Incidental Mutation 'R4831:Or10d5'
ID 372817
Institutional Source Beutler Lab
Gene Symbol Or10d5
Ensembl Gene ENSMUSG00000043331
Gene Name olfactory receptor family 10 subfamily D member 5
Synonyms MOR224-2, GA_x6K02T2PVTD-33651220-33650288, Olfr975
MMRRC Submission 042447-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.062) question?
Stock # R4831 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 39861133-39862065 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 39861408 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 220 (V220I)
Ref Sequence ENSEMBL: ENSMUSP00000150664 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054067] [ENSMUST00000169307] [ENSMUST00000213171] [ENSMUST00000213246] [ENSMUST00000216647] [ENSMUST00000217630]
AlphaFold Q8VG91
Predicted Effect probably benign
Transcript: ENSMUST00000054067
AA Change: V220I

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000059776
Gene: ENSMUSG00000043331
AA Change: V220I

DomainStartEndE-ValueType
Pfam:7tm_4 29 304 1.9e-51 PFAM
Pfam:7TM_GPCR_Srsx 33 249 1.8e-7 PFAM
Pfam:7tm_1 39 286 3.6e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000169307
SMART Domains Protein: ENSMUSP00000133083
Gene: ENSMUSG00000047352

DomainStartEndE-ValueType
Pfam:7tm_4 43 318 1.5e-48 PFAM
Pfam:7TM_GPCR_Srsx 47 271 1.1e-5 PFAM
Pfam:7tm_1 53 300 2.8e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213171
Predicted Effect probably benign
Transcript: ENSMUST00000213246
Predicted Effect probably benign
Transcript: ENSMUST00000216647
AA Change: V220I

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
Predicted Effect probably benign
Transcript: ENSMUST00000217630
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.6%
  • 20x: 93.3%
Validation Efficiency 99% (96/97)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 92 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2810408A11Rik C T 11: 69,791,403 (GRCm39) V59I possibly damaging Het
4930544M13Rik T G 13: 114,744,183 (GRCm39) noncoding transcript Het
Abca13 A T 11: 9,492,077 (GRCm39) K4373* probably null Het
Abtb2 A T 2: 103,513,820 (GRCm39) T410S probably benign Het
Adamts13 T C 2: 26,873,142 (GRCm39) probably null Het
Ahnak2 C G 12: 112,742,183 (GRCm39) D630H probably damaging Het
Aox3 T C 1: 58,191,725 (GRCm39) S426P probably damaging Het
Atxn10 C T 15: 85,271,260 (GRCm39) S266F probably benign Het
B4galnt4 G T 7: 140,647,634 (GRCm39) M407I probably damaging Het
B4galnt4 T A 7: 140,644,470 (GRCm39) probably null Het
Bclaf1 T A 10: 20,197,872 (GRCm39) probably benign Het
C4b C T 17: 34,955,864 (GRCm39) probably null Het
Cdc42bpg T C 19: 6,361,365 (GRCm39) F297S probably damaging Het
Cdh10 A T 15: 19,013,664 (GRCm39) T755S probably benign Het
Ceacam12 T A 7: 17,811,305 (GRCm39) probably null Het
Cfap65 C A 1: 74,956,454 (GRCm39) V1042F possibly damaging Het
Cfap77 T C 2: 28,875,844 (GRCm39) I89V probably benign Het
Cfh T C 1: 140,014,125 (GRCm39) D688G probably benign Het
Clip1 C G 5: 123,721,664 (GRCm39) A1182P probably damaging Het
Cyp2b10 T A 7: 25,614,921 (GRCm39) Y309* probably null Het
Dcaf5 T C 12: 80,385,858 (GRCm39) E756G probably benign Het
Dctn1 A T 6: 83,176,753 (GRCm39) Q1231L possibly damaging Het
Dennd1c T A 17: 57,373,428 (GRCm39) R682* probably null Het
Eml6 C A 11: 29,727,052 (GRCm39) E1319* probably null Het
Erap1 T C 13: 74,838,766 (GRCm39) I904T probably damaging Het
Eri1 A T 8: 35,943,673 (GRCm39) I207N possibly damaging Het
Farp1 G A 14: 121,514,469 (GRCm39) A933T probably damaging Het
Fcna T A 2: 25,515,353 (GRCm39) Q210L probably benign Het
Fhad1 A T 4: 141,643,378 (GRCm39) probably null Het
Fut8 T G 12: 77,440,603 (GRCm39) Y197D probably damaging Het
Garem1 G A 18: 21,262,825 (GRCm39) T663I probably benign Het
Gfm2 T C 13: 97,301,546 (GRCm39) S450P probably damaging Het
Gstk1 T G 6: 42,222,938 (GRCm39) probably benign Het
Helz2 C T 2: 180,879,210 (GRCm39) A803T probably damaging Het
Igsf9 T A 1: 172,319,455 (GRCm39) I280N probably damaging Het
Klhl10 A G 11: 100,336,669 (GRCm39) K219E probably benign Het
L3mbtl4 T A 17: 68,768,558 (GRCm39) V222D probably damaging Het
Lrrc9 A T 12: 72,546,453 (GRCm39) N1214Y probably damaging Het
Ltbp2 C T 12: 84,840,414 (GRCm39) E1051K possibly damaging Het
Mettl17 T C 14: 52,122,440 (GRCm39) F13S probably benign Het
Mettl24 C A 10: 40,559,413 (GRCm39) A21D possibly damaging Het
Mfsd6l T A 11: 68,447,331 (GRCm39) C61S probably benign Het
Mob4 T G 1: 55,191,899 (GRCm39) D204E probably benign Het
Mtus1 C G 8: 41,536,189 (GRCm39) R509T probably damaging Het
Nlrp4a T A 7: 26,149,844 (GRCm39) F484I possibly damaging Het
Nsrp1 T C 11: 76,941,444 (GRCm39) N88S probably benign Het
Odad2 G T 18: 7,222,564 (GRCm39) H568Q possibly damaging Het
Or2g25 T A 17: 37,970,969 (GRCm39) H85L probably benign Het
Or51b6b T C 7: 103,309,678 (GRCm39) T260A probably benign Het
Or6c2 T A 10: 129,362,449 (GRCm39) Y118N probably damaging Het
Parg A G 14: 31,924,408 (GRCm39) N69S probably benign Het
Pcdh9 A C 14: 94,125,377 (GRCm39) N264K probably damaging Het
Pcdhb22 G T 18: 37,653,615 (GRCm39) L694F probably damaging Het
Pcnt T C 10: 76,248,335 (GRCm39) E928G probably damaging Het
Pdzk1 G A 3: 96,775,751 (GRCm39) G373D probably benign Het
Pea15a A G 1: 172,026,740 (GRCm39) I89T probably damaging Het
Phc1 T A 6: 122,313,964 (GRCm39) probably benign Het
Pikfyve T A 1: 65,235,900 (GRCm39) C191S probably damaging Het
Pitpnm1 T A 19: 4,158,130 (GRCm39) D573E probably damaging Het
Pld5 A G 1: 176,102,450 (GRCm39) probably benign Het
Plscr2 A T 9: 92,173,130 (GRCm39) N89I possibly damaging Het
Pm20d2 A C 4: 33,179,293 (GRCm39) N315K probably damaging Het
Pnpla1 T A 17: 29,097,518 (GRCm39) M228K probably benign Het
Prim2 T C 1: 33,709,217 (GRCm39) probably benign Het
Ralgapa2 A G 2: 146,246,987 (GRCm39) probably benign Het
Rgs22 G T 15: 36,050,294 (GRCm39) H719N probably benign Het
Ror2 C T 13: 53,272,880 (GRCm39) D250N probably damaging Het
Saal1 A G 7: 46,349,071 (GRCm39) V281A probably benign Het
Selenof A T 3: 144,296,411 (GRCm39) K94N probably damaging Het
Slamf9 T A 1: 172,304,831 (GRCm39) C148* probably null Het
Slc4a7 T C 14: 14,772,699 (GRCm38) probably null Het
Slco1a5 A G 6: 142,180,431 (GRCm39) I657T probably benign Het
St3gal2 A T 8: 111,684,480 (GRCm39) H46L probably benign Het
Sucnr1 T G 3: 59,994,069 (GRCm39) M199R probably damaging Het
Taok1 T A 11: 77,444,500 (GRCm39) E525V probably null Het
Tbc1d10c T A 19: 4,235,445 (GRCm39) E298V probably damaging Het
Tll2 T A 19: 41,118,951 (GRCm39) H259L probably damaging Het
Tpcn1 A T 5: 120,691,554 (GRCm39) F300Y probably damaging Het
Uba6 T A 5: 86,279,197 (GRCm39) I642L probably benign Het
Ubqln5 T A 7: 103,778,829 (GRCm39) probably benign Het
Vmn1r27 A T 6: 58,192,827 (GRCm39) L9Q possibly damaging Het
Vmn2r100 C T 17: 19,741,672 (GRCm39) T128I probably benign Het
Vmn2r109 C T 17: 20,761,494 (GRCm39) G621D probably benign Het
Vmn2r49 C T 7: 9,720,352 (GRCm39) D380N probably benign Het
Vps13a C T 19: 16,655,356 (GRCm39) V1891I probably benign Het
Wbp2 G T 11: 115,971,463 (GRCm39) Y147* probably null Het
Wdr46 T A 17: 34,160,810 (GRCm39) N191K probably benign Het
Wdr46 T C 17: 34,168,373 (GRCm39) probably benign Het
Wnt2 A C 6: 18,023,285 (GRCm39) F121L probably benign Het
Xpnpep1 T A 19: 53,003,053 (GRCm39) D100V probably benign Het
Xpo4 T C 14: 57,827,559 (GRCm39) Y879C probably damaging Het
Zswim4 A T 8: 84,938,948 (GRCm39) V978D probably damaging Het
Other mutations in Or10d5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01480:Or10d5 APN 9 39,861,284 (GRCm39) missense probably benign 0.01
IGL01537:Or10d5 APN 9 39,861,921 (GRCm39) missense probably benign 0.00
IGL01963:Or10d5 APN 9 39,861,536 (GRCm39) missense probably damaging 1.00
IGL02400:Or10d5 APN 9 39,861,635 (GRCm39) missense probably benign
IGL03115:Or10d5 APN 9 39,862,040 (GRCm39) missense probably damaging 0.98
IGL03226:Or10d5 APN 9 39,861,719 (GRCm39) splice site probably null
R0088:Or10d5 UTSW 9 39,861,671 (GRCm39) missense probably benign 0.03
R0212:Or10d5 UTSW 9 39,861,236 (GRCm39) missense probably benign 0.44
R1668:Or10d5 UTSW 9 39,861,465 (GRCm39) missense possibly damaging 0.94
R1878:Or10d5 UTSW 9 39,862,053 (GRCm39) missense probably benign 0.35
R2225:Or10d5 UTSW 9 39,861,833 (GRCm39) missense possibly damaging 0.84
R2291:Or10d5 UTSW 9 39,861,630 (GRCm39) missense probably benign 0.19
R2420:Or10d5 UTSW 9 39,861,824 (GRCm39) missense possibly damaging 0.47
R2421:Or10d5 UTSW 9 39,861,824 (GRCm39) missense possibly damaging 0.47
R2422:Or10d5 UTSW 9 39,861,824 (GRCm39) missense possibly damaging 0.47
R2425:Or10d5 UTSW 9 39,861,137 (GRCm39) missense probably null 0.25
R2918:Or10d5 UTSW 9 39,861,660 (GRCm39) missense probably benign
R4536:Or10d5 UTSW 9 39,861,731 (GRCm39) missense probably damaging 1.00
R4709:Or10d5 UTSW 9 39,861,165 (GRCm39) missense probably damaging 0.97
R4921:Or10d5 UTSW 9 39,861,521 (GRCm39) missense probably damaging 0.98
R5113:Or10d5 UTSW 9 39,861,221 (GRCm39) missense probably damaging 0.99
R5141:Or10d5 UTSW 9 39,861,170 (GRCm39) missense probably benign 0.07
R5195:Or10d5 UTSW 9 39,861,975 (GRCm39) missense probably benign
R5213:Or10d5 UTSW 9 39,861,389 (GRCm39) missense probably damaging 0.99
R5568:Or10d5 UTSW 9 39,861,983 (GRCm39) missense probably benign 0.05
R6993:Or10d5 UTSW 9 39,861,933 (GRCm39) missense probably benign
R7080:Or10d5 UTSW 9 39,861,444 (GRCm39) missense probably damaging 1.00
R7436:Or10d5 UTSW 9 39,861,349 (GRCm39) nonsense probably null
R8178:Or10d5 UTSW 9 39,861,708 (GRCm39) missense probably benign 0.05
R8179:Or10d5 UTSW 9 39,861,708 (GRCm39) missense probably benign 0.05
R8382:Or10d5 UTSW 9 39,861,455 (GRCm39) missense probably benign 0.21
R8402:Or10d5 UTSW 9 39,861,713 (GRCm39) missense probably benign 0.39
R8511:Or10d5 UTSW 9 39,861,455 (GRCm39) missense probably benign 0.21
R8798:Or10d5 UTSW 9 39,862,013 (GRCm39) missense probably benign 0.40
R9068:Or10d5 UTSW 9 39,862,087 (GRCm39) unclassified probably benign
Predicted Primers PCR Primer
(F):5'- TCAATGCCTTTCTCAAAGCCAC -3'
(R):5'- TTACCCTACTGTGGACCCAATG -3'

Sequencing Primer
(F):5'- AATGCCTTTCTCAAAGCCACCTTTAC -3'
(R):5'- CCTACTGTGGACCCAATGAAGTG -3'
Posted On 2016-03-01