Incidental Mutation 'R4832:Zfp956'
ID 372898
Institutional Source Beutler Lab
Gene Symbol Zfp956
Ensembl Gene ENSMUSG00000045466
Gene Name zinc finger protein 956
Synonyms AI894139
MMRRC Submission 042448-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.103) question?
Stock # R4832 (G1)
Quality Score 197
Status Validated
Chromosome 6
Chromosomal Location 47930324-47942234 bp(+) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) T to G at 47928987 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000114227 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000101445] [ENSMUST00000140719]
AlphaFold Q3UZY6
Predicted Effect noncoding transcript
Transcript: ENSMUST00000095946
Predicted Effect probably benign
Transcript: ENSMUST00000101445
SMART Domains Protein: ENSMUSP00000098989
Gene: ENSMUSG00000045466

DomainStartEndE-ValueType
Pfam:DUF3669 39 99 2.1e-9 PFAM
KRAB 129 191 2.4e-1 SMART
ZnF_C2H2 325 347 2.24e-3 SMART
ZnF_C2H2 353 375 2.09e-3 SMART
ZnF_C2H2 381 403 6.78e-3 SMART
ZnF_C2H2 409 431 2.57e-3 SMART
ZnF_C2H2 437 459 3.16e-3 SMART
ZnF_C2H2 465 487 3.58e-2 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000114588
Predicted Effect noncoding transcript
Transcript: ENSMUST00000130463
Predicted Effect noncoding transcript
Transcript: ENSMUST00000130490
Predicted Effect noncoding transcript
Transcript: ENSMUST00000132381
Predicted Effect noncoding transcript
Transcript: ENSMUST00000154259
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156767
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212438
Predicted Effect noncoding transcript
Transcript: ENSMUST00000174790
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144782
Predicted Effect noncoding transcript
Transcript: ENSMUST00000173129
Predicted Effect noncoding transcript
Transcript: ENSMUST00000135828
Predicted Effect probably benign
Transcript: ENSMUST00000140719
SMART Domains Protein: ENSMUSP00000114227
Gene: ENSMUSG00000045466

DomainStartEndE-ValueType
Pfam:DUF3669 22 101 2.4e-16 PFAM
Blast:KRAB 129 179 2e-20 BLAST
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 93.9%
Validation Efficiency 98% (106/108)
Allele List at MGI
Other mutations in this stock
Total: 98 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110032F04Rik T C 3: 68,777,597 (GRCm39) V186A possibly damaging Het
1700088E04Rik A T 15: 79,019,409 (GRCm39) M198K probably damaging Het
4933402J07Rik A G 8: 88,294,601 (GRCm39) K84R probably null Het
Aamdc T C 7: 97,199,773 (GRCm39) probably null Het
Abcc9 A G 6: 142,617,282 (GRCm39) V594A probably damaging Het
Adamts13 G A 2: 26,879,414 (GRCm39) D656N probably benign Het
Adcy10 G T 1: 165,334,213 (GRCm39) C122F probably damaging Het
Adi1 A G 12: 28,725,252 (GRCm39) M1V probably null Het
Ahnak G A 19: 8,989,824 (GRCm39) probably benign Het
Akt1 G T 12: 112,623,521 (GRCm39) P313Q probably damaging Het
Ano3 A T 2: 110,498,067 (GRCm39) M758K probably damaging Het
Baz2a T A 10: 127,958,999 (GRCm39) N1168K probably benign Het
Bbs10 A G 10: 111,136,995 (GRCm39) K703E probably benign Het
Bcap29 A G 12: 31,674,202 (GRCm39) I131T probably benign Het
Brd10 G T 19: 29,694,616 (GRCm39) L1626I possibly damaging Het
Btnl6 T C 17: 34,732,966 (GRCm39) D299G possibly damaging Het
Ccdc66 A G 14: 27,222,524 (GRCm39) I73T probably benign Het
Cdh2 A G 18: 16,760,754 (GRCm39) S538P probably benign Het
Cfap54 T A 10: 92,803,390 (GRCm39) M1551L probably benign Het
Chd2 G A 7: 73,151,873 (GRCm39) A243V probably damaging Het
Cntnap1 T A 11: 101,073,845 (GRCm39) N665K probably damaging Het
Colgalt2 C T 1: 152,360,749 (GRCm39) T262I possibly damaging Het
Cyp24a1 T C 2: 170,338,098 (GRCm39) I149V probably benign Het
Cyp2a5 T A 7: 26,534,970 (GRCm39) probably null Het
Dab2 A G 15: 6,366,080 (GRCm39) probably null Het
Dnah17 T A 11: 117,917,606 (GRCm39) I4158F probably damaging Het
Dnm2 G A 9: 21,385,975 (GRCm39) probably null Het
Dpp7 A T 2: 25,242,398 (GRCm39) probably benign Het
Epha6 T A 16: 59,780,776 (GRCm39) I642F probably damaging Het
Erbb4 T C 1: 68,369,397 (GRCm39) S415G probably benign Het
Fancd2 A G 6: 113,530,683 (GRCm39) T439A probably benign Het
Fat1 G A 8: 45,466,102 (GRCm39) V1431M possibly damaging Het
Fhod3 G A 18: 25,223,305 (GRCm39) A884T probably benign Het
Fsip2 A G 2: 82,820,515 (GRCm39) D5416G possibly damaging Het
Gabarap C T 11: 69,882,678 (GRCm39) probably benign Het
Garre1 T C 7: 33,938,333 (GRCm39) probably benign Het
Gm11544 C T 11: 94,736,532 (GRCm39) noncoding transcript Het
Gnat2 A C 3: 108,007,964 (GRCm39) K304Q probably benign Het
Gpr141b T A 13: 19,913,840 (GRCm39) noncoding transcript Het
Gramd4 C T 15: 86,019,057 (GRCm39) A575V probably benign Het
Gtpbp10 G A 5: 5,589,295 (GRCm39) A274V possibly damaging Het
Gzmb A G 14: 56,497,679 (GRCm39) I187T probably damaging Het
H2-M10.2 G A 17: 36,595,219 (GRCm39) T315I probably damaging Het
Haus5 A T 7: 30,356,452 (GRCm39) F524I probably damaging Het
Herc1 A G 9: 66,403,253 (GRCm39) S4391G probably benign Het
Herc2 T A 7: 55,748,165 (GRCm39) L511* probably null Het
Htt T A 5: 34,982,184 (GRCm39) C923S probably benign Het
Idua T C 5: 108,817,247 (GRCm39) S7P probably benign Het
Ighv16-1 A T 12: 114,032,466 (GRCm39) L112Q probably damaging Het
Igkv1-110 A G 6: 68,248,185 (GRCm39) K98R probably benign Het
Kif15 G A 9: 122,831,191 (GRCm39) probably null Het
Leng9 C A 7: 4,152,029 (GRCm39) G216W probably damaging Het
Lrpprc A G 17: 85,014,584 (GRCm39) L1306S probably benign Het
Lztfl1 C A 9: 123,544,454 (GRCm39) E20D possibly damaging Het
Maob T C X: 16,582,662 (GRCm39) T400A probably benign Het
Map3k4 C T 17: 12,490,667 (GRCm39) E255K probably damaging Het
Megf9 G A 4: 70,452,665 (GRCm39) T132M probably damaging Het
Mob4 T C 1: 55,184,411 (GRCm39) probably benign Het
Mttp G A 3: 137,821,811 (GRCm39) A252V probably benign Het
Mxi1 A G 19: 53,358,745 (GRCm39) D226G probably damaging Het
Myh14 A G 7: 44,274,566 (GRCm39) S1249P probably benign Het
Mylk G A 16: 34,742,737 (GRCm39) G1083D probably benign Het
Mylk4 T G 13: 32,905,960 (GRCm39) I408L probably benign Het
Nbas A G 12: 13,533,740 (GRCm39) S1792G probably benign Het
Nelfb A G 2: 25,099,981 (GRCm39) V212A probably damaging Het
Nisch T C 14: 30,899,587 (GRCm39) probably benign Het
Nqo1 C G 8: 108,115,477 (GRCm39) D267H probably benign Het
Or8u10 C A 2: 85,915,190 (GRCm39) L310F probably benign Het
Pcid2 T A 8: 13,135,425 (GRCm39) I195F probably damaging Het
Pcnx2 A T 8: 126,478,927 (GRCm39) M2107K probably damaging Het
Pgd A T 4: 149,241,048 (GRCm39) probably benign Het
Prim2 T C 1: 33,503,145 (GRCm39) M430V probably benign Het
Prkaa1 A G 15: 5,190,101 (GRCm39) T40A probably damaging Het
Ptges T C 2: 30,793,232 (GRCm39) probably benign Het
Ptprn T C 1: 75,234,909 (GRCm39) E226G probably benign Het
Rab14 A G 2: 35,079,978 (GRCm39) F55S probably damaging Het
Ralgps2 A T 1: 156,684,637 (GRCm39) probably benign Het
Rgs11 C T 17: 26,426,542 (GRCm39) H258Y probably benign Het
Rhpn2 T C 7: 35,075,774 (GRCm39) probably null Het
Rprd2 A T 3: 95,681,483 (GRCm39) V452E probably damaging Het
Scube3 C A 17: 28,384,989 (GRCm39) H646Q probably damaging Het
Selp A T 1: 163,953,909 (GRCm39) I70F probably damaging Het
Septin2 A G 1: 93,426,849 (GRCm39) I153V probably damaging Het
Sh3rf3 G A 10: 58,649,905 (GRCm39) S170N probably benign Het
Skint4 A T 4: 112,000,963 (GRCm39) I353F possibly damaging Het
Slc16a12 A G 19: 34,657,780 (GRCm39) I41T possibly damaging Het
Snai2 T C 16: 14,524,881 (GRCm39) F129S probably damaging Het
Top3b C T 16: 16,708,526 (GRCm39) R629* probably null Het
Trim17 T A 11: 58,862,270 (GRCm39) V434E probably damaging Het
Ttn G A 2: 76,615,327 (GRCm39) P15051L probably damaging Het
Uggt2 A T 14: 119,239,259 (GRCm39) I1391N probably damaging Het
Usp8 A T 2: 126,596,958 (GRCm39) M923L probably damaging Het
Vmn1r176 T C 7: 23,534,463 (GRCm39) H230R possibly damaging Het
Vmn1r217 C A 13: 23,298,159 (GRCm39) D248Y probably damaging Het
Vmn2r14 A T 5: 109,363,976 (GRCm39) C647S probably damaging Het
Vwa5b1 A G 4: 138,332,851 (GRCm39) I237T probably damaging Het
Zan T A 5: 137,391,423 (GRCm39) D4687V unknown Het
Zfp273 T C 13: 67,973,484 (GRCm39) V204A probably benign Het
Other mutations in Zfp956
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01110:Zfp956 APN 6 47,940,346 (GRCm39) missense probably benign 0.28
ANU74:Zfp956 UTSW 6 47,940,507 (GRCm39) missense probably benign 0.00
R0603:Zfp956 UTSW 6 47,932,962 (GRCm39) missense probably damaging 1.00
R1243:Zfp956 UTSW 6 47,932,985 (GRCm39) missense probably damaging 0.98
R1879:Zfp956 UTSW 6 47,940,678 (GRCm39) missense probably benign 0.19
R1999:Zfp956 UTSW 6 47,940,805 (GRCm39) missense probably damaging 1.00
R2106:Zfp956 UTSW 6 47,941,359 (GRCm39) makesense probably null
R2150:Zfp956 UTSW 6 47,940,805 (GRCm39) missense probably damaging 1.00
R4737:Zfp956 UTSW 6 47,939,476 (GRCm39) missense probably damaging 0.99
R4740:Zfp956 UTSW 6 47,939,476 (GRCm39) missense probably damaging 0.99
R4751:Zfp956 UTSW 6 47,940,510 (GRCm39) missense probably benign 0.00
R5325:Zfp956 UTSW 6 47,928,012 (GRCm39) unclassified probably benign
R5523:Zfp956 UTSW 6 47,930,455 (GRCm39) start gained probably benign
R6842:Zfp956 UTSW 6 47,940,763 (GRCm39) missense possibly damaging 0.47
R7131:Zfp956 UTSW 6 47,932,781 (GRCm39) missense probably benign 0.00
R7367:Zfp956 UTSW 6 47,940,853 (GRCm39) missense probably damaging 1.00
R8806:Zfp956 UTSW 6 47,933,042 (GRCm39) missense probably benign 0.00
R9074:Zfp956 UTSW 6 47,939,462 (GRCm39) missense possibly damaging 0.67
R9248:Zfp956 UTSW 6 47,934,437 (GRCm39) missense possibly damaging 0.92
R9452:Zfp956 UTSW 6 47,940,370 (GRCm39) missense probably benign
R9464:Zfp956 UTSW 6 47,941,041 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCACTCCTTTCAGCAACAGAAGAG -3'
(R):5'- CTTGTGCTTTTGAAGGGCCC -3'

Sequencing Primer
(F):5'- CTTTCAGCAACAGAAGAGCCTGG -3'
(R):5'- GCTTTTGAAGGGCCCCTAAAGTAC -3'
Posted On 2016-03-01