Incidental Mutation 'R4829:Dennd4a'
| ID |
372680 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dennd4a
|
| Ensembl Gene |
ENSMUSG00000053641 |
| Gene Name |
DENN/MADD domain containing 4A |
| Synonyms |
F730015K02Rik |
| MMRRC Submission |
042445-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.432)
|
| Stock # |
R4829 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
9 |
| Chromosomal Location |
64811340-64919667 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 64889056 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 788
(V788A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000037915
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000038890]
|
| AlphaFold |
E9Q8V6 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000038890
AA Change: V788A
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000037915
Gene: ENSMUSG00000053641
AA Change: V788A
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
45 |
93 |
3.26e-5 |
PROSPERO |
|
uDENN
|
169 |
276 |
1.71e-28 |
SMART |
|
DENN
|
309 |
493 |
2.4e-73 |
SMART |
|
dDENN
|
559 |
633 |
4.15e-27 |
SMART |
|
low complexity region
|
724 |
735 |
N/A |
INTRINSIC |
|
low complexity region
|
936 |
950 |
N/A |
INTRINSIC |
|
low complexity region
|
1176 |
1191 |
N/A |
INTRINSIC |
|
low complexity region
|
1249 |
1262 |
N/A |
INTRINSIC |
|
low complexity region
|
1402 |
1417 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000216098
|
| Meta Mutation Damage Score |
0.2011 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.4%
- 20x: 92.8%
|
| Validation Efficiency |
98% (109/111) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a DENN domain-containing protein that may function as a guanine nucleotide exchange factor that specifically activates ras-related protein Rab-10. This protein also contains a interferon stimulated response element-binding domain and may be involved in regulating the v-myc avian myelocytomatosis viral (MYC) oncogene. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8. [provided by RefSeq, Mar 2016]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 95 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1110002E22Rik |
T |
C |
3: 138,069,019 (GRCm38) |
V1323A |
probably damaging |
Het |
| 1700029J07Rik |
T |
C |
8: 45,967,915 (GRCm38) |
I159V |
probably damaging |
Het |
| 1700061G19Rik |
A |
G |
17: 56,883,500 (GRCm38) |
|
probably null |
Het |
| Abcb1a |
T |
C |
5: 8,723,214 (GRCm38) |
L814P |
probably damaging |
Het |
| Acat1 |
C |
A |
9: 53,591,456 (GRCm38) |
G191V |
probably damaging |
Het |
| Adamts20 |
A |
T |
15: 94,326,396 (GRCm38) |
D1184E |
probably benign |
Het |
| Adssl1 |
T |
C |
12: 112,634,713 (GRCm38) |
L283P |
probably damaging |
Het |
| Arid4a |
A |
G |
12: 71,023,498 (GRCm38) |
|
probably null |
Het |
| Arid4b |
T |
A |
13: 14,184,438 (GRCm38) |
D599E |
probably benign |
Het |
| AW146154 |
T |
C |
7: 41,480,633 (GRCm38) |
K353R |
possibly damaging |
Het |
| Axdnd1 |
G |
T |
1: 156,376,646 (GRCm38) |
R547S |
possibly damaging |
Het |
| BC067074 |
A |
G |
13: 113,368,162 (GRCm38) |
I1942V |
probably benign |
Het |
| BC147527 |
G |
A |
13: 120,308,390 (GRCm38) |
C82Y |
possibly damaging |
Het |
| Bcat1 |
A |
T |
6: 145,015,475 (GRCm38) |
F134Y |
probably damaging |
Het |
| Camk2d |
C |
A |
3: 126,779,997 (GRCm38) |
|
probably benign |
Het |
| Catsperg2 |
T |
G |
7: 29,701,125 (GRCm38) |
K268T |
probably damaging |
Het |
| Ccar1 |
A |
C |
10: 62,745,335 (GRCm38) |
F1103L |
unknown |
Het |
| Ccdc141 |
T |
A |
2: 77,074,916 (GRCm38) |
E395D |
probably damaging |
Het |
| Cdc37l1 |
A |
G |
19: 28,990,583 (GRCm38) |
T16A |
probably benign |
Het |
| Cdca2 |
T |
A |
14: 67,693,753 (GRCm38) |
|
probably null |
Het |
| Cntn5 |
T |
G |
9: 9,976,283 (GRCm38) |
K219Q |
probably damaging |
Het |
| Col23a1 |
C |
A |
11: 51,557,586 (GRCm38) |
A202E |
unknown |
Het |
| Csmd1 |
G |
A |
8: 16,127,296 (GRCm38) |
L1318F |
probably damaging |
Het |
| Csnk1g3 |
C |
T |
18: 53,895,823 (GRCm38) |
A16V |
possibly damaging |
Het |
| Dab2 |
A |
G |
15: 6,424,681 (GRCm38) |
D224G |
probably damaging |
Het |
| Ddr1 |
A |
T |
17: 35,685,113 (GRCm38) |
C625S |
probably damaging |
Het |
| Dgcr2 |
T |
C |
16: 17,842,753 (GRCm38) |
E402G |
possibly damaging |
Het |
| Dhcr7 |
T |
G |
7: 143,837,917 (GRCm38) |
I81S |
probably damaging |
Het |
| Exd1 |
C |
T |
2: 119,520,326 (GRCm38) |
A485T |
probably benign |
Het |
| Fat1 |
C |
T |
8: 45,036,162 (GRCm38) |
T3467I |
probably damaging |
Het |
| Fblim1 |
T |
C |
4: 141,584,709 (GRCm38) |
E235G |
probably damaging |
Het |
| Fbxo38 |
T |
A |
18: 62,518,591 (GRCm38) |
M548L |
probably benign |
Het |
| Fstl5 |
T |
C |
3: 76,322,182 (GRCm38) |
Y97H |
probably damaging |
Het |
| Glb1l |
A |
T |
1: 75,200,350 (GRCm38) |
S481T |
probably damaging |
Het |
| Gm7102 |
C |
T |
19: 61,175,926 (GRCm38) |
G24R |
unknown |
Het |
| Gp2 |
A |
T |
7: 119,457,184 (GRCm38) |
V22E |
possibly damaging |
Het |
| Grin1 |
A |
G |
2: 25,318,724 (GRCm38) |
S55P |
possibly damaging |
Het |
| Herc2 |
A |
G |
7: 56,106,492 (GRCm38) |
D760G |
probably benign |
Het |
| Hpn |
A |
G |
7: 31,098,875 (GRCm38) |
|
probably benign |
Het |
| Hsf2 |
T |
C |
10: 57,496,170 (GRCm38) |
V73A |
probably damaging |
Het |
| Ighv1-42 |
T |
C |
12: 114,937,168 (GRCm38) |
Y80C |
probably benign |
Het |
| Ighv1-64 |
T |
C |
12: 115,507,726 (GRCm38) |
K57R |
probably benign |
Het |
| Klc1 |
T |
C |
12: 111,795,603 (GRCm38) |
I569T |
probably damaging |
Het |
| Klra3 |
T |
G |
6: 130,323,616 (GRCm38) |
K263N |
probably benign |
Het |
| Lrcol1 |
C |
A |
5: 110,354,527 (GRCm38) |
H90N |
probably benign |
Het |
| Mamdc4 |
T |
C |
2: 25,565,356 (GRCm38) |
E921G |
possibly damaging |
Het |
| Mark1 |
G |
A |
1: 184,905,527 (GRCm38) |
R622W |
possibly damaging |
Het |
| Mdga1 |
A |
G |
17: 29,846,369 (GRCm38) |
S696P |
possibly damaging |
Het |
| Mmp1b |
C |
T |
9: 7,370,729 (GRCm38) |
|
probably null |
Het |
| Mtnr1a |
T |
C |
8: 45,085,615 (GRCm38) |
|
probably benign |
Het |
| Myo5a |
T |
C |
9: 75,136,407 (GRCm38) |
I226T |
probably damaging |
Het |
| Ncoa6 |
G |
T |
2: 155,415,227 (GRCm38) |
P799T |
probably damaging |
Het |
| Npc1l1 |
C |
T |
11: 6,214,010 (GRCm38) |
|
probably null |
Het |
| Nxph3 |
T |
C |
11: 95,511,495 (GRCm38) |
E31G |
probably benign |
Het |
| Obscn |
T |
C |
11: 59,054,246 (GRCm38) |
I4649V |
probably null |
Het |
| Olfr1100 |
G |
A |
2: 86,978,574 (GRCm38) |
S74L |
probably damaging |
Het |
| Olfr875 |
G |
T |
9: 37,772,947 (GRCm38) |
C96F |
probably damaging |
Het |
| Olfr955 |
A |
T |
9: 39,470,367 (GRCm38) |
Y120N |
probably damaging |
Het |
| Olfr960 |
A |
T |
9: 39,623,438 (GRCm38) |
H103L |
probably damaging |
Het |
| P3h3 |
G |
A |
6: 124,841,638 (GRCm38) |
|
probably benign |
Het |
| Pcnx2 |
A |
T |
8: 125,861,058 (GRCm38) |
|
probably null |
Het |
| Pirb |
C |
T |
7: 3,717,603 (GRCm38) |
G299S |
probably benign |
Het |
| Pla2g4d |
A |
G |
2: 120,266,743 (GRCm38) |
S792P |
probably damaging |
Het |
| Plppr4 |
A |
T |
3: 117,335,591 (GRCm38) |
L76M |
possibly damaging |
Het |
| Ppp2r3a |
A |
T |
9: 101,212,510 (GRCm38) |
S205T |
possibly damaging |
Het |
| Prkdc |
G |
A |
16: 15,702,075 (GRCm38) |
D1126N |
possibly damaging |
Het |
| Prrt4 |
G |
A |
6: 29,177,182 (GRCm38) |
S196L |
probably benign |
Het |
| Ptpn21 |
A |
C |
12: 98,689,296 (GRCm38) |
S471A |
probably damaging |
Het |
| Ptprk |
C |
A |
10: 28,580,484 (GRCm38) |
S9* |
probably null |
Het |
| Rassf4 |
A |
T |
6: 116,645,142 (GRCm38) |
I163K |
possibly damaging |
Het |
| Rgs22 |
C |
A |
15: 36,103,888 (GRCm38) |
R142S |
probably damaging |
Het |
| Rit2 |
C |
A |
18: 31,212,673 (GRCm38) |
L73F |
probably damaging |
Het |
| Rrbp1 |
A |
C |
2: 143,989,687 (GRCm38) |
S187A |
probably benign |
Het |
| Rspo2 |
A |
T |
15: 43,093,187 (GRCm38) |
Y83* |
probably null |
Het |
| Scn5a |
C |
T |
9: 119,534,707 (GRCm38) |
V456M |
probably benign |
Het |
| Scn9a |
T |
A |
2: 66,551,713 (GRCm38) |
H290L |
probably benign |
Het |
| Smarca4 |
T |
C |
9: 21,639,327 (GRCm38) |
I452T |
probably damaging |
Het |
| Smc2 |
T |
A |
4: 52,449,612 (GRCm38) |
I198K |
probably damaging |
Het |
| Smim14 |
G |
A |
5: 65,460,603 (GRCm38) |
|
probably benign |
Het |
| Spg11 |
A |
C |
2: 122,108,455 (GRCm38) |
N339K |
probably benign |
Het |
| Spta1 |
A |
G |
1: 174,237,927 (GRCm38) |
E2014G |
probably benign |
Het |
| Stk4 |
T |
C |
2: 164,099,827 (GRCm38) |
|
probably null |
Het |
| Sypl |
C |
T |
12: 32,967,646 (GRCm38) |
T121M |
probably damaging |
Het |
| Tas2r120 |
T |
A |
6: 132,657,368 (GRCm38) |
F138I |
probably benign |
Het |
| Tet2 |
A |
C |
3: 133,476,620 (GRCm38) |
C1194W |
possibly damaging |
Het |
| Tex29 |
T |
C |
8: 11,855,668 (GRCm38) |
|
probably benign |
Het |
| Tnfrsf22 |
T |
A |
7: 143,643,330 (GRCm38) |
T91S |
possibly damaging |
Het |
| Tnik |
A |
T |
3: 28,539,541 (GRCm38) |
|
probably benign |
Het |
| Tnr |
A |
T |
1: 159,858,404 (GRCm38) |
I402F |
probably benign |
Het |
| Unc93b1 |
A |
T |
19: 3,944,293 (GRCm38) |
S475C |
probably damaging |
Het |
| Utrn |
T |
A |
10: 12,663,461 (GRCm38) |
E1937D |
probably benign |
Het |
| Vmn1r227 |
A |
T |
17: 20,735,665 (GRCm38) |
|
noncoding transcript |
Het |
| Vmn2r101 |
G |
A |
17: 19,611,967 (GRCm38) |
V742I |
probably benign |
Het |
| Vmn2r81 |
T |
C |
10: 79,247,801 (GRCm38) |
L3P |
possibly damaging |
Het |
| Zfp882 |
T |
G |
8: 71,914,389 (GRCm38) |
H353Q |
probably damaging |
Het |
|
| Other mutations in Dennd4a |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00476:Dennd4a
|
APN |
9 |
64,911,762 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01610:Dennd4a
|
APN |
9 |
64,906,884 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL01788:Dennd4a
|
APN |
9 |
64,842,621 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL01827:Dennd4a
|
APN |
9 |
64,842,561 (GRCm38) |
nonsense |
probably null |
|
|
IGL01828:Dennd4a
|
APN |
9 |
64,842,561 (GRCm38) |
nonsense |
probably null |
|
|
IGL01829:Dennd4a
|
APN |
9 |
64,842,561 (GRCm38) |
nonsense |
probably null |
|
|
IGL01979:Dennd4a
|
APN |
9 |
64,894,409 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL02100:Dennd4a
|
APN |
9 |
64,909,706 (GRCm38) |
splice site |
probably benign |
|
|
IGL02339:Dennd4a
|
APN |
9 |
64,842,561 (GRCm38) |
nonsense |
probably null |
|
|
IGL02341:Dennd4a
|
APN |
9 |
64,842,561 (GRCm38) |
nonsense |
probably null |
|
|
IGL02584:Dennd4a
|
APN |
9 |
64,851,298 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02607:Dennd4a
|
APN |
9 |
64,862,327 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL02654:Dennd4a
|
APN |
9 |
64,910,191 (GRCm38) |
splice site |
probably benign |
|
|
IGL02701:Dennd4a
|
APN |
9 |
64,897,353 (GRCm38) |
missense |
possibly damaging |
0.50 |
|
IGL03051:Dennd4a
|
APN |
9 |
64,862,414 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03257:Dennd4a
|
APN |
9 |
64,871,874 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
IGL03346:Dennd4a
|
APN |
9 |
64,888,526 (GRCm38) |
missense |
possibly damaging |
0.47 |
|
IGL03349:Dennd4a
|
APN |
9 |
64,888,974 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03398:Dennd4a
|
APN |
9 |
64,871,882 (GRCm38) |
missense |
probably benign |
0.32 |
|
R0010:Dennd4a
|
UTSW |
9 |
64,896,715 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0010:Dennd4a
|
UTSW |
9 |
64,896,715 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0129:Dennd4a
|
UTSW |
9 |
64,893,294 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0220:Dennd4a
|
UTSW |
9 |
64,852,445 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0396:Dennd4a
|
UTSW |
9 |
64,862,391 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0881:Dennd4a
|
UTSW |
9 |
64,851,383 (GRCm38) |
critical splice donor site |
probably null |
|
|
R1225:Dennd4a
|
UTSW |
9 |
64,911,675 (GRCm38) |
missense |
probably benign |
0.03 |
|
R1311:Dennd4a
|
UTSW |
9 |
64,910,004 (GRCm38) |
missense |
probably benign |
0.34 |
|
R1448:Dennd4a
|
UTSW |
9 |
64,906,045 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R1450:Dennd4a
|
UTSW |
9 |
64,911,665 (GRCm38) |
missense |
probably benign |
0.03 |
|
R1630:Dennd4a
|
UTSW |
9 |
64,871,882 (GRCm38) |
missense |
probably benign |
0.32 |
|
R1709:Dennd4a
|
UTSW |
9 |
64,889,605 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R1824:Dennd4a
|
UTSW |
9 |
64,859,358 (GRCm38) |
critical splice donor site |
probably null |
|
|
R1851:Dennd4a
|
UTSW |
9 |
64,862,030 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1870:Dennd4a
|
UTSW |
9 |
64,897,234 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1900:Dennd4a
|
UTSW |
9 |
64,897,336 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1911:Dennd4a
|
UTSW |
9 |
64,889,086 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1938:Dennd4a
|
UTSW |
9 |
64,842,490 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1954:Dennd4a
|
UTSW |
9 |
64,852,467 (GRCm38) |
missense |
probably benign |
0.02 |
|
R1955:Dennd4a
|
UTSW |
9 |
64,852,467 (GRCm38) |
missense |
probably benign |
0.02 |
|
R2049:Dennd4a
|
UTSW |
9 |
64,889,605 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R2129:Dennd4a
|
UTSW |
9 |
64,905,974 (GRCm38) |
splice site |
probably null |
|
|
R2138:Dennd4a
|
UTSW |
9 |
64,889,337 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2929:Dennd4a
|
UTSW |
9 |
64,852,417 (GRCm38) |
missense |
possibly damaging |
0.85 |
|
R3083:Dennd4a
|
UTSW |
9 |
64,906,081 (GRCm38) |
missense |
probably benign |
0.03 |
|
R3108:Dennd4a
|
UTSW |
9 |
64,912,387 (GRCm38) |
missense |
probably benign |
0.23 |
|
R3176:Dennd4a
|
UTSW |
9 |
64,888,993 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3177:Dennd4a
|
UTSW |
9 |
64,888,993 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3276:Dennd4a
|
UTSW |
9 |
64,888,993 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3277:Dennd4a
|
UTSW |
9 |
64,888,993 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3890:Dennd4a
|
UTSW |
9 |
64,872,028 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3953:Dennd4a
|
UTSW |
9 |
64,852,575 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3963:Dennd4a
|
UTSW |
9 |
64,862,331 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4059:Dennd4a
|
UTSW |
9 |
64,911,892 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R4499:Dennd4a
|
UTSW |
9 |
64,910,123 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
R4500:Dennd4a
|
UTSW |
9 |
64,910,123 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
R4501:Dennd4a
|
UTSW |
9 |
64,910,123 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
R4671:Dennd4a
|
UTSW |
9 |
64,894,407 (GRCm38) |
missense |
probably benign |
|
|
R4701:Dennd4a
|
UTSW |
9 |
64,897,357 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R4821:Dennd4a
|
UTSW |
9 |
64,897,249 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R4876:Dennd4a
|
UTSW |
9 |
64,896,590 (GRCm38) |
missense |
probably benign |
|
|
R4881:Dennd4a
|
UTSW |
9 |
64,838,844 (GRCm38) |
missense |
possibly damaging |
0.77 |
|
R4962:Dennd4a
|
UTSW |
9 |
64,906,003 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5225:Dennd4a
|
UTSW |
9 |
64,888,928 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R5557:Dennd4a
|
UTSW |
9 |
64,904,227 (GRCm38) |
missense |
probably benign |
0.07 |
|
R5649:Dennd4a
|
UTSW |
9 |
64,851,209 (GRCm38) |
splice site |
probably null |
|
|
R5868:Dennd4a
|
UTSW |
9 |
64,896,729 (GRCm38) |
missense |
probably benign |
0.02 |
|
R5876:Dennd4a
|
UTSW |
9 |
64,911,755 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6052:Dennd4a
|
UTSW |
9 |
64,886,945 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6411:Dennd4a
|
UTSW |
9 |
64,871,899 (GRCm38) |
missense |
probably benign |
0.04 |
|
R6596:Dennd4a
|
UTSW |
9 |
64,852,420 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6668:Dennd4a
|
UTSW |
9 |
64,886,965 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6915:Dennd4a
|
UTSW |
9 |
64,852,489 (GRCm38) |
nonsense |
probably null |
|
|
R7056:Dennd4a
|
UTSW |
9 |
64,906,923 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
R7107:Dennd4a
|
UTSW |
9 |
64,894,399 (GRCm38) |
missense |
possibly damaging |
0.79 |
|
R7203:Dennd4a
|
UTSW |
9 |
64,896,474 (GRCm38) |
missense |
probably benign |
0.05 |
|
R7238:Dennd4a
|
UTSW |
9 |
64,861,956 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7373:Dennd4a
|
UTSW |
9 |
64,897,269 (GRCm38) |
missense |
probably benign |
0.01 |
|
R7454:Dennd4a
|
UTSW |
9 |
64,852,570 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7546:Dennd4a
|
UTSW |
9 |
64,873,044 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7590:Dennd4a
|
UTSW |
9 |
64,888,587 (GRCm38) |
missense |
probably benign |
0.01 |
|
R7662:Dennd4a
|
UTSW |
9 |
64,852,431 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7782:Dennd4a
|
UTSW |
9 |
64,906,920 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R7909:Dennd4a
|
UTSW |
9 |
64,872,993 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
R7976:Dennd4a
|
UTSW |
9 |
64,852,512 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R8026:Dennd4a
|
UTSW |
9 |
64,873,030 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8034:Dennd4a
|
UTSW |
9 |
64,888,568 (GRCm38) |
missense |
probably benign |
0.01 |
|
R8089:Dennd4a
|
UTSW |
9 |
64,849,175 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8298:Dennd4a
|
UTSW |
9 |
64,906,875 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8397:Dennd4a
|
UTSW |
9 |
64,889,109 (GRCm38) |
missense |
probably benign |
|
|
R8425:Dennd4a
|
UTSW |
9 |
64,838,974 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8495:Dennd4a
|
UTSW |
9 |
64,886,879 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8855:Dennd4a
|
UTSW |
9 |
64,912,390 (GRCm38) |
missense |
probably benign |
|
|
R9219:Dennd4a
|
UTSW |
9 |
64,889,094 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R9275:Dennd4a
|
UTSW |
9 |
64,842,624 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9376:Dennd4a
|
UTSW |
9 |
64,912,692 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9485:Dennd4a
|
UTSW |
9 |
64,907,106 (GRCm38) |
nonsense |
probably null |
|
|
R9672:Dennd4a
|
UTSW |
9 |
64,893,358 (GRCm38) |
missense |
probably benign |
|
|
R9746:Dennd4a
|
UTSW |
9 |
64,894,511 (GRCm38) |
missense |
probably benign |
|
|
X0026:Dennd4a
|
UTSW |
9 |
64,897,320 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
Z1088:Dennd4a
|
UTSW |
9 |
64,872,022 (GRCm38) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GTGACTTTCTGTGTTCACCATTCAG -3'
(R):5'- AGTACAGGCTGGTCGTACTG -3'
Sequencing Primer
(F):5'- GCTTAATAAAGATGCTACCTTGGAC -3'
(R):5'- TACTGTCCACAGAGCTGCATGAG -3'
|
| Posted On |
2016-03-01 |
Incidental Mutation