Incidental Mutation 'R4866:Mapk10'
ID 374902
Institutional Source Beutler Lab
Gene Symbol Mapk10
Ensembl Gene ENSMUSG00000046709
Gene Name mitogen-activated protein kinase 10
Synonyms p493F12, C230008H04Rik, JNK3, Serk2
MMRRC Submission 042476-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4866 (G1)
Quality Score 225
Status Validated
Chromosome 5
Chromosomal Location 103056413-103359200 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 103111391 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 351 (D351G)
Ref Sequence ENSEMBL: ENSMUSP00000127193 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086854] [ENSMUST00000112846] [ENSMUST00000112847] [ENSMUST00000112848] [ENSMUST00000141573] [ENSMUST00000170792]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000086854
AA Change: D351G

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000084065
Gene: ENSMUSG00000046709
AA Change: D351G

DomainStartEndE-ValueType
S_TKc 64 359 5.76e-88 SMART
low complexity region 423 432 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000112846
AA Change: D351G

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000108467
Gene: ENSMUSG00000046709
AA Change: D351G

DomainStartEndE-ValueType
S_TKc 64 359 4.37e-88 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000112847
AA Change: D351G

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000108468
Gene: ENSMUSG00000046709
AA Change: D351G

DomainStartEndE-ValueType
S_TKc 64 359 4.37e-88 SMART
low complexity region 423 432 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000112848
AA Change: D381G

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000108469
Gene: ENSMUSG00000046709
AA Change: D381G

DomainStartEndE-ValueType
S_TKc 94 389 4.37e-88 SMART
low complexity region 453 462 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000141573
SMART Domains Protein: ENSMUSP00000142798
Gene: ENSMUSG00000046709

DomainStartEndE-ValueType
Pfam:Pkinase 64 125 1.3e-7 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000170792
AA Change: D351G

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000127193
Gene: ENSMUSG00000046709
AA Change: D351G

DomainStartEndE-ValueType
S_TKc 64 359 4.37e-88 SMART
Meta Mutation Damage Score 0.3282 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.0%
Validation Efficiency 99% (79/80)
MGI Phenotype FUNCTION: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals and are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2015]
PHENOTYPE: Mice homozygous for disruptions in this gene display a normal phenotype. They are resistant to kainic acid induced seizures and show increased resistance to MPTP induced Parkinson's disease. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 73 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca3 C T 17: 24,593,274 (GRCm39) R224C probably damaging Het
Abcc5 A T 16: 20,241,182 (GRCm39) M1K probably null Het
Ablim2 C T 5: 35,959,766 (GRCm39) R73C possibly damaging Het
Adam5 A C 8: 25,232,172 (GRCm39) probably null Het
Adam5 G A 8: 25,271,619 (GRCm39) T596I probably damaging Het
Apoa2 T C 1: 171,053,369 (GRCm39) probably null Het
Atad1 A T 19: 32,679,964 (GRCm39) H79Q probably benign Het
Atp8a2 T C 14: 59,928,916 (GRCm39) D1046G probably damaging Het
Bcam A G 7: 19,499,397 (GRCm39) Y209H probably benign Het
Brpf1 G A 6: 113,299,431 (GRCm39) V1120I probably damaging Het
Catsperb G A 12: 101,474,208 (GRCm39) C302Y probably damaging Het
Cbl A G 9: 44,064,166 (GRCm39) V790A probably benign Het
Ccdc60 T C 5: 116,310,549 (GRCm39) D171G probably damaging Het
Cd300c2 A T 11: 114,891,807 (GRCm39) C22* probably null Het
Cdan1 C A 2: 120,561,928 (GRCm39) probably benign Het
Cdk5rap1 C T 2: 154,212,876 (GRCm39) probably null Het
Cfap410 T A 10: 77,817,413 (GRCm39) probably null Het
Cfap65 T C 1: 74,964,716 (GRCm39) D479G probably damaging Het
Cmbl A G 15: 31,585,490 (GRCm39) K113E probably benign Het
Cog6 G A 3: 52,918,019 (GRCm39) T173I probably benign Het
Cts6 T A 13: 61,350,090 (GRCm39) probably null Het
Cyp11a1 G A 9: 57,933,380 (GRCm39) V413M probably damaging Het
Cyp2c39 G A 19: 39,502,020 (GRCm39) M136I probably benign Het
Dclre1b A T 3: 103,715,412 (GRCm39) Y29N probably damaging Het
Depdc1a T A 3: 159,221,764 (GRCm39) I236K probably damaging Het
Dhx36 A T 3: 62,380,198 (GRCm39) Y833N probably damaging Het
Dop1b G T 16: 93,560,318 (GRCm39) probably null Het
Elovl3 A G 19: 46,120,603 (GRCm39) E32G possibly damaging Het
Entrep1 A G 19: 23,952,790 (GRCm39) S507P possibly damaging Het
Epcam T C 17: 87,951,049 (GRCm39) V212A possibly damaging Het
Fcrl2 A T 3: 87,170,773 (GRCm39) C4S possibly damaging Het
Galnt16 T C 12: 80,630,851 (GRCm39) Y310H probably damaging Het
Gm12789 G A 4: 101,846,182 (GRCm39) probably benign Het
Gspt1 C T 16: 11,040,529 (GRCm39) R593H possibly damaging Het
Hmcn2 A T 2: 31,279,403 (GRCm39) T1802S possibly damaging Het
Igha A G 12: 113,223,129 (GRCm39) V166A probably benign Het
Itfg2 A G 6: 128,393,279 (GRCm39) probably benign Het
Jund T C 8: 71,152,254 (GRCm39) V183A probably damaging Het
Katnb1 T C 8: 95,824,132 (GRCm39) S471P possibly damaging Het
Kazn A G 4: 141,832,216 (GRCm39) F661S unknown Het
Kif19a G A 11: 114,658,053 (GRCm39) M37I probably benign Het
Lgr5 C T 10: 115,288,590 (GRCm39) V661I probably benign Het
Lvrn G T 18: 47,026,768 (GRCm39) A789S probably damaging Het
Mga T A 2: 119,794,535 (GRCm39) C2622S possibly damaging Het
Mios T G 6: 8,214,857 (GRCm39) F18V probably damaging Het
Mllt6 A G 11: 97,565,285 (GRCm39) D575G probably damaging Het
Mmp10 G A 9: 7,508,190 (GRCm39) V439M probably damaging Het
Myh4 A G 11: 67,139,453 (GRCm39) D590G probably benign Het
Ndufs2 C T 1: 171,074,618 (GRCm39) G14R probably benign Het
Or10ad1b T A 15: 98,125,371 (GRCm39) I52F probably damaging Het
Or51a7 A T 7: 102,614,927 (GRCm39) M207L probably benign Het
Or56a4 T C 7: 104,806,514 (GRCm39) Y125C possibly damaging Het
Or8g26 A G 9: 39,096,367 (GRCm39) K298E probably damaging Het
Plau G T 14: 20,887,872 (GRCm39) V39L probably benign Het
Ppp3cb A G 14: 20,573,911 (GRCm39) C275R probably damaging Het
Ppp4r4 T G 12: 103,566,706 (GRCm39) M51R possibly damaging Het
Prr5 A G 15: 84,626,105 (GRCm39) Y60C probably damaging Het
Ptprt T C 2: 161,402,159 (GRCm39) D1023G probably damaging Het
Raly T A 2: 154,703,816 (GRCm39) V129E probably damaging Het
Rsph10b A G 5: 143,885,347 (GRCm39) E249G probably benign Het
Sart1 A C 19: 5,432,248 (GRCm39) L577W probably damaging Het
Senp1 T C 15: 97,964,729 (GRCm39) E189G possibly damaging Het
Slc22a2 G T 17: 12,803,316 (GRCm39) C50F probably damaging Het
Spem1 A T 11: 69,711,755 (GRCm39) V303E probably damaging Het
Tgfb3 A G 12: 86,124,588 (GRCm39) V40A possibly damaging Het
Ttl T C 2: 128,923,147 (GRCm39) S163P probably damaging Het
Ttll9 C A 2: 152,844,920 (GRCm39) N429K probably benign Het
Uggt1 G A 1: 36,241,936 (GRCm39) R333* probably null Het
Zfhx2 A G 14: 55,302,993 (GRCm39) S1664P possibly damaging Het
Zfp51 T A 17: 21,682,012 (GRCm39) D70E possibly damaging Het
Zfp592 T A 7: 80,691,607 (GRCm39) V1262E probably damaging Het
Zfp595 C A 13: 67,465,760 (GRCm39) G168C probably damaging Het
Zswim9 A T 7: 12,995,095 (GRCm39) S354T probably damaging Het
Other mutations in Mapk10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01480:Mapk10 APN 5 103,074,018 (GRCm39) splice site probably benign
IGL01791:Mapk10 APN 5 103,144,514 (GRCm39) missense probably damaging 1.00
IGL01885:Mapk10 APN 5 103,144,455 (GRCm39) missense probably damaging 1.00
IGL02192:Mapk10 APN 5 103,137,513 (GRCm39) missense probably damaging 0.97
IGL02260:Mapk10 APN 5 103,186,534 (GRCm39) missense probably benign 0.09
IGL02409:Mapk10 APN 5 103,076,096 (GRCm39) missense possibly damaging 0.50
IGL03148:Mapk10 APN 5 103,073,971 (GRCm39) missense probably damaging 1.00
R0904:Mapk10 UTSW 5 103,135,146 (GRCm39) splice site probably benign
R1067:Mapk10 UTSW 5 103,139,723 (GRCm39) splice site probably benign
R1592:Mapk10 UTSW 5 103,186,487 (GRCm39) missense possibly damaging 0.89
R1812:Mapk10 UTSW 5 103,061,128 (GRCm39) missense probably damaging 1.00
R2364:Mapk10 UTSW 5 103,186,507 (GRCm39) missense possibly damaging 0.81
R2866:Mapk10 UTSW 5 103,186,548 (GRCm39) missense probably benign 0.25
R2867:Mapk10 UTSW 5 103,186,548 (GRCm39) missense probably benign 0.25
R2867:Mapk10 UTSW 5 103,186,548 (GRCm39) missense probably benign 0.25
R4622:Mapk10 UTSW 5 103,137,590 (GRCm39) missense probably damaging 1.00
R4860:Mapk10 UTSW 5 103,138,485 (GRCm39) missense probably damaging 1.00
R4860:Mapk10 UTSW 5 103,138,485 (GRCm39) missense probably damaging 1.00
R5901:Mapk10 UTSW 5 103,061,158 (GRCm39) missense probably damaging 1.00
R5986:Mapk10 UTSW 5 103,186,446 (GRCm39) missense probably benign 0.33
R6000:Mapk10 UTSW 5 103,114,342 (GRCm39) missense probably damaging 1.00
R6000:Mapk10 UTSW 5 103,114,341 (GRCm39) missense probably damaging 1.00
R7375:Mapk10 UTSW 5 103,124,256 (GRCm39) missense probably null 0.26
R7460:Mapk10 UTSW 5 103,186,443 (GRCm39) missense probably benign 0.37
R7753:Mapk10 UTSW 5 103,186,419 (GRCm39) nonsense probably null
R7879:Mapk10 UTSW 5 103,111,362 (GRCm39) missense probably benign 0.10
R7935:Mapk10 UTSW 5 103,139,792 (GRCm39) missense possibly damaging 0.92
R8059:Mapk10 UTSW 5 103,114,478 (GRCm39) missense probably damaging 1.00
R8846:Mapk10 UTSW 5 103,144,521 (GRCm39) missense probably damaging 1.00
R9030:Mapk10 UTSW 5 103,144,499 (GRCm39) missense probably damaging 1.00
R9043:Mapk10 UTSW 5 103,074,025 (GRCm39) splice site probably benign
R9106:Mapk10 UTSW 5 103,186,442 (GRCm39) missense probably damaging 1.00
R9115:Mapk10 UTSW 5 103,186,532 (GRCm39) missense
R9398:Mapk10 UTSW 5 103,061,152 (GRCm39) missense probably damaging 1.00
R9620:Mapk10 UTSW 5 103,114,473 (GRCm39) missense probably damaging 1.00
R9796:Mapk10 UTSW 5 103,135,101 (GRCm39) missense possibly damaging 0.93
Z1176:Mapk10 UTSW 5 103,139,753 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- TCCCATTCAAAGGAGGTCTGG -3'
(R):5'- ACTCTATTAGGATGACAGTGGCTC -3'

Sequencing Primer
(F):5'- TCCCTGTGTTGAAGAAGAGAGCAC -3'
(R):5'- AGGATGACAGTGGCTCTTTTCAG -3'
Posted On 2016-03-17