Incidental Mutation 'R4832:Erbb4'
| ID |
372867 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Erbb4
|
| Ensembl Gene |
ENSMUSG00000062209 |
| Gene Name |
erb-b2 receptor tyrosine kinase 4 |
| Synonyms |
Her4, ErbB4 |
| MMRRC Submission |
042448-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R4832 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
68071345-69147218 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 68369397 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Glycine
at position 415
(S415G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000115373
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000119142]
[ENSMUST00000121473]
[ENSMUST00000153432]
|
| AlphaFold |
Q61527 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000119142
AA Change: S415G
PolyPhen 2
Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
|
| SMART Domains |
Protein: ENSMUSP00000112713
Gene: ENSMUSG00000062209
AA Change: S415G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Recep_L_domain
|
55 |
167 |
5e-34 |
PFAM |
|
FU
|
183 |
223 |
2.07e1 |
SMART |
|
FU
|
226 |
268 |
5.78e-10 |
SMART |
|
Pfam:Recep_L_domain
|
358 |
478 |
1e-29 |
PFAM |
|
FU
|
493 |
544 |
6.45e-8 |
SMART |
|
FU
|
549 |
599 |
3.51e-9 |
SMART |
|
FU
|
611 |
659 |
2.32e0 |
SMART |
|
TyrKc
|
718 |
974 |
7.53e-133 |
SMART |
|
low complexity region
|
1007 |
1023 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000121473
AA Change: S415G
PolyPhen 2
Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
|
| SMART Domains |
Protein: ENSMUSP00000114123
Gene: ENSMUSG00000062209
AA Change: S415G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Recep_L_domain
|
55 |
167 |
1.6e-34 |
PFAM |
|
FU
|
183 |
223 |
2.07e1 |
SMART |
|
FU
|
226 |
268 |
5.78e-10 |
SMART |
|
Pfam:Recep_L_domain
|
358 |
478 |
5.5e-29 |
PFAM |
|
FU
|
493 |
544 |
6.45e-8 |
SMART |
|
FU
|
549 |
599 |
3.51e-9 |
SMART |
|
FU
|
611 |
659 |
2.32e0 |
SMART |
|
TyrKc
|
718 |
974 |
7.53e-133 |
SMART |
|
low complexity region
|
1007 |
1023 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000126682
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000153432
AA Change: S415G
PolyPhen 2
Score 0.020 (Sensitivity: 0.95; Specificity: 0.80)
|
| SMART Domains |
Protein: ENSMUSP00000115373
Gene: ENSMUSG00000062209
AA Change: S415G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Recep_L_domain
|
55 |
167 |
1.7e-34 |
PFAM |
|
FU
|
183 |
223 |
2.07e1 |
SMART |
|
FU
|
226 |
268 |
5.78e-10 |
SMART |
|
Pfam:Recep_L_domain
|
358 |
478 |
5.7e-29 |
PFAM |
|
FU
|
493 |
544 |
6.45e-8 |
SMART |
|
FU
|
549 |
599 |
3.51e-9 |
SMART |
|
FU
|
611 |
649 |
2.98e0 |
SMART |
|
PDB:2R4B|B
|
680 |
732 |
1e-25 |
PDB |
|
| Meta Mutation Damage Score |
0.1360 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.8%
- 20x: 93.9%
|
| Validation Efficiency |
98% (106/108) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for a targeted null mutation exhibit cardiac defects, alterations in hindbrain development, and midgestational lethality. Heterozygotes show schizophrenia-like behavior. Genetically rescued females show mammary defects. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(7) : Targeted(6) Gene trapped(1)
|
| Other mutations in this stock |
Total: 98 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1110032F04Rik |
T |
C |
3: 68,777,597 (GRCm39) |
V186A |
possibly damaging |
Het |
| 1700088E04Rik |
A |
T |
15: 79,019,409 (GRCm39) |
M198K |
probably damaging |
Het |
| 4933402J07Rik |
A |
G |
8: 88,294,601 (GRCm39) |
K84R |
probably null |
Het |
| Aamdc |
T |
C |
7: 97,199,773 (GRCm39) |
|
probably null |
Het |
| Abcc9 |
A |
G |
6: 142,617,282 (GRCm39) |
V594A |
probably damaging |
Het |
| Adamts13 |
G |
A |
2: 26,879,414 (GRCm39) |
D656N |
probably benign |
Het |
| Adcy10 |
G |
T |
1: 165,334,213 (GRCm39) |
C122F |
probably damaging |
Het |
| Adi1 |
A |
G |
12: 28,725,252 (GRCm39) |
M1V |
probably null |
Het |
| Ahnak |
G |
A |
19: 8,989,824 (GRCm39) |
|
probably benign |
Het |
| Akt1 |
G |
T |
12: 112,623,521 (GRCm39) |
P313Q |
probably damaging |
Het |
| Ano3 |
A |
T |
2: 110,498,067 (GRCm39) |
M758K |
probably damaging |
Het |
| Baz2a |
T |
A |
10: 127,958,999 (GRCm39) |
N1168K |
probably benign |
Het |
| Bbs10 |
A |
G |
10: 111,136,995 (GRCm39) |
K703E |
probably benign |
Het |
| Bcap29 |
A |
G |
12: 31,674,202 (GRCm39) |
I131T |
probably benign |
Het |
| Brd10 |
G |
T |
19: 29,694,616 (GRCm39) |
L1626I |
possibly damaging |
Het |
| Btnl6 |
T |
C |
17: 34,732,966 (GRCm39) |
D299G |
possibly damaging |
Het |
| Ccdc66 |
A |
G |
14: 27,222,524 (GRCm39) |
I73T |
probably benign |
Het |
| Cdh2 |
A |
G |
18: 16,760,754 (GRCm39) |
S538P |
probably benign |
Het |
| Cfap54 |
T |
A |
10: 92,803,390 (GRCm39) |
M1551L |
probably benign |
Het |
| Chd2 |
G |
A |
7: 73,151,873 (GRCm39) |
A243V |
probably damaging |
Het |
| Cntnap1 |
T |
A |
11: 101,073,845 (GRCm39) |
N665K |
probably damaging |
Het |
| Colgalt2 |
C |
T |
1: 152,360,749 (GRCm39) |
T262I |
possibly damaging |
Het |
| Cyp24a1 |
T |
C |
2: 170,338,098 (GRCm39) |
I149V |
probably benign |
Het |
| Cyp2a5 |
T |
A |
7: 26,534,970 (GRCm39) |
|
probably null |
Het |
| Dab2 |
A |
G |
15: 6,366,080 (GRCm39) |
|
probably null |
Het |
| Dnah17 |
T |
A |
11: 117,917,606 (GRCm39) |
I4158F |
probably damaging |
Het |
| Dnm2 |
G |
A |
9: 21,385,975 (GRCm39) |
|
probably null |
Het |
| Dpp7 |
A |
T |
2: 25,242,398 (GRCm39) |
|
probably benign |
Het |
| Epha6 |
T |
A |
16: 59,780,776 (GRCm39) |
I642F |
probably damaging |
Het |
| Fancd2 |
A |
G |
6: 113,530,683 (GRCm39) |
T439A |
probably benign |
Het |
| Fat1 |
G |
A |
8: 45,466,102 (GRCm39) |
V1431M |
possibly damaging |
Het |
| Fhod3 |
G |
A |
18: 25,223,305 (GRCm39) |
A884T |
probably benign |
Het |
| Fsip2 |
A |
G |
2: 82,820,515 (GRCm39) |
D5416G |
possibly damaging |
Het |
| Gabarap |
C |
T |
11: 69,882,678 (GRCm39) |
|
probably benign |
Het |
| Garre1 |
T |
C |
7: 33,938,333 (GRCm39) |
|
probably benign |
Het |
| Gm11544 |
C |
T |
11: 94,736,532 (GRCm39) |
|
noncoding transcript |
Het |
| Gnat2 |
A |
C |
3: 108,007,964 (GRCm39) |
K304Q |
probably benign |
Het |
| Gpr141b |
T |
A |
13: 19,913,840 (GRCm39) |
|
noncoding transcript |
Het |
| Gramd4 |
C |
T |
15: 86,019,057 (GRCm39) |
A575V |
probably benign |
Het |
| Gtpbp10 |
G |
A |
5: 5,589,295 (GRCm39) |
A274V |
possibly damaging |
Het |
| Gzmb |
A |
G |
14: 56,497,679 (GRCm39) |
I187T |
probably damaging |
Het |
| H2-M10.2 |
G |
A |
17: 36,595,219 (GRCm39) |
T315I |
probably damaging |
Het |
| Haus5 |
A |
T |
7: 30,356,452 (GRCm39) |
F524I |
probably damaging |
Het |
| Herc1 |
A |
G |
9: 66,403,253 (GRCm39) |
S4391G |
probably benign |
Het |
| Herc2 |
T |
A |
7: 55,748,165 (GRCm39) |
L511* |
probably null |
Het |
| Htt |
T |
A |
5: 34,982,184 (GRCm39) |
C923S |
probably benign |
Het |
| Idua |
T |
C |
5: 108,817,247 (GRCm39) |
S7P |
probably benign |
Het |
| Ighv16-1 |
A |
T |
12: 114,032,466 (GRCm39) |
L112Q |
probably damaging |
Het |
| Igkv1-110 |
A |
G |
6: 68,248,185 (GRCm39) |
K98R |
probably benign |
Het |
| Kif15 |
G |
A |
9: 122,831,191 (GRCm39) |
|
probably null |
Het |
| Leng9 |
C |
A |
7: 4,152,029 (GRCm39) |
G216W |
probably damaging |
Het |
| Lrpprc |
A |
G |
17: 85,014,584 (GRCm39) |
L1306S |
probably benign |
Het |
| Lztfl1 |
C |
A |
9: 123,544,454 (GRCm39) |
E20D |
possibly damaging |
Het |
| Maob |
T |
C |
X: 16,582,662 (GRCm39) |
T400A |
probably benign |
Het |
| Map3k4 |
C |
T |
17: 12,490,667 (GRCm39) |
E255K |
probably damaging |
Het |
| Megf9 |
G |
A |
4: 70,452,665 (GRCm39) |
T132M |
probably damaging |
Het |
| Mob4 |
T |
C |
1: 55,184,411 (GRCm39) |
|
probably benign |
Het |
| Mttp |
G |
A |
3: 137,821,811 (GRCm39) |
A252V |
probably benign |
Het |
| Mxi1 |
A |
G |
19: 53,358,745 (GRCm39) |
D226G |
probably damaging |
Het |
| Myh14 |
A |
G |
7: 44,274,566 (GRCm39) |
S1249P |
probably benign |
Het |
| Mylk |
G |
A |
16: 34,742,737 (GRCm39) |
G1083D |
probably benign |
Het |
| Mylk4 |
T |
G |
13: 32,905,960 (GRCm39) |
I408L |
probably benign |
Het |
| Nbas |
A |
G |
12: 13,533,740 (GRCm39) |
S1792G |
probably benign |
Het |
| Nelfb |
A |
G |
2: 25,099,981 (GRCm39) |
V212A |
probably damaging |
Het |
| Nisch |
T |
C |
14: 30,899,587 (GRCm39) |
|
probably benign |
Het |
| Nqo1 |
C |
G |
8: 108,115,477 (GRCm39) |
D267H |
probably benign |
Het |
| Or8u10 |
C |
A |
2: 85,915,190 (GRCm39) |
L310F |
probably benign |
Het |
| Pcid2 |
T |
A |
8: 13,135,425 (GRCm39) |
I195F |
probably damaging |
Het |
| Pcnx2 |
A |
T |
8: 126,478,927 (GRCm39) |
M2107K |
probably damaging |
Het |
| Pgd |
A |
T |
4: 149,241,048 (GRCm39) |
|
probably benign |
Het |
| Prim2 |
T |
C |
1: 33,503,145 (GRCm39) |
M430V |
probably benign |
Het |
| Prkaa1 |
A |
G |
15: 5,190,101 (GRCm39) |
T40A |
probably damaging |
Het |
| Ptges |
T |
C |
2: 30,793,232 (GRCm39) |
|
probably benign |
Het |
| Ptprn |
T |
C |
1: 75,234,909 (GRCm39) |
E226G |
probably benign |
Het |
| Rab14 |
A |
G |
2: 35,079,978 (GRCm39) |
F55S |
probably damaging |
Het |
| Ralgps2 |
A |
T |
1: 156,684,637 (GRCm39) |
|
probably benign |
Het |
| Rgs11 |
C |
T |
17: 26,426,542 (GRCm39) |
H258Y |
probably benign |
Het |
| Rhpn2 |
T |
C |
7: 35,075,774 (GRCm39) |
|
probably null |
Het |
| Rprd2 |
A |
T |
3: 95,681,483 (GRCm39) |
V452E |
probably damaging |
Het |
| Scube3 |
C |
A |
17: 28,384,989 (GRCm39) |
H646Q |
probably damaging |
Het |
| Selp |
A |
T |
1: 163,953,909 (GRCm39) |
I70F |
probably damaging |
Het |
| Septin2 |
A |
G |
1: 93,426,849 (GRCm39) |
I153V |
probably damaging |
Het |
| Sh3rf3 |
G |
A |
10: 58,649,905 (GRCm39) |
S170N |
probably benign |
Het |
| Skint4 |
A |
T |
4: 112,000,963 (GRCm39) |
I353F |
possibly damaging |
Het |
| Slc16a12 |
A |
G |
19: 34,657,780 (GRCm39) |
I41T |
possibly damaging |
Het |
| Snai2 |
T |
C |
16: 14,524,881 (GRCm39) |
F129S |
probably damaging |
Het |
| Top3b |
C |
T |
16: 16,708,526 (GRCm39) |
R629* |
probably null |
Het |
| Trim17 |
T |
A |
11: 58,862,270 (GRCm39) |
V434E |
probably damaging |
Het |
| Ttn |
G |
A |
2: 76,615,327 (GRCm39) |
P15051L |
probably damaging |
Het |
| Uggt2 |
A |
T |
14: 119,239,259 (GRCm39) |
I1391N |
probably damaging |
Het |
| Usp8 |
A |
T |
2: 126,596,958 (GRCm39) |
M923L |
probably damaging |
Het |
| Vmn1r176 |
T |
C |
7: 23,534,463 (GRCm39) |
H230R |
possibly damaging |
Het |
| Vmn1r217 |
C |
A |
13: 23,298,159 (GRCm39) |
D248Y |
probably damaging |
Het |
| Vmn2r14 |
A |
T |
5: 109,363,976 (GRCm39) |
C647S |
probably damaging |
Het |
| Vwa5b1 |
A |
G |
4: 138,332,851 (GRCm39) |
I237T |
probably damaging |
Het |
| Zan |
T |
A |
5: 137,391,423 (GRCm39) |
D4687V |
unknown |
Het |
| Zfp273 |
T |
C |
13: 67,973,484 (GRCm39) |
V204A |
probably benign |
Het |
| Zfp956 |
T |
G |
6: 47,928,987 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Erbb4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00965:Erbb4
|
APN |
1 |
68,110,789 (GRCm39) |
nonsense |
probably null |
|
|
IGL01020:Erbb4
|
APN |
1 |
68,337,608 (GRCm39) |
splice site |
probably benign |
|
|
IGL01349:Erbb4
|
APN |
1 |
68,385,752 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01386:Erbb4
|
APN |
1 |
68,383,090 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01516:Erbb4
|
APN |
1 |
68,367,404 (GRCm39) |
nonsense |
probably null |
|
|
IGL01536:Erbb4
|
APN |
1 |
68,329,441 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01721:Erbb4
|
APN |
1 |
68,293,722 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
IGL01832:Erbb4
|
APN |
1 |
68,293,725 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL02002:Erbb4
|
APN |
1 |
68,119,885 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02040:Erbb4
|
APN |
1 |
68,081,694 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02371:Erbb4
|
APN |
1 |
68,329,453 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02399:Erbb4
|
APN |
1 |
68,081,596 (GRCm39) |
splice site |
probably benign |
|
|
IGL02553:Erbb4
|
APN |
1 |
68,345,023 (GRCm39) |
missense |
probably benign |
0.17 |
|
IGL03118:Erbb4
|
APN |
1 |
68,081,878 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL03329:Erbb4
|
APN |
1 |
68,367,281 (GRCm39) |
missense |
probably benign |
0.30 |
|
IGL03405:Erbb4
|
APN |
1 |
68,369,397 (GRCm39) |
missense |
probably benign |
0.02 |
|
earthworm
|
UTSW |
1 |
68,289,739 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
excrescence
|
UTSW |
1 |
68,369,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Mole
|
UTSW |
1 |
68,599,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
P0018:Erbb4
|
UTSW |
1 |
68,110,835 (GRCm39) |
missense |
probably benign |
0.05 |
|
PIT4480001:Erbb4
|
UTSW |
1 |
68,114,702 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0193:Erbb4
|
UTSW |
1 |
68,083,119 (GRCm39) |
intron |
probably benign |
|
|
R0329:Erbb4
|
UTSW |
1 |
68,337,439 (GRCm39) |
splice site |
probably benign |
|
|
R0335:Erbb4
|
UTSW |
1 |
68,298,418 (GRCm39) |
missense |
probably benign |
|
|
R0362:Erbb4
|
UTSW |
1 |
68,369,429 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0579:Erbb4
|
UTSW |
1 |
68,081,621 (GRCm39) |
missense |
probably benign |
0.17 |
|
R0730:Erbb4
|
UTSW |
1 |
68,298,449 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1029:Erbb4
|
UTSW |
1 |
68,348,773 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1444:Erbb4
|
UTSW |
1 |
68,293,759 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1469:Erbb4
|
UTSW |
1 |
68,599,841 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1469:Erbb4
|
UTSW |
1 |
68,599,841 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1503:Erbb4
|
UTSW |
1 |
68,385,705 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1523:Erbb4
|
UTSW |
1 |
68,435,411 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1528:Erbb4
|
UTSW |
1 |
68,117,741 (GRCm39) |
nonsense |
probably null |
|
|
R1604:Erbb4
|
UTSW |
1 |
68,385,728 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R1611:Erbb4
|
UTSW |
1 |
68,079,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1642:Erbb4
|
UTSW |
1 |
68,370,393 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1905:Erbb4
|
UTSW |
1 |
68,114,569 (GRCm39) |
splice site |
probably benign |
|
|
R1929:Erbb4
|
UTSW |
1 |
68,238,047 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2046:Erbb4
|
UTSW |
1 |
68,337,482 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2139:Erbb4
|
UTSW |
1 |
68,385,788 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2271:Erbb4
|
UTSW |
1 |
68,238,047 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2298:Erbb4
|
UTSW |
1 |
68,081,690 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2356:Erbb4
|
UTSW |
1 |
68,117,755 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3821:Erbb4
|
UTSW |
1 |
68,345,072 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4007:Erbb4
|
UTSW |
1 |
68,779,560 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4012:Erbb4
|
UTSW |
1 |
68,599,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4077:Erbb4
|
UTSW |
1 |
68,079,496 (GRCm39) |
missense |
probably benign |
0.07 |
|
R4196:Erbb4
|
UTSW |
1 |
68,383,014 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R4536:Erbb4
|
UTSW |
1 |
68,385,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4561:Erbb4
|
UTSW |
1 |
68,383,080 (GRCm39) |
nonsense |
probably null |
|
|
R4642:Erbb4
|
UTSW |
1 |
68,289,791 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4737:Erbb4
|
UTSW |
1 |
68,383,059 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4739:Erbb4
|
UTSW |
1 |
68,383,059 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4780:Erbb4
|
UTSW |
1 |
68,337,473 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4801:Erbb4
|
UTSW |
1 |
68,369,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4802:Erbb4
|
UTSW |
1 |
68,369,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4811:Erbb4
|
UTSW |
1 |
68,293,703 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5068:Erbb4
|
UTSW |
1 |
68,083,061 (GRCm39) |
splice site |
probably null |
|
|
R5546:Erbb4
|
UTSW |
1 |
68,337,452 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5755:Erbb4
|
UTSW |
1 |
68,599,678 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R6189:Erbb4
|
UTSW |
1 |
68,083,075 (GRCm39) |
missense |
probably benign |
|
|
R6257:Erbb4
|
UTSW |
1 |
68,435,432 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6276:Erbb4
|
UTSW |
1 |
68,599,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6521:Erbb4
|
UTSW |
1 |
68,081,689 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6602:Erbb4
|
UTSW |
1 |
68,409,662 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6808:Erbb4
|
UTSW |
1 |
68,079,462 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7087:Erbb4
|
UTSW |
1 |
68,779,650 (GRCm39) |
missense |
probably null |
1.00 |
|
R7215:Erbb4
|
UTSW |
1 |
68,378,619 (GRCm39) |
missense |
probably benign |
|
|
R7356:Erbb4
|
UTSW |
1 |
68,378,514 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7509:Erbb4
|
UTSW |
1 |
68,289,739 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R7593:Erbb4
|
UTSW |
1 |
68,293,758 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7743:Erbb4
|
UTSW |
1 |
68,367,278 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7784:Erbb4
|
UTSW |
1 |
68,114,658 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7815:Erbb4
|
UTSW |
1 |
68,081,885 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7923:Erbb4
|
UTSW |
1 |
68,298,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8071:Erbb4
|
UTSW |
1 |
68,435,470 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8288:Erbb4
|
UTSW |
1 |
68,337,509 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8356:Erbb4
|
UTSW |
1 |
68,110,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8456:Erbb4
|
UTSW |
1 |
68,110,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8464:Erbb4
|
UTSW |
1 |
68,348,785 (GRCm39) |
missense |
probably benign |
|
|
R8783:Erbb4
|
UTSW |
1 |
68,079,331 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8830:Erbb4
|
UTSW |
1 |
68,114,627 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8881:Erbb4
|
UTSW |
1 |
68,382,997 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9053:Erbb4
|
UTSW |
1 |
68,289,779 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R9142:Erbb4
|
UTSW |
1 |
68,388,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9237:Erbb4
|
UTSW |
1 |
68,081,601 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R9350:Erbb4
|
UTSW |
1 |
68,329,638 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9374:Erbb4
|
UTSW |
1 |
68,779,642 (GRCm39) |
nonsense |
probably null |
|
|
R9434:Erbb4
|
UTSW |
1 |
68,081,773 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R9499:Erbb4
|
UTSW |
1 |
68,779,642 (GRCm39) |
nonsense |
probably null |
|
|
R9551:Erbb4
|
UTSW |
1 |
68,779,642 (GRCm39) |
nonsense |
probably null |
|
|
R9753:Erbb4
|
UTSW |
1 |
68,238,062 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0019:Erbb4
|
UTSW |
1 |
68,112,304 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Erbb4
|
UTSW |
1 |
68,367,418 (GRCm39) |
nonsense |
probably null |
|
|
Z1176:Erbb4
|
UTSW |
1 |
68,337,561 (GRCm39) |
frame shift |
probably null |
|
|
Z1177:Erbb4
|
UTSW |
1 |
68,348,802 (GRCm39) |
missense |
probably benign |
0.06 |
|
Z1177:Erbb4
|
UTSW |
1 |
68,329,635 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Erbb4
|
UTSW |
1 |
68,298,342 (GRCm39) |
frame shift |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TTTCAGGAGGCTCATCTTCAG -3'
(R):5'- AAAACATGGATTCTTGGTGTCGC -3'
Sequencing Primer
(F):5'- GGAGGCTCATCTTCAGAATTAATCAG -3'
(R):5'- CTTGGTGTCGCTCTTTAATAATA -3'
|
| Posted On |
2016-03-01 |
Incidental Mutation