|Institutional Source||Beutler Lab|
|Gene Name||wingless-type MMTV integration site family, member 6|
|Is this an essential gene?||Essential (E-score: 1.000)|
|Stock #||R4865 (G1)|
|Chromosomal Location||74771892-74785322 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||G to A at 74782629 bp|
|Amino Acid Change||Cysteine to Tyrosine at position 123 (C123Y)|
|Ref Sequence||ENSEMBL: ENSMUSP00000006716 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000006716]|
|Predicted Effect||probably damaging
AA Change: C123Y
PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
AA Change: C123Y
|Predicted Effect||noncoding transcript
|Meta Mutation Damage Score||0.9453|
|Coding Region Coverage||
|Validation Efficiency||98% (86/88)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is overexpressed in cervical cancer cell line and strongly coexpressed with another family member, WNT10A, in colorectal cancer cell line. The gene overexpression may play key roles in carcinogenesis. This gene and the WNT10A gene are clustered in the chromosome 2q35 region. The protein encoded by this gene is 97% identical to the mouse Wnt6 protein at the amino acid level. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired decidualization with reduced uterine stromal cell proliferation. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Wnt6||
(F):5'- TAGGCACCCTACCCACTTTG -3'
(R):5'- CTGCGCATCCATAAAGAGTCTTG -3'
(F):5'- ACACCTGCCTGGAGTCTGTC -3'
(R):5'- CGCATCCATAAAGAGTCTTGACTTC -3'