A |
9: 44,013,432 (GRCm39) |
H52Q |
possibly damaging |
Het |
| Mrgprb8 |
T |
G |
7: 48,038,656 (GRCm39) |
I109R |
probably benign |
Het |
| Mroh2a |
G |
A |
1: 88,165,666 (GRCm39) |
G512S |
probably damaging |
Het |
| Ncoa7 |
T |
A |
10: 30,598,655 (GRCm39) |
R89S |
possibly damaging |
Het |
| Nfkb2 |
G |
T |
19: 46,296,006 (GRCm39) |
E170D |
probably benign |
Het |
| Nin |
G |
T |
12: 70,137,325 (GRCm39) |
H84N |
possibly damaging |
Het |
| Nwd2 |
A |
T |
5: 63,962,893 (GRCm39) |
I826F |
possibly damaging |
Het |
| Or10d1 |
A |
G |
9: 39,484,441 (GRCm39) |
M38T |
probably benign |
Het |
| Or14c43 |
T |
C |
7: 86,115,117 (GRCm39) |
F166S |
probably damaging |
Het |
| Or1j11 |
G |
A |
2: 36,312,012 (GRCm39) |
V201I |
probably benign |
Het |
| Or4l15 |
C |
T |
14: 50,197,646 (GRCm39) |
M294I |
probably benign |
Het |
| Or52a5b |
T |
C |
7: 103,416,961 (GRCm39) |
I214M |
possibly damaging |
Het |
| Or5k3 |
A |
G |
16: 58,969,393 (GRCm39) |
Y60C |
probably damaging |
Het |
| Or5p73 |
T |
C |
7: 108,064,938 (GRCm39) |
S136P |
probably benign |
Het |
| Otof |
C |
T |
5: 30,576,748 (GRCm39) |
R168H |
probably damaging |
Het |
| Pcdha6 |
T |
C |
18: 37,101,485 (GRCm39) |
V226A |
possibly damaging |
Het |
| Pggt1b |
T |
C |
18: 46,391,166 (GRCm39) |
I200V |
possibly damaging |
Het |
| Ppat |
G |
A |
5: 77,098,811 (GRCm39) |
Q41* |
probably null |
Het |
| Ppfibp2 |
A |
T |
7: 107,342,192 (GRCm39) |
H27L |
probably damaging |
Het |
| Rbm27 |
T |
A |
18: 42,460,510 (GRCm39) |
I775N |
probably damaging |
Het |
| Rnf40 |
C |
T |
7: 127,191,812 (GRCm39) |
R349* |
probably null |
Het |
| Rtp3 |
A |
T |
9: 110,818,544 (GRCm39) |
W46R |
probably damaging |
Het |
| Sass6 |
C |
T |
3: 116,403,949 (GRCm39) |
R196W |
probably damaging |
Het |
| Sel1l |
A |
T |
12: 91,799,932 (GRCm39) |
D131E |
probably benign |
Het |
| Slain2 |
T |
C |
5: 73,106,066 (GRCm39) |
S234P |
probably damaging |
Het |
| Slc47a1 |
C |
T |
11: 61,264,176 (GRCm39) |
|
probably null |
Het |
| Sp140 |
CAGAAGAAG |
CAGAAG |
1: 85,538,529 (GRCm39) |
|
probably benign |
Het |
| Spata31e2 |
T |
C |
1: 26,724,440 (GRCm39) |
T247A |
probably benign |
Het |
| Spef2 |
A |
T |
15: 9,713,264 (GRCm39) |
Y369* |
probably null |
Het |
| Spred2 |
T |
A |
11: 19,948,233 (GRCm39) |
M76K |
possibly damaging |
Het |
| Svs5 |
T |
A |
2: 164,078,806 (GRCm39) |
D367V |
probably benign |
Het |
| Tasor2 |
G |
A |
13: 3,634,807 (GRCm39) |
P667S |
probably damaging |
Het |
| Tefm |
A |
T |
11: 80,027,947 (GRCm39) |
D270E |
probably benign |
Het |
| Tfcp2l1 |
C |
A |
1: 118,597,194 (GRCm39) |
P425H |
probably benign |
Het |
| Thbd |
A |
T |
2: 148,248,591 (GRCm39) |
C426S |
probably damaging |
Het |
| Timm10b |
T |
A |
7: 105,333,219 (GRCm39) |
D968E |
probably damaging |
Het |
| Tle2 |
C |
T |
10: 81,413,518 (GRCm39) |
T119I |
probably damaging |
Het |
| Tpr |
T |
A |
1: 150,324,948 (GRCm39) |
L2400* |
probably null |
Het |
| Trrap |
T |
C |
5: 144,782,402 (GRCm39) |
F3328S |
probably damaging |
Het |
| Vldlr |
G |
A |
19: 27,215,465 (GRCm39) |
C154Y |
probably damaging |
Het |
| Vmn1r79 |
T |
G |
7: 11,910,361 (GRCm39) |
M81R |
probably benign |
Het |
| Vps13d |
T |
C |
4: 144,812,000 (GRCm39) |
T3305A |
possibly damaging |
Het |
| Wdr62 |
T |
C |
7: 29,970,111 (GRCm39) |
E232G |
probably damaging |
Het |
| Wdr62 |
T |
A |
7: 29,940,890 (GRCm39) |
I843F |
probably benign |
Het |
| Zfp747l1 |
T |
C |
7: 126,984,179 (GRCm39) |
S308G |
probably benign |
Het |
| Zfp873 |
T |
A |
10: 81,896,353 (GRCm39) |
H361Q |
probably damaging |
Het |
| Zfp949 |
A |
C |
9: 88,452,047 (GRCm39) |
H539P |
probably damaging |
Het |
|
| Other mutations in Tnik |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00516:Tnik
|
APN |
3 |
28,708,367 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00726:Tnik
|
APN |
3 |
28,587,047 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01022:Tnik
|
APN |
3 |
28,679,377 (GRCm39) |
splice site |
probably null |
|
|
IGL01145:Tnik
|
APN |
3 |
28,658,316 (GRCm39) |
intron |
probably benign |
|
|
IGL01664:Tnik
|
APN |
3 |
28,692,628 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01843:Tnik
|
APN |
3 |
28,625,007 (GRCm39) |
splice site |
probably null |
|
|
IGL02378:Tnik
|
APN |
3 |
28,692,608 (GRCm39) |
nonsense |
probably null |
|
|
IGL02448:Tnik
|
APN |
3 |
28,675,226 (GRCm39) |
missense |
probably null |
0.01 |
|
IGL02756:Tnik
|
APN |
3 |
28,596,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03332:Tnik
|
APN |
3 |
28,720,304 (GRCm39) |
missense |
probably damaging |
1.00 |
|
delightful
|
UTSW |
3 |
28,658,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Hottie
|
UTSW |
3 |
28,317,792 (GRCm39) |
start codon destroyed |
probably null |
0.93 |
|
Knockout
|
UTSW |
3 |
28,715,927 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
Looker
|
UTSW |
3 |
28,715,853 (GRCm39) |
nonsense |
probably null |
|
|
Lovely
|
UTSW |
3 |
28,666,119 (GRCm39) |
critical splice donor site |
probably null |
|
|
Usher
|
UTSW |
3 |
28,618,246 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R0135:Tnik
|
UTSW |
3 |
28,661,394 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R0418:Tnik
|
UTSW |
3 |
28,625,029 (GRCm39) |
nonsense |
probably null |
|
|
R0540:Tnik
|
UTSW |
3 |
28,704,308 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0549:Tnik
|
UTSW |
3 |
28,625,069 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R0556:Tnik
|
UTSW |
3 |
28,679,367 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R0586:Tnik
|
UTSW |
3 |
28,631,510 (GRCm39) |
splice site |
probably benign |
|
|
R0607:Tnik
|
UTSW |
3 |
28,704,308 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0842:Tnik
|
UTSW |
3 |
28,648,235 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R1068:Tnik
|
UTSW |
3 |
28,587,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1171:Tnik
|
UTSW |
3 |
28,587,089 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1597:Tnik
|
UTSW |
3 |
28,658,418 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1638:Tnik
|
UTSW |
3 |
28,719,889 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1652:Tnik
|
UTSW |
3 |
28,658,442 (GRCm39) |
missense |
probably benign |
0.22 |
|
R1996:Tnik
|
UTSW |
3 |
28,719,829 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2333:Tnik
|
UTSW |
3 |
28,587,145 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2426:Tnik
|
UTSW |
3 |
28,700,830 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2509:Tnik
|
UTSW |
3 |
28,722,064 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3774:Tnik
|
UTSW |
3 |
28,692,568 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3775:Tnik
|
UTSW |
3 |
28,692,568 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4007:Tnik
|
UTSW |
3 |
28,658,430 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4119:Tnik
|
UTSW |
3 |
28,720,324 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4209:Tnik
|
UTSW |
3 |
28,413,214 (GRCm39) |
splice site |
probably benign |
|
|
R4441:Tnik
|
UTSW |
3 |
28,618,246 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R4611:Tnik
|
UTSW |
3 |
28,596,249 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4714:Tnik
|
UTSW |
3 |
28,648,226 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R4772:Tnik
|
UTSW |
3 |
28,661,359 (GRCm39) |
missense |
probably benign |
0.09 |
|
R4829:Tnik
|
UTSW |
3 |
28,593,690 (GRCm39) |
intron |
probably benign |
|
|
R4898:Tnik
|
UTSW |
3 |
28,704,235 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5029:Tnik
|
UTSW |
3 |
28,719,993 (GRCm39) |
splice site |
probably null |
|
|
R5278:Tnik
|
UTSW |
3 |
28,704,209 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5307:Tnik
|
UTSW |
3 |
28,596,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5330:Tnik
|
UTSW |
3 |
28,596,167 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5375:Tnik
|
UTSW |
3 |
28,648,241 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5459:Tnik
|
UTSW |
3 |
28,715,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5708:Tnik
|
UTSW |
3 |
28,666,120 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5749:Tnik
|
UTSW |
3 |
28,648,241 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5751:Tnik
|
UTSW |
3 |
28,648,241 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5780:Tnik
|
UTSW |
3 |
28,648,241 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5837:Tnik
|
UTSW |
3 |
28,722,202 (GRCm39) |
unclassified |
probably benign |
|
|
R5969:Tnik
|
UTSW |
3 |
28,675,097 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6244:Tnik
|
UTSW |
3 |
28,704,328 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6273:Tnik
|
UTSW |
3 |
28,631,649 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6457:Tnik
|
UTSW |
3 |
28,593,597 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6464:Tnik
|
UTSW |
3 |
28,666,119 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6473:Tnik
|
UTSW |
3 |
28,317,792 (GRCm39) |
start codon destroyed |
probably null |
0.93 |
|
R6737:Tnik
|
UTSW |
3 |
28,650,235 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R7049:Tnik
|
UTSW |
3 |
28,715,853 (GRCm39) |
nonsense |
probably null |
|
|
R7237:Tnik
|
UTSW |
3 |
28,692,568 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7267:Tnik
|
UTSW |
3 |
28,700,776 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7445:Tnik
|
UTSW |
3 |
28,718,058 (GRCm39) |
splice site |
probably null |
|
|
R7499:Tnik
|
UTSW |
3 |
28,684,743 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R7629:Tnik
|
UTSW |
3 |
28,715,877 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7654:Tnik
|
UTSW |
3 |
28,658,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7886:Tnik
|
UTSW |
3 |
28,720,288 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8096:Tnik
|
UTSW |
3 |
28,715,927 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R8210:Tnik
|
UTSW |
3 |
28,658,482 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8233:Tnik
|
UTSW |
3 |
28,609,086 (GRCm39) |
missense |
unknown |
|
|
R8386:Tnik
|
UTSW |
3 |
28,317,823 (GRCm39) |
missense |
unknown |
|
|
R8399:Tnik
|
UTSW |
3 |
28,548,159 (GRCm39) |
missense |
unknown |
|
|
R8490:Tnik
|
UTSW |
3 |
28,650,321 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8539:Tnik
|
UTSW |
3 |
28,596,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8751:Tnik
|
UTSW |
3 |
28,666,057 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8804:Tnik
|
UTSW |
3 |
28,648,202 (GRCm39) |
missense |
unknown |
|
|
R8966:Tnik
|
UTSW |
3 |
28,587,044 (GRCm39) |
missense |
unknown |
|
|
R8998:Tnik
|
UTSW |
3 |
28,719,920 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8999:Tnik
|
UTSW |
3 |
28,719,920 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9016:Tnik
|
UTSW |
3 |
28,692,544 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9154:Tnik
|
UTSW |
3 |
28,704,235 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9284:Tnik
|
UTSW |
3 |
28,593,570 (GRCm39) |
missense |
unknown |
|
|
R9290:Tnik
|
UTSW |
3 |
28,675,124 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9411:Tnik
|
UTSW |
3 |
28,684,754 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9484:Tnik
|
UTSW |
3 |
28,649,093 (GRCm39) |
missense |
unknown |
|
|
X0022:Tnik
|
UTSW |
3 |
28,722,100 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Tnik
|
UTSW |
3 |
28,661,477 (GRCm39) |
missense |
probably damaging |
0.96 |
|
Z1176:Tnik
|
UTSW |
3 |
28,658,473 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGTTCTCCAAGGACATGTCAC -3'
(R):5'- GCTTCTCACTAGGACTCATGCC -3'
Sequencing Primer
(F):5'- AAGTAATGTTCTGTAGGGAATGCC -3'
(R):5'- AGGACTCATGCCCTCCTTGTAATG -3'
|
| Posted On |
2016-03-01 |
Incidental Mutation