Mutagenetix > Incidental Mutation

Incidental Mutation 'R4825:Fubp1'

374435

Institutional Source

Beutler Lab

Gene Symbol

Fubp1

Ensembl Gene

ENSMUSG00000028034

Gene Name

far upstream element (FUSE) binding protein 1

Synonyms

9530027K12Rik, FBP, Fubp, Fubp4

MMRRC Submission

042441-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R4825 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

152210422-152236826 bp(+) (GRCm38)

Type of Mutation

splice site (6 bp from exon)

DNA Base Change (assembly)

T to C at 152217890 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000143354 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000106121] [ENSMUST00000106121] [ENSMUST00000166984] [ENSMUST00000166984] [ENSMUST00000196062] [ENSMUST00000196429] [ENSMUST00000196695] [ENSMUST00000196695] [ENSMUST00000196739] [ENSMUST00000196739] [ENSMUST00000198227] [ENSMUST00000198227] [ENSMUST00000199202] [ENSMUST00000199202] [ENSMUST00000199876] [ENSMUST00000200452] [ENSMUST00000200524] [ENSMUST00000200524]

AlphaFold

Q91WJ8

Predicted Effect

probably null
Transcript: ENSMUST00000106121

SMART Domains

Protein: ENSMUSP00000101727
Gene: ENSMUSG00000028034

Domain	Start	End	E-Value	Type
low complexity region	7	23	N/A	INTRINSIC
PDB:2KXH\|B	24	48	3e-8	PDB
KH	94	164	1.09e-17	SMART
KH	179	251	2.33e-17	SMART
KH	269	339	1.32e-16	SMART
low complexity region	344	366	N/A	INTRINSIC
KH	370	443	1.19e-14	SMART
low complexity region	513	527	N/A	INTRINSIC
low complexity region	530	556	N/A	INTRINSIC
Pfam:DUF1897	571	599	1.3e-7	PFAM
Pfam:DUF1897	600	624	1.3e-9	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000106121

SMART Domains

Protein: ENSMUSP00000101727
Gene: ENSMUSG00000028034

Domain	Start	End	E-Value	Type
low complexity region	7	23	N/A	INTRINSIC
PDB:2KXH\|B	24	48	3e-8	PDB
KH	94	164	1.09e-17	SMART
KH	179	251	2.33e-17	SMART
KH	269	339	1.32e-16	SMART
low complexity region	344	366	N/A	INTRINSIC
KH	370	443	1.19e-14	SMART
low complexity region	513	527	N/A	INTRINSIC
low complexity region	530	556	N/A	INTRINSIC
Pfam:DUF1897	571	599	1.3e-7	PFAM
Pfam:DUF1897	600	624	1.3e-9	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000166984

SMART Domains

Protein: ENSMUSP00000130145
Gene: ENSMUSG00000028034

Domain	Start	End	E-Value	Type
low complexity region	7	23	N/A	INTRINSIC
PDB:2KXH\|B	24	48	3e-8	PDB
KH	94	164	1.09e-17	SMART
KH	179	251	2.33e-17	SMART
KH	269	339	1.32e-16	SMART
low complexity region	344	366	N/A	INTRINSIC
KH	370	443	1.19e-14	SMART
low complexity region	513	527	N/A	INTRINSIC
low complexity region	530	556	N/A	INTRINSIC
Pfam:DUF1897	570	598	2e-7	PFAM
Pfam:DUF1897	599	631	9.2e-13	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000166984

SMART Domains

Protein: ENSMUSP00000130145
Gene: ENSMUSG00000028034

Domain	Start	End	E-Value	Type
low complexity region	7	23	N/A	INTRINSIC
PDB:2KXH\|B	24	48	3e-8	PDB
KH	94	164	1.09e-17	SMART
KH	179	251	2.33e-17	SMART
KH	269	339	1.32e-16	SMART
low complexity region	344	366	N/A	INTRINSIC
KH	370	443	1.19e-14	SMART
low complexity region	513	527	N/A	INTRINSIC
low complexity region	530	556	N/A	INTRINSIC
Pfam:DUF1897	570	598	2e-7	PFAM
Pfam:DUF1897	599	631	9.2e-13	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000196062

SMART Domains

Protein: ENSMUSP00000143718
Gene: ENSMUSG00000028034

Domain	Start	End	E-Value	Type
low complexity region	7	23	N/A	INTRINSIC
PDB:2KXH\|B	24	48	5e-10	PDB

Predicted Effect

probably benign
Transcript: ENSMUST00000196429

SMART Domains

Protein: ENSMUSP00000143478
Gene: ENSMUSG00000028034

Domain	Start	End	E-Value	Type
KH	1	69	1.1e-13	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000196695

SMART Domains

Protein: ENSMUSP00000143729
Gene: ENSMUSG00000028034

Domain	Start	End	E-Value	Type
low complexity region	7	23	N/A	INTRINSIC
PDB:2KXH\|B	24	48	3e-8	PDB
KH	95	165	7e-20	SMART
KH	180	252	1.5e-19	SMART
KH	270	340	8.2e-19	SMART
low complexity region	345	367	N/A	INTRINSIC
KH	371	444	7.3e-17	SMART
low complexity region	514	528	N/A	INTRINSIC
low complexity region	531	557	N/A	INTRINSIC
Pfam:DUF1897	572	600	1.1e-4	PFAM
Pfam:DUF1897	601	625	1.1e-6	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000196695

SMART Domains

Protein: ENSMUSP00000143729
Gene: ENSMUSG00000028034

Domain	Start	End	E-Value	Type
low complexity region	7	23	N/A	INTRINSIC
PDB:2KXH\|B	24	48	3e-8	PDB
KH	95	165	7e-20	SMART
KH	180	252	1.5e-19	SMART
KH	270	340	8.2e-19	SMART
low complexity region	345	367	N/A	INTRINSIC
KH	371	444	7.3e-17	SMART
low complexity region	514	528	N/A	INTRINSIC
low complexity region	531	557	N/A	INTRINSIC
Pfam:DUF1897	572	600	1.1e-4	PFAM
Pfam:DUF1897	601	625	1.1e-6	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000196739

SMART Domains

Protein: ENSMUSP00000143101
Gene: ENSMUSG00000028034

Domain	Start	End	E-Value	Type
low complexity region	7	23	N/A	INTRINSIC
PDB:2KXH\|B	24	48	2e-8	PDB
KH	95	165	1.09e-17	SMART
KH	180	252	2.33e-17	SMART
KH	270	340	1.32e-16	SMART
low complexity region	345	367	N/A	INTRINSIC
KH	371	444	1.19e-14	SMART
low complexity region	514	528	N/A	INTRINSIC
low complexity region	531	557	N/A	INTRINSIC
Pfam:DUF1897	568	596	1e-7	PFAM
Pfam:DUF1897	597	629	4.7e-13	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000196739

SMART Domains

Protein: ENSMUSP00000143101
Gene: ENSMUSG00000028034

Domain	Start	End	E-Value	Type
low complexity region	7	23	N/A	INTRINSIC
PDB:2KXH\|B	24	48	2e-8	PDB
KH	95	165	1.09e-17	SMART
KH	180	252	2.33e-17	SMART
KH	270	340	1.32e-16	SMART
low complexity region	345	367	N/A	INTRINSIC
KH	371	444	1.19e-14	SMART
low complexity region	514	528	N/A	INTRINSIC
low complexity region	531	557	N/A	INTRINSIC
Pfam:DUF1897	568	596	1e-7	PFAM
Pfam:DUF1897	597	629	4.7e-13	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000198227

SMART Domains

Protein: ENSMUSP00000143370
Gene: ENSMUSG00000028034

Domain	Start	End	E-Value	Type
low complexity region	7	23	N/A	INTRINSIC
PDB:2KXH\|B	24	48	2e-8	PDB
KH	94	164	6.9e-20	SMART
KH	179	251	1.5e-19	SMART
KH	269	339	8.1e-19	SMART
low complexity region	344	366	N/A	INTRINSIC
KH	370	443	7.2e-17	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000198227

SMART Domains

Protein: ENSMUSP00000143370
Gene: ENSMUSG00000028034

Domain	Start	End	E-Value	Type
low complexity region	7	23	N/A	INTRINSIC
PDB:2KXH\|B	24	48	2e-8	PDB
KH	94	164	6.9e-20	SMART
KH	179	251	1.5e-19	SMART
KH	269	339	8.1e-19	SMART
low complexity region	344	366	N/A	INTRINSIC
KH	370	443	7.2e-17	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000199127

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000199199

Predicted Effect

probably null
Transcript: ENSMUST00000199202

SMART Domains

Protein: ENSMUSP00000143204
Gene: ENSMUSG00000028034

Domain	Start	End	E-Value	Type
low complexity region	7	23	N/A	INTRINSIC
PDB:2KXH\|B	24	48	1e-8	PDB
KH	115	185	6.9e-20	SMART
KH	200	272	1.5e-19	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000199202

SMART Domains

Protein: ENSMUSP00000143204
Gene: ENSMUSG00000028034

Domain	Start	End	E-Value	Type
low complexity region	7	23	N/A	INTRINSIC
PDB:2KXH\|B	24	48	1e-8	PDB
KH	115	185	6.9e-20	SMART
KH	200	272	1.5e-19	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000199876

SMART Domains

Protein: ENSMUSP00000143618
Gene: ENSMUSG00000028034

Domain	Start	End	E-Value	Type
low complexity region	7	23	N/A	INTRINSIC
PDB:2KXH\|B	24	48	3e-8	PDB
KH	95	165	1.09e-17	SMART
KH	180	252	2.33e-17	SMART
KH	270	340	1.32e-16	SMART
low complexity region	345	367	N/A	INTRINSIC
KH	371	444	1.19e-14	SMART
low complexity region	514	528	N/A	INTRINSIC
low complexity region	531	557	N/A	INTRINSIC
Pfam:DUF1897	572	600	1.5e-7	PFAM
Pfam:DUF1897	601	625	1.5e-9	PFAM
transmembrane domain	654	676	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000200452

SMART Domains

Protein: ENSMUSP00000143019
Gene: ENSMUSG00000028034

Domain	Start	End	E-Value	Type
low complexity region	7	23	N/A	INTRINSIC
PDB:2KXH\|B	24	48	3e-8	PDB
KH	94	164	1.09e-17	SMART
KH	179	251	2.33e-17	SMART
KH	269	339	1.32e-16	SMART
low complexity region	344	366	N/A	INTRINSIC
KH	370	443	1.19e-14	SMART
low complexity region	513	527	N/A	INTRINSIC
low complexity region	530	556	N/A	INTRINSIC
Pfam:DUF1897	570	598	2e-7	PFAM
Pfam:DUF1897	599	631	9.2e-13	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000200524

SMART Domains

Protein: ENSMUSP00000143354
Gene: ENSMUSG00000028034

Domain	Start	End	E-Value	Type
low complexity region	7	23	N/A	INTRINSIC
PDB:2KXH\|B	24	48	3e-8	PDB
KH	95	165	6.9e-20	SMART
KH	180	252	1.5e-19	SMART
KH	270	340	8.1e-19	SMART
low complexity region	345	367	N/A	INTRINSIC
KH	371	444	7.2e-17	SMART
low complexity region	514	528	N/A	INTRINSIC
low complexity region	531	557	N/A	INTRINSIC
Pfam:DUF1897	571	599	1.5e-4	PFAM
Pfam:DUF1897	600	632	7e-10	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000200524

SMART Domains

Protein: ENSMUSP00000143354
Gene: ENSMUSG00000028034

Domain	Start	End	E-Value	Type
low complexity region	7	23	N/A	INTRINSIC
PDB:2KXH\|B	24	48	3e-8	PDB
KH	95	165	6.9e-20	SMART
KH	180	252	1.5e-19	SMART
KH	270	340	8.1e-19	SMART
low complexity region	345	367	N/A	INTRINSIC
KH	371	444	7.2e-17	SMART
low complexity region	514	528	N/A	INTRINSIC
low complexity region	531	557	N/A	INTRINSIC
Pfam:DUF1897	571	599	1.5e-4	PFAM
Pfam:DUF1897	600	632	7e-10	PFAM

Coding Region Coverage

1x: 99.1%
3x: 98.4%
10x: 96.8%
20x: 93.8%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a single stranded DNA-binding protein that binds to multiple DNA elements, including the far upstream element (FUSE) located upstream of c-myc. Binding to FUSE occurs on the non-coding strand, and is important to the regulation of c-myc in undifferentiated cells. This protein contains three domains, an amphipathic helix N-terminal domain, a DNA-binding central domain, and a C-terminal transactivation domain that contains three tyrosine-rich motifs. The N-terminal domain is thought to repress the activity of the C-terminal domain. This protein is also thought to bind RNA, and contains 3'-5' helicase activity with in vitro activity on both DNA-DNA and RNA-RNA duplexes. Aberrant expression of this gene has been found in malignant tissues, and this gene is important to neural system and lung development. Binding of this protein to viral RNA is thought to play a role in several viral diseases, including hepatitis C and hand, foot and mouth disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
PHENOTYPE: Mice homozygous for a null allele exhibit pre- and perinatal lethality, cerebral hyperplasia, pale liver, hypoplastic lungs, spleen, thymus and bone marrow, cardiac hypertrophy, placental distress, small size, and anemia associated with variable, multilineage hematopoietic deficiency. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 130 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700012B07Rik	C	A	11: 109,791,672	L229F	probably benign	Het
A930002H24Rik	A	C	17: 63,863,608	S62A	unknown	Het
Abca12	T	A	1: 71,302,685	Q1039L	possibly damaging	Het
Adgrg5	T	A	8: 94,941,734	F476I	possibly damaging	Het
AI314180	G	A	4: 58,850,911	L421F	probably damaging	Het
Alms1	A	G	6: 85,678,245	K2789E	probably damaging	Het
Arrdc2	G	A	8: 70,839,277		probably null	Het
Atp2b1	T	A	10: 99,009,564	I743K	probably damaging	Het
Atp6v1c2	C	T	12: 17,289,060	G230D	probably benign	Het
AU040320	G	A	4: 126,791,793	C54Y	probably damaging	Het
BC024139	C	T	15: 76,120,317	V680I	possibly damaging	Het
Bckdhb	A	G	9: 83,988,905	D156G	probably damaging	Het
Canx	T	A	11: 50,308,809	D143V	probably benign	Het
Ccdc180	T	A	4: 45,912,794	V591E	possibly damaging	Het
Ccno	T	C	13: 112,988,099	S68P	probably benign	Het
Cdc45	C	T	16: 18,784,863	E527K	probably damaging	Het
Cep290	T	A	10: 100,488,348	D14E	probably damaging	Het
Cgnl1	A	G	9: 71,630,524	V1238A	probably benign	Het
Ciz1	C	T	2: 32,371,741	A455V	probably damaging	Het
Coro2b	T	A	9: 62,454,623	Y86F	probably benign	Het
Csf2ra	C	T	19: 61,226,552	R158Q	probably benign	Het
Cubn	A	T	2: 13,325,225	I2615N	probably damaging	Het
Dhx8	C	T	11: 101,738,170	R129*	probably null	Het
Disc1	T	A	8: 125,135,302	M471K	possibly damaging	Het
Dmxl2	G	T	9: 54,404,041	L1799I	probably benign	Het
Dnah2	A	G	11: 69,423,205	S4108P	probably damaging	Het
Ehmt2	C	G	17: 34,906,964	P211R	probably benign	Het
Eif4g3	A	G	4: 138,194,081	D1557G	probably benign	Het
Epha5	T	C	5: 84,233,840	D384G	probably damaging	Het
Etl4	A	G	2: 20,806,927	I1274V	probably damaging	Het
Fam160a1	G	A	3: 85,673,432	P489S	possibly damaging	Het
Fip1l1	G	A	5: 74,588,205		probably null	Het
Glul	T	C	1: 153,903,044	V33A	probably benign	Het
Gm4846	A	G	1: 166,491,668	F167S	probably damaging	Het
Heatr6	T	A	11: 83,758,322	L168M	probably damaging	Het
Hif1a	T	A	12: 73,932,401	I233N	probably damaging	Het
Hivep2	T	A	10: 14,131,319	H1220Q	possibly damaging	Het
Igkv8-21	T	C	6: 70,315,426	I9M	probably benign	Het
Izumo1	T	A	7: 45,624,987	C62*	probably null	Het
Jakmip3	G	A	7: 139,026,766	E424K	probably damaging	Het
Klhl2	A	G	8: 64,752,813	V358A	probably damaging	Het
Klk10	C	G	7: 43,783,598	D139E	probably damaging	Het
Klk14	T	C	7: 43,692,076	C51R	probably damaging	Het
Klk5	T	G	7: 43,845,390	I99S	probably damaging	Het
L3hypdh	T	C	12: 72,077,393	T258A	probably benign	Het
Lrp5	A	G	19: 3,614,292	Y812H	probably damaging	Het
Lrrc40	T	A	3: 158,061,330	L474*	probably null	Het
Mkks	A	T	2: 136,880,655	M194K	probably benign	Het
Mmp20	A	G	9: 7,654,120	D347G	probably damaging	Het
Mmp27	A	G	9: 7,581,194	E460G	probably damaging	Het
Mms22l	T	C	4: 24,536,226	F605S	probably damaging	Het
Mpzl3	A	G	9: 45,068,329	S193G	probably benign	Het
Muc4	A	T	16: 32,751,747	T542S	probably benign	Het
Muc5b	T	C	7: 141,868,465	L4446P	possibly damaging	Het
Mxi1	C	A	19: 53,370,338	S131*	probably null	Het
Nanog	G	T	6: 122,713,340	A210S	probably benign	Het
Nrcam	C	T	12: 44,575,986	Q988*	probably null	Het
Nsg1	C	A	5: 38,159,047		probably benign	Het
Ogfod3	G	A	11: 121,195,201	A189V	probably benign	Het
Olfr1121	T	A	2: 87,372,088	C185*	probably null	Het
Olfr1228	T	C	2: 89,248,690		probably null	Het
Olfr1240	A	G	2: 89,439,865	V138A	probably benign	Het
Olfr1260	G	A	2: 89,978,153	C125Y	probably damaging	Het
Olfr1465	A	T	19: 13,314,320		probably null	Het
Olfr548-ps1	T	A	7: 102,542,380	V148E	possibly damaging	Het
Olfr58	T	G	9: 19,783,576	S148A	possibly damaging	Het
Olfr632	T	C	7: 103,937,503	V41A	probably benign	Het
Olfr920	A	T	9: 38,756,407	T240S	probably damaging	Het
Olfr980	A	T	9: 40,006,742	M69K	possibly damaging	Het
Orc3	A	T	4: 34,571,774	M665K	possibly damaging	Het
Pabpc1	A	G	15: 36,597,011	S591P	probably damaging	Het
Parp6	T	A	9: 59,624,362		probably null	Het
Pcdh1	T	C	18: 38,189,859	M974V	possibly damaging	Het
Pcdhb22	T	A	18: 37,520,660	V727E	possibly damaging	Het
Pex5l	T	C	3: 32,992,985	E272G	probably damaging	Het
Pglyrp2	G	T	17: 32,418,261	N264K	probably benign	Het
Phxr4	T	A	9: 13,431,586		probably benign	Het
Piezo2	A	G	18: 63,144,954	F293S	probably damaging	Het
Pkhd1	T	C	1: 20,537,401	D1077G	probably damaging	Het
Plekhs1	A	G	19: 56,473,268		probably null	Het
Prex1	G	T	2: 166,585,857	C788*	probably null	Het
Prrt3	A	T	6: 113,498,138	M41K	probably benign	Het
Ptgir	T	C	7: 16,908,843	V326A	probably damaging	Het
Ptprg	T	A	14: 12,220,654	D455E	probably damaging	Het
Ptpru	T	A	4: 131,799,603	Q686L	probably benign	Het
Pxdc1	G	T	13: 34,630,360	T190K	probably benign	Het
Rap1b	A	T	10: 117,818,582	C118S	probably benign	Het
Rapgef2	T	C	3: 79,083,227	M915V	probably benign	Het
Rnd2	C	T	11: 101,468,999	L57F	probably damaging	Het
Rpe65	C	T	3: 159,624,681	A495V	probably benign	Het
Samd15	A	G	12: 87,200,834	T98A	possibly damaging	Het
Sdk1	T	G	5: 141,582,294	D82E	probably benign	Het
Slc26a7	T	C	4: 14,546,309	D340G	probably benign	Het
Slc6a15	T	A	10: 103,418,060	M619K	probably benign	Het
Slc7a4	C	A	16: 17,574,521	D350Y	probably damaging	Het
Slk	T	G	19: 47,619,956	N449K	probably benign	Het
Spta1	A	T	1: 174,244,042		probably null	Het
Sptbn5	A	T	2: 120,055,893		probably benign	Het
Srd5a2	A	T	17: 74,047,805	V8D	probably benign	Het
Srgap3	G	A	6: 112,727,310	A906V	probably benign	Het
Stab2	A	T	10: 86,947,147	M679K	probably benign	Het
Stk3	T	C	15: 34,999,908	I291V	probably benign	Het
Supt6	T	A	11: 78,208,134	Q1637L	possibly damaging	Het
Svil	T	C	18: 5,114,564	F2047S	probably damaging	Het
Swsap1	A	G	9: 21,955,988	E76G	probably benign	Het
Syndig1	G	T	2: 149,899,553	G20C	probably damaging	Het
Synj2bp	A	T	12: 81,502,152	N104K	probably damaging	Het
Synpo2	T	A	3: 123,114,419	D416V	probably damaging	Het
Tacc3	G	T	5: 33,672,013	C620F	probably damaging	Het
Tanc1	A	G	2: 59,699,422	E19G	probably damaging	Het
Tarsl2	C	T	7: 65,647,554	A139V	probably benign	Het
Tbc1d22a	T	A	15: 86,351,734	C365S	probably damaging	Het
Tdpoz2	T	C	3: 93,652,074	H197R	possibly damaging	Het
Tha1	A	T	11: 117,869,379	N300K	probably damaging	Het
Tm6sf1	T	A	7: 81,865,260	F70L	probably damaging	Het
Tmem132b	T	A	5: 125,783,433	S581T	probably benign	Het
Tmem206	A	T	1: 191,340,843	I154F	probably damaging	Het
Tnfsf13	G	T	11: 69,685,249	S4*	probably null	Het
Tonsl	G	A	15: 76,633,248	S757L	probably benign	Het
Trem2	G	T	17: 48,351,691	R161S	possibly damaging	Het
Trpm2	A	T	10: 77,941,173	V430E	probably damaging	Het
Ttc14	T	A	3: 33,801,369	D154E	possibly damaging	Het
Ugt2b37	T	C	5: 87,250,639	M313V	possibly damaging	Het
Uhrf1bp1	G	A	17: 27,877,394	A107T	probably damaging	Het
Vmn2r24	A	G	6: 123,815,780	I689V	probably benign	Het
Wdr76	A	G	2: 121,542,494	T601A	probably benign	Het
Xirp1	T	C	9: 120,017,003	D938G	possibly damaging	Het
Zfp608	A	T	18: 54,897,969	D966E	probably benign	Het
Zfp957	A	G	14: 79,214,356	M1T	probably null	Het
Zkscan16	A	T	4: 58,957,809	H697L	possibly damaging	Het

Other mutations in Fubp1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01083:Fubp1	APN	3	152222234	missense	probably damaging	0.97
IGL01328:Fubp1	APN	3	152220218	missense	probably damaging	1.00
IGL01583:Fubp1	APN	3	152215624	missense	possibly damaging	0.71
IGL02886:Fubp1	APN	3	152220755	missense	possibly damaging	0.90
R0166:Fubp1	UTSW	3	152220204	nonsense	probably null
R0268:Fubp1	UTSW	3	152219713	missense	probably damaging	0.99
R0344:Fubp1	UTSW	3	152219713	missense	probably damaging	0.99
R0759:Fubp1	UTSW	3	152210637	small insertion	probably benign
R1159:Fubp1	UTSW	3	152215592	missense	possibly damaging	0.93
R1194:Fubp1	UTSW	3	152231969	frame shift	probably null
R1687:Fubp1	UTSW	3	152228201	unclassified	probably benign
R1818:Fubp1	UTSW	3	152222169	missense	probably damaging	1.00
R3880:Fubp1	UTSW	3	152220496	missense	probably damaging	1.00
R4247:Fubp1	UTSW	3	152231936	missense	possibly damaging	0.92
R4564:Fubp1	UTSW	3	152222936	nonsense	probably null
R4776:Fubp1	UTSW	3	152222068	splice site	probably null
R4793:Fubp1	UTSW	3	152223329	missense	possibly damaging	0.86
R5035:Fubp1	UTSW	3	152214851	missense	probably benign	0.01
R5167:Fubp1	UTSW	3	152221352	missense	possibly damaging	0.67
R5819:Fubp1	UTSW	3	152220553	missense	probably damaging	1.00
R5892:Fubp1	UTSW	3	152218314	intron	probably benign
R6254:Fubp1	UTSW	3	152232408	missense	possibly damaging	0.66
R6814:Fubp1	UTSW	3	152226146	missense	probably benign	0.33
R6872:Fubp1	UTSW	3	152226146	missense	probably benign	0.33
R7132:Fubp1	UTSW	3	152232024	critical splice donor site	probably null
R7612:Fubp1	UTSW	3	152218015	missense	possibly damaging	0.66
R7876:Fubp1	UTSW	3	152232291	missense	unknown
R7903:Fubp1	UTSW	3	152214861	nonsense	probably null
R7969:Fubp1	UTSW	3	152222246	critical splice donor site	probably null
R8201:Fubp1	UTSW	3	152222186	missense	probably damaging	1.00
R8219:Fubp1	UTSW	3	152220466	missense	probably damaging	1.00
R8262:Fubp1	UTSW	3	152220719	missense	probably damaging	1.00
R8434:Fubp1	UTSW	3	152220553	missense	probably damaging	1.00
R8859:Fubp1	UTSW	3	152232032	splice site	probably benign
R9186:Fubp1	UTSW	3	152220516	missense	probably damaging	0.96
R9217:Fubp1	UTSW	3	152218236	missense	probably benign	0.00
R9239:Fubp1	UTSW	3	152217849	missense	probably damaging	1.00
R9725:Fubp1	UTSW	3	152222186	missense	probably damaging	1.00
Z1176:Fubp1	UTSW	3	152222087	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TAAGAACCTGGCTGGGCTAC -3'
(R):5'- AAATACTTGAGTTTCCTAGCCACTCTC -3'

Sequencing Primer
(F):5'- CTGGGCTACTGGGAGACTTTAAG -3'
(R):5'- TGGACAAAACAACAAGTAATTCGTAC -3'

Posted On

2016-03-16