Incidental Mutation 'R4856:Lrrc66'
ID 373948
Institutional Source Beutler Lab
Gene Symbol Lrrc66
Ensembl Gene ENSMUSG00000067206
Gene Name leucine rich repeat containing 66
Synonyms
MMRRC Submission 042467-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.056) question?
Stock # R4856 (G1)
Quality Score 225
Status Not validated
Chromosome 5
Chromosomal Location 73763985-73789771 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 73765910 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 378 (F378L)
Ref Sequence ENSEMBL: ENSMUSP00000084423 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087177]
AlphaFold Q8K0B3
Predicted Effect probably benign
Transcript: ENSMUST00000087177
AA Change: F378L

PolyPhen 2 Score 0.105 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000084423
Gene: ENSMUSG00000067206
AA Change: F378L

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
LRR 140 162 1.81e1 SMART
LRR_TYP 163 186 9.44e-2 SMART
LRR 187 210 1.26e2 SMART
LRR 211 234 4.84e1 SMART
low complexity region 298 309 N/A INTRINSIC
transmembrane domain 369 391 N/A INTRINSIC
low complexity region 434 445 N/A INTRINSIC
low complexity region 842 859 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.4%
  • 20x: 92.8%
Validation Efficiency
Allele List at MGI

All alleles(2) : Targeted, other(1) Gene trapped(1)

Other mutations in this stock
Total: 85 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aebp2 G A 6: 140,589,799 (GRCm39) probably null Het
Arsi G A 18: 61,049,723 (GRCm39) G202E probably benign Het
Atp2b4 T A 1: 133,634,518 (GRCm39) I1177L probably benign Het
Bub3 A T 7: 131,163,297 (GRCm39) D76V probably damaging Het
Cacna2d4 G A 6: 119,255,217 (GRCm39) R578Q possibly damaging Het
Caprin2 A C 6: 148,774,509 (GRCm39) S268A probably benign Het
Card6 T C 15: 5,134,623 (GRCm39) probably null Het
Cdk13 A G 13: 17,894,319 (GRCm39) S1103P probably benign Het
Cfap221 T C 1: 119,861,934 (GRCm39) T614A probably damaging Het
Cfap221 T A 1: 119,912,488 (GRCm39) Y133F probably damaging Het
Clcc1 A G 3: 108,584,154 (GRCm39) T513A probably benign Het
Clec4g T A 8: 3,766,419 (GRCm39) probably benign Het
Cntln A C 4: 84,889,466 (GRCm39) E316D probably benign Het
Cpne2 T A 8: 95,290,592 (GRCm39) D392E probably benign Het
Cry1 G T 10: 84,984,634 (GRCm39) P147T probably damaging Het
Cyp4a29 T C 4: 115,110,078 (GRCm39) V440A probably benign Het
Ddx46 A G 13: 55,786,012 (GRCm39) D64G unknown Het
Dhx34 A G 7: 15,949,367 (GRCm39) S354P possibly damaging Het
Ecm2 A T 13: 49,676,263 (GRCm39) I327F possibly damaging Het
Elavl3 T C 9: 21,937,614 (GRCm39) K189E possibly damaging Het
Enam A T 5: 88,636,593 (GRCm39) R82* probably null Het
Erf A G 7: 24,945,636 (GRCm39) V45A probably damaging Het
Fat3 T A 9: 15,932,626 (GRCm39) I1436F probably benign Het
Flnc T C 6: 29,447,889 (GRCm39) Y1231H probably damaging Het
Ggta1 T A 2: 35,292,803 (GRCm39) H180L possibly damaging Het
Grin2c T C 11: 115,151,616 (GRCm39) T115A probably damaging Het
H6pd C T 4: 150,067,235 (GRCm39) V384M possibly damaging Het
Hba-x A G 11: 32,227,008 (GRCm39) E39G probably benign Het
Hnrnpul2 C T 19: 8,807,191 (GRCm39) P618S probably benign Het
Hpse2 C T 19: 42,777,396 (GRCm39) R590H probably damaging Het
Ighv1-54 C A 12: 115,157,423 (GRCm39) G75C probably damaging Het
Ighv8-11 C A 12: 115,530,774 (GRCm39) R118L possibly damaging Het
Iqcm A T 8: 76,615,228 (GRCm39) R436S possibly damaging Het
Islr T C 9: 58,064,889 (GRCm39) D206G probably damaging Het
Itih1 A G 14: 30,658,658 (GRCm39) probably null Het
Jam2 G A 16: 84,598,490 (GRCm39) D34N probably benign Het
Klhl14 A T 18: 21,691,029 (GRCm39) probably null Het
Lama2 TTTGCGCATT TTT 10: 26,919,639 (GRCm39) probably null Het
Map10 T A 8: 126,397,431 (GRCm39) Y275N probably damaging Het
Mpi T C 9: 57,452,590 (GRCm39) Y314C probably damaging Het
Mpp3 A G 11: 101,915,962 (GRCm39) Y55H probably benign Het
Nectin4 T C 1: 171,212,383 (GRCm39) V327A possibly damaging Het
Nlrp12 T A 7: 3,289,072 (GRCm39) D480V probably damaging Het
Nolc1 GAGCAGCAGCAGCAGCAGCAGCAGCAGC GAGCAGCAGCAGCAGCAGCAGCAGC 19: 46,071,594 (GRCm39) probably benign Het
Notch2 A T 3: 98,009,735 (GRCm39) Y554F probably damaging Het
Nrsn2 T C 2: 152,211,531 (GRCm39) K167E probably benign Het
Olr1 T A 6: 129,470,559 (GRCm39) K203* probably null Het
Or14j8 A T 17: 38,262,962 (GRCm39) S318T probably benign Het
Or2ag13 T A 7: 106,473,177 (GRCm39) I92F probably damaging Het
Or5b117 T C 19: 13,431,885 (GRCm39) probably null Het
Or8b3 A T 9: 38,314,764 (GRCm39) N195I probably damaging Het
Or9i2 T A 19: 13,815,643 (GRCm39) E298V probably damaging Het
Osbpl9 T C 4: 108,925,564 (GRCm39) N485S probably benign Het
Pbk T A 14: 66,052,650 (GRCm39) H164Q probably damaging Het
Pfn2 G T 3: 57,754,874 (GRCm39) N10K probably damaging Het
Pik3ca A G 3: 32,491,312 (GRCm39) D133G probably damaging Het
Pramel27 G T 4: 143,579,873 (GRCm39) R486L probably benign Het
Prl6a1 A T 13: 27,502,983 (GRCm39) D193V probably damaging Het
Rad21 G T 15: 51,831,896 (GRCm39) P395Q probably damaging Het
Reps1 T A 10: 17,999,373 (GRCm39) I720N probably damaging Het
Rpn2 T C 2: 157,159,964 (GRCm39) probably null Het
Rreb1 G A 13: 38,115,034 (GRCm39) V798M possibly damaging Het
Sardh C T 2: 27,134,489 (GRCm39) R9H probably benign Het
Scgb3a2 C T 18: 43,899,819 (GRCm39) P36S probably damaging Het
Scn10a C A 9: 119,523,375 (GRCm39) G6V possibly damaging Het
Scn10a C T 9: 119,523,376 (GRCm39) G6R possibly damaging Het
Scn3a T C 2: 65,291,376 (GRCm39) D1790G probably damaging Het
Sec24b A T 3: 129,777,619 (GRCm39) H1226Q probably benign Het
Shroom3 G T 5: 93,090,945 (GRCm39) V1151F probably damaging Het
Slc12a3 G A 8: 95,078,438 (GRCm39) probably null Het
Slitrk6 T C 14: 110,989,315 (GRCm39) T131A probably damaging Het
Spata1 C G 3: 146,175,529 (GRCm39) D326H probably damaging Het
Tex52 A T 6: 128,361,951 (GRCm39) probably null Het
Tma16 A C 8: 66,934,129 (GRCm39) C75W probably damaging Het
Tmem67 G A 4: 12,089,416 (GRCm39) probably benign Het
Trgv4 T C 13: 19,369,236 (GRCm39) V29A probably benign Het
Trmt10a A T 3: 137,854,146 (GRCm39) K75* probably null Het
Ttc3 T C 16: 94,191,142 (GRCm39) V228A probably benign Het
Ttn T C 2: 76,561,644 (GRCm39) D28954G probably damaging Het
Uggt2 A G 14: 119,273,376 (GRCm39) probably null Het
Vars1 T A 17: 35,234,702 (GRCm39) V1177E probably benign Het
Vmn1r59 T C 7: 5,457,532 (GRCm39) D76G possibly damaging Het
Vmn2r114 G T 17: 23,527,008 (GRCm39) A508E probably benign Het
Vps41 G A 13: 19,013,425 (GRCm39) V348M probably damaging Het
Zbtb43 T C 2: 33,343,944 (GRCm39) H427R probably damaging Het
Other mutations in Lrrc66
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00507:Lrrc66 APN 5 73,764,457 (GRCm39) missense probably benign 0.10
IGL00913:Lrrc66 APN 5 73,765,499 (GRCm39) missense possibly damaging 0.76
IGL00954:Lrrc66 APN 5 73,765,741 (GRCm39) missense possibly damaging 0.94
IGL01061:Lrrc66 APN 5 73,772,842 (GRCm39) missense probably benign 0.01
IGL01343:Lrrc66 APN 5 73,765,806 (GRCm39) missense probably damaging 0.98
IGL01714:Lrrc66 APN 5 73,787,320 (GRCm39) missense probably benign 0.10
IGL01822:Lrrc66 APN 5 73,787,311 (GRCm39) missense probably benign 0.17
IGL02005:Lrrc66 APN 5 73,766,077 (GRCm39) missense possibly damaging 0.83
IGL02166:Lrrc66 APN 5 73,764,634 (GRCm39) missense probably damaging 0.99
IGL02380:Lrrc66 APN 5 73,787,009 (GRCm39) missense possibly damaging 0.55
IGL03162:Lrrc66 APN 5 73,764,725 (GRCm39) missense probably benign
BB002:Lrrc66 UTSW 5 73,765,835 (GRCm39) missense possibly damaging 0.81
BB012:Lrrc66 UTSW 5 73,765,835 (GRCm39) missense possibly damaging 0.81
D4043:Lrrc66 UTSW 5 73,764,869 (GRCm39) missense probably benign 0.03
R0126:Lrrc66 UTSW 5 73,764,431 (GRCm39) missense probably benign 0.10
R0437:Lrrc66 UTSW 5 73,765,030 (GRCm39) missense probably benign 0.23
R0638:Lrrc66 UTSW 5 73,772,816 (GRCm39) splice site probably benign
R0658:Lrrc66 UTSW 5 73,768,287 (GRCm39) missense probably benign 0.40
R0729:Lrrc66 UTSW 5 73,765,757 (GRCm39) missense probably benign
R1603:Lrrc66 UTSW 5 73,764,769 (GRCm39) missense possibly damaging 0.61
R1774:Lrrc66 UTSW 5 73,768,198 (GRCm39) missense probably benign 0.16
R1831:Lrrc66 UTSW 5 73,764,769 (GRCm39) missense possibly damaging 0.61
R1832:Lrrc66 UTSW 5 73,764,769 (GRCm39) missense possibly damaging 0.61
R1902:Lrrc66 UTSW 5 73,764,965 (GRCm39) missense probably damaging 0.99
R2858:Lrrc66 UTSW 5 73,764,646 (GRCm39) missense probably benign 0.08
R4097:Lrrc66 UTSW 5 73,765,047 (GRCm39) missense possibly damaging 0.94
R4164:Lrrc66 UTSW 5 73,787,119 (GRCm39) splice site probably null
R4582:Lrrc66 UTSW 5 73,765,580 (GRCm39) missense possibly damaging 0.94
R4708:Lrrc66 UTSW 5 73,787,005 (GRCm39) missense probably benign 0.06
R4886:Lrrc66 UTSW 5 73,765,910 (GRCm39) missense probably benign 0.10
R5074:Lrrc66 UTSW 5 73,765,354 (GRCm39) missense probably damaging 1.00
R5464:Lrrc66 UTSW 5 73,765,622 (GRCm39) missense probably benign 0.05
R5640:Lrrc66 UTSW 5 73,765,977 (GRCm39) missense probably benign 0.00
R5709:Lrrc66 UTSW 5 73,766,206 (GRCm39) missense probably benign
R5811:Lrrc66 UTSW 5 73,772,860 (GRCm39) missense possibly damaging 0.82
R6146:Lrrc66 UTSW 5 73,765,432 (GRCm39) missense probably benign 0.10
R7037:Lrrc66 UTSW 5 73,764,504 (GRCm39) missense probably benign 0.10
R7041:Lrrc66 UTSW 5 73,765,899 (GRCm39) missense possibly damaging 0.81
R7141:Lrrc66 UTSW 5 73,787,320 (GRCm39) missense probably benign 0.10
R7201:Lrrc66 UTSW 5 73,787,240 (GRCm39) missense probably benign 0.11
R7250:Lrrc66 UTSW 5 73,768,224 (GRCm39) missense probably benign 0.03
R7367:Lrrc66 UTSW 5 73,765,724 (GRCm39) missense probably benign 0.13
R7773:Lrrc66 UTSW 5 73,764,664 (GRCm39) missense probably damaging 0.98
R7925:Lrrc66 UTSW 5 73,765,835 (GRCm39) missense possibly damaging 0.81
R8057:Lrrc66 UTSW 5 73,764,875 (GRCm39) nonsense probably null
R8167:Lrrc66 UTSW 5 73,786,952 (GRCm39) nonsense probably null
R8552:Lrrc66 UTSW 5 73,768,228 (GRCm39) missense probably benign 0.16
R8834:Lrrc66 UTSW 5 73,765,928 (GRCm39) missense possibly damaging 0.56
R8992:Lrrc66 UTSW 5 73,787,227 (GRCm39) missense probably benign 0.04
R9017:Lrrc66 UTSW 5 73,765,244 (GRCm39) missense possibly damaging 0.94
R9051:Lrrc66 UTSW 5 73,765,268 (GRCm39) missense probably benign 0.00
R9051:Lrrc66 UTSW 5 73,765,267 (GRCm39) missense probably benign 0.05
Predicted Primers PCR Primer
(F):5'- CGAAGGGTTCTGGTTCTCAG -3'
(R):5'- CAGGGATGGACATGCACCTTTC -3'

Sequencing Primer
(F):5'- CTGGTTCTCAGAAAGATGTAGGTG -3'
(R):5'- CACCTTTCTGCTCTGGGGAAG -3'
Posted On 2016-03-01