Incidental Mutation 'R4830:Slc22a15'
ID 372727
Institutional Source Beutler Lab
Gene Symbol Slc22a15
Ensembl Gene ENSMUSG00000033147
Gene Name solute carrier family 22 (organic anion/cation transporter), member 15
Synonyms 2610034P21Rik, A530052I06Rik
MMRRC Submission 042446-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # R4830 (G1)
Quality Score 225
Status Validated
Chromosome 3
Chromosomal Location 101763092-101831769 bp(-) (GRCm39)
Type of Mutation intron
DNA Base Change (assembly) T to C at 101782919 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000139518 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000106928] [ENSMUST00000183255] [ENSMUST00000190824]
AlphaFold Q504N2
Predicted Effect probably benign
Transcript: ENSMUST00000106928
SMART Domains Protein: ENSMUSP00000102541
Gene: ENSMUSG00000033147

DomainStartEndE-ValueType
transmembrane domain 20 42 N/A INTRINSIC
Pfam:Sugar_tr 58 495 6.9e-29 PFAM
Pfam:MFS_1 69 450 3.4e-24 PFAM
low complexity region 524 532 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000182130
Predicted Effect noncoding transcript
Transcript: ENSMUST00000183098
Predicted Effect probably benign
Transcript: ENSMUST00000183255
SMART Domains Protein: ENSMUSP00000138357
Gene: ENSMUSG00000033147

DomainStartEndE-ValueType
transmembrane domain 20 42 N/A INTRINSIC
Pfam:Sugar_tr 56 244 5.2e-13 PFAM
Pfam:MFS_1 69 244 7.6e-13 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000183293
Predicted Effect probably benign
Transcript: ENSMUST00000190824
SMART Domains Protein: ENSMUSP00000139518
Gene: ENSMUSG00000033147

DomainStartEndE-ValueType
signal peptide 1 36 N/A INTRINSIC
Pfam:Sugar_tr 88 341 3.3e-5 PFAM
low complexity region 369 377 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.7%
  • 20x: 93.5%
Validation Efficiency 97% (71/73)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Organic ion transporters, such as SLC22A15, transport various medically and physiologically important compounds, including pharmaceuticals, toxins, hormones, neurotransmitters, and cellular metabolites. These transporters are also referred to as amphiphilic solute facilitators (ASFs).[supplied by OMIM, Apr 2004]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcd3 C A 3: 121,553,933 (GRCm39) G643V probably damaging Het
Adamtsl1 A G 4: 86,274,619 (GRCm39) E1225G probably damaging Het
Agbl5 G A 5: 31,048,059 (GRCm39) R111H probably damaging Het
Ankle2 A C 5: 110,389,879 (GRCm39) K446Q probably damaging Het
Boc A C 16: 44,310,520 (GRCm39) M800R probably damaging Het
Ccnt1 A T 15: 98,441,332 (GRCm39) N645K probably damaging Het
Cd93 G A 2: 148,285,299 (GRCm39) Q16* probably null Het
Cpsf4l G T 11: 113,600,328 (GRCm39) probably benign Het
Cuzd1 T A 7: 130,919,783 (GRCm39) D111V probably damaging Het
Dab2 T C 15: 6,457,008 (GRCm39) C232R probably benign Het
Dmpk A T 7: 18,821,453 (GRCm39) Y237F probably damaging Het
Dnah6 T A 6: 73,021,745 (GRCm39) T3526S possibly damaging Het
Dock2 T C 11: 34,223,767 (GRCm39) probably null Het
Dsp G A 13: 38,376,840 (GRCm39) V1542I probably benign Het
Dst T A 1: 34,237,586 (GRCm39) probably null Het
Esd T C 14: 74,978,600 (GRCm39) L54S probably damaging Het
Exd1 C T 2: 119,350,807 (GRCm39) A485T probably benign Het
Gm3604 A T 13: 62,516,857 (GRCm39) N500K probably damaging Het
Grhl2 T A 15: 37,335,903 (GRCm39) probably null Het
Gsto1 C T 19: 47,852,830 (GRCm39) R222C probably benign Het
Inpp4a T A 1: 37,410,861 (GRCm39) M343K probably damaging Het
Itpripl2 T C 7: 118,090,280 (GRCm39) Q93R probably benign Het
Jakmip2 G A 18: 43,700,208 (GRCm39) T450I probably benign Het
Kdm6b A T 11: 69,294,620 (GRCm39) I1186N unknown Het
Kif1a T C 1: 92,948,931 (GRCm39) probably null Het
Klhl20 T C 1: 160,925,946 (GRCm39) K434R probably benign Het
Lemd3 T C 10: 120,767,853 (GRCm39) D697G probably damaging Het
Lipo3 A G 19: 33,753,987 (GRCm39) S383P probably damaging Het
Ltn1 C A 16: 87,176,582 (GRCm39) K1741N probably damaging Het
Lvrn A T 18: 47,038,418 (GRCm39) T991S probably damaging Het
Macroh2a2 C T 10: 61,575,132 (GRCm39) D355N possibly damaging Het
Mast3 C A 8: 71,241,559 (GRCm39) R151L possibly damaging Het
Mplkipl1 C T 19: 61,164,364 (GRCm39) G24R unknown Het
Muc4 G C 16: 32,753,919 (GRCm38) R1265P probably benign Het
Myoz1 T C 14: 20,705,377 (GRCm39) K14E probably damaging Het
Neb G T 2: 52,082,532 (GRCm39) Q5450K probably damaging Het
Nedd1 T A 10: 92,522,120 (GRCm39) N639I probably damaging Het
Nlrp4e A T 7: 23,036,165 (GRCm39) N673Y probably benign Het
Nop53 C T 7: 15,676,129 (GRCm39) R190Q probably damaging Het
Notch4 T C 17: 34,789,092 (GRCm39) Y468H probably damaging Het
Obscn T C 11: 58,958,433 (GRCm39) T3507A probably damaging Het
Opn5 T C 17: 42,922,187 (GRCm39) H5R probably benign Het
Or4l15 T C 14: 50,197,681 (GRCm39) N283D probably damaging Het
Patl1 T C 19: 11,902,515 (GRCm39) M349T probably benign Het
Phactr3 A G 2: 177,925,811 (GRCm39) N362S probably damaging Het
Pirb C T 7: 3,720,602 (GRCm39) G299S probably benign Het
Rapgef5 G A 12: 117,719,809 (GRCm39) R579Q probably damaging Het
Rgl1 T C 1: 152,430,081 (GRCm39) D234G probably benign Het
Serpinb3a C T 1: 106,976,316 (GRCm39) E122K probably benign Het
Slc25a12 A T 2: 71,127,149 (GRCm39) V344E probably damaging Het
Slc43a2 T C 11: 75,434,119 (GRCm39) L99P probably damaging Het
Smim27 G T 4: 40,269,719 (GRCm39) probably null Het
Smtn A G 11: 3,470,736 (GRCm39) probably benign Het
Szt2 A T 4: 118,226,445 (GRCm39) Y3001N unknown Het
Tgfbr3 G T 5: 107,257,585 (GRCm39) P825T probably damaging Het
Tnpo3 T C 6: 29,568,937 (GRCm39) T472A probably benign Het
Trf T A 9: 103,105,114 (GRCm39) D66V probably damaging Het
Vmn1r124 A G 7: 20,993,624 (GRCm39) C307R probably damaging Het
Vps13b T A 15: 35,452,370 (GRCm39) F656Y possibly damaging Het
Zic1 G T 9: 91,244,584 (GRCm39) S358R probably damaging Het
Other mutations in Slc22a15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00846:Slc22a15 APN 3 101,768,136 (GRCm39) missense probably benign 0.00
IGL01120:Slc22a15 APN 3 101,804,482 (GRCm39) missense probably damaging 1.00
IGL01345:Slc22a15 APN 3 101,787,492 (GRCm39) missense probably benign 0.00
IGL01871:Slc22a15 APN 3 101,768,110 (GRCm39) splice site probably benign
IGL01880:Slc22a15 APN 3 101,768,164 (GRCm39) missense probably benign 0.32
R0310:Slc22a15 UTSW 3 101,767,827 (GRCm39) missense probably benign 0.12
R1758:Slc22a15 UTSW 3 101,767,769 (GRCm39) nonsense probably null
R1937:Slc22a15 UTSW 3 101,787,505 (GRCm39) critical splice acceptor site probably null
R3804:Slc22a15 UTSW 3 101,804,590 (GRCm39) missense probably damaging 1.00
R5564:Slc22a15 UTSW 3 101,771,905 (GRCm39) missense probably benign 0.34
R5684:Slc22a15 UTSW 3 101,770,271 (GRCm39) missense probably damaging 1.00
R6034:Slc22a15 UTSW 3 101,770,235 (GRCm39) missense possibly damaging 0.80
R6034:Slc22a15 UTSW 3 101,770,235 (GRCm39) missense possibly damaging 0.80
R6114:Slc22a15 UTSW 3 101,768,168 (GRCm39) nonsense probably null
R6481:Slc22a15 UTSW 3 101,790,899 (GRCm39) missense possibly damaging 0.88
R6641:Slc22a15 UTSW 3 101,783,022 (GRCm39) missense possibly damaging 0.52
R6945:Slc22a15 UTSW 3 101,831,430 (GRCm39) missense probably damaging 0.99
R7354:Slc22a15 UTSW 3 101,771,897 (GRCm39) missense probably benign 0.09
R7373:Slc22a15 UTSW 3 101,785,213 (GRCm39) missense possibly damaging 0.78
R7431:Slc22a15 UTSW 3 101,805,256 (GRCm39) missense probably benign 0.13
R7758:Slc22a15 UTSW 3 101,805,251 (GRCm39) critical splice donor site probably null
R8058:Slc22a15 UTSW 3 101,771,926 (GRCm39) missense probably benign
R8129:Slc22a15 UTSW 3 101,822,658 (GRCm39) missense possibly damaging 0.82
R8838:Slc22a15 UTSW 3 101,790,849 (GRCm39) missense probably damaging 1.00
R9652:Slc22a15 UTSW 3 101,790,848 (GRCm39) missense possibly damaging 0.94
Predicted Primers PCR Primer
(F):5'- AGTGCTGCATCCCAGATACC -3'
(R):5'- GACCAGCTACATTTGCCACC -3'

Sequencing Primer
(F):5'- GATACCCCAGATGGTAGCTTAATAGC -3'
(R):5'- GAGGGAAGATGGCTTTATAAGATTC -3'
Posted On 2016-03-01