Mutagenetix > Incidental Mutation

Incidental Mutation 'R4857:Rp1'

374012

Institutional Source

Beutler Lab

Gene Symbol

Rp1

Ensembl Gene

ENSMUSG00000025900

Gene Name

retinitis pigmentosa 1 (human)

Synonyms

Dcdc3, mG145, Orp1, oxygen-regulated protein 1, Rp1h

MMRRC Submission

042468-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.099) question?

Stock #

R4857 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

3999557-4409241 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 4352316 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Asparagine at position 180 (K180N)

Ref Sequence

ENSEMBL: ENSMUSP00000146439 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000027032] [ENSMUST00000194992] [ENSMUST00000208660]

AlphaFold

P56716

Predicted Effect

probably benign
Transcript: ENSMUST00000027032
AA Change: K170N

PolyPhen 2 Score 0.277 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000027032
Gene: ENSMUSG00000025900
AA Change: K170N

Domain	Start	End	E-Value	Type
DCX	30	117	4.37e-39	SMART
low complexity region	120	133	N/A	INTRINSIC
DCX	152	236	7.17e-35	SMART
low complexity region	343	354	N/A	INTRINSIC
low complexity region	403	414	N/A	INTRINSIC
low complexity region	462	473	N/A	INTRINSIC
low complexity region	646	661	N/A	INTRINSIC
low complexity region	1113	1123	N/A	INTRINSIC
low complexity region	1396	1412	N/A	INTRINSIC
low complexity region	1434	1444	N/A	INTRINSIC
low complexity region	1648	1661	N/A	INTRINSIC

Predicted Effect

possibly damaging
Transcript: ENSMUST00000194992
AA Change: K180N

PolyPhen 2 Score 0.539 (Sensitivity: 0.88; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000142146
Gene: ENSMUSG00000025900
AA Change: K180N

Domain	Start	End	E-Value	Type
DCX	40	127	4.37e-39	SMART
low complexity region	130	143	N/A	INTRINSIC
DCX	162	246	7.17e-35	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000208660
AA Change: K180N

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000208793

Meta Mutation Damage Score

0.6467

Coding Region Coverage

1x: 99.1%
3x: 98.3%
10x: 96.3%
20x: 92.3%

Validation Efficiency

97% (115/119)

MGI Phenotype

FUNCTION: This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains, which bind microtubules and regulate microtubule polymerization. The encoded protein is a photoreceptor microtubule-associated protein and is required for correct stacking of outer segment disc. This protein and the RP1L1 protein, another retinal-specific protein, play essential and synergistic roles in affecting photosensitivity and outer segment morphogenesis of rod photoreceptors. Because of its response to in vivo retinal oxygen levels, this protein was initially named ORP1 (oxygen-regulated protein-1). This protein was subsequently designated RP1 (retinitis pigmentosa 1) when it was found that mutations in this gene cause autosomal dominant retinitis pigmentosa. Mutations in this gene also cause autosomal recessive retinitis pigmentosa. Two transcript variants encoding distinct isoforms are resulted from alternative promoters and alternative splicing. [provided by RefSeq, Sep 2010]
PHENOTYPE: Mice homozygous for disruptions in this gene experience progressive degeneration in photoreceptors but are otherwise phenotypically normal. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 100 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930548G14Rik	C	T	15: 46,625,531 (GRCm38)		noncoding transcript	Het
Aasdh	A	T	5: 76,887,284 (GRCm38)	F428L	probably benign	Het
Abca13	A	G	11: 9,294,143 (GRCm38)	N2002S	probably benign	Het
Acot7	T	G	4: 152,237,754 (GRCm38)	F248V	possibly damaging	Het
Acsf2	A	G	11: 94,569,338 (GRCm38)	I396T	probably benign	Het
Agbl1	A	G	7: 76,419,835 (GRCm38)	N372D	probably benign	Het
Ahctf1	A	T	1: 179,799,357 (GRCm38)		probably benign	Het
Akap11	T	C	14: 78,498,860 (GRCm38)	D1830G		Het
Bcl7b	A	G	5: 135,173,179 (GRCm38)	*59W	probably null	Het
Bdh1	A	G	16: 31,447,548 (GRCm38)		probably null	Het
Bin3	A	G	14: 70,128,895 (GRCm38)	N69S	probably benign	Het
Bltp3b	A	T	10: 89,779,963 (GRCm38)	N156I	probably damaging	Het
Bsdc1	T	C	4: 129,471,892 (GRCm38)		probably benign	Het
Cacna1i	T	C	15: 80,369,662 (GRCm38)	V700A	probably damaging	Het
Calcr	T	C	6: 3,708,511 (GRCm38)	N225S	probably benign	Het
Cby2	C	T	14: 75,593,038 (GRCm38)	E8K	probably damaging	Het
Cdh23	A	G	10: 60,391,784 (GRCm38)	S1173P	probably damaging	Het
Cftr	C	T	6: 18,320,975 (GRCm38)	T1428M	possibly damaging	Het
Chd1l	T	C	3: 97,572,659 (GRCm38)	K591E	probably benign	Het
Chrd	C	T	16: 20,738,758 (GRCm38)	P709L	possibly damaging	Het
Ckap4	T	C	10: 84,533,488 (GRCm38)	R127G	possibly damaging	Het
Cnbd2	T	C	2: 156,367,565 (GRCm38)	F476S	probably benign	Het
Dclk3	T	C	9: 111,468,648 (GRCm38)	V420A	probably benign	Het
Dnah5	A	G	15: 28,345,807 (GRCm38)	D2431G	probably benign	Het
Duox1	T	A	2: 122,315,731 (GRCm38)	I10N	probably benign	Het
Ece2	T	A	16: 20,617,806 (GRCm38)	V126D	probably damaging	Het
Elfn1	T	C	5: 139,973,085 (GRCm38)	Y615H	probably damaging	Het
Epha1	T	C	6: 42,361,482 (GRCm38)	D720G	probably benign	Het
Fras1	A	G	5: 96,778,159 (GRCm38)	I3741V	probably benign	Het
Gm53	A	T	11: 96,251,736 (GRCm38)		noncoding transcript	Het
Grb10	G	T	11: 11,951,469 (GRCm38)		probably benign	Het
Grid2ip	A	G	5: 143,382,629 (GRCm38)	H568R	probably damaging	Het
Gsap	A	T	5: 21,287,799 (GRCm38)		probably null	Het
Gse1	T	C	8: 120,572,757 (GRCm38)		probably benign	Het
Gstm1	T	C	3: 108,016,408 (GRCm38)	R94G	possibly damaging	Het
Gtf2ird1	A	G	5: 134,362,544 (GRCm38)	F866L	probably damaging	Het
Haao	T	A	17: 83,838,580 (GRCm38)		probably null	Het
Hcn4	A	T	9: 58,859,570 (GRCm38)	I805F	unknown	Het
Hemk1	A	T	9: 107,329,448 (GRCm38)		probably benign	Het
Il12rb1	A	T	8: 70,810,588 (GRCm38)	Y33F	possibly damaging	Het
Il19	T	A	1: 130,935,946 (GRCm38)	I103F	probably damaging	Het
Itpr1	A	G	6: 108,410,867 (GRCm38)	N1522S	probably benign	Het
Klhdc8a	A	G	1: 132,303,105 (GRCm38)	Y236C	probably damaging	Het
Klhl3	C	T	13: 58,018,806 (GRCm38)	G404S	probably damaging	Het
Large2	T	C	2: 92,366,634 (GRCm38)		probably benign	Het
Lgi1	C	A	19: 38,306,250 (GRCm38)	A490E	probably damaging	Het
Lmbr1	A	G	5: 29,323,809 (GRCm38)	L112P	probably damaging	Het
Lmo7	T	A	14: 101,887,348 (GRCm38)		probably null	Het
Lpin1	A	C	12: 16,563,630 (GRCm38)	I479S	possibly damaging	Het
Lrrc40	T	A	3: 158,066,229 (GRCm38)		probably benign	Het
Lrrc9	A	G	12: 72,499,692 (GRCm38)	N1218S	possibly damaging	Het
Map3k9	A	G	12: 81,724,627 (GRCm38)	V729A	probably benign	Het
Marf1	A	T	16: 14,128,611 (GRCm38)	Y1215*	probably null	Het
Moap1	T	A	12: 102,742,565 (GRCm38)	I242L	probably benign	Het
Mpo	A	G	11: 87,796,281 (GRCm38)	K218E	probably benign	Het
Mpz	C	T	1: 171,158,810 (GRCm38)	R98C	probably damaging	Het
Neb	T	G	2: 52,201,980 (GRCm38)	K5024T	probably damaging	Het
Nlrp4b	C	T	7: 10,715,298 (GRCm38)	T109I	probably benign	Het
Noc3l	T	A	19: 38,792,800 (GRCm38)		probably null	Het
Nosip	G	A	7: 45,076,678 (GRCm38)	V220I	probably benign	Het
Nyap1	A	C	5: 137,735,578 (GRCm38)	S398A	probably damaging	Het
Or12d17	A	G	17: 37,466,823 (GRCm38)	M206V	possibly damaging	Het
Or4a68	T	G	2: 89,439,623 (GRCm38)	I219L	probably damaging	Het
Or4f54	A	G	2: 111,293,143 (GRCm38)	N292D	possibly damaging	Het
Osbpl7	T	C	11: 97,056,669 (GRCm38)		probably benign	Het
Pard3	A	T	8: 127,324,054 (GRCm38)	Y199F	probably damaging	Het
Pcdha11	G	A	18: 37,011,452 (GRCm38)	V199I	probably benign	Het
Pcdhga8	A	T	18: 37,726,914 (GRCm38)	N341I	probably damaging	Het
Pcsk4	A	G	10: 80,325,039 (GRCm38)	S318P	probably damaging	Het
Phldb1	C	A	9: 44,696,092 (GRCm38)	R1272L	probably damaging	Het
Phlpp2	A	G	8: 109,877,010 (GRCm38)	T103A	probably damaging	Het
Pibf1	T	A	14: 99,186,501 (GRCm38)	Y503*	probably null	Het
Pkn1	A	T	8: 83,684,227 (GRCm38)		probably null	Het
Pramel22	A	T	4: 143,656,588 (GRCm38)	N20K	possibly damaging	Het
Ptprf	A	G	4: 118,217,197 (GRCm38)		probably benign	Het
Rbm19	C	A	5: 120,132,833 (GRCm38)		probably benign	Het
Rcan1	T	C	16: 92,465,906 (GRCm38)	D5G	possibly damaging	Het
Recql5	A	T	11: 115,928,212 (GRCm38)	L176Q	probably damaging	Het
Rev3l	T	A	10: 39,838,459 (GRCm38)	L2393Q	probably damaging	Het
Sdk1	T	C	5: 142,161,776 (GRCm38)	V1461A	probably benign	Het
Sdk2	A	T	11: 113,821,382 (GRCm38)	L1653*	probably null	Het
Shroom3	G	T	5: 92,943,086 (GRCm38)	V1151F	probably damaging	Het
Skint10	A	T	4: 112,746,633 (GRCm38)	V119D	possibly damaging	Het
Sncaip	T	C	18: 52,869,225 (GRCm38)	S273P	probably benign	Het
Sp1	T	G	15: 102,430,974 (GRCm38)	I449S	probably damaging	Het
Spata31h1	T	C	10: 82,283,848 (GRCm38)	T4443A	possibly damaging	Het
Spats2	T	C	15: 99,174,420 (GRCm38)	L78P	probably damaging	Het
Stambp	T	A	6: 83,556,366 (GRCm38)	N305I	probably benign	Het
Stim2	A	T	5: 54,118,546 (GRCm38)	S688C	probably damaging	Het
Sytl3	A	G	17: 6,736,581 (GRCm38)	N355S	probably damaging	Het
Taf4b	C	T	18: 14,804,578 (GRCm38)	A236V	probably null	Het
Tnfaip6	A	G	2: 52,051,074 (GRCm38)		probably null	Het
Trpc2	T	A	7: 102,083,969 (GRCm38)	S416T	probably benign	Het
Ttn	T	C	2: 76,738,866 (GRCm38)	T27228A	probably damaging	Het
Ush2a	T	A	1: 188,537,720 (GRCm38)	D1721E	probably benign	Het
Usp47	T	A	7: 112,082,552 (GRCm38)	H523Q	probably damaging	Het
Vmn1r8	A	T	6: 57,036,353 (GRCm38)	I130F	probably benign	Het
Vps13b	A	G	15: 35,456,654 (GRCm38)	S749G	probably benign	Het
Xrcc5	C	A	1: 72,326,265 (GRCm38)	T283K	possibly damaging	Het
Ydjc	A	G	16: 17,148,138 (GRCm38)		probably benign	Het

Other mutations in Rp1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00323:Rp1	APN	1	4,346,746 (GRCm38)	missense	probably damaging	0.98
IGL00593:Rp1	APN	1	4,345,403 (GRCm38)	missense	possibly damaging	0.70
IGL00956:Rp1	APN	1	4,352,212 (GRCm38)	missense	probably damaging	1.00
IGL01070:Rp1	APN	1	4,345,238 (GRCm38)	missense	probably damaging	1.00
IGL01531:Rp1	APN	1	4,348,945 (GRCm38)	missense	probably benign	0.00
IGL01668:Rp1	APN	1	4,345,718 (GRCm38)	missense	probably damaging	1.00
IGL01907:Rp1	APN	1	4,348,507 (GRCm38)	missense	possibly damaging	0.56
IGL02055:Rp1	APN	1	4,352,522 (GRCm38)	missense	probably damaging	1.00
IGL02071:Rp1	APN	1	4,345,310 (GRCm38)	missense	possibly damaging	0.46
IGL02128:Rp1	APN	1	4,347,385 (GRCm38)	missense	probably damaging	0.99
IGL02244:Rp1	APN	1	4,348,780 (GRCm38)	missense	probably benign	0.00
IGL02381:Rp1	APN	1	4,352,390 (GRCm38)	missense	probably benign	0.01
IGL02499:Rp1	APN	1	4,349,048 (GRCm38)	missense	probably benign	0.17
IGL02619:Rp1	APN	1	4,348,450 (GRCm38)	missense	possibly damaging	0.73
IGL02832:Rp1	APN	1	4,349,713 (GRCm38)	missense	probably benign	0.03
IGL02861:Rp1	APN	1	4,346,152 (GRCm38)	nonsense	probably null
IGL03288:Rp1	APN	1	4,349,524 (GRCm38)	missense	possibly damaging	0.88
IGL03290:Rp1	APN	1	4,350,041 (GRCm38)	missense	probably damaging	1.00
IGL03303:Rp1	APN	1	4,344,817 (GRCm38)	missense	probably damaging	1.00
R0041:Rp1	UTSW	1	4,344,628 (GRCm38)	missense	probably benign	0.36
R0111:Rp1	UTSW	1	4,344,760 (GRCm38)	missense	probably damaging	1.00
R0363:Rp1	UTSW	1	4,347,718 (GRCm38)	missense	probably damaging	1.00
R0440:Rp1	UTSW	1	4,345,640 (GRCm38)	missense	probably damaging	1.00
R0442:Rp1	UTSW	1	4,346,747 (GRCm38)	missense	probably benign	0.09
R0528:Rp1	UTSW	1	4,344,865 (GRCm38)	missense	possibly damaging	0.82
R0586:Rp1	UTSW	1	4,347,837 (GRCm38)	missense	possibly damaging	0.76
R0639:Rp1	UTSW	1	4,346,498 (GRCm38)	missense	probably benign	0.00
R0856:Rp1	UTSW	1	4,344,655 (GRCm38)	missense	probably benign	0.05
R0908:Rp1	UTSW	1	4,344,655 (GRCm38)	missense	probably benign	0.05
R0968:Rp1	UTSW	1	4,345,352 (GRCm38)	missense	probably benign	0.00
R1099:Rp1	UTSW	1	4,352,290 (GRCm38)	missense	possibly damaging	0.45
R1242:Rp1	UTSW	1	4,344,962 (GRCm38)	missense	probably benign	0.03
R1301:Rp1	UTSW	1	4,345,936 (GRCm38)	missense	possibly damaging	0.56
R1327:Rp1	UTSW	1	4,347,970 (GRCm38)	missense	probably benign	0.01
R1403:Rp1	UTSW	1	4,346,297 (GRCm38)	missense	possibly damaging	0.73
R1403:Rp1	UTSW	1	4,346,297 (GRCm38)	missense	possibly damaging	0.73
R1406:Rp1	UTSW	1	4,351,921 (GRCm38)	missense	possibly damaging	0.88
R1406:Rp1	UTSW	1	4,351,921 (GRCm38)	missense	possibly damaging	0.88
R1440:Rp1	UTSW	1	4,347,396 (GRCm38)	missense	probably damaging	1.00
R1509:Rp1	UTSW	1	4,348,537 (GRCm38)	missense	probably benign	0.20
R1509:Rp1	UTSW	1	4,347,694 (GRCm38)	missense	probably damaging	0.98
R1538:Rp1	UTSW	1	4,345,676 (GRCm38)	missense	probably damaging	1.00
R1609:Rp1	UTSW	1	4,349,201 (GRCm38)	missense	probably damaging	1.00
R1666:Rp1	UTSW	1	4,349,863 (GRCm38)	missense	probably damaging	1.00
R1703:Rp1	UTSW	1	4,345,169 (GRCm38)	missense	probably damaging	1.00
R1782:Rp1	UTSW	1	4,349,089 (GRCm38)	missense	probably benign	0.00
R1799:Rp1	UTSW	1	4,348,832 (GRCm38)	missense	possibly damaging	0.94
R1848:Rp1	UTSW	1	4,347,232 (GRCm38)	missense	possibly damaging	0.76
R1908:Rp1	UTSW	1	4,348,720 (GRCm38)	missense	probably damaging	0.99
R1919:Rp1	UTSW	1	4,352,671 (GRCm38)	missense	probably damaging	0.99
R2087:Rp1	UTSW	1	4,348,352 (GRCm38)	missense	probably damaging	1.00
R2211:Rp1	UTSW	1	4,348,139 (GRCm38)	missense	probably damaging	0.96
R2278:Rp1	UTSW	1	4,348,027 (GRCm38)	missense	possibly damaging	0.51
R2287:Rp1	UTSW	1	4,345,959 (GRCm38)	nonsense	probably null
R2316:Rp1	UTSW	1	4,345,640 (GRCm38)	missense	probably damaging	1.00
R2346:Rp1	UTSW	1	4,348,013 (GRCm38)	missense	probably damaging	1.00
R2878:Rp1	UTSW	1	4,348,139 (GRCm38)	missense	probably damaging	1.00
R3023:Rp1	UTSW	1	4,352,675 (GRCm38)	missense	probably damaging	1.00
R3025:Rp1	UTSW	1	4,352,675 (GRCm38)	missense	probably damaging	1.00
R3716:Rp1	UTSW	1	4,349,765 (GRCm38)	missense	probably benign	0.38
R3814:Rp1	UTSW	1	4,349,708 (GRCm38)	missense	probably benign
R3929:Rp1	UTSW	1	4,352,645 (GRCm38)	missense	probably damaging	1.00
R4064:Rp1	UTSW	1	4,345,400 (GRCm38)	missense	probably benign	0.08
R4426:Rp1	UTSW	1	4,347,924 (GRCm38)	missense	probably benign	0.13
R4557:Rp1	UTSW	1	4,344,663 (GRCm38)	missense	possibly damaging	0.61
R4764:Rp1	UTSW	1	4,345,878 (GRCm38)	missense	probably damaging	0.96
R4845:Rp1	UTSW	1	4,349,228 (GRCm38)	missense	probably benign	0.02
R4850:Rp1	UTSW	1	4,348,675 (GRCm38)	missense	probably damaging	1.00
R4857:Rp1	UTSW	1	4,352,317 (GRCm38)	missense	probably damaging	1.00
R5159:Rp1	UTSW	1	4,346,203 (GRCm38)	missense	possibly damaging	0.73
R5226:Rp1	UTSW	1	4,348,033 (GRCm38)	missense	probably benign	0.01
R5327:Rp1	UTSW	1	4,349,360 (GRCm38)	splice site	probably null
R5352:Rp1	UTSW	1	4,347,098 (GRCm38)	missense	probably benign	0.00
R5504:Rp1	UTSW	1	4,349,890 (GRCm38)	missense	probably damaging	1.00
R5527:Rp1	UTSW	1	4,346,393 (GRCm38)	missense	possibly damaging	0.75
R5529:Rp1	UTSW	1	4,345,832 (GRCm38)	missense	probably benign	0.42
R5569:Rp1	UTSW	1	4,345,237 (GRCm38)	missense	probably damaging	1.00
R5622:Rp1	UTSW	1	4,347,837 (GRCm38)	missense	possibly damaging	0.76
R5970:Rp1	UTSW	1	4,348,462 (GRCm38)	missense	probably benign	0.05
R5992:Rp1	UTSW	1	4,148,703 (GRCm38)	missense	unknown
R6004:Rp1	UTSW	1	4,197,585 (GRCm38)	missense	unknown
R6018:Rp1	UTSW	1	4,352,836 (GRCm38)	missense	possibly damaging	0.83
R6074:Rp1	UTSW	1	4,345,379 (GRCm38)	missense	probably benign	0.02
R6127:Rp1	UTSW	1	4,349,311 (GRCm38)	missense	possibly damaging	0.80
R6187:Rp1	UTSW	1	4,349,869 (GRCm38)	missense	probably damaging	1.00
R6301:Rp1	UTSW	1	4,347,254 (GRCm38)	missense	probably benign	0.04
R6317:Rp1	UTSW	1	4,041,989 (GRCm38)	missense	unknown
R6405:Rp1	UTSW	1	4,345,771 (GRCm38)	missense	probably damaging	1.00
R6445:Rp1	UTSW	1	4,226,617 (GRCm38)	missense	unknown
R6466:Rp1	UTSW	1	4,347,886 (GRCm38)	missense	probably benign	0.01
R6501:Rp1	UTSW	1	4,311,280 (GRCm38)	intron	probably benign
R6547:Rp1	UTSW	1	4,170,305 (GRCm38)	missense	unknown
R6604:Rp1	UTSW	1	4,019,128 (GRCm38)	missense	unknown
R6700:Rp1	UTSW	1	4,349,896 (GRCm38)	missense	probably damaging	1.00
R6706:Rp1	UTSW	1	4,142,664 (GRCm38)	missense	unknown
R6831:Rp1	UTSW	1	4,349,864 (GRCm38)	splice site	probably null
R6918:Rp1	UTSW	1	3,999,608 (GRCm38)	missense	unknown
R6973:Rp1	UTSW	1	4,351,994 (GRCm38)	nonsense	probably null
R6981:Rp1	UTSW	1	4,345,655 (GRCm38)	missense	probably benign	0.06
R7009:Rp1	UTSW	1	4,042,068 (GRCm38)	missense	unknown
R7078:Rp1	UTSW	1	4,206,791 (GRCm38)	missense	unknown
R7112:Rp1	UTSW	1	4,349,018 (GRCm38)	missense	probably benign	0.43
R7135:Rp1	UTSW	1	4,348,168 (GRCm38)	missense	possibly damaging	0.83
R7165:Rp1	UTSW	1	4,349,917 (GRCm38)	missense	probably damaging	0.99
R7199:Rp1	UTSW	1	4,347,290 (GRCm38)	missense	possibly damaging	0.73
R7232:Rp1	UTSW	1	4,228,601 (GRCm38)	missense	unknown
R7367:Rp1	UTSW	1	4,347,998 (GRCm38)	missense	probably benign	0.42
R7484:Rp1	UTSW	1	4,345,481 (GRCm38)	missense	probably benign	0.10
R7500:Rp1	UTSW	1	4,311,278 (GRCm38)	missense	unknown
R7569:Rp1	UTSW	1	4,284,840 (GRCm38)	missense	unknown
R7642:Rp1	UTSW	1	4,147,831 (GRCm38)	missense	unknown
R7693:Rp1	UTSW	1	4,347,403 (GRCm38)	missense	probably damaging	1.00
R7742:Rp1	UTSW	1	4,170,234 (GRCm38)	missense	unknown
R7759:Rp1	UTSW	1	4,344,884 (GRCm38)	missense	probably benign
R7784:Rp1	UTSW	1	4,142,658 (GRCm38)	missense	unknown
R7816:Rp1	UTSW	1	4,347,703 (GRCm38)	missense	probably damaging	0.98
R7866:Rp1	UTSW	1	4,347,701 (GRCm38)	missense	probably benign	0.02
R8215:Rp1	UTSW	1	4,245,095 (GRCm38)	missense	unknown
R8281:Rp1	UTSW	1	4,347,916 (GRCm38)	missense	probably damaging	1.00
R8294:Rp1	UTSW	1	4,345,997 (GRCm38)	missense	probably benign	0.09
R8309:Rp1	UTSW	1	4,347,089 (GRCm38)	missense	probably benign	0.00
R8311:Rp1	UTSW	1	4,348,349 (GRCm38)	missense	probably benign	0.11
R8500:Rp1	UTSW	1	4,346,590 (GRCm38)	missense	possibly damaging	0.91
R8559:Rp1	UTSW	1	4,349,561 (GRCm38)	missense	probably damaging	1.00
R8672:Rp1	UTSW	1	4,348,784 (GRCm38)	missense	possibly damaging	0.55
R8688:Rp1	UTSW	1	4,346,405 (GRCm38)	missense	probably benign	0.01
R8792:Rp1	UTSW	1	4,024,868 (GRCm38)	missense	unknown
R8859:Rp1	UTSW	1	4,349,960 (GRCm38)	missense	probably benign	0.07
R8945:Rp1	UTSW	1	4,349,594 (GRCm38)	missense	probably benign	0.42
R8959:Rp1	UTSW	1	4,349,427 (GRCm38)	intron	probably benign
R8979:Rp1	UTSW	1	4,148,714 (GRCm38)	missense	unknown
R9126:Rp1	UTSW	1	4,346,913 (GRCm38)	missense	probably damaging	0.99
R9156:Rp1	UTSW	1	4,163,938 (GRCm38)	missense	unknown
R9160:Rp1	UTSW	1	4,346,497 (GRCm38)	missense	probably benign	0.00
R9221:Rp1	UTSW	1	4,245,043 (GRCm38)	missense	unknown
R9263:Rp1	UTSW	1	4,348,937 (GRCm38)	missense	probably benign	0.02
R9263:Rp1	UTSW	1	4,348,452 (GRCm38)	missense	probably benign	0.25
R9302:Rp1	UTSW	1	4,346,566 (GRCm38)	missense	probably damaging	1.00
R9318:Rp1	UTSW	1	4,348,265 (GRCm38)	missense	probably benign	0.09
R9414:Rp1	UTSW	1	4,243,618 (GRCm38)	missense	unknown
R9474:Rp1	UTSW	1	4,092,615 (GRCm38)	critical splice donor site	probably null
R9478:Rp1	UTSW	1	4,347,322 (GRCm38)	missense	probably benign	0.06
R9529:Rp1	UTSW	1	4,346,224 (GRCm38)	missense	probably benign
R9572:Rp1	UTSW	1	4,348,439 (GRCm38)	missense	probably benign
R9673:Rp1	UTSW	1	4,267,569 (GRCm38)	missense	unknown
R9709:Rp1	UTSW	1	4,042,032 (GRCm38)	missense	unknown
R9716:Rp1	UTSW	1	4,142,610 (GRCm38)	critical splice donor site	probably null
RF003:Rp1	UTSW	1	4,344,694 (GRCm38)	missense	probably damaging	0.99
V1662:Rp1	UTSW	1	4,349,560 (GRCm38)	missense	probably damaging	1.00
X0012:Rp1	UTSW	1	4,347,695 (GRCm38)	missense	probably damaging	0.96

Predicted Primers

PCR Primer
(F):5'- TGAGCAAGCACTGTTCTTCCC -3'
(R):5'- AAGAAGGTGCTGCCAGTTGAC -3'

Sequencing Primer
(F):5'- GAGCAAGCACTGTTCTTCCCATATG -3'
(R):5'- GCCAATATGTCCACCATG -3'

Posted On

2016-03-01