Incidental Mutation 'R4857:Duox1'
| ID |
374027 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Duox1
|
| Ensembl Gene |
ENSMUSG00000033268 |
| Gene Name |
dual oxidase 1 |
| Synonyms |
NOXEF1, LNOX1, 9930101G15Rik, THOX1 |
| MMRRC Submission |
042468-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R4857 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
2 |
| Chromosomal Location |
122146153-122178453 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 122146212 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Asparagine
at position 10
(I10N)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000097060
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000099461]
[ENSMUST00000110537]
[ENSMUST00000147788]
[ENSMUST00000148417]
[ENSMUST00000154412]
|
| AlphaFold |
A2AQ92 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000099461
AA Change: I10N
PolyPhen 2
Score 0.048 (Sensitivity: 0.94; Specificity: 0.83)
|
| SMART Domains |
Protein: ENSMUSP00000097060
Gene: ENSMUSG00000033268
AA Change: I10N
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
Pfam:An_peroxidase
|
29 |
557 |
2.1e-134 |
PFAM |
|
transmembrane domain
|
594 |
616 |
N/A |
INTRINSIC |
|
EFh
|
819 |
847 |
1.82e-4 |
SMART |
|
EFh
|
855 |
883 |
3.45e-5 |
SMART |
|
transmembrane domain
|
1044 |
1066 |
N/A |
INTRINSIC |
|
Pfam:Ferric_reduct
|
1087 |
1236 |
5.3e-21 |
PFAM |
|
Pfam:FAD_binding_8
|
1272 |
1374 |
8.5e-21 |
PFAM |
|
Pfam:NAD_binding_6
|
1380 |
1534 |
3.5e-33 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000110537
|
| SMART Domains |
Protein: ENSMUSP00000106166
Gene: ENSMUSG00000027224
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DuoxA
|
9 |
290 |
3.9e-128 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000147788
|
| SMART Domains |
Protein: ENSMUSP00000116280
Gene: ENSMUSG00000027224
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DuoxA
|
9 |
134 |
5.9e-57 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000148417
|
| SMART Domains |
Protein: ENSMUSP00000116963
Gene: ENSMUSG00000027224
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DuoxA
|
9 |
210 |
1.2e-99 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000154412
|
| SMART Domains |
Protein: ENSMUSP00000116911
Gene: ENSMUSG00000027224
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DuoxA
|
9 |
100 |
6.3e-37 |
PFAM |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.3%
- 10x: 96.3%
- 20x: 92.3%
|
| Validation Efficiency |
97% (115/119) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2012]
|
| Allele List at MGI |
All alleles(6) : Targeted, other(3) Gene trapped(3)
|
| Other mutations in this stock |
Total: 101 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930548G14Rik |
C |
T |
15: 46,488,927 (GRCm39) |
|
noncoding transcript |
Het |
| Aasdh |
A |
T |
5: 77,035,131 (GRCm39) |
F428L |
probably benign |
Het |
| Abca13 |
A |
G |
11: 9,244,143 (GRCm39) |
N2002S |
probably benign |
Het |
| Acot7 |
T |
G |
4: 152,322,211 (GRCm39) |
F248V |
possibly damaging |
Het |
| Acsf2 |
A |
G |
11: 94,460,164 (GRCm39) |
I396T |
probably benign |
Het |
| Agbl1 |
A |
G |
7: 76,069,583 (GRCm39) |
N372D |
probably benign |
Het |
| Ahctf1 |
A |
T |
1: 179,626,922 (GRCm39) |
|
probably benign |
Het |
| Akap11 |
T |
C |
14: 78,736,300 (GRCm39) |
D1830G |
|
Het |
| Bcl7b |
A |
G |
5: 135,202,033 (GRCm39) |
*59W |
probably null |
Het |
| Bdh1 |
A |
G |
16: 31,266,366 (GRCm39) |
|
probably null |
Het |
| Bin3 |
A |
G |
14: 70,366,344 (GRCm39) |
N69S |
probably benign |
Het |
| Bltp3b |
A |
T |
10: 89,615,825 (GRCm39) |
N156I |
probably damaging |
Het |
| Bsdc1 |
T |
C |
4: 129,365,685 (GRCm39) |
|
probably benign |
Het |
| Cacna1i |
T |
C |
15: 80,253,863 (GRCm39) |
V700A |
probably damaging |
Het |
| Calcr |
T |
C |
6: 3,708,511 (GRCm39) |
N225S |
probably benign |
Het |
| Cby2 |
C |
T |
14: 75,830,478 (GRCm39) |
E8K |
probably damaging |
Het |
| Cdh23 |
A |
G |
10: 60,227,563 (GRCm39) |
S1173P |
probably damaging |
Het |
| Cftr |
C |
T |
6: 18,320,974 (GRCm39) |
T1428M |
possibly damaging |
Het |
| Chd1l |
T |
C |
3: 97,479,975 (GRCm39) |
K591E |
probably benign |
Het |
| Chrd |
C |
T |
16: 20,557,508 (GRCm39) |
P709L |
possibly damaging |
Het |
| Ckap4 |
T |
C |
10: 84,369,352 (GRCm39) |
R127G |
possibly damaging |
Het |
| Cnbd2 |
T |
C |
2: 156,209,485 (GRCm39) |
F476S |
probably benign |
Het |
| Dclk3 |
T |
C |
9: 111,297,716 (GRCm39) |
V420A |
probably benign |
Het |
| Dnah5 |
A |
G |
15: 28,345,953 (GRCm39) |
D2431G |
probably benign |
Het |
| Ece2 |
T |
A |
16: 20,436,556 (GRCm39) |
V126D |
probably damaging |
Het |
| Elfn1 |
T |
C |
5: 139,958,840 (GRCm39) |
Y615H |
probably damaging |
Het |
| Epha1 |
T |
C |
6: 42,338,416 (GRCm39) |
D720G |
probably benign |
Het |
| Fras1 |
A |
G |
5: 96,926,018 (GRCm39) |
I3741V |
probably benign |
Het |
| Gm53 |
A |
T |
11: 96,142,562 (GRCm39) |
|
noncoding transcript |
Het |
| Grb10 |
G |
T |
11: 11,901,469 (GRCm39) |
|
probably benign |
Het |
| Grid2ip |
A |
G |
5: 143,368,384 (GRCm39) |
H568R |
probably damaging |
Het |
| Gsap |
A |
T |
5: 21,492,797 (GRCm39) |
|
probably null |
Het |
| Gse1 |
T |
C |
8: 121,299,496 (GRCm39) |
|
probably benign |
Het |
| Gstm1 |
T |
C |
3: 107,923,724 (GRCm39) |
R94G |
possibly damaging |
Het |
| Gtf2ird1 |
A |
G |
5: 134,391,398 (GRCm39) |
F866L |
probably damaging |
Het |
| Haao |
T |
A |
17: 84,146,009 (GRCm39) |
|
probably null |
Het |
| Hcn4 |
A |
T |
9: 58,766,853 (GRCm39) |
I805F |
unknown |
Het |
| Hemk1 |
A |
T |
9: 107,206,647 (GRCm39) |
|
probably benign |
Het |
| Il12rb1 |
A |
T |
8: 71,263,232 (GRCm39) |
Y33F |
possibly damaging |
Het |
| Il19 |
T |
A |
1: 130,863,683 (GRCm39) |
I103F |
probably damaging |
Het |
| Itpr1 |
A |
G |
6: 108,387,828 (GRCm39) |
N1522S |
probably benign |
Het |
| Klhdc8a |
A |
G |
1: 132,230,843 (GRCm39) |
Y236C |
probably damaging |
Het |
| Klhl3 |
C |
T |
13: 58,166,620 (GRCm39) |
G404S |
probably damaging |
Het |
| Large2 |
T |
C |
2: 92,196,979 (GRCm39) |
|
probably benign |
Het |
| Lgi1 |
C |
A |
19: 38,294,698 (GRCm39) |
A490E |
probably damaging |
Het |
| Lmbr1 |
A |
G |
5: 29,528,807 (GRCm39) |
L112P |
probably damaging |
Het |
| Lmo7 |
T |
A |
14: 102,124,784 (GRCm39) |
|
probably null |
Het |
| Lpin1 |
A |
C |
12: 16,613,631 (GRCm39) |
I479S |
possibly damaging |
Het |
| Lrrc40 |
T |
A |
3: 157,771,866 (GRCm39) |
|
probably benign |
Het |
| Lrrc9 |
A |
G |
12: 72,546,466 (GRCm39) |
N1218S |
possibly damaging |
Het |
| Map3k9 |
A |
G |
12: 81,771,401 (GRCm39) |
V729A |
probably benign |
Het |
| Marf1 |
A |
T |
16: 13,946,475 (GRCm39) |
Y1215* |
probably null |
Het |
| Moap1 |
T |
A |
12: 102,708,824 (GRCm39) |
I242L |
probably benign |
Het |
| Mpo |
A |
G |
11: 87,687,107 (GRCm39) |
K218E |
probably benign |
Het |
| Mpz |
C |
T |
1: 170,986,379 (GRCm39) |
R98C |
probably damaging |
Het |
| Neb |
T |
G |
2: 52,091,992 (GRCm39) |
K5024T |
probably damaging |
Het |
| Nlrp4b |
C |
T |
7: 10,449,225 (GRCm39) |
T109I |
probably benign |
Het |
| Noc3l |
T |
A |
19: 38,781,244 (GRCm39) |
|
probably null |
Het |
| Nosip |
G |
A |
7: 44,726,102 (GRCm39) |
V220I |
probably benign |
Het |
| Nyap1 |
A |
C |
5: 137,733,840 (GRCm39) |
S398A |
probably damaging |
Het |
| Or12d17 |
A |
G |
17: 37,777,714 (GRCm39) |
M206V |
possibly damaging |
Het |
| Or4a68 |
T |
G |
2: 89,269,967 (GRCm39) |
I219L |
probably damaging |
Het |
| Or4f54 |
A |
G |
2: 111,123,488 (GRCm39) |
N292D |
possibly damaging |
Het |
| Osbpl7 |
T |
C |
11: 96,947,495 (GRCm39) |
|
probably benign |
Het |
| Pard3 |
A |
T |
8: 128,050,535 (GRCm39) |
Y199F |
probably damaging |
Het |
| Pcdha11 |
G |
A |
18: 37,144,505 (GRCm39) |
V199I |
probably benign |
Het |
| Pcdhga8 |
A |
T |
18: 37,859,967 (GRCm39) |
N341I |
probably damaging |
Het |
| Pcsk4 |
A |
G |
10: 80,160,873 (GRCm39) |
S318P |
probably damaging |
Het |
| Phldb1 |
C |
A |
9: 44,607,389 (GRCm39) |
R1272L |
probably damaging |
Het |
| Phlpp2 |
A |
G |
8: 110,603,642 (GRCm39) |
T103A |
probably damaging |
Het |
| Pibf1 |
T |
A |
14: 99,423,937 (GRCm39) |
Y503* |
probably null |
Het |
| Pkn1 |
A |
T |
8: 84,410,856 (GRCm39) |
|
probably null |
Het |
| Pramel22 |
A |
T |
4: 143,383,158 (GRCm39) |
N20K |
possibly damaging |
Het |
| Ptprf |
A |
G |
4: 118,074,394 (GRCm39) |
|
probably benign |
Het |
| Rbm19 |
C |
A |
5: 120,270,898 (GRCm39) |
|
probably benign |
Het |
| Rcan1 |
T |
C |
16: 92,262,794 (GRCm39) |
D5G |
possibly damaging |
Het |
| Recql5 |
A |
T |
11: 115,819,038 (GRCm39) |
L176Q |
probably damaging |
Het |
| Rev3l |
T |
A |
10: 39,714,455 (GRCm39) |
L2393Q |
probably damaging |
Het |
| Rp1 |
C |
A |
1: 4,422,539 (GRCm39) |
K180N |
probably damaging |
Het |
| Rp1 |
T |
A |
1: 4,422,540 (GRCm39) |
K180M |
probably damaging |
Het |
| Sdk1 |
T |
C |
5: 142,147,531 (GRCm39) |
V1461A |
probably benign |
Het |
| Sdk2 |
A |
T |
11: 113,712,208 (GRCm39) |
L1653* |
probably null |
Het |
| Shroom3 |
G |
T |
5: 93,090,945 (GRCm39) |
V1151F |
probably damaging |
Het |
| Skint10 |
A |
T |
4: 112,603,830 (GRCm39) |
V119D |
possibly damaging |
Het |
| Sncaip |
T |
C |
18: 53,002,297 (GRCm39) |
S273P |
probably benign |
Het |
| Sp1 |
T |
G |
15: 102,339,409 (GRCm39) |
I449S |
probably damaging |
Het |
| Spata31h1 |
T |
C |
10: 82,119,682 (GRCm39) |
T4443A |
possibly damaging |
Het |
| Spats2 |
T |
C |
15: 99,072,301 (GRCm39) |
L78P |
probably damaging |
Het |
| Stambp |
T |
A |
6: 83,533,348 (GRCm39) |
N305I |
probably benign |
Het |
| Stim2 |
A |
T |
5: 54,275,888 (GRCm39) |
S688C |
probably damaging |
Het |
| Sytl3 |
A |
G |
17: 7,003,980 (GRCm39) |
N355S |
probably damaging |
Het |
| Taf4b |
C |
T |
18: 14,937,635 (GRCm39) |
A236V |
probably null |
Het |
| Tnfaip6 |
A |
G |
2: 51,941,086 (GRCm39) |
|
probably null |
Het |
| Trpc2 |
T |
A |
7: 101,733,176 (GRCm39) |
S416T |
probably benign |
Het |
| Ttn |
T |
C |
2: 76,569,210 (GRCm39) |
T27228A |
probably damaging |
Het |
| Ush2a |
T |
A |
1: 188,269,917 (GRCm39) |
D1721E |
probably benign |
Het |
| Usp47 |
T |
A |
7: 111,681,759 (GRCm39) |
H523Q |
probably damaging |
Het |
| Vmn1r8 |
A |
T |
6: 57,013,338 (GRCm39) |
I130F |
probably benign |
Het |
| Vps13b |
A |
G |
15: 35,456,800 (GRCm39) |
S749G |
probably benign |
Het |
| Xrcc5 |
C |
A |
1: 72,365,424 (GRCm39) |
T283K |
possibly damaging |
Het |
| Ydjc |
A |
G |
16: 16,966,002 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Duox1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00650:Duox1
|
APN |
2 |
122,163,622 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
IGL00956:Duox1
|
APN |
2 |
122,153,787 (GRCm39) |
missense |
probably benign |
0.42 |
|
IGL01413:Duox1
|
APN |
2 |
122,151,191 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01444:Duox1
|
APN |
2 |
122,170,571 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01633:Duox1
|
APN |
2 |
122,164,279 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01814:Duox1
|
APN |
2 |
122,176,753 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01868:Duox1
|
APN |
2 |
122,168,888 (GRCm39) |
missense |
probably benign |
|
|
IGL02096:Duox1
|
APN |
2 |
122,174,655 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02126:Duox1
|
APN |
2 |
122,176,817 (GRCm39) |
missense |
probably benign |
0.21 |
|
IGL02342:Duox1
|
APN |
2 |
122,177,793 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02687:Duox1
|
APN |
2 |
122,166,896 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02708:Duox1
|
APN |
2 |
122,156,498 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL02935:Duox1
|
APN |
2 |
122,155,000 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
antiquity
|
UTSW |
2 |
122,170,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Dejavous
|
UTSW |
2 |
122,151,345 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1706_Duox1_051
|
UTSW |
2 |
122,149,953 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5032_duox1_732
|
UTSW |
2 |
122,167,798 (GRCm39) |
missense |
probably benign |
|
|
Vaguely
|
UTSW |
2 |
122,156,616 (GRCm39) |
nonsense |
probably null |
|
|
D4043:Duox1
|
UTSW |
2 |
122,175,276 (GRCm39) |
missense |
probably benign |
|
|
R0047:Duox1
|
UTSW |
2 |
122,177,122 (GRCm39) |
unclassified |
probably benign |
|
|
R0047:Duox1
|
UTSW |
2 |
122,177,122 (GRCm39) |
unclassified |
probably benign |
|
|
R0241:Duox1
|
UTSW |
2 |
122,163,878 (GRCm39) |
splice site |
probably benign |
|
|
R0479:Duox1
|
UTSW |
2 |
122,176,861 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0834:Duox1
|
UTSW |
2 |
122,176,982 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1105:Duox1
|
UTSW |
2 |
122,168,183 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1205:Duox1
|
UTSW |
2 |
122,158,406 (GRCm39) |
nonsense |
probably null |
|
|
R1281:Duox1
|
UTSW |
2 |
122,157,569 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1302:Duox1
|
UTSW |
2 |
122,177,760 (GRCm39) |
missense |
probably benign |
0.24 |
|
R1532:Duox1
|
UTSW |
2 |
122,175,204 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1706:Duox1
|
UTSW |
2 |
122,149,953 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1719:Duox1
|
UTSW |
2 |
122,169,125 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1753:Duox1
|
UTSW |
2 |
122,163,910 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1827:Duox1
|
UTSW |
2 |
122,177,861 (GRCm39) |
nonsense |
probably null |
|
|
R1828:Duox1
|
UTSW |
2 |
122,177,861 (GRCm39) |
nonsense |
probably null |
|
|
R1940:Duox1
|
UTSW |
2 |
122,156,465 (GRCm39) |
missense |
probably benign |
0.06 |
|
R1944:Duox1
|
UTSW |
2 |
122,177,001 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2069:Duox1
|
UTSW |
2 |
122,163,543 (GRCm39) |
missense |
probably benign |
|
|
R2113:Duox1
|
UTSW |
2 |
122,167,735 (GRCm39) |
missense |
probably benign |
|
|
R2202:Duox1
|
UTSW |
2 |
122,175,194 (GRCm39) |
missense |
probably benign |
0.19 |
|
R2314:Duox1
|
UTSW |
2 |
122,164,211 (GRCm39) |
nonsense |
probably null |
|
|
R2507:Duox1
|
UTSW |
2 |
122,163,619 (GRCm39) |
missense |
probably benign |
0.34 |
|
R2508:Duox1
|
UTSW |
2 |
122,163,619 (GRCm39) |
missense |
probably benign |
0.34 |
|
R3177:Duox1
|
UTSW |
2 |
122,170,597 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3277:Duox1
|
UTSW |
2 |
122,170,597 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4124:Duox1
|
UTSW |
2 |
122,167,902 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4271:Duox1
|
UTSW |
2 |
122,154,856 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4411:Duox1
|
UTSW |
2 |
122,168,115 (GRCm39) |
missense |
probably benign |
0.30 |
|
R4419:Duox1
|
UTSW |
2 |
122,157,607 (GRCm39) |
missense |
probably benign |
|
|
R4420:Duox1
|
UTSW |
2 |
122,157,607 (GRCm39) |
missense |
probably benign |
|
|
R4578:Duox1
|
UTSW |
2 |
122,164,258 (GRCm39) |
missense |
probably benign |
0.15 |
|
R4628:Duox1
|
UTSW |
2 |
122,176,733 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4665:Duox1
|
UTSW |
2 |
122,149,956 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4666:Duox1
|
UTSW |
2 |
122,149,956 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4730:Duox1
|
UTSW |
2 |
122,164,312 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4767:Duox1
|
UTSW |
2 |
122,163,922 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R4904:Duox1
|
UTSW |
2 |
122,151,345 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5032:Duox1
|
UTSW |
2 |
122,167,798 (GRCm39) |
missense |
probably benign |
|
|
R5201:Duox1
|
UTSW |
2 |
122,158,403 (GRCm39) |
missense |
probably benign |
|
|
R5474:Duox1
|
UTSW |
2 |
122,177,106 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5835:Duox1
|
UTSW |
2 |
122,158,341 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5939:Duox1
|
UTSW |
2 |
122,176,832 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5941:Duox1
|
UTSW |
2 |
122,174,637 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5943:Duox1
|
UTSW |
2 |
122,163,916 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5970:Duox1
|
UTSW |
2 |
122,170,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6023:Duox1
|
UTSW |
2 |
122,168,165 (GRCm39) |
missense |
probably benign |
0.19 |
|
R6050:Duox1
|
UTSW |
2 |
122,149,956 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6064:Duox1
|
UTSW |
2 |
122,151,243 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6093:Duox1
|
UTSW |
2 |
122,177,755 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6188:Duox1
|
UTSW |
2 |
122,150,275 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6246:Duox1
|
UTSW |
2 |
122,157,655 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6259:Duox1
|
UTSW |
2 |
122,175,264 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6290:Duox1
|
UTSW |
2 |
122,164,288 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6300:Duox1
|
UTSW |
2 |
122,168,181 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6341:Duox1
|
UTSW |
2 |
122,168,202 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6498:Duox1
|
UTSW |
2 |
122,150,088 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6883:Duox1
|
UTSW |
2 |
122,155,065 (GRCm39) |
splice site |
probably null |
|
|
R7002:Duox1
|
UTSW |
2 |
122,150,358 (GRCm39) |
nonsense |
probably null |
|
|
R7410:Duox1
|
UTSW |
2 |
122,176,874 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7421:Duox1
|
UTSW |
2 |
122,153,711 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7608:Duox1
|
UTSW |
2 |
122,156,616 (GRCm39) |
nonsense |
probably null |
|
|
R7702:Duox1
|
UTSW |
2 |
122,160,120 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R7766:Duox1
|
UTSW |
2 |
122,167,782 (GRCm39) |
missense |
probably benign |
|
|
R7833:Duox1
|
UTSW |
2 |
122,154,869 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7980:Duox1
|
UTSW |
2 |
122,177,801 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R8275:Duox1
|
UTSW |
2 |
122,175,249 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8717:Duox1
|
UTSW |
2 |
122,168,152 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R8992:Duox1
|
UTSW |
2 |
122,175,186 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9196:Duox1
|
UTSW |
2 |
122,150,689 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9344:Duox1
|
UTSW |
2 |
122,168,163 (GRCm39) |
missense |
probably benign |
0.14 |
|
R9397:Duox1
|
UTSW |
2 |
122,150,783 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R9491:Duox1
|
UTSW |
2 |
122,156,907 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9510:Duox1
|
UTSW |
2 |
122,160,023 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9521:Duox1
|
UTSW |
2 |
122,159,216 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R9562:Duox1
|
UTSW |
2 |
122,151,203 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9565:Duox1
|
UTSW |
2 |
122,151,203 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9569:Duox1
|
UTSW |
2 |
122,148,971 (GRCm39) |
missense |
probably benign |
|
|
Z1176:Duox1
|
UTSW |
2 |
122,163,519 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGAACTAGAGGCCTTCCGAG -3'
(R):5'- TTCACATCAGGAGAACTTACCTCAC -3'
Sequencing Primer
(F):5'- CTAGAGGCCTTCCGAGAGAGTG -3'
(R):5'- GGAGAACTTACCTCACAAAACAGG -3'
|
| Posted On |
2016-03-01 |
Incidental Mutation