Mutagenetix > Incidental Mutation

Incidental Mutation 'R4863:Vmn2r61'

374653

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r61

Ensembl Gene

ENSMUSG00000090967

Gene Name

vomeronasal 2, receptor 61

Synonyms

EG637873, Casr-rs2, Gprc2a-rs2

MMRRC Submission

042473-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.087) question?

Stock #

R4863 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

42260053-42300755 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 42300708 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Serine at position 851 (T851S)

Ref Sequence

ENSEMBL: ENSMUSP00000129576 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000166131]

AlphaFold

L7N2B8

Predicted Effect

probably benign
Transcript: ENSMUST00000166131
AA Change: T851S

PolyPhen 2 Score 0.027 (Sensitivity: 0.95; Specificity: 0.81)

SMART Domains

Protein: ENSMUSP00000129576
Gene: ENSMUSG00000090967
AA Change: T851S

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	77	471	4e-42	PFAM
Pfam:NCD3G	514	567	1.9e-21	PFAM
Pfam:7tm_3	600	835	6.2e-52	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000173044

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.3%
20x: 95.2%

Validation Efficiency

99% (105/106)

Allele List at MGI

Other mutations in this stock

Total: 98 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2210407C18Rik	A	T	11: 58,612,512		probably null	Het
4930578I06Rik	C	T	14: 63,973,209	R190H	probably benign	Het
A530032D15Rik	C	T	1: 85,088,800		probably benign	Het
Abcc12	T	A	8: 86,538,376	I647F	probably damaging	Het
Acnat2	C	A	4: 49,380,172	W384L	probably damaging	Het
Acvr1	A	G	2: 58,477,711	L146P	possibly damaging	Het
Ankrd16	T	A	2: 11,784,316	M238K	probably benign	Het
BC005561	A	T	5: 104,517,750	D46V	possibly damaging	Het
Cd3eap	T	A	7: 19,357,759	Q141L	probably damaging	Het
Clmn	A	T	12: 104,797,094	I91N	probably damaging	Het
Cog8	A	T	8: 107,050,174	L523H	probably damaging	Het
Cpxm2	T	A	7: 132,059,747	K437M	probably benign	Het
Dhx57	A	T	17: 80,253,111	V999E	probably damaging	Het
Dnpep	T	C	1: 75,309,230		probably benign	Het
Dok3	G	A	13: 55,523,457	R434W	probably damaging	Het
Dpysl5	C	T	5: 30,784,343	H275Y	probably benign	Het
Ednra	A	T	8: 77,667,383	N361K	probably damaging	Het
Ei24	A	T	9: 36,784,565	S210R	probably damaging	Het
Erich3	T	A	3: 154,764,804	V158E	unknown	Het
Fam193a	T	A	5: 34,466,205	V1379E	possibly damaging	Het
Fasn	A	G	11: 120,808,828	V2304A	probably damaging	Het
Fcgbp	A	C	7: 28,086,344	D402A	probably benign	Het
Fkbp14	T	C	6: 54,585,945		probably benign	Het
Fnip1	G	A	11: 54,515,556	V1160I	possibly damaging	Het
Fsd2	T	C	7: 81,552,964	K289R	probably null	Het
Fuca2	A	T	10: 13,505,907	D188V	probably damaging	Het
Gfpt2	T	C	11: 49,810,970	V116A	probably benign	Het
Gm10770	T	A	2: 150,178,896	K234*	probably null	Het
Gm9887	A	G	12: 69,371,989		probably benign	Het
Gtf3c2	A	G	5: 31,159,233		probably benign	Het
H2-M10.3	T	C	17: 36,366,636	D250G	probably damaging	Het
Hapln4	G	A	8: 70,084,492	V26M	possibly damaging	Het
Hook3	G	A	8: 26,038,029	A611V	probably damaging	Het
Hr	T	C	14: 70,571,972	L1141P	probably damaging	Het
Ifngr1	T	C	10: 19,609,416	S388P	probably damaging	Het
Itga3	T	A	11: 95,061,967	Q326L	probably damaging	Het
Itgb3	T	A	11: 104,665,520	I729N	probably damaging	Het
Kcnab2	A	G	4: 152,401,946	S132P	probably damaging	Het
Lama3	C	T	18: 12,539,793	A2481V	probably damaging	Het
Lama3	T	C	18: 12,498,678		probably benign	Het
Lce1e	A	T	3: 92,707,871	C56*	probably null	Het
Lmcd1	T	C	6: 112,287,871		probably benign	Het
Lrrc14	T	A	15: 76,713,362		probably null	Het
Map4k5	G	A	12: 69,818,438	P591L	probably benign	Het
Mapk13	C	A	17: 28,776,310	D168E	probably damaging	Het
Marf1	A	C	16: 14,132,665	H952Q	possibly damaging	Het
Megf6	T	C	4: 154,254,281		probably null	Het
Mical3	T	C	6: 121,033,787	I411M	probably damaging	Het
Myo5a	A	T	9: 75,217,507	K1781N	probably damaging	Het
N4bp2	T	C	5: 65,808,130	V1174A	probably benign	Het
Ncdn	A	T	4: 126,750,423	L202Q	probably damaging	Het
Ncor1	T	A	11: 62,392,638	M408L	possibly damaging	Het
Nf1	T	C	11: 79,409,409	L249P	probably damaging	Het
Nlrp9b	T	A	7: 20,049,596		probably null	Het
Nxpe3	A	T	16: 55,849,633	Y370N	probably damaging	Het
P2rx2	T	A	5: 110,341,568	T167S	probably benign	Het
Pcdhb19	G	T	18: 37,499,108	R652L	probably benign	Het
Pcdhga12	T	C	18: 37,768,281	L722P	probably benign	Het
Pde6a	A	T	18: 61,245,592	I329F	probably damaging	Het
Pdpr	T	A	8: 111,101,951	S29T	probably benign	Het
Pfkfb3	T	C	2: 11,486,312	D173G	probably benign	Het
Plcd4	A	G	1: 74,565,802		probably null	Het
Pou2f2	A	G	7: 25,097,108		probably benign	Het
Ppp1r14c	TGGCGGCGGCGGCGGCGG	TGGCGGCGGCGGCGG	10: 3,366,702		probably benign	Het
Ppp1r42	T	C	1: 10,003,386		probably benign	Het
Ptpre	C	T	7: 135,669,132	H346Y	probably benign	Het
Ptpro	T	A	6: 137,443,594	V1007D	probably damaging	Het
Rab12	A	T	17: 66,498,108	Y142N	probably damaging	Het
Rai14	A	C	15: 10,572,470	M857R	probably damaging	Het
Ranbp2	A	G	10: 58,492,421	K2753R	probably damaging	Het
Rasa4	A	T	5: 136,103,911	K6*	probably null	Het
Rasgef1a	A	G	6: 118,089,139	M438V	probably benign	Het
Recql	T	G	6: 142,359,006		probably benign	Het
Rftn2	A	G	1: 55,172,039	V425A	probably benign	Het
Ror1	A	G	4: 100,409,804	Y234C	probably damaging	Het
Sap30l	T	A	11: 57,806,054	L70Q	probably damaging	Het
Scn4a	T	C	11: 106,320,002	R1730G	probably damaging	Het
Serinc5	T	G	13: 92,690,980	I268R	probably damaging	Het
Sin3b	G	A	8: 72,744,948	V432I	possibly damaging	Het
Slc30a6	T	C	17: 74,412,654	M203T	possibly damaging	Het
Soat1	T	C	1: 156,432,328	N481S	probably damaging	Het
Sos2	G	A	12: 69,640,154	T206I	probably benign	Het
Sp100	G	T	1: 85,705,003	A132S	probably benign	Het
Spata31d1c	T	A	13: 65,035,790	L382*	probably null	Het
Stard9	T	A	2: 120,700,860	W2533R	probably benign	Het
Tas2r126	A	G	6: 42,435,390	T286A	probably benign	Het
Tedc2	T	A	17: 24,217,936	K275M	probably damaging	Het
Ten1	A	T	11: 116,218,231	K242N	probably benign	Het
Tial1	C	T	7: 128,455,028	V1I	probably damaging	Het
Tle2	G	A	10: 81,588,891	R649H	possibly damaging	Het
Tmem178	A	G	17: 80,944,945	D86G	probably benign	Het
Trim29	T	A	9: 43,329,575	D528E	possibly damaging	Het
Vmn2r72	T	A	7: 85,750,598	Q414H	possibly damaging	Het
Yars	A	T	4: 129,189,882		probably benign	Het
Yipf4	A	G	17: 74,494,092	Q135R	probably damaging	Het
Zfp341	G	A	2: 154,645,866		probably benign	Het
Zfp426	T	C	9: 20,470,038	Y536C	probably damaging	Het
Zp2	T	G	7: 120,135,772	Y430S	probably damaging	Het

Other mutations in Vmn2r61

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00158:Vmn2r61	APN	7	42300751	missense	possibly damaging	0.96
IGL00824:Vmn2r61	APN	7	42267014	missense	probably benign	0.03
IGL00903:Vmn2r61	APN	7	42300511	missense	probably damaging	1.00
IGL01125:Vmn2r61	APN	7	42260126	missense	probably damaging	1.00
IGL01393:Vmn2r61	APN	7	42266834	missense	probably benign	0.08
IGL01712:Vmn2r61	APN	7	42260237	missense	probably damaging	0.98
IGL01822:Vmn2r61	APN	7	42300706	missense	probably benign	0.18
IGL01835:Vmn2r61	APN	7	42300591	missense	probably benign	0.12
IGL01844:Vmn2r61	APN	7	42260215	missense	probably benign	0.00
IGL01953:Vmn2r61	APN	7	42300189	missense	probably damaging	1.00
IGL02032:Vmn2r61	APN	7	42300042	missense	probably damaging	0.99
IGL02054:Vmn2r61	APN	7	42276734	critical splice donor site	probably null
IGL02569:Vmn2r61	APN	7	42276646	missense	probably damaging	1.00
IGL02697:Vmn2r61	APN	7	42275468	missense	possibly damaging	0.55
IGL02958:Vmn2r61	APN	7	42299937	missense	probably benign
IGL03290:Vmn2r61	APN	7	42265984	missense	probably benign	0.00
IGL03337:Vmn2r61	APN	7	42267085	missense	possibly damaging	0.58
IGL03369:Vmn2r61	APN	7	42260093	missense	probably benign
IGL03402:Vmn2r61	APN	7	42260255	missense	probably benign
R0026:Vmn2r61	UTSW	7	42275474	missense	possibly damaging	0.64
R0319:Vmn2r61	UTSW	7	42300517	missense	probably damaging	0.99
R0433:Vmn2r61	UTSW	7	42265911	missense	probably benign	0.02
R0555:Vmn2r61	UTSW	7	42266018	missense	probably benign	0.02
R0691:Vmn2r61	UTSW	7	42300420	missense	probably damaging	1.00
R1701:Vmn2r61	UTSW	7	42300511	missense	probably damaging	1.00
R1718:Vmn2r61	UTSW	7	42300697	missense	probably benign
R1835:Vmn2r61	UTSW	7	42266652	nonsense	probably null
R1920:Vmn2r61	UTSW	7	42300286	missense	possibly damaging	0.73
R2069:Vmn2r61	UTSW	7	42300001	missense	probably benign	0.06
R2326:Vmn2r61	UTSW	7	42266863	missense	probably damaging	1.00
R2402:Vmn2r61	UTSW	7	42300105	missense	possibly damaging	0.90
R3103:Vmn2r61	UTSW	7	42266643	missense	possibly damaging	0.73
R3107:Vmn2r61	UTSW	7	42267067	missense	possibly damaging	0.82
R4426:Vmn2r61	UTSW	7	42300733	missense	probably benign
R4426:Vmn2r61	UTSW	7	42300735	missense	probably benign
R4484:Vmn2r61	UTSW	7	42300696	missense	probably benign
R4748:Vmn2r61	UTSW	7	42267141	missense	probably damaging	0.96
R4835:Vmn2r61	UTSW	7	42267035	missense	possibly damaging	0.52
R4923:Vmn2r61	UTSW	7	42267096	missense	probably damaging	1.00
R4968:Vmn2r61	UTSW	7	42300054	missense	probably benign	0.14
R5114:Vmn2r61	UTSW	7	42300529	missense	possibly damaging	0.92
R5297:Vmn2r61	UTSW	7	42260222	missense	probably benign
R5497:Vmn2r61	UTSW	7	42275482	missense	possibly damaging	0.95
R5508:Vmn2r61	UTSW	7	42266818	missense	possibly damaging	0.52
R5587:Vmn2r61	UTSW	7	42300487	missense	probably damaging	1.00
R5615:Vmn2r61	UTSW	7	42267253	missense	probably benign	0.00
R5615:Vmn2r61	UTSW	7	42300493	missense	probably damaging	1.00
R5782:Vmn2r61	UTSW	7	42299829	missense	probably damaging	1.00
R6136:Vmn2r61	UTSW	7	42267031	missense	probably damaging	1.00
R6207:Vmn2r61	UTSW	7	42260192	missense	probably benign	0.01
R6265:Vmn2r61	UTSW	7	42266491	missense	probably benign	0.01
R6272:Vmn2r61	UTSW	7	42299818	missense	probably damaging	1.00
R6355:Vmn2r61	UTSW	7	42267235	missense	probably benign	0.00
R6469:Vmn2r61	UTSW	7	42265859	nonsense	probably null
R6554:Vmn2r61	UTSW	7	42276715	missense	probably damaging	1.00
R6699:Vmn2r61	UTSW	7	42300156	missense	probably benign
R6768:Vmn2r61	UTSW	7	42300324	missense	probably damaging	1.00
R6824:Vmn2r61	UTSW	7	42299979	missense	probably benign	0.10
R6930:Vmn2r61	UTSW	7	42299940	missense	probably benign	0.02
R7053:Vmn2r61	UTSW	7	42267133	missense	probably damaging	0.96
R7238:Vmn2r61	UTSW	7	42267205	missense	possibly damaging	0.73
R7332:Vmn2r61	UTSW	7	42260110	missense	probably benign	0.00
R7359:Vmn2r61	UTSW	7	42265983	missense	probably benign	0.11
R7553:Vmn2r61	UTSW	7	42266781	missense	not run
R7710:Vmn2r61	UTSW	7	42267048	missense	probably damaging	1.00
R7732:Vmn2r61	UTSW	7	42266673	missense	probably benign
R7839:Vmn2r61	UTSW	7	42266608	missense	probably damaging	0.97
R7916:Vmn2r61	UTSW	7	42300511	missense	probably damaging	1.00
R8026:Vmn2r61	UTSW	7	42266717	missense	probably benign	0.02
R8440:Vmn2r61	UTSW	7	42266656	missense	probably benign	0.02
R8499:Vmn2r61	UTSW	7	42300276	missense	probably damaging	0.99
R8771:Vmn2r61	UTSW	7	42266770	missense	probably damaging	0.99
R8847:Vmn2r61	UTSW	7	42300586	missense	probably damaging	1.00
R8986:Vmn2r61	UTSW	7	42265901	nonsense	probably null
R9290:Vmn2r61	UTSW	7	42265961	missense	probably benign	0.27
R9311:Vmn2r61	UTSW	7	42300668	missense	possibly damaging	0.92
R9324:Vmn2r61	UTSW	7	42267195	missense	probably benign	0.00
R9476:Vmn2r61	UTSW	7	42300169	missense	probably damaging	1.00
R9521:Vmn2r61	UTSW	7	42267202	missense	probably damaging	0.99
R9619:Vmn2r61	UTSW	7	42276712	missense	probably damaging	0.98
R9729:Vmn2r61	UTSW	7	42300493	missense	probably damaging	1.00
Z1088:Vmn2r61	UTSW	7	42299964	missense	possibly damaging	0.93
Z1176:Vmn2r61	UTSW	7	42260161	missense	possibly damaging	0.46
Z1176:Vmn2r61	UTSW	7	42266742	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- TTCCTTTCATTCAGCATGCAGG -3'
(R):5'- AACTAACGGTTTCAGTACACAGAG -3'

Sequencing Primer
(F):5'- CAGCATGCAGGTATTCTTCTG -3'
(R):5'- GCTTTGGCACGGTTTAAAC -3'

Posted On

2016-03-17