Incidental Mutation 'R4835:Myt1'
| ID |
373132 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Myt1
|
| Ensembl Gene |
ENSMUSG00000010505 |
| Gene Name |
myelin transcription factor 1 |
| Synonyms |
NZF-2b, NZF-2a, Nztf2, Nzf2 |
| MMRRC Submission |
042450-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R4835 (G1)
|
| Quality Score |
111 |
|
Status
|
Validated
|
| Chromosome |
2 |
| Chromosomal Location |
181405125-181469590 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 181439255 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Glycine
at position 259
(E259G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000104388
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000081125]
[ENSMUST00000108756]
[ENSMUST00000108757]
[ENSMUST00000183403]
|
| AlphaFold |
Q8CFC2 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000081125
AA Change: E301G
PolyPhen 2
Score 0.692 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000079900
Gene: ENSMUSG00000010505
AA Change: E301G
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:zf-C2HC
|
71 |
99 |
8.7e-16 |
PFAM |
|
low complexity region
|
155 |
160 |
N/A |
INTRINSIC |
|
low complexity region
|
185 |
201 |
N/A |
INTRINSIC |
|
coiled coil region
|
300 |
354 |
N/A |
INTRINSIC |
|
low complexity region
|
388 |
405 |
N/A |
INTRINSIC |
|
Pfam:zf-C2HC
|
485 |
512 |
2.9e-14 |
PFAM |
|
Pfam:zf-C2HC
|
529 |
557 |
4.3e-16 |
PFAM |
|
Pfam:MYT1
|
604 |
660 |
2e-28 |
PFAM |
|
Pfam:MYT1
|
659 |
835 |
2.3e-56 |
PFAM |
|
Pfam:zf-C2HC
|
843 |
871 |
2e-18 |
PFAM |
|
Pfam:zf-C2HC
|
887 |
915 |
1.9e-18 |
PFAM |
|
Pfam:zf-C2HC
|
936 |
964 |
2.1e-16 |
PFAM |
|
Pfam:zf-C2HC
|
989 |
1017 |
8.4e-16 |
PFAM |
|
coiled coil region
|
1037 |
1109 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000108756
AA Change: E259G
PolyPhen 2
Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000104387
Gene: ENSMUSG00000010505
AA Change: E259G
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:zf-C2HC
|
27 |
57 |
5.1e-18 |
PFAM |
|
low complexity region
|
113 |
118 |
N/A |
INTRINSIC |
|
low complexity region
|
143 |
159 |
N/A |
INTRINSIC |
|
coiled coil region
|
258 |
312 |
N/A |
INTRINSIC |
|
low complexity region
|
346 |
363 |
N/A |
INTRINSIC |
|
Pfam:zf-C2HC
|
441 |
471 |
5e-17 |
PFAM |
|
Pfam:zf-C2HC
|
485 |
515 |
3.1e-18 |
PFAM |
|
Pfam:MYT1
|
562 |
618 |
2.4e-32 |
PFAM |
|
Pfam:MYT1
|
617 |
794 |
2e-74 |
PFAM |
|
Pfam:zf-C2HC
|
799 |
829 |
1.9e-19 |
PFAM |
|
Pfam:zf-C2HC
|
843 |
873 |
9.7e-20 |
PFAM |
|
Pfam:zf-C2HC
|
892 |
922 |
2.2e-18 |
PFAM |
|
Pfam:zf-C2HC
|
945 |
975 |
1.7e-16 |
PFAM |
|
coiled coil region
|
995 |
1067 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000108757
AA Change: E259G
PolyPhen 2
Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000104388
Gene: ENSMUSG00000010505
AA Change: E259G
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:zf-C2HC
|
27 |
57 |
1e-17 |
PFAM |
|
low complexity region
|
113 |
118 |
N/A |
INTRINSIC |
|
low complexity region
|
143 |
159 |
N/A |
INTRINSIC |
|
coiled coil region
|
258 |
312 |
N/A |
INTRINSIC |
|
low complexity region
|
346 |
363 |
N/A |
INTRINSIC |
|
Pfam:zf-C2HC
|
441 |
471 |
1e-16 |
PFAM |
|
Pfam:zf-C2HC
|
485 |
510 |
6.2e-12 |
PFAM |
|
Pfam:MYT1
|
524 |
580 |
2.7e-32 |
PFAM |
|
Pfam:MYT1
|
579 |
756 |
2.3e-74 |
PFAM |
|
Pfam:zf-C2HC
|
761 |
791 |
3.8e-19 |
PFAM |
|
Pfam:zf-C2HC
|
805 |
835 |
1.9e-19 |
PFAM |
|
Pfam:zf-C2HC
|
854 |
884 |
4.3e-18 |
PFAM |
|
Pfam:zf-C2HC
|
907 |
937 |
3.3e-16 |
PFAM |
|
coiled coil region
|
957 |
1029 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000129843
|
| SMART Domains |
Protein: ENSMUSP00000115697
Gene: ENSMUSG00000010505
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
50 |
67 |
N/A |
INTRINSIC |
|
Pfam:zf-C2HC
|
147 |
174 |
6.2e-15 |
PFAM |
|
Pfam:zf-C2HC
|
191 |
219 |
9.2e-17 |
PFAM |
|
Pfam:MYT1
|
266 |
322 |
7.3e-29 |
PFAM |
|
Pfam:MYT1
|
321 |
497 |
7.2e-57 |
PFAM |
|
Pfam:zf-C2HC
|
505 |
533 |
9.6e-19 |
PFAM |
|
Pfam:zf-C2HC
|
554 |
582 |
4.4e-17 |
PFAM |
|
Pfam:zf-C2HC
|
607 |
635 |
1.8e-16 |
PFAM |
|
coiled coil region
|
654 |
726 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000129856
|
| SMART Domains |
Protein: ENSMUSP00000122011
Gene: ENSMUSG00000010505
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:zf-C2HC
|
63 |
91 |
1.4e-16 |
PFAM |
|
low complexity region
|
147 |
152 |
N/A |
INTRINSIC |
|
Pfam:zf-C2HC
|
177 |
204 |
4.6e-15 |
PFAM |
|
Pfam:zf-C2HC
|
221 |
249 |
6.7e-17 |
PFAM |
|
Pfam:MYT1
|
296 |
352 |
5.2e-29 |
PFAM |
|
Pfam:MYT1
|
351 |
527 |
4.5e-57 |
PFAM |
|
Pfam:zf-C2HC
|
535 |
556 |
1.4e-13 |
PFAM |
|
Pfam:zf-C2HC
|
556 |
584 |
3.5e-19 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000130079
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000142245
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000156190
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000183403
|
| Meta Mutation Damage Score |
0.0965 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.8%
- 20x: 93.8%
|
| Validation Efficiency |
98% (96/98) |
| MGI Phenotype |
FUNCTION: This gene is a member of the myelin transcription factor 1 gene family. The encoded protein, a zinc finger DNA-binding protein, is involved in regulation of oligodendrocyte differentiation and proliferation in the developing central nervous system. The gene product has a role in remyelination through regeneration of oligodendrocyte lineage cells in response to demyelination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]
PHENOTYPE: Mice homozygous for a knock-out allele die shortly after birth displaying improper diaphragm innervation and a failture to initiate breathing; mutant embryonic pancreata contain abnormal islet cells that express multiple hormones. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 91 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930432E11Rik |
A |
T |
7: 29,274,326 (GRCm39) |
|
noncoding transcript |
Het |
| 4933434E20Rik |
A |
G |
3: 89,970,516 (GRCm39) |
N17D |
probably benign |
Het |
| A1bg |
T |
C |
15: 60,792,100 (GRCm39) |
D176G |
probably benign |
Het |
| Abcg5 |
A |
T |
17: 84,966,076 (GRCm39) |
M428K |
possibly damaging |
Het |
| Adam1a |
A |
T |
5: 121,657,752 (GRCm39) |
C514S |
probably damaging |
Het |
| Angptl3 |
A |
G |
4: 98,925,649 (GRCm39) |
Q325R |
probably benign |
Het |
| Ankrd26 |
C |
T |
6: 118,525,811 (GRCm39) |
W378* |
probably null |
Het |
| Apob |
T |
C |
12: 8,065,391 (GRCm39) |
V4087A |
possibly damaging |
Het |
| Auts2 |
A |
G |
5: 131,494,931 (GRCm39) |
I117T |
probably damaging |
Het |
| AW146154 |
T |
A |
7: 41,129,892 (GRCm39) |
E408V |
probably damaging |
Het |
| Bicd1 |
A |
T |
6: 149,385,588 (GRCm39) |
N107I |
probably benign |
Het |
| Blm |
T |
C |
7: 80,159,294 (GRCm39) |
S281G |
probably benign |
Het |
| Btaf1 |
T |
A |
19: 36,979,858 (GRCm39) |
D1542E |
probably benign |
Het |
| C2cd2l |
A |
G |
9: 44,226,442 (GRCm39) |
|
probably null |
Het |
| Capn8 |
C |
A |
1: 182,432,116 (GRCm39) |
N362K |
probably damaging |
Het |
| Ccdc14 |
T |
G |
16: 34,525,408 (GRCm39) |
S186A |
probably damaging |
Het |
| Cdca4 |
A |
G |
12: 112,785,167 (GRCm39) |
L187P |
probably damaging |
Het |
| Chil6 |
T |
A |
3: 106,313,290 (GRCm39) |
K20* |
probably null |
Het |
| Cmss1 |
A |
T |
16: 57,136,545 (GRCm39) |
L109* |
probably null |
Het |
| Cmtm6 |
G |
T |
9: 114,560,410 (GRCm39) |
W36L |
probably benign |
Het |
| Cnksr3 |
T |
G |
10: 7,110,757 (GRCm39) |
I35L |
possibly damaging |
Het |
| Col4a2 |
G |
T |
8: 11,473,570 (GRCm39) |
G534* |
probably null |
Het |
| Col5a1 |
T |
G |
2: 27,915,656 (GRCm39) |
V180G |
probably damaging |
Het |
| Ctnna3 |
T |
C |
10: 63,417,723 (GRCm39) |
F154L |
probably benign |
Het |
| Fabp7 |
G |
A |
10: 57,661,676 (GRCm39) |
V50M |
possibly damaging |
Het |
| Fam170a |
T |
A |
18: 50,415,050 (GRCm39) |
V232D |
probably damaging |
Het |
| Fam186a |
T |
G |
15: 99,843,689 (GRCm39) |
T852P |
unknown |
Het |
| Fam20a |
T |
C |
11: 109,564,389 (GRCm39) |
I455V |
probably benign |
Het |
| Fbxl6 |
C |
T |
15: 76,421,004 (GRCm39) |
V324M |
probably damaging |
Het |
| Galnt18 |
T |
C |
7: 111,378,730 (GRCm39) |
T9A |
probably damaging |
Het |
| Golgb1 |
T |
A |
16: 36,711,769 (GRCm39) |
M191K |
possibly damaging |
Het |
| Gpld1 |
A |
G |
13: 25,166,699 (GRCm39) |
T650A |
probably benign |
Het |
| Gprc5d |
A |
G |
6: 135,093,515 (GRCm39) |
F131L |
probably benign |
Het |
| H2az2 |
C |
T |
11: 6,389,437 (GRCm39) |
G7E |
unknown |
Het |
| Haus4 |
A |
T |
14: 54,783,292 (GRCm39) |
|
probably null |
Het |
| Helq |
A |
G |
5: 100,922,029 (GRCm39) |
I725T |
possibly damaging |
Het |
| Igsf23 |
T |
A |
7: 19,675,755 (GRCm39) |
D117V |
possibly damaging |
Het |
| Kiz |
A |
T |
2: 146,784,008 (GRCm39) |
S514C |
probably damaging |
Het |
| Klhl6 |
A |
T |
16: 19,775,783 (GRCm39) |
N258K |
probably benign |
Het |
| Krt72 |
G |
C |
15: 101,689,508 (GRCm39) |
|
probably null |
Het |
| Large1 |
A |
T |
8: 73,774,975 (GRCm39) |
I245N |
probably damaging |
Het |
| Lrrc31 |
T |
C |
3: 30,733,306 (GRCm39) |
I469M |
probably damaging |
Het |
| Lypd4 |
T |
A |
7: 24,566,121 (GRCm39) |
I68F |
probably benign |
Het |
| Mast1 |
A |
G |
8: 85,650,408 (GRCm39) |
S442P |
probably damaging |
Het |
| Mmp20 |
T |
A |
9: 7,645,300 (GRCm39) |
H283Q |
probably benign |
Het |
| Mrps5 |
G |
A |
2: 127,445,627 (GRCm39) |
V385M |
possibly damaging |
Het |
| Ms4a15 |
T |
C |
19: 10,956,590 (GRCm39) |
K241E |
possibly damaging |
Het |
| Myt1l |
C |
A |
12: 29,945,304 (GRCm39) |
T1023K |
unknown |
Het |
| Ncapd3 |
T |
C |
9: 26,997,342 (GRCm39) |
L1221P |
probably damaging |
Het |
| Ncoa6 |
A |
G |
2: 155,249,053 (GRCm39) |
V1417A |
possibly damaging |
Het |
| Nmnat1 |
A |
G |
4: 149,557,802 (GRCm39) |
V80A |
possibly damaging |
Het |
| Nwd2 |
A |
G |
5: 63,965,189 (GRCm39) |
E1591G |
probably benign |
Het |
| Or10ac1 |
A |
G |
6: 42,515,770 (GRCm39) |
F62S |
probably damaging |
Het |
| Or8j3b |
A |
G |
2: 86,204,853 (GRCm39) |
L301S |
possibly damaging |
Het |
| Osbpl1a |
A |
T |
18: 12,901,593 (GRCm39) |
|
probably null |
Het |
| Papln |
T |
C |
12: 83,821,194 (GRCm39) |
I204T |
probably damaging |
Het |
| Phf1 |
A |
G |
17: 27,153,652 (GRCm39) |
T97A |
probably benign |
Het |
| Plxnb1 |
A |
G |
9: 108,934,442 (GRCm39) |
D890G |
probably damaging |
Het |
| Ppp1r12b |
G |
T |
1: 134,883,471 (GRCm39) |
A17E |
probably benign |
Het |
| Ptgir |
A |
G |
7: 16,640,794 (GRCm39) |
M29V |
possibly damaging |
Het |
| Rbp2 |
G |
A |
9: 98,389,876 (GRCm39) |
C96Y |
probably damaging |
Het |
| Rgmb |
A |
T |
17: 16,027,624 (GRCm39) |
M365K |
possibly damaging |
Het |
| Ric1 |
A |
G |
19: 29,572,936 (GRCm39) |
N792S |
possibly damaging |
Het |
| Ruvbl1 |
T |
C |
6: 88,474,211 (GRCm39) |
Y405H |
possibly damaging |
Het |
| Scaf4 |
A |
G |
16: 90,047,195 (GRCm39) |
M394T |
unknown |
Het |
| Siglech |
T |
A |
7: 55,418,177 (GRCm39) |
C48* |
probably null |
Het |
| Skic2 |
A |
G |
17: 35,061,897 (GRCm39) |
V695A |
possibly damaging |
Het |
| Slc2a5 |
A |
G |
4: 150,224,462 (GRCm39) |
T320A |
probably benign |
Het |
| Slc6a7 |
T |
C |
18: 61,135,277 (GRCm39) |
Y417C |
probably benign |
Het |
| Sox21 |
A |
G |
14: 118,472,336 (GRCm39) |
C238R |
possibly damaging |
Het |
| Tbata |
A |
T |
10: 61,019,132 (GRCm39) |
K109N |
probably damaging |
Het |
| Tecpr2 |
T |
G |
12: 110,921,164 (GRCm39) |
S1246A |
probably benign |
Het |
| Tekt3 |
A |
G |
11: 62,972,085 (GRCm39) |
D247G |
probably benign |
Het |
| Tenm3 |
A |
T |
8: 48,766,271 (GRCm39) |
|
probably null |
Het |
| Thada |
A |
T |
17: 84,748,532 (GRCm39) |
|
probably null |
Het |
| Tpcn2 |
C |
T |
7: 144,826,088 (GRCm39) |
G204R |
probably damaging |
Het |
| Tpm2 |
T |
C |
4: 43,519,220 (GRCm39) |
|
probably null |
Het |
| Trbv24 |
T |
C |
6: 41,195,026 (GRCm39) |
|
probably benign |
Het |
| Tyw1 |
A |
G |
5: 130,305,899 (GRCm39) |
R341G |
probably benign |
Het |
| Vmn1r183 |
T |
G |
7: 23,754,564 (GRCm39) |
N122K |
probably benign |
Het |
| Vmn2r61 |
T |
A |
7: 41,916,459 (GRCm39) |
H357Q |
possibly damaging |
Het |
| Vps13b |
C |
T |
15: 35,869,518 (GRCm39) |
T2674I |
probably damaging |
Het |
| Vps13b |
T |
C |
15: 35,910,439 (GRCm39) |
L3401P |
probably benign |
Het |
| Vps16 |
T |
G |
2: 130,280,220 (GRCm39) |
|
probably benign |
Het |
| Vrtn |
T |
A |
12: 84,696,468 (GRCm39) |
I406N |
probably damaging |
Het |
| Vwa8 |
A |
T |
14: 79,172,053 (GRCm39) |
Y278F |
probably benign |
Het |
| Washc4 |
A |
T |
10: 83,415,376 (GRCm39) |
I789F |
possibly damaging |
Het |
| Zbtb20 |
C |
A |
16: 43,438,761 (GRCm39) |
T627K |
probably damaging |
Het |
| Zfyve16 |
A |
T |
13: 92,658,693 (GRCm39) |
I406K |
probably benign |
Het |
| Zfyve9 |
A |
C |
4: 108,575,195 (GRCm39) |
S629A |
possibly damaging |
Het |
| Zpld1 |
A |
T |
16: 55,068,618 (GRCm39) |
N164K |
probably damaging |
Het |
|
| Other mutations in Myt1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00478:Myt1
|
APN |
2 |
181,442,908 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00816:Myt1
|
APN |
2 |
181,449,308 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL01062:Myt1
|
APN |
2 |
181,439,522 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01069:Myt1
|
APN |
2 |
181,467,749 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01292:Myt1
|
APN |
2 |
181,446,805 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01521:Myt1
|
APN |
2 |
181,467,704 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01926:Myt1
|
APN |
2 |
181,463,790 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01976:Myt1
|
APN |
2 |
181,437,532 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02066:Myt1
|
APN |
2 |
181,438,982 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02109:Myt1
|
APN |
2 |
181,457,410 (GRCm39) |
splice site |
probably benign |
|
|
IGL02209:Myt1
|
APN |
2 |
181,439,027 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL02499:Myt1
|
APN |
2 |
181,467,342 (GRCm39) |
splice site |
probably benign |
|
|
IGL03064:Myt1
|
APN |
2 |
181,439,594 (GRCm39) |
missense |
probably benign |
0.31 |
|
IGL03394:Myt1
|
APN |
2 |
181,439,638 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4366001:Myt1
|
UTSW |
2 |
181,467,731 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0003:Myt1
|
UTSW |
2 |
181,443,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0003:Myt1
|
UTSW |
2 |
181,443,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0362:Myt1
|
UTSW |
2 |
181,405,186 (GRCm39) |
unclassified |
probably benign |
|
|
R0627:Myt1
|
UTSW |
2 |
181,437,482 (GRCm39) |
missense |
probably benign |
0.10 |
|
R0650:Myt1
|
UTSW |
2 |
181,424,408 (GRCm39) |
nonsense |
probably null |
|
|
R0735:Myt1
|
UTSW |
2 |
181,449,180 (GRCm39) |
unclassified |
probably benign |
|
|
R0744:Myt1
|
UTSW |
2 |
181,439,298 (GRCm39) |
intron |
probably benign |
|
|
R1115:Myt1
|
UTSW |
2 |
181,453,024 (GRCm39) |
nonsense |
probably null |
|
|
R1460:Myt1
|
UTSW |
2 |
181,444,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1471:Myt1
|
UTSW |
2 |
181,438,904 (GRCm39) |
missense |
probably benign |
|
|
R1836:Myt1
|
UTSW |
2 |
181,439,068 (GRCm39) |
missense |
probably benign |
|
|
R1905:Myt1
|
UTSW |
2 |
181,439,549 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2007:Myt1
|
UTSW |
2 |
181,437,552 (GRCm39) |
missense |
probably benign |
|
|
R2040:Myt1
|
UTSW |
2 |
181,467,717 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2140:Myt1
|
UTSW |
2 |
181,467,772 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2323:Myt1
|
UTSW |
2 |
181,448,350 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2926:Myt1
|
UTSW |
2 |
181,467,803 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R3895:Myt1
|
UTSW |
2 |
181,461,863 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4093:Myt1
|
UTSW |
2 |
181,453,191 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4649:Myt1
|
UTSW |
2 |
181,439,207 (GRCm39) |
missense |
probably benign |
|
|
R4693:Myt1
|
UTSW |
2 |
181,437,532 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4775:Myt1
|
UTSW |
2 |
181,464,470 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5111:Myt1
|
UTSW |
2 |
181,437,678 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5120:Myt1
|
UTSW |
2 |
181,439,413 (GRCm39) |
missense |
probably benign |
0.25 |
|
R5622:Myt1
|
UTSW |
2 |
181,438,915 (GRCm39) |
missense |
probably benign |
|
|
R6457:Myt1
|
UTSW |
2 |
181,405,218 (GRCm39) |
splice site |
probably null |
|
|
R6704:Myt1
|
UTSW |
2 |
181,453,005 (GRCm39) |
start codon destroyed |
probably null |
|
|
R6752:Myt1
|
UTSW |
2 |
181,442,875 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6944:Myt1
|
UTSW |
2 |
181,439,387 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R7337:Myt1
|
UTSW |
2 |
181,444,756 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R7362:Myt1
|
UTSW |
2 |
181,439,033 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7368:Myt1
|
UTSW |
2 |
181,424,384 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R7385:Myt1
|
UTSW |
2 |
181,409,498 (GRCm39) |
splice site |
probably null |
|
|
R7411:Myt1
|
UTSW |
2 |
181,456,899 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7593:Myt1
|
UTSW |
2 |
181,439,532 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R7790:Myt1
|
UTSW |
2 |
181,439,390 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8035:Myt1
|
UTSW |
2 |
181,437,532 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8156:Myt1
|
UTSW |
2 |
181,464,554 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8338:Myt1
|
UTSW |
2 |
181,443,655 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8419:Myt1
|
UTSW |
2 |
181,424,399 (GRCm39) |
nonsense |
probably null |
|
|
R8553:Myt1
|
UTSW |
2 |
181,439,344 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R9071:Myt1
|
UTSW |
2 |
181,448,420 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R9144:Myt1
|
UTSW |
2 |
181,467,805 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9290:Myt1
|
UTSW |
2 |
181,437,667 (GRCm39) |
missense |
probably benign |
0.31 |
|
R9462:Myt1
|
UTSW |
2 |
181,467,729 (GRCm39) |
nonsense |
probably null |
|
|
R9502:Myt1
|
UTSW |
2 |
181,461,991 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9668:Myt1
|
UTSW |
2 |
181,452,135 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9700:Myt1
|
UTSW |
2 |
181,452,177 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF006:Myt1
|
UTSW |
2 |
181,439,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Myt1
|
UTSW |
2 |
181,449,395 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Myt1
|
UTSW |
2 |
181,438,955 (GRCm39) |
missense |
probably damaging |
0.97 |
|
| Predicted Primers |
PCR Primer
(F):5'- GTAGCTAAGTTGAGCCCCAC -3'
(R):5'- ATGGGAGGTGTCTTCCCCAAAG -3'
Sequencing Primer
(F):5'- AGCTAAGTTGAGCCCCACTGTTG -3'
(R):5'- GGAGGTGTCTTCCCCAAAGATAAC -3'
|
| Posted On |
2016-03-01 |
Incidental Mutation