Incidental Mutation 'R4858:Krt15'
ID 372250
Institutional Source Beutler Lab
Gene Symbol Krt15
Ensembl Gene ENSMUSG00000054146
Gene Name keratin 15
Synonyms Krt1-15, K15
MMRRC Submission 042469-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.081) question?
Stock # R4858 (G1)
Quality Score 203
Status Validated
Chromosome 11
Chromosomal Location 100022584-100026754 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 100022897 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Arginine at position 439 (S439R)
Ref Sequence ENSEMBL: ENSMUSP00000103034 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000107411]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000107411
AA Change: S439R

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000103034
Gene: ENSMUSG00000054146
AA Change: S439R

DomainStartEndE-ValueType
low complexity region 3 96 N/A INTRINSIC
Filament 97 409 5.06e-173 SMART
low complexity region 421 434 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000148502
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.2%
  • 10x: 96.0%
  • 20x: 91.5%
Validation Efficiency 94% (103/109)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region on chromosome 17q21.2. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired esophageal epithelial regeneration with thicker epithelia due to enhanced basal cell proliferation. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 80 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgb T C 10: 10,225,321 (GRCm39) Y1415C probably damaging Het
Adgrf1 T C 17: 43,614,563 (GRCm39) S216P probably damaging Het
Ankrd12 T C 17: 66,338,428 (GRCm39) D197G probably damaging Het
Aoc3 C A 11: 101,222,488 (GRCm39) H198Q probably damaging Het
Aox1 C A 1: 58,143,640 (GRCm39) H1253N probably benign Het
Arg1 T A 10: 24,798,536 (GRCm39) E38V possibly damaging Het
Baz2b T A 2: 59,738,087 (GRCm39) M1741L probably benign Het
Bend4 T C 5: 67,574,915 (GRCm39) E322G probably damaging Het
Brpf1 T C 6: 113,294,639 (GRCm39) V661A possibly damaging Het
C2cd3 A T 7: 100,104,160 (GRCm39) T2058S probably damaging Het
Camk4 T C 18: 33,309,266 (GRCm39) V223A probably damaging Het
Casp1 C T 9: 5,306,742 (GRCm39) R395C probably damaging Het
Ccdc180 T G 4: 45,923,244 (GRCm39) I1066S probably damaging Het
Ccne1 A G 7: 37,798,744 (GRCm39) F292L probably damaging Het
Ccz1 A T 5: 143,949,628 (GRCm39) M100K probably damaging Het
Cep128 T C 12: 91,226,936 (GRCm39) T678A probably benign Het
Cep290 G A 10: 100,330,773 (GRCm39) R151Q probably benign Het
Crip3 A G 17: 46,741,673 (GRCm39) probably benign Het
Ddx60 A G 8: 62,474,348 (GRCm39) M1479V possibly damaging Het
Defb40 T A 8: 19,025,093 (GRCm39) I38F probably benign Het
Dnajb2 C T 1: 75,220,198 (GRCm39) T221I possibly damaging Het
Dpysl3 T C 18: 43,467,079 (GRCm39) I279V probably damaging Het
Echs1 G A 7: 139,692,499 (GRCm39) probably benign Het
Efl1 T A 7: 82,320,835 (GRCm39) N89K probably damaging Het
Extl3 T C 14: 65,313,443 (GRCm39) T580A probably benign Het
Fam171a2 C T 11: 102,330,982 (GRCm39) G193E probably damaging Het
Fam234a A T 17: 26,435,591 (GRCm39) D264E probably benign Het
Fbxw20 A T 9: 109,063,763 (GRCm39) V3D possibly damaging Het
Fig4 G A 10: 41,109,586 (GRCm39) P637L probably benign Het
Fnbp1l G A 3: 122,339,964 (GRCm39) T496I probably benign Het
Fry T C 5: 150,325,108 (GRCm39) V1175A possibly damaging Het
Gm5617 C T 9: 48,406,968 (GRCm39) A34V possibly damaging Het
Gnai1 A T 5: 18,496,596 (GRCm39) V109E probably benign Het
H2-K2 A T 17: 34,216,298 (GRCm39) Y283N probably benign Het
Hectd2 A T 19: 36,582,682 (GRCm39) I471F probably damaging Het
Hsdl2 T C 4: 59,612,812 (GRCm39) probably null Het
Igkv3-1 T C 6: 70,681,028 (GRCm39) S76P probably damaging Het
Lama2 TTTGCGCATT TTT 10: 26,919,639 (GRCm39) probably null Het
Lima1 G A 15: 99,717,457 (GRCm39) T23I probably benign Het
Map4k1 C A 7: 28,688,195 (GRCm39) H248Q probably damaging Het
Mcf2l C A 8: 13,063,972 (GRCm39) T1004K probably damaging Het
Meak7 T G 8: 120,499,262 (GRCm39) T77P probably benign Het
Micall1 T A 15: 79,007,146 (GRCm39) probably benign Het
Ms4a14 A G 19: 11,278,976 (GRCm39) I1194T probably benign Het
Mtor T C 4: 148,539,273 (GRCm39) *257Q probably null Het
Mucl3 G A 17: 35,948,468 (GRCm39) T377I possibly damaging Het
Ncan T A 8: 70,556,705 (GRCm39) T961S probably benign Het
Odad4 A G 11: 100,441,147 (GRCm39) N126S probably damaging Het
Or10z1 A T 1: 174,078,262 (GRCm39) I77N probably damaging Het
Or1e29 T A 11: 73,667,372 (GRCm39) L260F probably benign Het
Or1f19 T C 16: 3,410,706 (GRCm39) S149P probably damaging Het
Or2t49 T A 11: 58,392,735 (GRCm39) I216F probably damaging Het
Or8h10 T G 2: 86,808,693 (GRCm39) Y149S probably damaging Het
Or9e1 T A 11: 58,732,033 (GRCm39) L31H possibly damaging Het
Pcdhgb2 A G 18: 37,825,153 (GRCm39) R715G probably benign Het
Pik3c3 T C 18: 30,477,131 (GRCm39) probably null Het
Pkhd1l1 A T 15: 44,354,497 (GRCm39) D296V probably damaging Het
Plekhh2 A G 17: 84,908,125 (GRCm39) I1189V probably damaging Het
Psg18 A T 7: 18,087,409 (GRCm39) L83Q possibly damaging Het
Rps6kc1 A G 1: 190,532,515 (GRCm39) W496R probably damaging Het
Setd5 C T 6: 113,126,527 (GRCm39) T1188I probably damaging Het
Slc4a3 T C 1: 75,531,729 (GRCm39) F899L probably damaging Het
Slitrk6 T C 14: 110,989,315 (GRCm39) T131A probably damaging Het
Speg G T 1: 75,398,379 (GRCm39) R1942L probably damaging Het
Sulf2 C A 2: 165,923,524 (GRCm39) R565L probably benign Het
Tcerg1 T C 18: 42,657,046 (GRCm39) M176T unknown Het
Tfcp2l1 T C 1: 118,597,239 (GRCm39) I440T possibly damaging Het
Tgm7 A T 2: 120,929,445 (GRCm39) probably null Het
Tjp2 C A 19: 24,099,484 (GRCm39) G433V probably damaging Het
Tmc7 C T 7: 118,142,565 (GRCm39) G608R probably damaging Het
Tmed4 A G 11: 6,224,456 (GRCm39) F68S possibly damaging Het
Tmem30b G A 12: 73,592,686 (GRCm39) P143L probably damaging Het
Tnfrsf23 C T 7: 143,235,217 (GRCm39) C49Y probably damaging Het
Tnni3k A T 3: 154,492,445 (GRCm39) probably null Het
Trav12-2 G T 14: 53,854,150 (GRCm39) M41I probably benign Het
Trim6 T A 7: 103,881,692 (GRCm39) Y314* probably null Het
Utp25 A G 1: 192,796,072 (GRCm39) Y686H probably damaging Het
Vmn2r118 A G 17: 55,899,894 (GRCm39) V670A probably damaging Het
Zfp438 A T 18: 5,213,154 (GRCm39) D601E probably benign Het
Zfp606 T A 7: 12,226,983 (GRCm39) I310N possibly damaging Het
Other mutations in Krt15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02194:Krt15 APN 11 100,022,839 (GRCm39) utr 3 prime probably benign
IGL02304:Krt15 APN 11 100,024,503 (GRCm39) missense possibly damaging 0.79
R0361:Krt15 UTSW 11 100,024,007 (GRCm39) missense probably benign 0.13
R1562:Krt15 UTSW 11 100,024,007 (GRCm39) missense probably benign 0.13
R2113:Krt15 UTSW 11 100,026,484 (GRCm39) missense unknown
R5185:Krt15 UTSW 11 100,024,259 (GRCm39) missense probably damaging 1.00
R6967:Krt15 UTSW 11 100,025,339 (GRCm39) missense probably damaging 0.98
R7294:Krt15 UTSW 11 100,022,848 (GRCm39) missense possibly damaging 0.71
R7371:Krt15 UTSW 11 100,026,386 (GRCm39) missense possibly damaging 0.79
R7372:Krt15 UTSW 11 100,026,386 (GRCm39) missense possibly damaging 0.79
R7389:Krt15 UTSW 11 100,026,386 (GRCm39) missense possibly damaging 0.79
R7390:Krt15 UTSW 11 100,026,386 (GRCm39) missense possibly damaging 0.79
R7391:Krt15 UTSW 11 100,026,386 (GRCm39) missense possibly damaging 0.79
R7392:Krt15 UTSW 11 100,026,386 (GRCm39) missense possibly damaging 0.79
R7420:Krt15 UTSW 11 100,026,386 (GRCm39) missense possibly damaging 0.79
R7421:Krt15 UTSW 11 100,026,386 (GRCm39) missense possibly damaging 0.79
R7423:Krt15 UTSW 11 100,026,386 (GRCm39) missense possibly damaging 0.79
R7424:Krt15 UTSW 11 100,026,386 (GRCm39) missense possibly damaging 0.79
R9405:Krt15 UTSW 11 100,022,961 (GRCm39) missense probably benign 0.37
X0025:Krt15 UTSW 11 100,026,343 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- AGAGATCCTCTAAGGCACGG -3'
(R):5'- TAGGAAACCAGCTCTTGCCTC -3'

Sequencing Primer
(F):5'- GACTGGAGCCTGTTTTCCCAG -3'
(R):5'- GAGCAATTCACCATAGCTCTTGG -3'
Posted On 2016-03-01