Incidental Mutation 'R4860:Adcy4'
| ID |
372448 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Adcy4
|
| Ensembl Gene |
ENSMUSG00000022220 |
| Gene Name |
adenylate cyclase 4 |
| Synonyms |
|
| MMRRC Submission |
042471-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R4860 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
14 |
| Chromosomal Location |
56006514-56021552 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 56019384 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 89
(T89A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000130530
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000002398]
[ENSMUST00000022830]
[ENSMUST00000168716]
[ENSMUST00000170223]
[ENSMUST00000178399]
[ENSMUST00000227031]
[ENSMUST00000228476]
|
| AlphaFold |
Q91WF3 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000002398
AA Change: T89A
PolyPhen 2
Score 0.682 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000002398
Gene: ENSMUSG00000022220
AA Change: T89A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
28 |
48 |
N/A |
INTRINSIC |
|
low complexity region
|
66 |
80 |
N/A |
INTRINSIC |
|
low complexity region
|
145 |
161 |
N/A |
INTRINSIC |
|
CYCc
|
218 |
426 |
1.56e-62 |
SMART |
|
Pfam:DUF1053
|
479 |
581 |
2.4e-35 |
PFAM |
|
transmembrane domain
|
607 |
629 |
N/A |
INTRINSIC |
|
transmembrane domain
|
661 |
683 |
N/A |
INTRINSIC |
|
transmembrane domain
|
717 |
739 |
N/A |
INTRINSIC |
|
transmembrane domain
|
746 |
768 |
N/A |
INTRINSIC |
|
transmembrane domain
|
792 |
809 |
N/A |
INTRINSIC |
|
CYCc
|
835 |
1057 |
4.46e-40 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000022830
|
| SMART Domains |
Protein: ENSMUSP00000022830
Gene: ENSMUSG00000022221
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Pkinase
|
22 |
288 |
2.8e-38 |
PFAM |
|
Pfam:Pkinase_Tyr
|
22 |
288 |
3e-34 |
PFAM |
|
Pfam:RHIM
|
408 |
458 |
2.4e-19 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000168716
|
| SMART Domains |
Protein: ENSMUSP00000126306
Gene: ENSMUSG00000022221
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Pkinase
|
1 |
223 |
1.2e-30 |
PFAM |
|
Pfam:Pkinase_Tyr
|
1 |
224 |
3.1e-27 |
PFAM |
|
Pfam:RHIM
|
344 |
395 |
2.4e-14 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000170223
AA Change: T89A
PolyPhen 2
Score 0.682 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000130530
Gene: ENSMUSG00000022220
AA Change: T89A
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
29 |
51 |
N/A |
INTRINSIC |
|
transmembrane domain
|
61 |
80 |
N/A |
INTRINSIC |
|
transmembrane domain
|
92 |
114 |
N/A |
INTRINSIC |
|
transmembrane domain
|
119 |
138 |
N/A |
INTRINSIC |
|
transmembrane domain
|
145 |
162 |
N/A |
INTRINSIC |
|
transmembrane domain
|
172 |
194 |
N/A |
INTRINSIC |
|
CYCc
|
218 |
426 |
1.56e-62 |
SMART |
|
Pfam:DUF1053
|
479 |
581 |
1.6e-24 |
PFAM |
|
transmembrane domain
|
607 |
629 |
N/A |
INTRINSIC |
|
transmembrane domain
|
661 |
683 |
N/A |
INTRINSIC |
|
transmembrane domain
|
717 |
739 |
N/A |
INTRINSIC |
|
transmembrane domain
|
746 |
768 |
N/A |
INTRINSIC |
|
transmembrane domain
|
792 |
809 |
N/A |
INTRINSIC |
|
CYCc
|
835 |
1057 |
4.46e-40 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000178399
|
| SMART Domains |
Protein: ENSMUSP00000137278
Gene: ENSMUSG00000022221
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Pkinase
|
1 |
223 |
1.2e-30 |
PFAM |
|
Pfam:Pkinase_Tyr
|
1 |
224 |
3.1e-27 |
PFAM |
|
Pfam:RHIM
|
344 |
395 |
2.4e-14 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000226361
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000227031
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000228175
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000227072
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000228077
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000228476
|
| Meta Mutation Damage Score |
0.1136 |
| Coding Region Coverage |
- 1x: 98.9%
- 3x: 97.9%
- 10x: 95.0%
- 20x: 87.3%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Mouse studies show that adenylate cyclase 4, along with adenylate cyclases 2 and 3, is expressed in olfactory cilia, suggesting that several different adenylate cyclases may couple to olfactory receptors and that there may be multiple receptor-mediated mechanisms for the generation of cAMP signals. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]
PHENOTYPE: Mice homozygous for disruptions of this gene display a normal phenotype. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 92 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700030K09Rik |
T |
C |
8: 73,209,267 (GRCm39) |
S466P |
possibly damaging |
Het |
| Ablim1 |
T |
C |
19: 57,068,298 (GRCm39) |
T267A |
probably damaging |
Het |
| Acap2 |
A |
T |
16: 30,922,317 (GRCm39) |
L724Q |
possibly damaging |
Het |
| Acsbg3 |
A |
G |
17: 57,195,655 (GRCm39) |
N684S |
probably benign |
Het |
| Agrp |
T |
C |
8: 106,294,000 (GRCm39) |
E41G |
probably benign |
Het |
| Ajm1 |
T |
C |
2: 25,468,765 (GRCm39) |
Y382C |
probably damaging |
Het |
| Akr1d1 |
G |
A |
6: 37,541,426 (GRCm39) |
V308M |
probably damaging |
Het |
| Ap1m2 |
C |
T |
9: 21,220,970 (GRCm39) |
R54Q |
probably benign |
Het |
| Arhgap45 |
T |
A |
10: 79,862,900 (GRCm39) |
V692E |
probably damaging |
Het |
| Arid5b |
G |
T |
10: 68,078,925 (GRCm39) |
N137K |
probably damaging |
Het |
| Arsi |
G |
A |
18: 61,049,723 (GRCm39) |
G202E |
probably benign |
Het |
| BC048679 |
T |
C |
7: 81,145,468 (GRCm39) |
N27D |
probably benign |
Het |
| Ccdc78 |
A |
G |
17: 26,007,674 (GRCm39) |
N237S |
probably benign |
Het |
| Cd46 |
G |
A |
1: 194,744,704 (GRCm39) |
L345F |
possibly damaging |
Het |
| Cngb3 |
A |
T |
4: 19,425,569 (GRCm39) |
N459I |
possibly damaging |
Het |
| Ctnnd2 |
A |
G |
15: 30,881,313 (GRCm39) |
E731G |
probably damaging |
Het |
| Ctsh |
A |
G |
9: 89,936,601 (GRCm39) |
E26G |
probably benign |
Het |
| Cul1 |
G |
T |
6: 47,494,080 (GRCm39) |
K464N |
probably benign |
Het |
| Cul1 |
T |
A |
6: 47,494,125 (GRCm39) |
S479R |
probably damaging |
Het |
| Dcaf5 |
A |
T |
12: 80,387,006 (GRCm39) |
D373E |
probably benign |
Het |
| Dhcr7 |
A |
G |
7: 143,394,237 (GRCm39) |
Q126R |
probably benign |
Het |
| Dok2 |
T |
C |
14: 71,014,956 (GRCm39) |
F228L |
probably damaging |
Het |
| Dpep3 |
T |
G |
8: 106,702,821 (GRCm39) |
I314L |
probably benign |
Het |
| Eps8 |
A |
G |
6: 137,491,293 (GRCm39) |
F362L |
probably damaging |
Het |
| Espn |
G |
T |
4: 152,223,303 (GRCm39) |
R250S |
probably damaging |
Het |
| Faf1 |
A |
C |
4: 109,600,093 (GRCm39) |
N163H |
probably damaging |
Het |
| Fcho1 |
C |
T |
8: 72,163,125 (GRCm39) |
V635I |
probably benign |
Het |
| Garin5b |
C |
T |
7: 4,760,468 (GRCm39) |
|
probably null |
Het |
| Gask1b |
C |
A |
3: 79,843,981 (GRCm39) |
S36* |
probably null |
Het |
| Gm7579 |
G |
A |
7: 141,765,645 (GRCm39) |
C17Y |
unknown |
Het |
| Gpx8 |
G |
T |
13: 113,182,042 (GRCm39) |
Y130* |
probably null |
Het |
| Gvin1 |
A |
T |
7: 105,762,643 (GRCm39) |
Y609N |
possibly damaging |
Het |
| Hectd4 |
T |
A |
5: 121,443,881 (GRCm39) |
M30K |
probably benign |
Het |
| Iqub |
T |
C |
6: 24,450,841 (GRCm39) |
D586G |
probably damaging |
Het |
| Klhl25 |
T |
C |
7: 75,516,798 (GRCm39) |
I568T |
probably benign |
Het |
| Larp6 |
A |
G |
9: 60,645,093 (GRCm39) |
E411G |
probably damaging |
Het |
| Lepr |
A |
C |
4: 101,646,534 (GRCm39) |
I822L |
probably benign |
Het |
| Lrig3 |
C |
A |
10: 125,846,921 (GRCm39) |
D896E |
probably benign |
Het |
| Lrp1 |
C |
T |
10: 127,389,693 (GRCm39) |
G3114D |
probably damaging |
Het |
| Lyset |
A |
T |
12: 102,710,314 (GRCm39) |
|
probably benign |
Het |
| Macf1 |
A |
T |
4: 123,380,543 (GRCm39) |
Y1263N |
probably damaging |
Het |
| Mapk10 |
T |
C |
5: 103,138,485 (GRCm39) |
D180G |
probably damaging |
Het |
| Matr3 |
T |
A |
18: 35,714,693 (GRCm39) |
V113E |
probably damaging |
Het |
| Mbd4 |
A |
T |
6: 115,825,887 (GRCm39) |
F368Y |
possibly damaging |
Het |
| Mcpt8 |
G |
A |
14: 56,319,737 (GRCm39) |
R238W |
probably benign |
Het |
| Mcrip2 |
G |
T |
17: 26,083,621 (GRCm39) |
T86N |
possibly damaging |
Het |
| Mink1 |
A |
G |
11: 70,502,418 (GRCm39) |
N1043S |
probably damaging |
Het |
| Muc4 |
G |
A |
16: 32,754,616 (GRCm38) |
G1497R |
probably benign |
Het |
| Muc4 |
T |
A |
16: 32,754,625 (GRCm38) |
S1500T |
probably benign |
Het |
| Nbeal2 |
G |
A |
9: 110,464,262 (GRCm39) |
T1128I |
probably benign |
Het |
| Nrg2 |
T |
A |
18: 36,329,600 (GRCm39) |
Y205F |
probably damaging |
Het |
| Nubp2 |
A |
G |
17: 25,103,430 (GRCm39) |
M149T |
probably benign |
Het |
| Or4d2b |
T |
A |
11: 87,780,051 (GRCm39) |
M224L |
probably damaging |
Het |
| Or8d6 |
G |
T |
9: 39,853,800 (GRCm39) |
M81I |
probably benign |
Het |
| Or8j3c |
T |
C |
2: 86,253,301 (GRCm39) |
T240A |
probably damaging |
Het |
| Pax3 |
A |
G |
1: 78,169,093 (GRCm39) |
I191T |
possibly damaging |
Het |
| Pdcd5 |
T |
C |
7: 35,343,135 (GRCm39) |
N137D |
possibly damaging |
Het |
| Pik3c2a |
G |
A |
7: 115,939,391 (GRCm39) |
A1649V |
probably damaging |
Het |
| Pkhd1l1 |
T |
C |
15: 44,400,774 (GRCm39) |
S2183P |
possibly damaging |
Het |
| Plekho1 |
T |
A |
3: 95,896,305 (GRCm39) |
Q388L |
possibly damaging |
Het |
| Ppfibp1 |
A |
G |
6: 146,892,012 (GRCm39) |
T91A |
probably benign |
Het |
| Ptger4 |
G |
T |
15: 5,272,087 (GRCm39) |
N177K |
probably benign |
Het |
| Reln |
A |
G |
5: 22,106,749 (GRCm39) |
F3207S |
probably benign |
Het |
| Rigi |
G |
T |
4: 40,210,000 (GRCm39) |
S644R |
probably damaging |
Het |
| Ripk4 |
C |
T |
16: 97,552,736 (GRCm39) |
R194H |
probably damaging |
Het |
| Rnf112 |
A |
T |
11: 61,343,570 (GRCm39) |
C112S |
possibly damaging |
Het |
| Rprd1b |
T |
G |
2: 157,916,855 (GRCm39) |
Y278* |
probably null |
Het |
| Sel1l |
A |
G |
12: 91,798,376 (GRCm39) |
L140P |
probably damaging |
Het |
| Shroom3 |
G |
T |
5: 93,090,945 (GRCm39) |
V1151F |
probably damaging |
Het |
| Slc38a3 |
A |
G |
9: 107,532,263 (GRCm39) |
V423A |
probably damaging |
Het |
| Slitrk6 |
T |
C |
14: 110,989,315 (GRCm39) |
T131A |
probably damaging |
Het |
| Slmap |
A |
T |
14: 26,181,364 (GRCm39) |
V323E |
probably benign |
Het |
| Smim6 |
T |
C |
11: 115,804,330 (GRCm39) |
V39A |
probably benign |
Het |
| Sorbs1 |
T |
C |
19: 40,325,449 (GRCm39) |
T382A |
probably benign |
Het |
| Sparc |
G |
A |
11: 55,290,037 (GRCm39) |
T218I |
possibly damaging |
Het |
| Steap1 |
A |
T |
5: 5,786,589 (GRCm39) |
F283I |
probably damaging |
Het |
| Stil |
A |
G |
4: 114,895,671 (GRCm39) |
T586A |
probably benign |
Het |
| Tbce |
T |
A |
13: 14,194,380 (GRCm39) |
D93V |
probably damaging |
Het |
| Tcf12 |
C |
T |
9: 71,766,122 (GRCm39) |
G504S |
probably null |
Het |
| Tex55 |
A |
G |
16: 38,648,507 (GRCm39) |
S201P |
probably damaging |
Het |
| Tle4 |
A |
T |
19: 14,441,709 (GRCm39) |
I435K |
probably benign |
Het |
| Tmem245 |
A |
G |
4: 56,899,164 (GRCm39) |
F254S |
probably damaging |
Het |
| Tubgcp3 |
T |
C |
8: 12,699,722 (GRCm39) |
K377R |
probably benign |
Het |
| Ush2a |
A |
T |
1: 188,285,472 (GRCm39) |
T2003S |
probably benign |
Het |
| Usp53 |
A |
G |
3: 122,755,012 (GRCm39) |
S32P |
possibly damaging |
Het |
| Vmn1r78 |
T |
A |
7: 11,886,683 (GRCm39) |
L98Q |
probably damaging |
Het |
| Vmn2r116 |
A |
C |
17: 23,620,777 (GRCm39) |
Q837P |
probably benign |
Het |
| Vmn2r3 |
T |
C |
3: 64,183,022 (GRCm39) |
I226V |
probably benign |
Het |
| Vmn2r84 |
T |
A |
10: 130,221,712 (GRCm39) |
D836V |
probably damaging |
Het |
| Vps13d |
A |
G |
4: 144,813,731 (GRCm39) |
F165L |
probably benign |
Het |
| Vstm4 |
A |
G |
14: 32,585,742 (GRCm39) |
E103G |
possibly damaging |
Het |
| Zfp870 |
A |
T |
17: 33,102,314 (GRCm39) |
C339* |
probably null |
Het |
|
| Other mutations in Adcy4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00917:Adcy4
|
APN |
14 |
56,011,120 (GRCm39) |
splice site |
probably null |
|
|
IGL02406:Adcy4
|
APN |
14 |
56,007,504 (GRCm39) |
missense |
possibly damaging |
0.45 |
|
IGL02503:Adcy4
|
APN |
14 |
56,008,962 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02543:Adcy4
|
APN |
14 |
56,006,627 (GRCm39) |
missense |
probably benign |
|
|
IGL02616:Adcy4
|
APN |
14 |
56,020,971 (GRCm39) |
splice site |
probably null |
|
|
IGL03002:Adcy4
|
APN |
14 |
56,011,013 (GRCm39) |
missense |
probably benign |
0.31 |
|
IGL03026:Adcy4
|
APN |
14 |
56,015,467 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03190:Adcy4
|
APN |
14 |
56,016,510 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03247:Adcy4
|
APN |
14 |
56,007,553 (GRCm39) |
missense |
probably damaging |
1.00 |
|
stressed
|
UTSW |
14 |
56,016,556 (GRCm39) |
splice site |
probably null |
|
|
IGL03098:Adcy4
|
UTSW |
14 |
56,019,038 (GRCm39) |
missense |
probably null |
0.82 |
|
R0098:Adcy4
|
UTSW |
14 |
56,007,284 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R0102:Adcy4
|
UTSW |
14 |
56,008,990 (GRCm39) |
missense |
probably benign |
0.29 |
|
R0396:Adcy4
|
UTSW |
14 |
56,009,745 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0482:Adcy4
|
UTSW |
14 |
56,012,029 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R0634:Adcy4
|
UTSW |
14 |
56,019,054 (GRCm39) |
missense |
probably benign |
|
|
R0691:Adcy4
|
UTSW |
14 |
56,010,104 (GRCm39) |
splice site |
probably benign |
|
|
R0704:Adcy4
|
UTSW |
14 |
56,010,213 (GRCm39) |
missense |
probably benign |
|
|
R0815:Adcy4
|
UTSW |
14 |
56,021,056 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0863:Adcy4
|
UTSW |
14 |
56,021,056 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1446:Adcy4
|
UTSW |
14 |
56,007,480 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1462:Adcy4
|
UTSW |
14 |
56,015,765 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R1462:Adcy4
|
UTSW |
14 |
56,015,765 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R1463:Adcy4
|
UTSW |
14 |
56,016,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1624:Adcy4
|
UTSW |
14 |
56,019,384 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1799:Adcy4
|
UTSW |
14 |
56,008,929 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1878:Adcy4
|
UTSW |
14 |
56,007,362 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2007:Adcy4
|
UTSW |
14 |
56,015,770 (GRCm39) |
missense |
possibly damaging |
0.45 |
|
R2156:Adcy4
|
UTSW |
14 |
56,006,627 (GRCm39) |
missense |
probably benign |
0.09 |
|
R2425:Adcy4
|
UTSW |
14 |
56,015,474 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2517:Adcy4
|
UTSW |
14 |
56,019,403 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3882:Adcy4
|
UTSW |
14 |
56,012,003 (GRCm39) |
missense |
probably benign |
0.27 |
|
R4021:Adcy4
|
UTSW |
14 |
56,012,635 (GRCm39) |
splice site |
probably null |
|
|
R4022:Adcy4
|
UTSW |
14 |
56,012,635 (GRCm39) |
splice site |
probably null |
|
|
R4411:Adcy4
|
UTSW |
14 |
56,006,900 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4530:Adcy4
|
UTSW |
14 |
56,016,485 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4560:Adcy4
|
UTSW |
14 |
56,016,407 (GRCm39) |
splice site |
probably null |
|
|
R4704:Adcy4
|
UTSW |
14 |
56,012,482 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4780:Adcy4
|
UTSW |
14 |
56,012,493 (GRCm39) |
missense |
probably benign |
0.07 |
|
R4860:Adcy4
|
UTSW |
14 |
56,019,384 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R4868:Adcy4
|
UTSW |
14 |
56,011,179 (GRCm39) |
missense |
probably benign |
|
|
R4890:Adcy4
|
UTSW |
14 |
56,016,486 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4920:Adcy4
|
UTSW |
14 |
56,016,486 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4948:Adcy4
|
UTSW |
14 |
56,016,486 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4952:Adcy4
|
UTSW |
14 |
56,016,486 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4953:Adcy4
|
UTSW |
14 |
56,016,486 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4987:Adcy4
|
UTSW |
14 |
56,010,934 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4991:Adcy4
|
UTSW |
14 |
56,010,922 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5080:Adcy4
|
UTSW |
14 |
56,009,832 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5620:Adcy4
|
UTSW |
14 |
56,009,824 (GRCm39) |
nonsense |
probably null |
|
|
R5652:Adcy4
|
UTSW |
14 |
56,010,900 (GRCm39) |
missense |
probably benign |
|
|
R5726:Adcy4
|
UTSW |
14 |
56,021,118 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5910:Adcy4
|
UTSW |
14 |
56,016,470 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5958:Adcy4
|
UTSW |
14 |
56,016,556 (GRCm39) |
splice site |
probably null |
|
|
R6280:Adcy4
|
UTSW |
14 |
56,016,500 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6318:Adcy4
|
UTSW |
14 |
56,006,681 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6598:Adcy4
|
UTSW |
14 |
56,007,502 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6947:Adcy4
|
UTSW |
14 |
56,015,848 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7012:Adcy4
|
UTSW |
14 |
56,017,376 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7147:Adcy4
|
UTSW |
14 |
56,017,182 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7386:Adcy4
|
UTSW |
14 |
56,015,784 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7414:Adcy4
|
UTSW |
14 |
56,019,090 (GRCm39) |
missense |
probably benign |
0.15 |
|
R7431:Adcy4
|
UTSW |
14 |
56,010,129 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7490:Adcy4
|
UTSW |
14 |
56,007,890 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R7552:Adcy4
|
UTSW |
14 |
56,010,922 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7672:Adcy4
|
UTSW |
14 |
56,018,362 (GRCm39) |
missense |
probably benign |
0.14 |
|
R8003:Adcy4
|
UTSW |
14 |
56,019,092 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8042:Adcy4
|
UTSW |
14 |
56,012,696 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8100:Adcy4
|
UTSW |
14 |
56,009,722 (GRCm39) |
nonsense |
probably null |
|
|
R8343:Adcy4
|
UTSW |
14 |
56,012,697 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8801:Adcy4
|
UTSW |
14 |
56,009,452 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8811:Adcy4
|
UTSW |
14 |
56,010,221 (GRCm39) |
missense |
probably benign |
|
|
R8993:Adcy4
|
UTSW |
14 |
56,016,156 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8993:Adcy4
|
UTSW |
14 |
56,008,835 (GRCm39) |
missense |
probably null |
1.00 |
|
R9026:Adcy4
|
UTSW |
14 |
56,016,426 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0025:Adcy4
|
UTSW |
14 |
56,007,848 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Adcy4
|
UTSW |
14 |
56,018,413 (GRCm39) |
missense |
probably benign |
0.06 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCTGAATGCCCGTGATGTTG -3'
(R):5'- CTTTGTGCGCATGCTTTTCAGATAC -3'
Sequencing Primer
(F):5'- GCGCCCAGGGTCTAAATTTGAG -3'
(R):5'- GGTTTGAAGGACACCTAACTTGCTC -3'
|
| Posted On |
2016-03-01 |
Incidental Mutation