Incidental Mutation 'R4836:Kdm5b'
| ID |
374517 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Kdm5b
|
| Ensembl Gene |
ENSMUSG00000042207 |
| Gene Name |
lysine (K)-specific demethylase 5B |
| Synonyms |
Jarid1b, Plu1, Rb-Bp2, 2210016I17Rik, 2010009J12Rik, PLU-1, D1Ertd202e |
| MMRRC Submission |
042451-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.268)
|
| Stock # |
R4836 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
134560171-134635285 bp(+) (GRCm38) |
| Type of Mutation |
splice site |
| DNA Base Change (assembly) |
C to A
at 134593315 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000107817
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000047714]
[ENSMUST00000112198]
|
| AlphaFold |
Q80Y84 |
| PDB Structure |
Solution structure of the ARID domain of Jarid1b protein [SOLUTION NMR]
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000047714
|
| SMART Domains |
Protein: ENSMUSP00000038138
Gene: ENSMUSG00000042207
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
7 |
30 |
N/A |
INTRINSIC |
|
JmjN
|
31 |
72 |
2.87e-20 |
SMART |
|
ARID
|
94 |
183 |
7.39e-32 |
SMART |
|
BRIGHT
|
98 |
188 |
1.51e-35 |
SMART |
|
low complexity region
|
228 |
239 |
N/A |
INTRINSIC |
|
PHD
|
311 |
357 |
6.15e-14 |
SMART |
|
JmjC
|
453 |
619 |
2.33e-67 |
SMART |
|
Pfam:zf-C5HC2
|
692 |
744 |
2.2e-17 |
PFAM |
|
Pfam:PLU-1
|
757 |
1088 |
5.6e-92 |
PFAM |
|
low complexity region
|
1097 |
1109 |
N/A |
INTRINSIC |
|
PHD
|
1178 |
1222 |
6.2e-10 |
SMART |
|
low complexity region
|
1225 |
1236 |
N/A |
INTRINSIC |
|
low complexity region
|
1406 |
1417 |
N/A |
INTRINSIC |
|
low complexity region
|
1470 |
1484 |
N/A |
INTRINSIC |
|
PHD
|
1486 |
1536 |
1.18e-6 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000112197
|
| SMART Domains |
Protein: ENSMUSP00000107816
Gene: ENSMUSG00000042207
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
7 |
30 |
N/A |
INTRINSIC |
|
JmjN
|
31 |
72 |
2.87e-20 |
SMART |
|
ARID
|
94 |
183 |
7.39e-32 |
SMART |
|
BRIGHT
|
98 |
188 |
1.51e-35 |
SMART |
|
low complexity region
|
225 |
236 |
N/A |
INTRINSIC |
|
PHD
|
308 |
354 |
6.15e-14 |
SMART |
|
JmjC
|
450 |
595 |
2.6e-24 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000112198
|
| SMART Domains |
Protein: ENSMUSP00000107817
Gene: ENSMUSG00000042207
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
7 |
30 |
N/A |
INTRINSIC |
|
JmjN
|
31 |
72 |
2.87e-20 |
SMART |
|
ARID
|
94 |
183 |
7.39e-32 |
SMART |
|
BRIGHT
|
98 |
188 |
1.51e-35 |
SMART |
|
low complexity region
|
228 |
239 |
N/A |
INTRINSIC |
|
PHD
|
311 |
357 |
6.15e-14 |
SMART |
|
JmjC
|
453 |
619 |
2.33e-67 |
SMART |
|
Pfam:zf-C5HC2
|
692 |
745 |
6.7e-21 |
PFAM |
|
Pfam:PLU-1
|
756 |
1088 |
6e-94 |
PFAM |
|
low complexity region
|
1097 |
1109 |
N/A |
INTRINSIC |
|
PHD
|
1178 |
1222 |
6.2e-10 |
SMART |
|
low complexity region
|
1225 |
1236 |
N/A |
INTRINSIC |
|
low complexity region
|
1406 |
1417 |
N/A |
INTRINSIC |
|
low complexity region
|
1470 |
1484 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000186128
|
| Meta Mutation Damage Score |
0.9755 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.6%
- 20x: 93.2%
|
| Validation Efficiency |
98% (87/89) |
| MGI Phenotype |
FUNCTION: This gene encodes a lysine-specific histone demethylase that belongs to the jumonji/ARID domain-containing family of histone demethylases. The encoded protein is capable of demethylating tri-, di- and monomethylated lysine 4 of histone H3. This protein plays a role in the transcriptional repression or certain tumor suppressor genes and is upregulated in certain cancer cells. This protein may also play a role in genome stability and DNA repair. Homozygous mutant mice display decreased body weight, decreased female fertility, lower uterine weight, and a delay in mammary development. Knockout of this gene has also been associated with embryonic lethality. [provided by RefSeq, Dec 2016]
PHENOTYPE: Mice homozygous for a gene trapped allele exhibit decreased body weight, background-sensitive premature mortality, decreased female fertility, delayed mammary gland development, decreased serum estradiol levels, and reduced mammary epithelial cell proliferation in early puberty. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 78 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 5830411N06Rik |
T |
C |
7: 140,299,108 |
I1051T |
probably benign |
Het |
| Acox1 |
A |
T |
11: 116,175,326 |
S453T |
probably benign |
Het |
| AF366264 |
C |
T |
8: 13,838,007 |
S28N |
probably benign |
Het |
| Ahnak2 |
A |
T |
12: 112,774,116 |
V368D |
probably damaging |
Het |
| Ankrd53 |
A |
T |
6: 83,768,152 |
Y448F |
probably damaging |
Het |
| Arhgef15 |
A |
T |
11: 68,949,925 |
|
probably benign |
Het |
| Atg2b |
T |
C |
12: 105,646,814 |
N1166S |
probably benign |
Het |
| Atl3 |
C |
T |
19: 7,509,545 |
R77* |
probably null |
Het |
| Bend6 |
T |
C |
1: 33,883,573 |
|
probably benign |
Het |
| Ccnt1 |
C |
A |
15: 98,567,563 |
R25L |
probably damaging |
Het |
| Cct4 |
A |
G |
11: 23,002,898 |
T525A |
probably benign |
Het |
| Cep350 |
T |
C |
1: 155,928,833 |
I835V |
probably damaging |
Het |
| Clcn1 |
G |
T |
6: 42,309,964 |
V652L |
probably damaging |
Het |
| Cntln |
T |
A |
4: 85,049,720 |
Y725* |
probably null |
Het |
| Cog5 |
T |
C |
12: 31,919,733 |
F21L |
probably benign |
Het |
| D6Ertd527e |
GGCAGCAGCAGCA |
GGCAGCAGCAGCAGCA |
6: 87,111,424 |
|
probably benign |
Het |
| Dnm2 |
A |
T |
9: 21,491,330 |
|
probably benign |
Het |
| Dnmt1 |
C |
T |
9: 20,908,558 |
V1430I |
probably damaging |
Het |
| Dpep1 |
A |
G |
8: 123,200,367 |
D285G |
probably damaging |
Het |
| Eef2kmt |
C |
T |
16: 5,249,003 |
V129M |
probably damaging |
Het |
| Epha3 |
A |
T |
16: 63,583,557 |
M726K |
probably damaging |
Het |
| Fat3 |
A |
G |
9: 16,377,723 |
L168P |
probably damaging |
Het |
| Frem3 |
T |
A |
8: 80,663,397 |
F1759Y |
probably damaging |
Het |
| Fubp3 |
T |
A |
2: 31,608,141 |
S56R |
possibly damaging |
Het |
| Gm1965 |
T |
C |
6: 89,145,410 |
|
noncoding transcript |
Het |
| Gm5592 |
C |
T |
7: 41,215,534 |
|
probably benign |
Het |
| Hils1 |
T |
A |
11: 94,968,017 |
L46* |
probably null |
Het |
| Irs1 |
TGGGGTGGACATCGAACTGAAGGAG |
TG |
1: 82,287,732 |
913 |
probably null |
Het |
| Isl1 |
A |
G |
13: 116,303,083 |
M243T |
probably benign |
Het |
| Itpr1 |
A |
T |
6: 108,389,537 |
I142F |
probably damaging |
Het |
| Jak1 |
T |
C |
4: 101,155,066 |
T1069A |
probably damaging |
Het |
| Jmjd1c |
T |
C |
10: 67,233,446 |
V1848A |
probably benign |
Het |
| Kdm5a |
T |
C |
6: 120,412,402 |
V930A |
probably damaging |
Het |
| Lexm |
T |
A |
4: 106,610,527 |
|
probably null |
Het |
| Lilra5 |
T |
C |
7: 4,238,714 |
F171L |
possibly damaging |
Het |
| Map1b |
A |
G |
13: 99,431,054 |
S1720P |
unknown |
Het |
| Mcpt1 |
A |
T |
14: 56,019,560 |
Q185L |
probably damaging |
Het |
| Mmp20 |
T |
A |
9: 7,644,026 |
D238E |
possibly damaging |
Het |
| Mov10l1 |
A |
T |
15: 89,020,269 |
I784F |
possibly damaging |
Het |
| Mroh2b |
C |
T |
15: 4,904,270 |
P101S |
probably damaging |
Het |
| Myh3 |
G |
T |
11: 67,096,939 |
A1413S |
probably benign |
Het |
| Nat6 |
A |
T |
9: 107,583,539 |
Y211F |
probably damaging |
Het |
| Npdc1 |
G |
A |
2: 25,408,945 |
D284N |
probably damaging |
Het |
| Olfr1009 |
A |
G |
2: 85,721,449 |
I15V |
probably benign |
Het |
| Olfr1054 |
A |
T |
2: 86,333,227 |
M43K |
probably benign |
Het |
| Olfr1056 |
G |
A |
2: 86,355,750 |
L211F |
probably benign |
Het |
| Olfr1196 |
A |
G |
2: 88,701,200 |
I43T |
probably damaging |
Het |
| Olfr330 |
A |
C |
11: 58,529,482 |
M168R |
probably damaging |
Het |
| Olfr533 |
A |
G |
7: 140,467,076 |
R292G |
probably damaging |
Het |
| Palld |
T |
A |
8: 61,687,381 |
T531S |
probably benign |
Het |
| Parp4 |
A |
G |
14: 56,585,738 |
E105G |
probably benign |
Het |
| Phf11a |
A |
T |
14: 59,287,579 |
S59T |
probably damaging |
Het |
| Ppp1r12b |
G |
T |
1: 134,955,733 |
A17E |
probably benign |
Het |
| Rad50 |
A |
T |
11: 53,650,653 |
I1252N |
probably damaging |
Het |
| Ramp3 |
A |
G |
11: 6,674,761 |
|
probably null |
Het |
| Rrbp1 |
G |
A |
2: 143,988,417 |
T610I |
possibly damaging |
Het |
| Slc4a10 |
A |
G |
2: 62,268,187 |
Y555C |
probably damaging |
Het |
| Slc5a2 |
A |
G |
7: 128,267,505 |
|
probably null |
Het |
| Smoc1 |
T |
A |
12: 81,179,548 |
D371E |
probably damaging |
Het |
| Stmn1 |
T |
A |
4: 134,470,184 |
|
probably benign |
Het |
| Sulf1 |
C |
T |
1: 12,842,686 |
L715F |
probably benign |
Het |
| Surf1 |
T |
C |
2: 26,914,243 |
T180A |
possibly damaging |
Het |
| Syne2 |
A |
G |
12: 75,979,819 |
I3474V |
probably damaging |
Het |
| Tchh |
A |
T |
3: 93,445,148 |
R632W |
unknown |
Het |
| Tchh |
A |
T |
3: 93,447,588 |
D1445V |
unknown |
Het |
| Tctn1 |
A |
T |
5: 122,245,505 |
M505K |
probably benign |
Het |
| Tdrkh |
T |
A |
3: 94,425,590 |
I150N |
probably damaging |
Het |
| Tespa1 |
C |
T |
10: 130,362,159 |
T350I |
probably benign |
Het |
| Thbs1 |
A |
G |
2: 118,115,018 |
Y326C |
possibly damaging |
Het |
| Tmem208 |
C |
T |
8: 105,328,664 |
S119F |
probably damaging |
Het |
| Tmprss6 |
G |
C |
15: 78,445,388 |
A91G |
probably damaging |
Het |
| Trp53bp2 |
C |
T |
1: 182,431,582 |
R67W |
probably damaging |
Het |
| Ttn |
A |
G |
2: 76,711,197 |
I25488T |
possibly damaging |
Het |
| Txnl4a |
A |
G |
18: 80,222,253 |
E111G |
probably damaging |
Het |
| Unc13b |
T |
G |
4: 43,237,137 |
I3402M |
probably damaging |
Het |
| Vmn1r188 |
A |
C |
13: 22,088,121 |
I82L |
probably benign |
Het |
| Zfp65 |
A |
G |
13: 67,708,875 |
V95A |
probably benign |
Het |
| Zfp985 |
T |
A |
4: 147,584,155 |
S493R |
probably damaging |
Het |
|
| Other mutations in Kdm5b |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00230:Kdm5b
|
APN |
1 |
134,620,955 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01458:Kdm5b
|
APN |
1 |
134,621,986 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
IGL01567:Kdm5b
|
APN |
1 |
134,602,540 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01625:Kdm5b
|
APN |
1 |
134,617,968 (GRCm38) |
missense |
possibly damaging |
0.74 |
|
IGL01970:Kdm5b
|
APN |
1 |
134,600,727 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02183:Kdm5b
|
APN |
1 |
134,624,931 (GRCm38) |
missense |
probably benign |
0.09 |
|
IGL02592:Kdm5b
|
APN |
1 |
134,624,853 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL02695:Kdm5b
|
APN |
1 |
134,604,485 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
IGL02697:Kdm5b
|
APN |
1 |
134,588,773 (GRCm38) |
splice site |
probably benign |
|
|
IGL03036:Kdm5b
|
APN |
1 |
134,608,937 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03056:Kdm5b
|
APN |
1 |
134,587,979 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL03206:Kdm5b
|
APN |
1 |
134,627,317 (GRCm38) |
missense |
probably benign |
|
|
IGL03342:Kdm5b
|
APN |
1 |
134,602,576 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL03388:Kdm5b
|
APN |
1 |
134,627,322 (GRCm38) |
missense |
probably benign |
|
|
amaryllis
|
UTSW |
1 |
134,609,061 (GRCm38) |
critical splice donor site |
probably null |
|
|
PIT4486001:Kdm5b
|
UTSW |
1 |
134,628,685 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0233:Kdm5b
|
UTSW |
1 |
134,604,634 (GRCm38) |
splice site |
probably benign |
|
|
R0334:Kdm5b
|
UTSW |
1 |
134,604,522 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R0504:Kdm5b
|
UTSW |
1 |
134,621,023 (GRCm38) |
critical splice donor site |
probably null |
|
|
R0505:Kdm5b
|
UTSW |
1 |
134,602,571 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R0521:Kdm5b
|
UTSW |
1 |
134,618,033 (GRCm38) |
missense |
possibly damaging |
0.65 |
|
R1004:Kdm5b
|
UTSW |
1 |
134,588,904 (GRCm38) |
missense |
possibly damaging |
0.71 |
|
R1087:Kdm5b
|
UTSW |
1 |
134,600,637 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1126:Kdm5b
|
UTSW |
1 |
134,613,991 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R1221:Kdm5b
|
UTSW |
1 |
134,599,091 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R1230:Kdm5b
|
UTSW |
1 |
134,613,254 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1345:Kdm5b
|
UTSW |
1 |
134,630,550 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R1482:Kdm5b
|
UTSW |
1 |
134,624,897 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1582:Kdm5b
|
UTSW |
1 |
134,624,853 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1653:Kdm5b
|
UTSW |
1 |
134,602,481 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1693:Kdm5b
|
UTSW |
1 |
134,597,576 (GRCm38) |
splice site |
probably benign |
|
|
R1721:Kdm5b
|
UTSW |
1 |
134,613,181 (GRCm38) |
splice site |
probably benign |
|
|
R1741:Kdm5b
|
UTSW |
1 |
134,618,017 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R1762:Kdm5b
|
UTSW |
1 |
134,604,467 (GRCm38) |
nonsense |
probably null |
|
|
R1820:Kdm5b
|
UTSW |
1 |
134,597,670 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
R1872:Kdm5b
|
UTSW |
1 |
134,624,994 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1966:Kdm5b
|
UTSW |
1 |
134,613,873 (GRCm38) |
splice site |
probably null |
|
|
R2056:Kdm5b
|
UTSW |
1 |
134,613,214 (GRCm38) |
missense |
probably benign |
0.05 |
|
R2059:Kdm5b
|
UTSW |
1 |
134,613,214 (GRCm38) |
missense |
probably benign |
0.05 |
|
R2405:Kdm5b
|
UTSW |
1 |
134,609,016 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R3417:Kdm5b
|
UTSW |
1 |
134,587,977 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3771:Kdm5b
|
UTSW |
1 |
134,613,345 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3783:Kdm5b
|
UTSW |
1 |
134,630,542 (GRCm38) |
missense |
probably benign |
|
|
R3803:Kdm5b
|
UTSW |
1 |
134,615,941 (GRCm38) |
missense |
probably benign |
0.07 |
|
R3980:Kdm5b
|
UTSW |
1 |
134,619,670 (GRCm38) |
missense |
probably benign |
0.11 |
|
R3983:Kdm5b
|
UTSW |
1 |
134,631,304 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R4013:Kdm5b
|
UTSW |
1 |
134,627,329 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
R4162:Kdm5b
|
UTSW |
1 |
134,625,161 (GRCm38) |
missense |
probably benign |
0.01 |
|
R4701:Kdm5b
|
UTSW |
1 |
134,606,012 (GRCm38) |
intron |
probably benign |
|
|
R4791:Kdm5b
|
UTSW |
1 |
134,630,800 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R4924:Kdm5b
|
UTSW |
1 |
134,631,351 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5135:Kdm5b
|
UTSW |
1 |
134,588,746 (GRCm38) |
intron |
probably benign |
|
|
R5248:Kdm5b
|
UTSW |
1 |
134,620,997 (GRCm38) |
missense |
probably benign |
0.11 |
|
R5290:Kdm5b
|
UTSW |
1 |
134,622,099 (GRCm38) |
splice site |
probably null |
|
|
R5358:Kdm5b
|
UTSW |
1 |
134,607,694 (GRCm38) |
nonsense |
probably null |
|
|
R5388:Kdm5b
|
UTSW |
1 |
134,608,897 (GRCm38) |
nonsense |
probably null |
|
|
R5396:Kdm5b
|
UTSW |
1 |
134,622,098 (GRCm38) |
splice site |
probably null |
|
|
R5397:Kdm5b
|
UTSW |
1 |
134,622,098 (GRCm38) |
splice site |
probably null |
|
|
R5398:Kdm5b
|
UTSW |
1 |
134,622,098 (GRCm38) |
splice site |
probably null |
|
|
R5399:Kdm5b
|
UTSW |
1 |
134,622,098 (GRCm38) |
splice site |
probably null |
|
|
R5529:Kdm5b
|
UTSW |
1 |
134,588,003 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5540:Kdm5b
|
UTSW |
1 |
134,631,241 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R5661:Kdm5b
|
UTSW |
1 |
134,599,073 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5663:Kdm5b
|
UTSW |
1 |
134,630,635 (GRCm38) |
missense |
probably benign |
|
|
R5822:Kdm5b
|
UTSW |
1 |
134,588,773 (GRCm38) |
splice site |
probably benign |
|
|
R6226:Kdm5b
|
UTSW |
1 |
134,608,878 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6368:Kdm5b
|
UTSW |
1 |
134,599,207 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6681:Kdm5b
|
UTSW |
1 |
134,613,269 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R6715:Kdm5b
|
UTSW |
1 |
134,609,061 (GRCm38) |
critical splice donor site |
probably null |
|
|
R7132:Kdm5b
|
UTSW |
1 |
134,599,106 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7202:Kdm5b
|
UTSW |
1 |
134,624,759 (GRCm38) |
missense |
probably benign |
|
|
R7258:Kdm5b
|
UTSW |
1 |
134,621,021 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7335:Kdm5b
|
UTSW |
1 |
134,560,439 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7420:Kdm5b
|
UTSW |
1 |
134,604,497 (GRCm38) |
missense |
probably benign |
0.14 |
|
R7426:Kdm5b
|
UTSW |
1 |
134,595,833 (GRCm38) |
missense |
probably benign |
0.02 |
|
R7452:Kdm5b
|
UTSW |
1 |
134,624,948 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7595:Kdm5b
|
UTSW |
1 |
134,608,966 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7612:Kdm5b
|
UTSW |
1 |
134,624,918 (GRCm38) |
nonsense |
probably null |
|
|
R7704:Kdm5b
|
UTSW |
1 |
134,587,931 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7846:Kdm5b
|
UTSW |
1 |
134,617,840 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8115:Kdm5b
|
UTSW |
1 |
134,619,673 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
R8146:Kdm5b
|
UTSW |
1 |
134,625,126 (GRCm38) |
missense |
probably benign |
0.05 |
|
R8160:Kdm5b
|
UTSW |
1 |
134,613,919 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8527:Kdm5b
|
UTSW |
1 |
134,605,774 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
R8542:Kdm5b
|
UTSW |
1 |
134,605,774 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
R8930:Kdm5b
|
UTSW |
1 |
134,616,272 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8932:Kdm5b
|
UTSW |
1 |
134,616,272 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8950:Kdm5b
|
UTSW |
1 |
134,613,926 (GRCm38) |
missense |
possibly damaging |
0.84 |
|
R9089:Kdm5b
|
UTSW |
1 |
134,607,768 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R9109:Kdm5b
|
UTSW |
1 |
134,600,755 (GRCm38) |
critical splice donor site |
probably null |
|
|
R9133:Kdm5b
|
UTSW |
1 |
134,602,585 (GRCm38) |
missense |
probably benign |
|
|
R9298:Kdm5b
|
UTSW |
1 |
134,600,755 (GRCm38) |
critical splice donor site |
probably null |
|
|
R9423:Kdm5b
|
UTSW |
1 |
134,587,967 (GRCm38) |
missense |
possibly damaging |
0.85 |
|
R9630:Kdm5b
|
UTSW |
1 |
134,585,233 (GRCm38) |
critical splice donor site |
probably null |
|
|
R9670:Kdm5b
|
UTSW |
1 |
134,630,502 (GRCm38) |
nonsense |
probably null |
|
|
X0063:Kdm5b
|
UTSW |
1 |
134,588,876 (GRCm38) |
missense |
probably benign |
0.07 |
|
Z1176:Kdm5b
|
UTSW |
1 |
134,625,035 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1177:Kdm5b
|
UTSW |
1 |
134,595,798 (GRCm38) |
frame shift |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- CCCGAGGAGATAAGCACTTG -3'
(R):5'- TCCAGCACTTACATTCAGGATCC -3'
Sequencing Primer
(F):5'- GGTTATTGTCTTCAGGCACACCAG -3'
(R):5'- GGATCCAATAAAATACTCACCTCTG -3'
|
| Posted On |
2016-03-16 |
Incidental Mutation