Incidental Mutation 'R4863:Abcc12'
| ID |
374664 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Abcc12
|
| Ensembl Gene |
ENSMUSG00000036872 |
| Gene Name |
ATP-binding cassette, sub-family C (CFTR/MRP), member 12 |
| Synonyms |
4930467B22Rik, MRP9 |
| MMRRC Submission |
042473-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.062)
|
| Stock # |
R4863 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
8 |
| Chromosomal Location |
86482260-86580686 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 86538376 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Phenylalanine
at position 647
(I647F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000123578
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000080115]
[ENSMUST00000129898]
[ENSMUST00000131423]
[ENSMUST00000131806]
[ENSMUST00000152438]
[ENSMUST00000156610]
|
| AlphaFold |
Q80WJ6 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000080115
AA Change: I647F
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000079014
Gene: ENSMUSG00000036872
AA Change: I647F
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ABC_membrane
|
123 |
392 |
3.6e-19 |
PFAM |
|
AAA
|
506 |
679 |
3.33e-13 |
SMART |
|
low complexity region
|
739 |
752 |
N/A |
INTRINSIC |
|
Pfam:ABC_membrane
|
791 |
1079 |
1.3e-26 |
PFAM |
|
AAA
|
1153 |
1346 |
1.07e-11 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000129898
AA Change: I647F
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000122577
Gene: ENSMUSG00000036872
AA Change: I647F
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ABC_membrane
|
123 |
392 |
1.2e-19 |
PFAM |
|
AAA
|
506 |
679 |
3.33e-13 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000131423
AA Change: I647F
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000122402
Gene: ENSMUSG00000036872
AA Change: I647F
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ABC_membrane
|
123 |
392 |
1.1e-21 |
PFAM |
|
AAA
|
506 |
679 |
3.33e-13 |
SMART |
|
low complexity region
|
739 |
752 |
N/A |
INTRINSIC |
|
Pfam:ABC_membrane
|
792 |
1077 |
1.6e-34 |
PFAM |
|
AAA
|
1153 |
1346 |
1.07e-11 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000131806
AA Change: I647F
PolyPhen 2
Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000116866
Gene: ENSMUSG00000036872
AA Change: I647F
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ABC_membrane
|
123 |
392 |
1.3e-19 |
PFAM |
|
AAA
|
506 |
679 |
3.33e-13 |
SMART |
|
low complexity region
|
739 |
752 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000152438
AA Change: I647F
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000114582
Gene: ENSMUSG00000036872
AA Change: I647F
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ABC_membrane
|
123 |
392 |
1.2e-19 |
PFAM |
|
AAA
|
506 |
679 |
3.33e-13 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000156066
|
| SMART Domains |
Protein: ENSMUSP00000120282
Gene: ENSMUSG00000036872
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
25 |
38 |
N/A |
INTRINSIC |
|
Pfam:ABC_membrane
|
78 |
363 |
3.8e-35 |
PFAM |
|
Pfam:ABC_tran
|
430 |
508 |
5.7e-16 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000156610
AA Change: I647F
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000123578
Gene: ENSMUSG00000036872
AA Change: I647F
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ABC_membrane
|
123 |
392 |
5.9e-20 |
PFAM |
|
AAA
|
506 |
661 |
1.07e-7 |
SMART |
|
| Meta Mutation Damage Score |
0.4094 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.3%
- 20x: 95.2%
|
| Validation Efficiency |
99% (105/106) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two ATP-binding domains and 12 transmembrane regions. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White. This gene is a member of the MRP subfamily which is involved in multi-drug resistance. This gene and another subfamily member are arranged head-to-tail on chromosome 16q12.1. Increased expression of this gene is associated with breast cancer. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 98 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2210407C18Rik |
A |
T |
11: 58,612,512 (GRCm38) |
|
probably null |
Het |
| 4930578I06Rik |
C |
T |
14: 63,973,209 (GRCm38) |
R190H |
probably benign |
Het |
| A530032D15Rik |
C |
T |
1: 85,088,800 (GRCm38) |
|
probably benign |
Het |
| Acnat2 |
C |
A |
4: 49,380,172 (GRCm38) |
W384L |
probably damaging |
Het |
| Acvr1 |
A |
G |
2: 58,477,711 (GRCm38) |
L146P |
possibly damaging |
Het |
| Ankrd16 |
T |
A |
2: 11,784,316 (GRCm38) |
M238K |
probably benign |
Het |
| BC005561 |
A |
T |
5: 104,517,750 (GRCm38) |
D46V |
possibly damaging |
Het |
| Cd3eap |
T |
A |
7: 19,357,759 (GRCm38) |
Q141L |
probably damaging |
Het |
| Clmn |
A |
T |
12: 104,797,094 (GRCm38) |
I91N |
probably damaging |
Het |
| Cog8 |
A |
T |
8: 107,050,174 (GRCm38) |
L523H |
probably damaging |
Het |
| Cpxm2 |
T |
A |
7: 132,059,747 (GRCm38) |
K437M |
probably benign |
Het |
| Dhx57 |
A |
T |
17: 80,253,111 (GRCm38) |
V999E |
probably damaging |
Het |
| Dnpep |
T |
C |
1: 75,309,230 (GRCm38) |
|
probably benign |
Het |
| Dok3 |
G |
A |
13: 55,523,457 (GRCm38) |
R434W |
probably damaging |
Het |
| Dpysl5 |
C |
T |
5: 30,784,343 (GRCm38) |
H275Y |
probably benign |
Het |
| Ednra |
A |
T |
8: 77,667,383 (GRCm38) |
N361K |
probably damaging |
Het |
| Ei24 |
A |
T |
9: 36,784,565 (GRCm38) |
S210R |
probably damaging |
Het |
| Erich3 |
T |
A |
3: 154,764,804 (GRCm38) |
V158E |
unknown |
Het |
| Fam193a |
T |
A |
5: 34,466,205 (GRCm38) |
V1379E |
possibly damaging |
Het |
| Fasn |
A |
G |
11: 120,808,828 (GRCm38) |
V2304A |
probably damaging |
Het |
| Fcgbp |
A |
C |
7: 28,086,344 (GRCm38) |
D402A |
probably benign |
Het |
| Fkbp14 |
T |
C |
6: 54,585,945 (GRCm38) |
|
probably benign |
Het |
| Fnip1 |
G |
A |
11: 54,515,556 (GRCm38) |
V1160I |
possibly damaging |
Het |
| Fsd2 |
T |
C |
7: 81,552,964 (GRCm38) |
K289R |
probably null |
Het |
| Fuca2 |
A |
T |
10: 13,505,907 (GRCm38) |
D188V |
probably damaging |
Het |
| Gfpt2 |
T |
C |
11: 49,810,970 (GRCm38) |
V116A |
probably benign |
Het |
| Gm10770 |
T |
A |
2: 150,178,896 (GRCm38) |
K234* |
probably null |
Het |
| Gm9887 |
A |
G |
12: 69,371,989 (GRCm38) |
|
probably benign |
Het |
| Gtf3c2 |
A |
G |
5: 31,159,233 (GRCm38) |
|
probably benign |
Het |
| H2-M10.3 |
T |
C |
17: 36,366,636 (GRCm38) |
D250G |
probably damaging |
Het |
| Hapln4 |
G |
A |
8: 70,084,492 (GRCm38) |
V26M |
possibly damaging |
Het |
| Hook3 |
G |
A |
8: 26,038,029 (GRCm38) |
A611V |
probably damaging |
Het |
| Hr |
T |
C |
14: 70,571,972 (GRCm38) |
L1141P |
probably damaging |
Het |
| Ifngr1 |
T |
C |
10: 19,609,416 (GRCm38) |
S388P |
probably damaging |
Het |
| Itga3 |
T |
A |
11: 95,061,967 (GRCm38) |
Q326L |
probably damaging |
Het |
| Itgb3 |
T |
A |
11: 104,665,520 (GRCm38) |
I729N |
probably damaging |
Het |
| Kcnab2 |
A |
G |
4: 152,401,946 (GRCm38) |
S132P |
probably damaging |
Het |
| Lama3 |
T |
C |
18: 12,498,678 (GRCm38) |
|
probably benign |
Het |
| Lama3 |
C |
T |
18: 12,539,793 (GRCm38) |
A2481V |
probably damaging |
Het |
| Lce1e |
A |
T |
3: 92,707,871 (GRCm38) |
C56* |
probably null |
Het |
| Lmcd1 |
T |
C |
6: 112,287,871 (GRCm38) |
|
probably benign |
Het |
| Lrrc14 |
T |
A |
15: 76,713,362 (GRCm38) |
|
probably null |
Het |
| Map4k5 |
G |
A |
12: 69,818,438 (GRCm38) |
P591L |
probably benign |
Het |
| Mapk13 |
C |
A |
17: 28,776,310 (GRCm38) |
D168E |
probably damaging |
Het |
| Marf1 |
A |
C |
16: 14,132,665 (GRCm38) |
H952Q |
possibly damaging |
Het |
| Megf6 |
T |
C |
4: 154,254,281 (GRCm38) |
|
probably null |
Het |
| Mical3 |
T |
C |
6: 121,033,787 (GRCm38) |
I411M |
probably damaging |
Het |
| Myo5a |
A |
T |
9: 75,217,507 (GRCm38) |
K1781N |
probably damaging |
Het |
| N4bp2 |
T |
C |
5: 65,808,130 (GRCm38) |
V1174A |
probably benign |
Het |
| Ncdn |
A |
T |
4: 126,750,423 (GRCm38) |
L202Q |
probably damaging |
Het |
| Ncor1 |
T |
A |
11: 62,392,638 (GRCm38) |
M408L |
possibly damaging |
Het |
| Nf1 |
T |
C |
11: 79,409,409 (GRCm38) |
L249P |
probably damaging |
Het |
| Nlrp9b |
T |
A |
7: 20,049,596 (GRCm38) |
|
probably null |
Het |
| Nxpe3 |
A |
T |
16: 55,849,633 (GRCm38) |
Y370N |
probably damaging |
Het |
| P2rx2 |
T |
A |
5: 110,341,568 (GRCm38) |
T167S |
probably benign |
Het |
| Pcdhb19 |
G |
T |
18: 37,499,108 (GRCm38) |
R652L |
probably benign |
Het |
| Pcdhga12 |
T |
C |
18: 37,768,281 (GRCm38) |
L722P |
probably benign |
Het |
| Pde6a |
A |
T |
18: 61,245,592 (GRCm38) |
I329F |
probably damaging |
Het |
| Pdpr |
T |
A |
8: 111,101,951 (GRCm38) |
S29T |
probably benign |
Het |
| Pfkfb3 |
T |
C |
2: 11,486,312 (GRCm38) |
D173G |
probably benign |
Het |
| Plcd4 |
A |
G |
1: 74,565,802 (GRCm38) |
|
probably null |
Het |
| Pou2f2 |
A |
G |
7: 25,097,108 (GRCm38) |
|
probably benign |
Het |
| Ppp1r14c |
TGGCGGCGGCGGCGGCGG |
TGGCGGCGGCGGCGG |
10: 3,366,702 (GRCm38) |
|
probably benign |
Het |
| Ppp1r42 |
T |
C |
1: 10,003,386 (GRCm38) |
|
probably benign |
Het |
| Ptpre |
C |
T |
7: 135,669,132 (GRCm38) |
H346Y |
probably benign |
Het |
| Ptpro |
T |
A |
6: 137,443,594 (GRCm38) |
V1007D |
probably damaging |
Het |
| Rab12 |
A |
T |
17: 66,498,108 (GRCm38) |
Y142N |
probably damaging |
Het |
| Rai14 |
A |
C |
15: 10,572,470 (GRCm38) |
M857R |
probably damaging |
Het |
| Ranbp2 |
A |
G |
10: 58,492,421 (GRCm38) |
K2753R |
probably damaging |
Het |
| Rasa4 |
A |
T |
5: 136,103,911 (GRCm38) |
K6* |
probably null |
Het |
| Rasgef1a |
A |
G |
6: 118,089,139 (GRCm38) |
M438V |
probably benign |
Het |
| Recql |
T |
G |
6: 142,359,006 (GRCm38) |
|
probably benign |
Het |
| Rftn2 |
A |
G |
1: 55,172,039 (GRCm38) |
V425A |
probably benign |
Het |
| Ror1 |
A |
G |
4: 100,409,804 (GRCm38) |
Y234C |
probably damaging |
Het |
| Sap30l |
T |
A |
11: 57,806,054 (GRCm38) |
L70Q |
probably damaging |
Het |
| Scn4a |
T |
C |
11: 106,320,002 (GRCm38) |
R1730G |
probably damaging |
Het |
| Serinc5 |
T |
G |
13: 92,690,980 (GRCm38) |
I268R |
probably damaging |
Het |
| Sin3b |
G |
A |
8: 72,744,948 (GRCm38) |
V432I |
possibly damaging |
Het |
| Slc30a6 |
T |
C |
17: 74,412,654 (GRCm38) |
M203T |
possibly damaging |
Het |
| Soat1 |
T |
C |
1: 156,432,328 (GRCm38) |
N481S |
probably damaging |
Het |
| Sos2 |
G |
A |
12: 69,640,154 (GRCm38) |
T206I |
probably benign |
Het |
| Sp100 |
G |
T |
1: 85,705,003 (GRCm38) |
A132S |
probably benign |
Het |
| Spata31d1c |
T |
A |
13: 65,035,790 (GRCm38) |
L382* |
probably null |
Het |
| Stard9 |
T |
A |
2: 120,700,860 (GRCm38) |
W2533R |
probably benign |
Het |
| Tas2r126 |
A |
G |
6: 42,435,390 (GRCm38) |
T286A |
probably benign |
Het |
| Tedc2 |
T |
A |
17: 24,217,936 (GRCm38) |
K275M |
probably damaging |
Het |
| Ten1 |
A |
T |
11: 116,218,231 (GRCm38) |
K242N |
probably benign |
Het |
| Tial1 |
C |
T |
7: 128,455,028 (GRCm38) |
V1I |
probably damaging |
Het |
| Tle2 |
G |
A |
10: 81,588,891 (GRCm38) |
R649H |
possibly damaging |
Het |
| Tmem178 |
A |
G |
17: 80,944,945 (GRCm38) |
D86G |
probably benign |
Het |
| Trim29 |
T |
A |
9: 43,329,575 (GRCm38) |
D528E |
possibly damaging |
Het |
| Vmn2r61 |
A |
T |
7: 42,300,708 (GRCm38) |
T851S |
probably benign |
Het |
| Vmn2r72 |
T |
A |
7: 85,750,598 (GRCm38) |
Q414H |
possibly damaging |
Het |
| Yars |
A |
T |
4: 129,189,882 (GRCm38) |
|
probably benign |
Het |
| Yipf4 |
A |
G |
17: 74,494,092 (GRCm38) |
Q135R |
probably damaging |
Het |
| Zfp341 |
G |
A |
2: 154,645,866 (GRCm38) |
|
probably benign |
Het |
| Zfp426 |
T |
C |
9: 20,470,038 (GRCm38) |
Y536C |
probably damaging |
Het |
| Zp2 |
T |
G |
7: 120,135,772 (GRCm38) |
Y430S |
probably damaging |
Het |
|
| Other mutations in Abcc12 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01362:Abcc12
|
APN |
8 |
86,534,693 (GRCm38) |
missense |
probably benign |
0.45 |
|
IGL01504:Abcc12
|
APN |
8 |
86,557,602 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01593:Abcc12
|
APN |
8 |
86,557,650 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02164:Abcc12
|
APN |
8 |
86,527,404 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02173:Abcc12
|
APN |
8 |
86,566,442 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02175:Abcc12
|
APN |
8 |
86,535,013 (GRCm38) |
splice site |
probably null |
|
|
IGL02405:Abcc12
|
APN |
8 |
86,558,153 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL02620:Abcc12
|
APN |
8 |
86,505,314 (GRCm38) |
splice site |
probably null |
|
|
IGL02635:Abcc12
|
APN |
8 |
86,509,682 (GRCm38) |
splice site |
probably benign |
|
|
IGL03241:Abcc12
|
APN |
8 |
86,509,807 (GRCm38) |
missense |
possibly damaging |
0.77 |
|
PIT4544001:Abcc12
|
UTSW |
8 |
86,505,246 (GRCm38) |
missense |
possibly damaging |
0.58 |
|
R0023:Abcc12
|
UTSW |
8 |
86,538,333 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0023:Abcc12
|
UTSW |
8 |
86,538,333 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0116:Abcc12
|
UTSW |
8 |
86,534,998 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0131:Abcc12
|
UTSW |
8 |
86,531,568 (GRCm38) |
missense |
probably benign |
|
|
R0131:Abcc12
|
UTSW |
8 |
86,531,568 (GRCm38) |
missense |
probably benign |
|
|
R0132:Abcc12
|
UTSW |
8 |
86,531,568 (GRCm38) |
missense |
probably benign |
|
|
R0308:Abcc12
|
UTSW |
8 |
86,557,752 (GRCm38) |
splice site |
probably benign |
|
|
R0589:Abcc12
|
UTSW |
8 |
86,560,472 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
R1451:Abcc12
|
UTSW |
8 |
86,557,693 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1564:Abcc12
|
UTSW |
8 |
86,517,486 (GRCm38) |
missense |
probably benign |
0.10 |
|
R1740:Abcc12
|
UTSW |
8 |
86,509,771 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
R1740:Abcc12
|
UTSW |
8 |
86,505,497 (GRCm38) |
nonsense |
probably null |
|
|
R1970:Abcc12
|
UTSW |
8 |
86,527,281 (GRCm38) |
missense |
probably benign |
0.27 |
|
R2017:Abcc12
|
UTSW |
8 |
86,563,988 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2026:Abcc12
|
UTSW |
8 |
86,558,233 (GRCm38) |
missense |
probably benign |
0.30 |
|
R2402:Abcc12
|
UTSW |
8 |
86,509,141 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3085:Abcc12
|
UTSW |
8 |
86,543,907 (GRCm38) |
splice site |
probably benign |
|
|
R3115:Abcc12
|
UTSW |
8 |
86,540,024 (GRCm38) |
critical splice donor site |
probably null |
|
|
R3176:Abcc12
|
UTSW |
8 |
86,506,866 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3276:Abcc12
|
UTSW |
8 |
86,506,866 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3847:Abcc12
|
UTSW |
8 |
86,553,391 (GRCm38) |
missense |
probably benign |
0.05 |
|
R3911:Abcc12
|
UTSW |
8 |
86,528,419 (GRCm38) |
splice site |
probably benign |
|
|
R4031:Abcc12
|
UTSW |
8 |
86,517,448 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4297:Abcc12
|
UTSW |
8 |
86,531,525 (GRCm38) |
splice site |
probably null |
|
|
R4298:Abcc12
|
UTSW |
8 |
86,531,525 (GRCm38) |
splice site |
probably null |
|
|
R4299:Abcc12
|
UTSW |
8 |
86,531,525 (GRCm38) |
splice site |
probably null |
|
|
R4688:Abcc12
|
UTSW |
8 |
86,548,694 (GRCm38) |
missense |
possibly damaging |
0.46 |
|
R4810:Abcc12
|
UTSW |
8 |
86,560,842 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4892:Abcc12
|
UTSW |
8 |
86,509,802 (GRCm38) |
missense |
probably benign |
0.28 |
|
R5288:Abcc12
|
UTSW |
8 |
86,566,539 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5303:Abcc12
|
UTSW |
8 |
86,509,786 (GRCm38) |
missense |
probably benign |
0.15 |
|
R5332:Abcc12
|
UTSW |
8 |
86,524,830 (GRCm38) |
splice site |
probably null |
|
|
R5386:Abcc12
|
UTSW |
8 |
86,517,489 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R5457:Abcc12
|
UTSW |
8 |
86,509,844 (GRCm38) |
missense |
probably benign |
0.03 |
|
R5900:Abcc12
|
UTSW |
8 |
86,566,520 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R6035:Abcc12
|
UTSW |
8 |
86,517,404 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R6035:Abcc12
|
UTSW |
8 |
86,517,404 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R6291:Abcc12
|
UTSW |
8 |
86,566,544 (GRCm38) |
missense |
possibly damaging |
0.72 |
|
R6518:Abcc12
|
UTSW |
8 |
86,509,089 (GRCm38) |
|
|
|
|
R6677:Abcc12
|
UTSW |
8 |
86,534,752 (GRCm38) |
missense |
possibly damaging |
0.58 |
|
R7258:Abcc12
|
UTSW |
8 |
86,560,857 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R7411:Abcc12
|
UTSW |
8 |
86,560,850 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R7619:Abcc12
|
UTSW |
8 |
86,566,553 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7808:Abcc12
|
UTSW |
8 |
86,507,939 (GRCm38) |
missense |
probably benign |
0.03 |
|
R7828:Abcc12
|
UTSW |
8 |
86,528,275 (GRCm38) |
missense |
probably benign |
0.08 |
|
R7834:Abcc12
|
UTSW |
8 |
86,558,230 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7834:Abcc12
|
UTSW |
8 |
86,531,550 (GRCm38) |
missense |
possibly damaging |
0.81 |
|
R7939:Abcc12
|
UTSW |
8 |
86,548,804 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7989:Abcc12
|
UTSW |
8 |
86,505,479 (GRCm38) |
missense |
probably benign |
0.02 |
|
R8290:Abcc12
|
UTSW |
8 |
86,512,282 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8681:Abcc12
|
UTSW |
8 |
86,505,279 (GRCm38) |
missense |
possibly damaging |
0.74 |
|
R8795:Abcc12
|
UTSW |
8 |
86,531,584 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
R8811:Abcc12
|
UTSW |
8 |
86,553,394 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8939:Abcc12
|
UTSW |
8 |
86,517,318 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8940:Abcc12
|
UTSW |
8 |
86,560,811 (GRCm38) |
missense |
probably benign |
0.45 |
|
R9711:Abcc12
|
UTSW |
8 |
86,548,759 (GRCm38) |
missense |
probably damaging |
1.00 |
|
X0027:Abcc12
|
UTSW |
8 |
86,553,291 (GRCm38) |
missense |
probably damaging |
0.99 |
|
Z1088:Abcc12
|
UTSW |
8 |
86,560,279 (GRCm38) |
splice site |
probably null |
|
|
Z1176:Abcc12
|
UTSW |
8 |
86,550,601 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1177:Abcc12
|
UTSW |
8 |
86,527,384 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
| Predicted Primers |
PCR Primer
(F):5'- CCCTGTTCAGGTAAAGCCAC -3'
(R):5'- CTCCTGATATACAAAGACCATGGGG -3'
Sequencing Primer
(F):5'- CCTACTGGTGGAAATGGCATATTTAG -3'
(R):5'- CAGACTTAATAATGATGGGCAGTGC -3'
|
| Posted On |
2016-03-17 |
Incidental Mutation