Incidental Mutation 'R4826:Prr27'
ID 374140
Institutional Source Beutler Lab
Gene Symbol Prr27
Ensembl Gene ENSMUSG00000002240
Gene Name proline rich 27
Synonyms 4930432K09Rik
MMRRC Submission 042442-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4826 (G1)
Quality Score 225
Status Validated
Chromosome 5
Chromosomal Location 87973556-87994245 bp(+) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) A to C at 87998825 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000098617 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000002310] [ENSMUST00000101056]
AlphaFold Q3SYJ2
Predicted Effect probably benign
Transcript: ENSMUST00000002310
SMART Domains Protein: ENSMUSP00000002310
Gene: ENSMUSG00000002240

DomainStartEndE-ValueType
low complexity region 49 57 N/A INTRINSIC
low complexity region 104 130 N/A INTRINSIC
low complexity region 137 153 N/A INTRINSIC
low complexity region 179 194 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000101056
SMART Domains Protein: ENSMUSP00000098617
Gene: ENSMUSG00000002240

DomainStartEndE-ValueType
low complexity region 57 65 N/A INTRINSIC
low complexity region 112 138 N/A INTRINSIC
low complexity region 145 161 N/A INTRINSIC
low complexity region 187 202 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000180954
Predicted Effect noncoding transcript
Transcript: ENSMUST00000181439
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 94.0%
Validation Efficiency 100% (72/72)
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca14 A T 7: 119,815,470 (GRCm39) R239S probably damaging Het
Acin1 A G 14: 54,902,074 (GRCm39) S573P probably damaging Het
Acta2 A T 19: 34,229,223 (GRCm39) Y55* probably null Het
Aifm2 T C 10: 61,561,768 (GRCm39) M38T probably benign Het
Ank2 C A 3: 126,749,650 (GRCm39) V460L probably benign Het
Ap1b1 T C 11: 4,968,043 (GRCm39) S185P probably benign Het
Arsj A G 3: 126,232,451 (GRCm39) Y399C probably damaging Het
Ciao3 A G 17: 25,999,306 (GRCm39) H240R probably damaging Het
Clec2d T C 6: 129,161,122 (GRCm39) V73A probably benign Het
Cntln T G 4: 84,923,281 (GRCm39) M582R probably benign Het
Cyp4a10 C T 4: 115,375,541 (GRCm39) P8L probably benign Het
Dip2b A G 15: 100,067,162 (GRCm39) N555D probably damaging Het
Dusp4 T A 8: 35,285,671 (GRCm39) F311I probably damaging Het
Eif4g3 T C 4: 137,905,256 (GRCm39) V1245A possibly damaging Het
Ephb3 G A 16: 21,033,745 (GRCm39) R23H possibly damaging Het
Ext2 T C 2: 93,592,975 (GRCm39) T410A probably benign Het
Fam193a A G 5: 34,593,875 (GRCm39) E124G probably damaging Het
Fat4 T A 3: 39,037,106 (GRCm39) V3586E probably damaging Het
Frmd4a T C 2: 4,606,108 (GRCm39) S611P probably damaging Het
Gcn1 A G 5: 115,731,752 (GRCm39) T956A probably benign Het
Gm10549 C A 18: 33,603,838 (GRCm39) T107K unknown Het
Herc6 T A 6: 57,624,072 (GRCm39) M614K probably benign Het
Hspg2 T C 4: 137,292,706 (GRCm39) C4095R probably damaging Het
Hyal5 T C 6: 24,891,575 (GRCm39) I463T possibly damaging Het
Icam5 C T 9: 20,949,099 (GRCm39) A817V possibly damaging Het
Igf2r A T 17: 12,920,240 (GRCm39) D1366E probably damaging Het
Ints7 G A 1: 191,344,018 (GRCm39) V553I probably damaging Het
Iqgap2 T A 13: 95,899,783 (GRCm39) I92F probably damaging Het
Itgb1 T A 8: 129,446,789 (GRCm39) C435S probably damaging Het
Lrrc71 T C 3: 87,650,615 (GRCm39) M216V probably benign Het
Mgam T C 6: 40,657,582 (GRCm39) V979A possibly damaging Het
Mplkipl1 C T 19: 61,164,364 (GRCm39) G24R unknown Het
Myh9 A T 15: 77,673,146 (GRCm39) Y400* probably null Het
Nbeal1 A G 1: 60,290,501 (GRCm39) R1033G possibly damaging Het
Nit1 T C 1: 171,173,166 (GRCm39) probably benign Het
Nlrp1c-ps A G 11: 71,133,343 (GRCm39) noncoding transcript Het
Nt5c1a T C 4: 123,102,365 (GRCm39) V97A probably damaging Het
Or12k5 A G 2: 36,895,345 (GRCm39) Y94H probably damaging Het
Or13a18 T A 7: 140,190,232 (GRCm39) M51K probably benign Het
Or1a1b A G 11: 74,097,157 (GRCm39) M295T possibly damaging Het
Or56a5 G T 7: 104,793,175 (GRCm39) N108K probably damaging Het
Or9m1 T A 2: 87,733,693 (GRCm39) D109V probably damaging Het
Pde4a T A 9: 21,103,676 (GRCm39) probably null Het
Pkn2 T C 3: 142,515,270 (GRCm39) K640R probably damaging Het
Pla2g6 A G 15: 79,192,879 (GRCm39) S263P possibly damaging Het
Prkg1 A G 19: 31,742,006 (GRCm39) S73P possibly damaging Het
Rad54b G T 4: 11,599,753 (GRCm39) W319L probably damaging Het
Rassf8 T A 6: 145,762,276 (GRCm39) L349H probably damaging Het
Rmc1 G T 18: 12,318,836 (GRCm39) probably benign Het
Rnf113a2 T A 12: 84,464,388 (GRCm39) N93K probably benign Het
Sapcd2 C T 2: 25,262,768 (GRCm39) A109V probably benign Het
Slamf9 C A 1: 172,304,008 (GRCm39) H118N probably benign Het
Slc37a1 A G 17: 31,541,147 (GRCm39) Y213C probably damaging Het
Slc5a1 A G 5: 33,316,494 (GRCm39) D580G probably benign Het
Slc7a2 T A 8: 41,364,083 (GRCm39) I432N probably damaging Het
Tas2r114 A T 6: 131,666,800 (GRCm39) L76Q probably damaging Het
Tcerg1 C T 18: 42,668,180 (GRCm39) P391L unknown Het
Tdrd12 A C 7: 35,203,582 (GRCm39) V314G probably benign Het
Zbtb7b A G 3: 89,288,080 (GRCm39) L246S probably benign Het
Other mutations in Prr27
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02027:Prr27 APN 5 87,991,302 (GRCm39) missense possibly damaging 0.90
IGL02617:Prr27 APN 5 87,990,518 (GRCm39) missense probably benign 0.00
IGL02995:Prr27 APN 5 87,990,675 (GRCm39) missense probably benign
IGL03270:Prr27 APN 5 87,983,537 (GRCm39) utr 5 prime probably benign
R0531:Prr27 UTSW 5 87,990,537 (GRCm39) missense probably benign 0.02
R0637:Prr27 UTSW 5 87,999,005 (GRCm39) unclassified probably benign
R1498:Prr27 UTSW 5 87,998,600 (GRCm39) unclassified probably benign
R1599:Prr27 UTSW 5 87,991,084 (GRCm39) missense probably benign 0.00
R1744:Prr27 UTSW 5 87,990,906 (GRCm39) missense possibly damaging 0.46
R1980:Prr27 UTSW 5 87,991,261 (GRCm39) missense probably benign 0.03
R4033:Prr27 UTSW 5 87,991,164 (GRCm39) nonsense probably null
R4304:Prr27 UTSW 5 87,990,766 (GRCm39) missense probably benign 0.00
R4306:Prr27 UTSW 5 87,990,766 (GRCm39) missense probably benign 0.00
R4307:Prr27 UTSW 5 87,990,766 (GRCm39) missense probably benign 0.00
R4308:Prr27 UTSW 5 87,990,766 (GRCm39) missense probably benign 0.00
R4347:Prr27 UTSW 5 87,990,531 (GRCm39) missense possibly damaging 0.46
R4675:Prr27 UTSW 5 87,991,100 (GRCm39) missense possibly damaging 0.94
R4908:Prr27 UTSW 5 87,990,888 (GRCm39) missense probably benign 0.01
R5361:Prr27 UTSW 5 87,991,203 (GRCm39) missense probably damaging 0.96
R5426:Prr27 UTSW 5 87,998,744 (GRCm39) unclassified probably benign
R7268:Prr27 UTSW 5 87,991,135 (GRCm39) missense probably damaging 0.99
R7785:Prr27 UTSW 5 87,991,131 (GRCm39) missense probably benign
R8087:Prr27 UTSW 5 87,994,168 (GRCm39) missense probably benign 0.00
R8250:Prr27 UTSW 5 87,990,556 (GRCm39) missense possibly damaging 0.89
R8270:Prr27 UTSW 5 87,994,171 (GRCm39) missense possibly damaging 0.82
R8375:Prr27 UTSW 5 87,990,710 (GRCm39) nonsense probably null
R9070:Prr27 UTSW 5 87,990,994 (GRCm39) missense probably benign
R9071:Prr27 UTSW 5 87,990,994 (GRCm39) missense probably benign
R9101:Prr27 UTSW 5 87,991,330 (GRCm39) missense probably damaging 0.99
R9186:Prr27 UTSW 5 87,990,994 (GRCm39) missense probably benign
R9188:Prr27 UTSW 5 87,990,994 (GRCm39) missense probably benign
R9189:Prr27 UTSW 5 87,990,994 (GRCm39) missense probably benign
R9318:Prr27 UTSW 5 87,990,994 (GRCm39) missense probably benign
R9367:Prr27 UTSW 5 87,990,994 (GRCm39) missense probably benign
R9590:Prr27 UTSW 5 87,990,994 (GRCm39) missense probably benign
R9592:Prr27 UTSW 5 87,990,994 (GRCm39) missense probably benign
R9593:Prr27 UTSW 5 87,990,994 (GRCm39) missense probably benign
R9760:Prr27 UTSW 5 87,990,994 (GRCm39) missense probably benign
R9762:Prr27 UTSW 5 87,990,994 (GRCm39) missense probably benign
Z1088:Prr27 UTSW 5 87,990,505 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- ATCACCTTCTGCAAACTGGAG -3'
(R):5'- CGAGACAAGAATCTGCAGCG -3'

Sequencing Primer
(F):5'- AATGAGAAGTGCCCGTACTGCC -3'
(R):5'- CAAGAATCTGCAGCGTGGCG -3'
Posted On 2016-03-01