Mutagenetix > Incidental Mutation

Incidental Mutation 'R4842:Gm27013'

371911

Institutional Source

Beutler Lab

Gene Symbol

Gm27013

Ensembl Gene

ENSMUSG00000098025

Gene Name

predicted gene, 27013

Synonyms

MMRRC Submission

042455-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.159) question?

Stock #

R4842 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

130519764-130546306 bp(-) (GRCm38)

Type of Mutation

unclassified

DNA Base Change (assembly)

T to A at 130520737 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s):

AlphaFold

no structure available at present

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000182441

Coding Region Coverage

1x: 99.1%
3x: 98.5%
10x: 96.7%
20x: 93.6%

Validation Efficiency

95% (107/113)

Allele List at MGI

Other mutations in this stock

Total: 99 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1600012H06Rik	A	T	17: 14,943,739 (GRCm38)	I43L	possibly damaging	Het
4930449A18Rik	T	A	3: 59,841,732 (GRCm38)		noncoding transcript	Het
Abcc8	T	C	7: 46,150,828 (GRCm38)	K510R	probably damaging	Het
Adamtsl3	C	T	7: 82,528,861 (GRCm38)	R511C	probably damaging	Het
Arhgap11a	T	C	2: 113,839,762 (GRCm38)	S339G	probably damaging	Het
C2cd3	A	G	7: 100,416,190 (GRCm38)	T728A	probably benign	Het
Cand1	C	A	10: 119,213,546 (GRCm38)		probably null	Het
Catspere1	A	T	1: 177,872,058 (GRCm38)		noncoding transcript	Het
Ccdc121rt2	A	T	5: 112,450,240 (GRCm38)	K218*	probably null	Het
Cd209c	G	T	8: 3,945,905 (GRCm38)	R2S	probably benign	Het
Cdc16	A	G	8: 13,781,644 (GRCm38)		probably benign	Het
Ces1g	C	T	8: 93,333,695 (GRCm38)	E99K	probably benign	Het
Chrna7	A	C	7: 63,212,448 (GRCm38)	L10R	probably benign	Het
Clnk	C	T	5: 38,713,069 (GRCm38)		probably null	Het
Cntrob	C	G	11: 69,315,394 (GRCm38)	L315F	possibly damaging	Het
Ctdp1	A	G	18: 80,408,726 (GRCm38)	S145P	unknown	Het
Dennd2a	T	C	6: 39,497,110 (GRCm38)	D430G	probably damaging	Het
Dnajc16	A	G	4: 141,774,625 (GRCm38)	F298S	probably damaging	Het
Dock5	T	C	14: 67,817,563 (GRCm38)	D618G	probably damaging	Het
Drc3	G	A	11: 60,370,535 (GRCm38)	A171T	probably benign	Het
Ecel1	A	T	1: 87,153,301 (GRCm38)	N322K	probably damaging	Het
Eftud2	A	G	11: 102,854,814 (GRCm38)	F362L	probably damaging	Het
Egfr	C	T	11: 16,911,607 (GRCm38)	H1129Y	probably benign	Het
Eif2b1	A	G	5: 124,576,908 (GRCm38)	S102P	probably damaging	Het
Erich3	T	A	3: 154,704,843 (GRCm38)	F112I	possibly damaging	Het
Fam107b	T	C	2: 3,778,543 (GRCm38)	L261S	probably damaging	Het
Fat3	A	C	9: 15,997,587 (GRCm38)	V2373G	probably damaging	Het
Fcgbpl1	T	A	7: 28,150,722 (GRCm38)	C1198S	probably damaging	Het
Gadd45a	A	T	6: 67,036,889 (GRCm38)	L58Q	probably damaging	Het
Gask1b	G	A	3: 79,936,605 (GRCm38)	R377H	probably damaging	Het
Gipr	C	T	7: 19,162,676 (GRCm38)	R165H	probably damaging	Het
Gje1	C	T	10: 14,717,338 (GRCm38)	G45R	probably null	Het
Gldc	T	A	19: 30,133,732 (GRCm38)	N548I	possibly damaging	Het
Gm13035	A	G	4: 146,073,423 (GRCm38)		noncoding transcript	Het
Gm5436	A	T	12: 84,258,810 (GRCm38)		noncoding transcript	Het
Grik3	C	A	4: 125,691,176 (GRCm38)	N612K	probably damaging	Het
H2bc13	C	T	13: 21,716,064 (GRCm38)		probably benign	Het
Hfm1	C	A	5: 106,892,751 (GRCm38)	W716L	probably damaging	Het
Il5ra	T	C	6: 106,738,375 (GRCm38)	Y166C	probably damaging	Het
Iqcb1	A	G	16: 36,835,590 (GRCm38)	E113G	probably benign	Het
Kcnk10	A	T	12: 98,434,916 (GRCm38)	M486K	probably benign	Het
Kcnv2	A	G	19: 27,323,790 (GRCm38)	D347G	probably damaging	Het
Kif21b	C	A	1: 136,145,220 (GRCm38)	H119N	probably damaging	Het
Lamb1	C	T	12: 31,287,433 (GRCm38)	H388Y	probably damaging	Het
Leng9	T	C	7: 4,149,386 (GRCm38)	D97G	probably damaging	Het
Lmbr1	G	A	5: 29,287,426 (GRCm38)	T55I	probably damaging	Het
Lrp1	G	T	10: 127,583,936 (GRCm38)	R935S	probably damaging	Het
Lrp2	A	T	2: 69,469,411 (GRCm38)	V3099E	probably benign	Het
Lrrcc1	C	A	3: 14,562,511 (GRCm38)	D503E	probably benign	Het
Map1a	T	A	2: 121,302,086 (GRCm38)	S890T	probably damaging	Het
Msh2	C	A	17: 87,723,413 (GRCm38)	A906E	probably benign	Het
Mybph	A	T	1: 134,198,495 (GRCm38)	E349V	probably damaging	Het
Myh7b	C	A	2: 155,633,989 (GRCm38)	L1935M	probably benign	Het
Myh9	T	C	15: 77,769,253 (GRCm38)	E1348G	probably damaging	Het
Myzap	A	G	9: 71,548,755 (GRCm38)	S328P	probably damaging	Het
Nbeal1	T	C	1: 60,253,375 (GRCm38)	L1062P	probably damaging	Het
Nepro	G	A	16: 44,734,797 (GRCm38)	S412N	probably null	Het
Nr1h3	A	G	2: 91,190,218 (GRCm38)	F257L	probably benign	Het
Nudt5	T	C	2: 5,864,428 (GRCm38)	V155A	probably benign	Het
Ofcc1	G	A	13: 40,015,388 (GRCm38)	T841I	probably damaging	Het
Or13a25	A	T	7: 140,667,589 (GRCm38)	I94F	probably damaging	Het
Or52d3	A	T	7: 104,580,215 (GRCm38)	I190L	probably benign	Het
Or6ae1	A	G	7: 140,162,689 (GRCm38)	L87P	possibly damaging	Het
Pde1a	T	A	2: 80,128,837 (GRCm38)		probably benign	Het
Pde4dip	T	A	3: 97,793,528 (GRCm38)	H220L	probably damaging	Het
Pde9a	T	A	17: 31,443,161 (GRCm38)		probably null	Het
Pnkp	C	A	7: 44,861,646 (GRCm38)		probably null	Het
Pnpla7	A	G	2: 24,980,052 (GRCm38)	T15A	probably benign	Het
Polq	G	T	16: 37,048,783 (GRCm38)		probably null	Het
Ppfia2	C	T	10: 106,854,957 (GRCm38)	T553I	probably benign	Het
Ptk6	T	G	2: 181,196,991 (GRCm38)	N323T	possibly damaging	Het
Rhox3c	G	A	X: 37,470,424 (GRCm38)	A60T	probably damaging	Het
Rnf4	T	A	5: 34,348,709 (GRCm38)	V61E	probably damaging	Het
Rnf5	A	G	17: 34,602,003 (GRCm38)		probably benign	Het
Sardh	A	G	2: 27,191,955 (GRCm38)	V853A	probably benign	Het
Scfd1	T	C	12: 51,389,326 (GRCm38)	V86A	probably damaging	Het
Scube3	G	A	17: 28,164,123 (GRCm38)	C425Y	probably damaging	Het
Sema5a	C	T	15: 32,609,417 (GRCm38)	H490Y	probably benign	Het
Sfta2	T	C	17: 35,649,881 (GRCm38)		probably benign	Het
Sh3d19	T	C	3: 86,123,742 (GRCm38)	Y738H	probably damaging	Het
Shc2	T	C	10: 79,622,461 (GRCm38)	R463G	probably damaging	Het
Socs7	T	A	11: 97,377,003 (GRCm38)	I320N	possibly damaging	Het
Speer2	A	T	16: 69,858,100 (GRCm38)	M159K	probably benign	Het
Sppl2c	A	C	11: 104,187,652 (GRCm38)	H426P	probably benign	Het
Stag3	T	G	5: 138,309,365 (GRCm38)		probably null	Het
Stxbp5	C	A	10: 9,762,891 (GRCm38)	V1055L	probably benign	Het
Synpo	A	T	18: 60,603,612 (GRCm38)	S421T	probably damaging	Het
Taf6l	A	G	19: 8,782,406 (GRCm38)	V135A	possibly damaging	Het
Tas2r116	G	A	6: 132,855,697 (GRCm38)	S87N	probably benign	Het
Tomm6	T	C	17: 47,688,069 (GRCm38)		probably benign	Het
Trabd	T	C	15: 89,082,712 (GRCm38)	M113T	probably benign	Het
Trim58	G	A	11: 58,651,324 (GRCm38)	G370E	probably damaging	Het
Ttc41	C	T	10: 86,731,125 (GRCm38)	R552C	probably benign	Het
Vit	T	C	17: 78,601,879 (GRCm38)	S252P	probably benign	Het
Vma21-ps	T	A	4: 52,496,943 (GRCm38)	D101V	probably damaging	Het
Vmn1r173	A	T	7: 23,702,936 (GRCm38)	I199F	probably damaging	Het
Vmn2r114	T	A	17: 23,310,362 (GRCm38)	R255S	probably benign	Het
Vmn2r17	A	G	5: 109,434,380 (GRCm38)	N545S	probably damaging	Het
Zfp865	A	G	7: 5,031,641 (GRCm38)	Y875C	probably damaging	Het

Other mutations in Gm27013

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R4175:Gm27013	UTSW	6	130,677,147 (GRCm38)	missense	probably benign	0.00
R4229:Gm27013	UTSW	6	130,677,345 (GRCm38)	missense	possibly damaging	0.89
R4408:Gm27013	UTSW	6	130,677,765 (GRCm38)	missense	possibly damaging	0.90
R4585:Gm27013	UTSW	6	130,521,040 (GRCm38)	unclassified	noncoding transcript
R4586:Gm27013	UTSW	6	130,521,040 (GRCm38)	unclassified	noncoding transcript
R4823:Gm27013	UTSW	6	130,522,223 (GRCm38)	exon	noncoding transcript
R4840:Gm27013	UTSW	6	130,678,116 (GRCm38)	missense	probably benign	0.00
R4943:Gm27013	UTSW	6	130,676,200 (GRCm38)	nonsense	probably null
R4998:Gm27013	UTSW	6	130,676,538 (GRCm38)	missense	probably damaging	0.98
R5087:Gm27013	UTSW	6	130,677,670 (GRCm38)	missense	probably damaging	0.98
R5271:Gm27013	UTSW	6	130,676,915 (GRCm38)	missense	probably damaging	1.00
R5507:Gm27013	UTSW	6	130,675,979 (GRCm38)	missense	probably damaging	1.00
R5767:Gm27013	UTSW	6	130,675,958 (GRCm38)	missense	possibly damaging	0.78

Predicted Primers

PCR Primer
(F):5'- TAAGGCTTCTCTCCTGTATGGATTC -3'
(R):5'- CCTCAAGTCTTAAAGTGAGCCATG -3'

Sequencing Primer
(F):5'- GCTTCTCTCCTGTATGGATTCTGTAG -3'
(R):5'- GTCTTAAAGTGAGCCATGAAAACTG -3'

Posted On

2016-03-01