Mutagenetix > Incidental Mutation

Incidental Mutation 'R0281:Ryr3'

37495

Institutional Source

Beutler Lab

Gene Symbol

Ryr3

Ensembl Gene

ENSMUSG00000057378

Gene Name

ryanodine receptor 3

Synonyms

calcium release channel isoform 3

MMRRC Submission

038503-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.368) question?

Stock #

R0281 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

112631355-113217096 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 112686810 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 3303 (S3303P)

Ref Sequence

ENSEMBL: ENSMUSP00000147196 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000080673] [ENSMUST00000091818] [ENSMUST00000134358] [ENSMUST00000208151] [ENSMUST00000208290]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000080673
AA Change: S3303P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000079503
Gene: ENSMUSG00000057378
AA Change: S3303P

Domain	Start	End	E-Value	Type
low complexity region	90	99	N/A	INTRINSIC
MIR	100	155	3.27e-4	SMART
MIR	162	207	7.52e-4	SMART
MIR	215	269	8.06e-4	SMART
MIR	275	368	8.4e-25	SMART
Pfam:RYDR_ITPR	438	642	1.1e-71	PFAM
SPRY	657	795	1.16e-24	SMART
Pfam:RyR	848	942	1.5e-34	PFAM
Pfam:RyR	962	1056	1.2e-32	PFAM
SPRY	1084	1207	7.99e-37	SMART
SPRY	1325	1465	6.25e-30	SMART
low complexity region	1757	1772	N/A	INTRINSIC
low complexity region	1773	1788	N/A	INTRINSIC
low complexity region	1932	1957	N/A	INTRINSIC
Pfam:RYDR_ITPR	2018	2228	1.8e-59	PFAM
Pfam:RyR	2595	2689	1.2e-36	PFAM
Pfam:RyR	2713	2801	2.1e-31	PFAM
low complexity region	2877	2887	N/A	INTRINSIC
low complexity region	3169	3184	N/A	INTRINSIC
low complexity region	3327	3338	N/A	INTRINSIC
PDB:2BCX\|B	3462	3491	9e-12	PDB
low complexity region	3532	3540	N/A	INTRINSIC
coiled coil region	3585	3614	N/A	INTRINSIC
Pfam:RIH_assoc	3715	3848	4.9e-40	PFAM
low complexity region	3855	3875	N/A	INTRINSIC
SCOP:d1sra__	3893	3989	1e-10	SMART
low complexity region	4096	4134	N/A	INTRINSIC
transmembrane domain	4178	4200	N/A	INTRINSIC
Pfam:RR_TM4-6	4227	4497	4.7e-96	PFAM
Pfam:Ion_trans	4599	4762	2e-11	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000091818
AA Change: S3323P

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000089426
Gene: ENSMUSG00000057378
AA Change: S3323P

Domain	Start	End	E-Value	Type
low complexity region	110	119	N/A	INTRINSIC
MIR	120	175	3.27e-4	SMART
MIR	182	227	7.52e-4	SMART
MIR	235	289	8.06e-4	SMART
MIR	295	388	8.4e-25	SMART
Pfam:RYDR_ITPR	460	655	1.2e-64	PFAM
SPRY	677	815	1.16e-24	SMART
Pfam:RyR	869	959	3.3e-38	PFAM
Pfam:RyR	983	1073	2.5e-32	PFAM
SPRY	1104	1227	7.99e-37	SMART
SPRY	1345	1485	6.25e-30	SMART
low complexity region	1777	1792	N/A	INTRINSIC
low complexity region	1793	1808	N/A	INTRINSIC
low complexity region	1952	1977	N/A	INTRINSIC
Pfam:RYDR_ITPR	2040	2248	5.8e-67	PFAM
Pfam:RyR	2616	2706	6.3e-33	PFAM
Pfam:RyR	2734	2818	6.6e-26	PFAM
low complexity region	2897	2907	N/A	INTRINSIC
low complexity region	3189	3204	N/A	INTRINSIC
PDB:2BCX\|B	3487	3516	1e-11	PDB
low complexity region	3557	3565	N/A	INTRINSIC
coiled coil region	3610	3639	N/A	INTRINSIC
Pfam:RIH_assoc	3744	3862	3.5e-34	PFAM
low complexity region	3880	3900	N/A	INTRINSIC
SCOP:d1sra__	3918	4014	1e-10	SMART
low complexity region	4121	4159	N/A	INTRINSIC
transmembrane domain	4203	4225	N/A	INTRINSIC
Pfam:RR_TM4-6	4252	4522	1.1e-98	PFAM
Pfam:Ion_trans	4625	4799	6.2e-16	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000134358
AA Change: S3303P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Predicted Effect

probably damaging
Transcript: ENSMUST00000208151
AA Change: S3303P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

Predicted Effect

probably damaging
Transcript: ENSMUST00000208290
AA Change: S3303P

PolyPhen 2 Score 0.975 (Sensitivity: 0.76; Specificity: 0.96)

Meta Mutation Damage Score

0.5694

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 96.7%
20x: 93.9%

Validation Efficiency

98% (104/106)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a ryanodine receptor, which functions to release calcium from intracellular storage for use in many cellular processes. For example, the encoded protein is involved in skeletal muscle contraction by releasing calcium from the sarcoplasmic reticulum followed by depolarization of T-tubules. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
PHENOTYPE: Homozygotes for targeted null mutations exhibit impaired muscle contraction at an early age, changes in hippocampal synaptic plasticity, increased locomotor activity with a tendency to circle, and impaired relearning of a spatial task. [provided by MGI curators]

Allele List at MGI

All alleles(10) : Targeted, knock-out(5) Targeted, other(2) Gene trapped(3)

Other mutations in this stock

Total: 101 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700061G19Rik	T	A	17: 56,885,169 (GRCm38)	Y577*	probably null	Het
2610507B11Rik	C	T	11: 78,271,924 (GRCm38)	L871F	possibly damaging	Het
4933430I17Rik	A	T	4: 62,546,067 (GRCm38)	R374*	probably null	Het
5930422O12Rik	A	T	8: 33,429,379 (GRCm38)	R76*	probably null	Het
A1cf	G	A	19: 31,945,814 (GRCm38)	A505T	probably benign	Het
Abcc5	T	A	16: 20,422,400 (GRCm38)	I12F	probably damaging	Het
Abcf2	T	C	5: 24,566,564 (GRCm38)	E555G	probably damaging	Het
Acan	A	T	7: 79,100,285 (GRCm38)	E1601D	probably damaging	Het
Adam2	T	A	14: 66,037,606 (GRCm38)	K559N	probably benign	Het
Akap11	A	C	14: 78,510,089 (GRCm38)	D1619E	possibly damaging	Het
Ankrd11	T	C	8: 122,895,568 (GRCm38)	D515G	probably benign	Het
Ankrd27	T	A	7: 35,619,371 (GRCm38)	N562K	probably damaging	Het
Atp10b	T	C	11: 43,153,304 (GRCm38)	I119T	probably benign	Het
Atr	T	C	9: 95,937,566 (GRCm38)	I2202T	probably benign	Het
BC067074	A	T	13: 113,369,143 (GRCm38)	I727F	probably damaging	Het
Brd4	T	A	17: 32,213,540 (GRCm38)		probably benign	Het
Catsperg2	C	T	7: 29,706,571 (GRCm38)	C634Y	possibly damaging	Het
Cep192	A	G	18: 67,828,482 (GRCm38)		probably benign	Het
Cfap65	T	A	1: 74,927,071 (GRCm38)	I366F	probably damaging	Het
Cnga4	G	T	7: 105,407,668 (GRCm38)	R326L	probably damaging	Het
Cntnap5b	T	A	1: 100,072,153 (GRCm38)	M212K	probably benign	Het
Col6a6	T	A	9: 105,784,116 (GRCm38)	M265L	probably benign	Het
Cyp26b1	A	T	6: 84,574,556 (GRCm38)	F417Y	probably damaging	Het
Dhx15	A	T	5: 52,150,746 (GRCm38)	M768K	probably benign	Het
Drc7	G	A	8: 95,071,253 (GRCm38)	R433H	possibly damaging	Het
Duox2	C	T	2: 122,292,304 (GRCm38)	V550M	probably benign	Het
Elmo2	A	G	2: 165,296,890 (GRCm38)	L456P	probably damaging	Het
Fbxo39	T	C	11: 72,317,530 (GRCm38)	I236T	probably benign	Het
Fezf2	A	G	14: 12,343,977 (GRCm38)	C305R	probably damaging	Het
Fndc3b	C	A	3: 27,457,006 (GRCm38)	C785F	probably benign	Het
Gm12253	T	C	11: 58,440,012 (GRCm38)		probably benign	Het
Gnat2	T	A	3: 108,095,562 (GRCm38)	Y95*	probably null	Het
Gopc	T	C	10: 52,350,678 (GRCm38)	K220E	probably damaging	Het
Hectd4	G	A	5: 121,254,251 (GRCm38)	D193N	possibly damaging	Het
Hexa	G	A	9: 59,554,226 (GRCm38)		probably null	Het
Hspa4l	T	C	3: 40,785,408 (GRCm38)		probably benign	Het
Hspa5	T	C	2: 34,774,320 (GRCm38)	S301P	probably damaging	Het
Ice1	A	T	13: 70,604,047 (GRCm38)	S1307T	possibly damaging	Het
Igtp	T	C	11: 58,206,054 (GRCm38)	L17P	probably damaging	Het
Itk	T	C	11: 46,353,916 (GRCm38)	Y225C	probably damaging	Het
Kifc3	A	G	8: 95,103,460 (GRCm38)	V560A	probably damaging	Het
Lama1	A	G	17: 67,817,569 (GRCm38)	N2875D	probably damaging	Het
Lasp1	C	A	11: 97,806,851 (GRCm38)	C32*	probably null	Het
Lcp2	T	A	11: 34,069,854 (GRCm38)		probably benign	Het
Lhx9	C	T	1: 138,832,904 (GRCm38)	G236D	probably benign	Het
Lrrc38	A	T	4: 143,350,409 (GRCm38)	I81F	probably damaging	Het
Ly6a	C	T	15: 74,995,387 (GRCm38)	V94M	probably benign	Het
Map3k13	A	G	16: 21,914,157 (GRCm38)	E503G	probably damaging	Het
Mertk	T	C	2: 128,782,621 (GRCm38)		probably benign	Het
Mkl2	T	A	16: 13,412,163 (GRCm38)	I915N	probably damaging	Het
Msantd2	G	A	9: 37,523,219 (GRCm38)	D252N	possibly damaging	Het
Mtmr12	T	A	15: 12,257,706 (GRCm38)	L290*	probably null	Het
Myo3a	T	C	2: 22,245,598 (GRCm38)	I92T	probably benign	Het
Naglu	T	A	11: 101,074,027 (GRCm38)	N313K	probably damaging	Het
Nceh1	T	C	3: 27,222,804 (GRCm38)	V92A	possibly damaging	Het
Ncf4	A	G	15: 78,250,883 (GRCm38)	T47A	probably damaging	Het
Nrp1	T	A	8: 128,460,683 (GRCm38)	F403L	probably damaging	Het
Nxph3	T	C	11: 95,511,256 (GRCm38)	T111A	possibly damaging	Het
Obscn	T	A	11: 59,038,615 (GRCm38)	E6061V	probably damaging	Het
Obsl1	C	A	1: 75,492,927 (GRCm38)	G1149W	probably damaging	Het
Olfr1162	C	T	2: 88,050,412 (GRCm38)	V71I	possibly damaging	Het
Olfr1370	T	A	13: 21,072,374 (GRCm38)	Y309F	probably benign	Het
Olfr1487	A	G	19: 13,619,485 (GRCm38)	T65A	probably benign	Het
Olfr267	A	T	4: 58,784,981 (GRCm38)	V247E	probably damaging	Het
Olfr292	A	G	7: 86,694,860 (GRCm38)	T135A	probably benign	Het
Olfr493	A	C	7: 108,346,914 (GRCm38)	D22E	probably benign	Het
Olfr814	T	A	10: 129,874,546 (GRCm38)	L70F	possibly damaging	Het
Pde9a	T	C	17: 31,455,106 (GRCm38)	V55A	probably damaging	Het
Pip4k2c	A	T	10: 127,205,821 (GRCm38)		probably null	Het
Plvap	T	C	8: 71,511,382 (GRCm38)	N112S	probably damaging	Het
Pop1	T	A	15: 34,529,858 (GRCm38)		probably null	Het
Ppip5k2	T	C	1: 97,716,553 (GRCm38)	H1113R	possibly damaging	Het
Ptprk	A	T	10: 28,573,392 (GRCm38)	I962F	probably damaging	Het
Rad51ap2	T	C	12: 11,457,042 (GRCm38)	S322P	possibly damaging	Het
Rasal1	A	G	5: 120,674,605 (GRCm38)	T565A	probably benign	Het
Rbm15	C	A	3: 107,331,155 (GRCm38)	R642S	probably damaging	Het
Rpsa	G	A	9: 120,131,003 (GRCm38)	E211K	possibly damaging	Het
Scg2	T	A	1: 79,435,512 (GRCm38)	N458I	possibly damaging	Het
Setx	A	G	2: 29,179,643 (GRCm38)	T2487A	probably benign	Het
Slc4a5	G	A	6: 83,267,567 (GRCm38)		probably benign	Het
Slc8a2	T	A	7: 16,140,989 (GRCm38)	D387E	probably benign	Het
Smarcc2	A	G	10: 128,474,722 (GRCm38)	T407A	probably benign	Het
Snap25	A	G	2: 136,777,464 (GRCm38)	D179G	probably damaging	Het
Socs4	T	C	14: 47,289,868 (GRCm38)	S74P	probably benign	Het
Sp6	T	A	11: 97,021,925 (GRCm38)	Y155N	probably benign	Het
Srrt	C	T	5: 137,296,127 (GRCm38)		probably benign	Het
Steap1	C	T	5: 5,736,431 (GRCm38)	M335I	probably benign	Het
Stra6	A	T	9: 58,145,489 (GRCm38)	Y250F	probably benign	Het
Svil	T	C	18: 5,094,582 (GRCm38)	S1421P	probably damaging	Het
Tcea3	G	A	4: 136,271,366 (GRCm38)	C317Y	probably damaging	Het
Tmco6	T	C	18: 36,737,704 (GRCm38)	L117S	probably damaging	Het
Trp53bp1	T	C	2: 121,270,237 (GRCm38)	K89E	probably damaging	Het
Trp63	T	A	16: 25,764,302 (GRCm38)		probably benign	Het
Ube2d2a	A	G	18: 35,800,132 (GRCm38)	Y74C	probably damaging	Het
Usp19	T	G	9: 108,498,509 (GRCm38)	F885V	probably damaging	Het
Utp18	T	A	11: 93,882,177 (GRCm38)		probably benign	Het
Vmn2r116	T	C	17: 23,401,413 (GRCm38)	I707T	possibly damaging	Het
Vmn2r68	T	A	7: 85,233,249 (GRCm38)		probably benign	Het
Vmn2r68	C	G	7: 85,233,258 (GRCm38)		probably null	Het
Zfp318	C	T	17: 46,412,614 (GRCm38)	P1848S	probably benign	Het
Zfp984	G	T	4: 147,755,265 (GRCm38)	N376K	probably benign	Het

Other mutations in Ryr3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00435:Ryr3	APN	2	112,660,149 (GRCm38)	missense	probably damaging	0.98
IGL00531:Ryr3	APN	2	112,663,012 (GRCm38)	splice site	probably benign
IGL00785:Ryr3	APN	2	112,836,103 (GRCm38)	missense	possibly damaging	0.95
IGL00901:Ryr3	APN	2	112,886,589 (GRCm38)	missense	probably damaging	1.00
IGL00910:Ryr3	APN	2	112,728,934 (GRCm38)	splice site	probably benign
IGL00970:Ryr3	APN	2	112,764,676 (GRCm38)	missense	probably damaging	1.00
IGL01083:Ryr3	APN	2	112,751,846 (GRCm38)	splice site	probably benign
IGL01105:Ryr3	APN	2	112,751,805 (GRCm38)	missense	probably damaging	1.00
IGL01287:Ryr3	APN	2	112,709,073 (GRCm38)	missense	probably damaging	1.00
IGL01343:Ryr3	APN	2	112,660,054 (GRCm38)	missense	probably damaging	1.00
IGL01472:Ryr3	APN	2	112,672,248 (GRCm38)	missense	probably benign	0.20
IGL01552:Ryr3	APN	2	112,825,883 (GRCm38)	missense	possibly damaging	0.53
IGL01594:Ryr3	APN	2	112,772,728 (GRCm38)	missense	probably damaging	1.00
IGL01723:Ryr3	APN	2	112,650,111 (GRCm38)	critical splice donor site	probably null
IGL01837:Ryr3	APN	2	112,801,320 (GRCm38)	missense	probably damaging	1.00
IGL01868:Ryr3	APN	2	112,803,158 (GRCm38)	splice site	probably benign
IGL01907:Ryr3	APN	2	112,869,001 (GRCm38)	splice site	probably benign
IGL02005:Ryr3	APN	2	112,663,263 (GRCm38)	splice site	probably benign
IGL02014:Ryr3	APN	2	112,946,915 (GRCm38)	missense	possibly damaging	0.86
IGL02109:Ryr3	APN	2	112,949,157 (GRCm38)	missense	probably benign
IGL02178:Ryr3	APN	2	112,825,799 (GRCm38)	missense	probably benign	0.17
IGL02185:Ryr3	APN	2	112,967,203 (GRCm38)	missense	probably damaging	0.99
IGL02189:Ryr3	APN	2	112,754,838 (GRCm38)	splice site	probably benign
IGL02200:Ryr3	APN	2	112,849,510 (GRCm38)	missense	probably damaging	0.98
IGL02302:Ryr3	APN	2	112,964,356 (GRCm38)	missense	probably damaging	1.00
IGL02305:Ryr3	APN	2	112,645,277 (GRCm38)	missense	probably damaging	0.96
IGL02306:Ryr3	APN	2	112,834,114 (GRCm38)	missense	probably damaging	0.98
IGL02306:Ryr3	APN	2	112,847,399 (GRCm38)	critical splice donor site	probably null
IGL02340:Ryr3	APN	2	112,947,004 (GRCm38)	splice site	probably benign
IGL02398:Ryr3	APN	2	112,847,422 (GRCm38)	missense	probably benign	0.05
IGL02407:Ryr3	APN	2	112,754,958 (GRCm38)	missense	probably damaging	1.00
IGL02426:Ryr3	APN	2	112,900,905 (GRCm38)	missense	possibly damaging	0.59
IGL02452:Ryr3	APN	2	112,833,990 (GRCm38)	missense	probably damaging	1.00
IGL02453:Ryr3	APN	2	112,681,728 (GRCm38)	splice site	probably benign
IGL02585:Ryr3	APN	2	112,712,303 (GRCm38)	missense	probably damaging	1.00
IGL02724:Ryr3	APN	2	112,902,576 (GRCm38)	critical splice donor site	probably null
IGL02817:Ryr3	APN	2	112,844,623 (GRCm38)	critical splice donor site	probably null
IGL02861:Ryr3	APN	2	112,652,841 (GRCm38)	missense	possibly damaging	0.89
IGL03038:Ryr3	APN	2	112,668,120 (GRCm38)	missense	possibly damaging	0.83
IGL03059:Ryr3	APN	2	112,800,047 (GRCm38)	missense	probably damaging	1.00
IGL03136:Ryr3	APN	2	112,675,974 (GRCm38)	splice site	probably benign
IGL03137:Ryr3	APN	2	112,910,397 (GRCm38)	missense	probably benign
IGL03166:Ryr3	APN	2	112,641,112 (GRCm38)	nonsense	probably null
IGL03177:Ryr3	APN	2	113,028,671 (GRCm38)	missense	probably benign	0.39
IGL03205:Ryr3	APN	2	112,632,142 (GRCm38)	missense	probably damaging	1.00
IGL03224:Ryr3	APN	2	112,954,336 (GRCm38)	nonsense	probably null
IGL03249:Ryr3	APN	2	112,640,656 (GRCm38)	missense	probably benign	0.32
IGL03370:Ryr3	APN	2	112,756,599 (GRCm38)	missense	possibly damaging	0.69
intruder	UTSW	2	112,672,246 (GRCm38)	nonsense	probably null
usurper	UTSW	2	112,800,022 (GRCm38)	missense	probably damaging	1.00
ANU74:Ryr3	UTSW	2	112,831,230 (GRCm38)	critical splice acceptor site	probably null
BB006:Ryr3	UTSW	2	112,834,188 (GRCm38)	missense	probably benign	0.00
BB016:Ryr3	UTSW	2	112,834,188 (GRCm38)	missense	probably benign	0.00
F5426:Ryr3	UTSW	2	112,766,338 (GRCm38)	splice site	probably benign
PIT4494001:Ryr3	UTSW	2	112,841,876 (GRCm38)	missense	probably damaging	0.99
R0022:Ryr3	UTSW	2	112,640,666 (GRCm38)	missense	probably damaging	1.00
R0022:Ryr3	UTSW	2	112,640,666 (GRCm38)	missense	probably damaging	1.00
R0051:Ryr3	UTSW	2	112,869,075 (GRCm38)	missense	probably damaging	1.00
R0051:Ryr3	UTSW	2	112,869,075 (GRCm38)	missense	probably damaging	1.00
R0085:Ryr3	UTSW	2	112,859,763 (GRCm38)	missense	probably damaging	1.00
R0097:Ryr3	UTSW	2	112,800,055 (GRCm38)	missense	probably damaging	1.00
R0097:Ryr3	UTSW	2	112,800,055 (GRCm38)	missense	probably damaging	1.00
R0098:Ryr3	UTSW	2	112,901,031 (GRCm38)	missense	probably damaging	1.00
R0098:Ryr3	UTSW	2	112,901,031 (GRCm38)	missense	probably damaging	1.00
R0116:Ryr3	UTSW	2	112,803,165 (GRCm38)	missense	probably damaging	0.99
R0302:Ryr3	UTSW	2	112,647,123 (GRCm38)	splice site	probably benign
R0306:Ryr3	UTSW	2	112,775,655 (GRCm38)	critical splice donor site	probably null
R0445:Ryr3	UTSW	2	112,866,054 (GRCm38)	missense	probably benign	0.16
R0463:Ryr3	UTSW	2	112,661,701 (GRCm38)	missense	probably damaging	1.00
R0592:Ryr3	UTSW	2	112,678,481 (GRCm38)	missense	probably damaging	1.00
R0622:Ryr3	UTSW	2	112,662,555 (GRCm38)	missense	probably damaging	1.00
R0656:Ryr3	UTSW	2	112,648,306 (GRCm38)	splice site	probably benign
R0735:Ryr3	UTSW	2	112,732,982 (GRCm38)	missense	probably benign	0.11
R0783:Ryr3	UTSW	2	112,756,327 (GRCm38)	splice site	probably benign
R0789:Ryr3	UTSW	2	112,780,973 (GRCm38)	splice site	probably null
R0835:Ryr3	UTSW	2	112,650,138 (GRCm38)	missense	probably benign	0.16
R0879:Ryr3	UTSW	2	113,030,243 (GRCm38)	missense	probably benign	0.02
R0924:Ryr3	UTSW	2	112,841,833 (GRCm38)	missense	probably damaging	1.00
R0930:Ryr3	UTSW	2	112,841,833 (GRCm38)	missense	probably damaging	1.00
R0931:Ryr3	UTSW	2	112,653,702 (GRCm38)	missense	probably damaging	1.00
R1037:Ryr3	UTSW	2	112,869,108 (GRCm38)	missense	probably benign	0.42
R1169:Ryr3	UTSW	2	112,733,014 (GRCm38)	missense	probably benign	0.01
R1170:Ryr3	UTSW	2	112,946,987 (GRCm38)	missense	probably damaging	1.00
R1178:Ryr3	UTSW	2	112,964,380 (GRCm38)	missense	probably benign	0.00
R1187:Ryr3	UTSW	2	112,958,176 (GRCm38)	missense	probably damaging	1.00
R1289:Ryr3	UTSW	2	112,645,285 (GRCm38)	missense	probably damaging	1.00
R1337:Ryr3	UTSW	2	112,779,963 (GRCm38)	missense	possibly damaging	0.46
R1342:Ryr3	UTSW	2	112,750,803 (GRCm38)	missense	probably damaging	1.00
R1349:Ryr3	UTSW	2	112,834,201 (GRCm38)	missense	probably damaging	1.00
R1372:Ryr3	UTSW	2	112,834,201 (GRCm38)	missense	probably damaging	1.00
R1434:Ryr3	UTSW	2	112,645,259 (GRCm38)	missense	probably damaging	1.00
R1438:Ryr3	UTSW	2	112,757,701 (GRCm38)	missense	probably benign	0.18
R1467:Ryr3	UTSW	2	112,753,002 (GRCm38)	splice site	probably benign
R1470:Ryr3	UTSW	2	112,653,007 (GRCm38)	missense	probably benign
R1470:Ryr3	UTSW	2	112,653,007 (GRCm38)	missense	probably benign
R1474:Ryr3	UTSW	2	112,909,962 (GRCm38)	missense	probably damaging	1.00
R1481:Ryr3	UTSW	2	112,636,522 (GRCm38)	splice site	probably benign
R1513:Ryr3	UTSW	2	112,709,197 (GRCm38)	nonsense	probably null
R1524:Ryr3	UTSW	2	112,869,082 (GRCm38)	missense	probably damaging	0.98
R1525:Ryr3	UTSW	2	112,678,090 (GRCm38)	missense	probably damaging	1.00
R1526:Ryr3	UTSW	2	112,661,657 (GRCm38)	missense	probably damaging	1.00
R1611:Ryr3	UTSW	2	112,653,505 (GRCm38)	missense	possibly damaging	0.72
R1640:Ryr3	UTSW	2	112,900,833 (GRCm38)	missense	probably damaging	1.00
R1662:Ryr3	UTSW	2	112,709,273 (GRCm38)	missense	probably damaging	0.99
R1764:Ryr3	UTSW	2	112,860,460 (GRCm38)	missense	probably damaging	1.00
R1769:Ryr3	UTSW	2	112,751,768 (GRCm38)	critical splice donor site	probably null
R1776:Ryr3	UTSW	2	112,957,253 (GRCm38)	missense	probably damaging	0.99
R1780:Ryr3	UTSW	2	112,867,292 (GRCm38)	missense	probably damaging	0.98
R1840:Ryr3	UTSW	2	112,750,820 (GRCm38)	missense	probably damaging	1.00
R1864:Ryr3	UTSW	2	112,730,328 (GRCm38)	missense	possibly damaging	0.65
R1872:Ryr3	UTSW	2	112,709,137 (GRCm38)	missense	possibly damaging	0.94
R1960:Ryr3	UTSW	2	112,794,467 (GRCm38)	missense	probably damaging	1.00
R1994:Ryr3	UTSW	2	112,654,492 (GRCm38)	missense	probably null	0.93
R2018:Ryr3	UTSW	2	112,781,065 (GRCm38)	missense	probably benign	0.24
R2019:Ryr3	UTSW	2	112,781,065 (GRCm38)	missense	probably benign	0.24
R2029:Ryr3	UTSW	2	112,647,016 (GRCm38)	missense	possibly damaging	0.82
R2051:Ryr3	UTSW	2	112,756,641 (GRCm38)	missense	probably damaging	1.00
R2060:Ryr3	UTSW	2	112,954,364 (GRCm38)	missense	possibly damaging	0.92
R2061:Ryr3	UTSW	2	112,663,004 (GRCm38)	missense	possibly damaging	0.83
R2067:Ryr3	UTSW	2	112,946,957 (GRCm38)	missense	probably damaging	1.00
R2106:Ryr3	UTSW	2	112,638,129 (GRCm38)	missense	probably damaging	1.00
R2129:Ryr3	UTSW	2	112,678,370 (GRCm38)	splice site	probably benign
R2140:Ryr3	UTSW	2	112,875,148 (GRCm38)	missense	probably benign	0.01
R2176:Ryr3	UTSW	2	112,666,335 (GRCm38)	missense	possibly damaging	0.48
R2241:Ryr3	UTSW	2	112,801,392 (GRCm38)	missense	probably damaging	1.00
R2261:Ryr3	UTSW	2	112,675,873 (GRCm38)	missense	probably damaging	0.99
R2262:Ryr3	UTSW	2	112,675,873 (GRCm38)	missense	probably damaging	0.99
R2276:Ryr3	UTSW	2	112,649,319 (GRCm38)	missense	possibly damaging	0.79
R2279:Ryr3	UTSW	2	112,649,319 (GRCm38)	missense	possibly damaging	0.79
R2403:Ryr3	UTSW	2	112,686,628 (GRCm38)	missense	probably damaging	1.00
R2510:Ryr3	UTSW	2	112,675,904 (GRCm38)	missense	probably benign	0.18
R2568:Ryr3	UTSW	2	112,675,874 (GRCm38)	missense	probably damaging	1.00
R3013:Ryr3	UTSW	2	112,640,281 (GRCm38)	missense	probably damaging	1.00
R3431:Ryr3	UTSW	2	112,656,531 (GRCm38)	missense	probably damaging	1.00
R3552:Ryr3	UTSW	2	112,751,787 (GRCm38)	missense	probably damaging	1.00
R3761:Ryr3	UTSW	2	112,754,913 (GRCm38)	missense	probably benign
R3909:Ryr3	UTSW	2	112,636,608 (GRCm38)	missense	probably damaging	1.00
R3923:Ryr3	UTSW	2	112,841,873 (GRCm38)	missense	possibly damaging	0.92
R3924:Ryr3	UTSW	2	113,028,703 (GRCm38)	splice site	probably benign
R3927:Ryr3	UTSW	2	112,675,873 (GRCm38)	missense	probably damaging	0.99
R3947:Ryr3	UTSW	2	112,675,873 (GRCm38)	missense	probably damaging	0.99
R3949:Ryr3	UTSW	2	112,675,873 (GRCm38)	missense	probably damaging	0.99
R3976:Ryr3	UTSW	2	112,675,837 (GRCm38)	missense	possibly damaging	0.49
R4004:Ryr3	UTSW	2	112,675,873 (GRCm38)	missense	probably damaging	0.99
R4022:Ryr3	UTSW	2	112,675,873 (GRCm38)	missense	probably damaging	0.99
R4084:Ryr3	UTSW	2	112,900,908 (GRCm38)	missense	probably damaging	0.99
R4106:Ryr3	UTSW	2	112,675,873 (GRCm38)	missense	probably damaging	0.99
R4108:Ryr3	UTSW	2	112,675,873 (GRCm38)	missense	probably damaging	0.99
R4109:Ryr3	UTSW	2	112,675,873 (GRCm38)	missense	probably damaging	0.99
R4131:Ryr3	UTSW	2	112,926,983 (GRCm38)	splice site	probably null
R4156:Ryr3	UTSW	2	112,653,675 (GRCm38)	missense	probably damaging	1.00
R4172:Ryr3	UTSW	2	112,794,470 (GRCm38)	missense	probably damaging	1.00
R4234:Ryr3	UTSW	2	112,910,407 (GRCm38)	missense	probably damaging	1.00
R4399:Ryr3	UTSW	2	112,946,844 (GRCm38)	missense	probably benign	0.01
R4409:Ryr3	UTSW	2	112,730,308 (GRCm38)	missense	probably damaging	1.00
R4418:Ryr3	UTSW	2	112,831,224 (GRCm38)	missense	probably damaging	1.00
R4466:Ryr3	UTSW	2	112,653,102 (GRCm38)	missense	possibly damaging	0.92
R4525:Ryr3	UTSW	2	112,653,621 (GRCm38)	missense	probably damaging	0.98
R4573:Ryr3	UTSW	2	112,755,174 (GRCm38)	splice site	probably null
R4589:Ryr3	UTSW	2	112,875,133 (GRCm38)	missense	probably damaging	1.00
R4653:Ryr3	UTSW	2	112,652,763 (GRCm38)	missense	probably damaging	1.00
R4664:Ryr3	UTSW	2	112,996,555 (GRCm38)	intron	probably benign
R4710:Ryr3	UTSW	2	112,766,301 (GRCm38)	missense	probably damaging	1.00
R4734:Ryr3	UTSW	2	112,910,502 (GRCm38)	missense	probably damaging	0.99
R4741:Ryr3	UTSW	2	112,803,268 (GRCm38)	missense	probably damaging	0.99
R4748:Ryr3	UTSW	2	112,964,405 (GRCm38)	missense	possibly damaging	0.95
R4749:Ryr3	UTSW	2	112,964,405 (GRCm38)	missense	possibly damaging	0.95
R4754:Ryr3	UTSW	2	112,757,639 (GRCm38)	missense	possibly damaging	0.94
R4764:Ryr3	UTSW	2	112,733,031 (GRCm38)	critical splice acceptor site	probably null
R4812:Ryr3	UTSW	2	112,912,236 (GRCm38)	missense	probably damaging	1.00
R4822:Ryr3	UTSW	2	112,652,745 (GRCm38)	missense	probably damaging	1.00
R4841:Ryr3	UTSW	2	112,648,373 (GRCm38)	missense	probably damaging	1.00
R4849:Ryr3	UTSW	2	112,908,462 (GRCm38)	missense	probably damaging	1.00
R4917:Ryr3	UTSW	2	112,831,185 (GRCm38)	missense	probably damaging	1.00
R4942:Ryr3	UTSW	2	112,836,257 (GRCm38)	missense	probably damaging	0.99
R4990:Ryr3	UTSW	2	112,909,973 (GRCm38)	missense	probably damaging	1.00
R4990:Ryr3	UTSW	2	112,635,777 (GRCm38)	missense	probably damaging	1.00
R5049:Ryr3	UTSW	2	112,640,171 (GRCm38)	missense	probably damaging	1.00
R5055:Ryr3	UTSW	2	112,831,159 (GRCm38)	missense	probably benign	0.00
R5112:Ryr3	UTSW	2	112,902,665 (GRCm38)	missense	probably damaging	1.00
R5160:Ryr3	UTSW	2	112,646,927 (GRCm38)	missense	probably damaging	1.00
R5169:Ryr3	UTSW	2	112,670,660 (GRCm38)	missense	possibly damaging	0.63
R5176:Ryr3	UTSW	2	112,757,667 (GRCm38)	missense	possibly damaging	0.95
R5182:Ryr3	UTSW	2	112,755,150 (GRCm38)	missense	probably damaging	1.00
R5206:Ryr3	UTSW	2	112,844,711 (GRCm38)	missense	probably damaging	1.00
R5263:Ryr3	UTSW	2	112,718,002 (GRCm38)	missense	possibly damaging	0.65
R5272:Ryr3	UTSW	2	112,653,213 (GRCm38)	missense	probably damaging	1.00
R5332:Ryr3	UTSW	2	112,902,693 (GRCm38)	missense	probably damaging	1.00
R5340:Ryr3	UTSW	2	112,834,125 (GRCm38)	missense	probably damaging	0.99
R5359:Ryr3	UTSW	2	112,775,841 (GRCm38)	splice site	probably null
R5434:Ryr3	UTSW	2	112,794,469 (GRCm38)	missense	probably damaging	1.00
R5454:Ryr3	UTSW	2	112,730,302 (GRCm38)	splice site	probably null
R5501:Ryr3	UTSW	2	112,662,504 (GRCm38)	missense	possibly damaging	0.80
R5560:Ryr3	UTSW	2	112,754,877 (GRCm38)	missense	probably damaging	1.00
R5580:Ryr3	UTSW	2	112,841,948 (GRCm38)	missense	probably damaging	1.00
R5621:Ryr3	UTSW	2	112,900,984 (GRCm38)	nonsense	probably null
R5731:Ryr3	UTSW	2	112,641,572 (GRCm38)	missense	probably damaging	1.00
R5757:Ryr3	UTSW	2	112,841,975 (GRCm38)	missense	probably damaging	1.00
R5758:Ryr3	UTSW	2	112,841,975 (GRCm38)	missense	probably damaging	1.00
R5768:Ryr3	UTSW	2	112,753,097 (GRCm38)	missense	probably benign	0.05
R5783:Ryr3	UTSW	2	112,652,998 (GRCm38)	missense	probably benign	0.06
R5799:Ryr3	UTSW	2	112,686,580 (GRCm38)	missense	probably damaging	1.00
R5829:Ryr3	UTSW	2	112,859,731 (GRCm38)	missense	probably damaging	1.00
R5883:Ryr3	UTSW	2	113,030,292 (GRCm38)	intron	probably benign
R5911:Ryr3	UTSW	2	112,908,487 (GRCm38)	missense	probably damaging	1.00
R5968:Ryr3	UTSW	2	112,647,049 (GRCm38)	missense	probably benign	0.22
R5972:Ryr3	UTSW	2	112,834,064 (GRCm38)	missense	probably damaging	0.99
R5978:Ryr3	UTSW	2	112,672,269 (GRCm38)	missense	probably benign	0.00
R6084:Ryr3	UTSW	2	112,908,493 (GRCm38)	missense	probably damaging	1.00
R6117:Ryr3	UTSW	2	112,635,396 (GRCm38)	missense	probably damaging	1.00
R6126:Ryr3	UTSW	2	112,757,670 (GRCm38)	missense	probably damaging	1.00
R6128:Ryr3	UTSW	2	112,954,294 (GRCm38)	critical splice donor site	probably null
R6157:Ryr3	UTSW	2	112,841,899 (GRCm38)	missense	probably damaging	0.98
R6258:Ryr3	UTSW	2	112,660,104 (GRCm38)	missense	probably damaging	1.00
R6260:Ryr3	UTSW	2	112,660,104 (GRCm38)	missense	probably damaging	1.00
R6373:Ryr3	UTSW	2	112,656,544 (GRCm38)	missense	probably damaging	1.00
R6377:Ryr3	UTSW	2	112,632,185 (GRCm38)	missense	probably damaging	1.00
R6443:Ryr3	UTSW	2	112,675,933 (GRCm38)	missense	possibly damaging	0.88
R6478:Ryr3	UTSW	2	112,660,068 (GRCm38)	missense	probably damaging	1.00
R6512:Ryr3	UTSW	2	112,867,378 (GRCm38)	missense	possibly damaging	0.83
R6684:Ryr3	UTSW	2	112,753,088 (GRCm38)	missense	probably damaging	1.00
R6753:Ryr3	UTSW	2	112,652,610 (GRCm38)	missense	probably damaging	0.99
R6812:Ryr3	UTSW	2	112,946,906 (GRCm38)	missense	probably damaging	1.00
R6910:Ryr3	UTSW	2	112,958,175 (GRCm38)	missense	probably damaging	1.00
R6930:Ryr3	UTSW	2	112,860,354 (GRCm38)	missense	probably damaging	1.00
R6946:Ryr3	UTSW	2	112,831,200 (GRCm38)	missense	probably damaging	1.00
R6950:Ryr3	UTSW	2	112,686,825 (GRCm38)	missense	possibly damaging	0.78
R6973:Ryr3	UTSW	2	112,766,311 (GRCm38)	missense	probably damaging	0.99
R6984:Ryr3	UTSW	2	112,875,091 (GRCm38)	missense	probably damaging	1.00
R7020:Ryr3	UTSW	2	112,753,078 (GRCm38)	missense	probably benign	0.00
R7037:Ryr3	UTSW	2	112,949,130 (GRCm38)	nonsense	probably null
R7166:Ryr3	UTSW	2	112,875,028 (GRCm38)	missense	probably damaging	1.00
R7172:Ryr3	UTSW	2	112,661,657 (GRCm38)	missense	probably damaging	1.00
R7177:Ryr3	UTSW	2	112,900,843 (GRCm38)	missense	probably damaging	1.00
R7188:Ryr3	UTSW	2	113,028,644 (GRCm38)	missense	probably damaging	1.00
R7202:Ryr3	UTSW	2	112,766,319 (GRCm38)	missense	probably damaging	1.00
R7228:Ryr3	UTSW	2	112,861,852 (GRCm38)	missense	probably damaging	1.00
R7256:Ryr3	UTSW	2	112,672,246 (GRCm38)	nonsense	probably null
R7293:Ryr3	UTSW	2	112,902,603 (GRCm38)	missense	probably benign	0.13
R7331:Ryr3	UTSW	2	112,763,665 (GRCm38)	missense	possibly damaging	0.80
R7380:Ryr3	UTSW	2	112,640,157 (GRCm38)	missense	probably damaging	1.00
R7391:Ryr3	UTSW	2	112,780,977 (GRCm38)	critical splice donor site	probably null
R7455:Ryr3	UTSW	2	112,728,866 (GRCm38)	missense	probably damaging	0.99
R7466:Ryr3	UTSW	2	112,926,957 (GRCm38)	missense	probably benign	0.40
R7481:Ryr3	UTSW	2	112,678,094 (GRCm38)	missense	possibly damaging	0.95
R7481:Ryr3	UTSW	2	112,678,093 (GRCm38)	missense	probably benign	0.16
R7497:Ryr3	UTSW	2	112,730,473 (GRCm38)	missense	probably benign	0.06
R7502:Ryr3	UTSW	2	112,712,361 (GRCm38)	missense	probably benign	0.00
R7505:Ryr3	UTSW	2	112,712,429 (GRCm38)	missense	probably damaging	0.99
R7581:Ryr3	UTSW	2	112,753,027 (GRCm38)	missense	probably damaging	0.99
R7606:Ryr3	UTSW	2	112,645,245 (GRCm38)	nonsense	probably null
R7677:Ryr3	UTSW	2	112,833,900 (GRCm38)	missense	probably benign
R7703:Ryr3	UTSW	2	112,859,765 (GRCm38)	missense	probably damaging	1.00
R7713:Ryr3	UTSW	2	112,635,346 (GRCm38)	missense	probably benign	0.12
R7784:Ryr3	UTSW	2	112,775,695 (GRCm38)	missense	probably damaging	1.00
R7831:Ryr3	UTSW	2	112,926,838 (GRCm38)	missense	possibly damaging	0.92
R7851:Ryr3	UTSW	2	112,678,517 (GRCm38)	missense	probably benign	0.05
R7873:Ryr3	UTSW	2	112,730,428 (GRCm38)	missense	probably benign	0.28
R7890:Ryr3	UTSW	2	112,926,912 (GRCm38)	missense	probably damaging	1.00
R7899:Ryr3	UTSW	2	112,646,950 (GRCm38)	missense	possibly damaging	0.86
R7904:Ryr3	UTSW	2	112,781,024 (GRCm38)	missense	probably damaging	1.00
R7929:Ryr3	UTSW	2	112,834,188 (GRCm38)	missense	probably benign	0.00
R7982:Ryr3	UTSW	2	112,669,249 (GRCm38)	small deletion	probably benign
R8018:Ryr3	UTSW	2	112,678,432 (GRCm38)	missense	probably damaging	1.00
R8043:Ryr3	UTSW	2	112,875,077 (GRCm38)	missense	probably damaging	1.00
R8043:Ryr3	UTSW	2	112,775,664 (GRCm38)	missense	probably damaging	1.00
R8095:Ryr3	UTSW	2	112,668,043 (GRCm38)	critical splice donor site	probably null
R8097:Ryr3	UTSW	2	112,670,270 (GRCm38)	splice site	probably null
R8181:Ryr3	UTSW	2	112,778,243 (GRCm38)	missense	probably damaging	0.98
R8276:Ryr3	UTSW	2	112,640,617 (GRCm38)	missense	probably damaging	1.00
R8329:Ryr3	UTSW	2	112,662,510 (GRCm38)	missense	possibly damaging	0.94
R8345:Ryr3	UTSW	2	112,652,925 (GRCm38)	missense	probably benign	0.01
R8361:Ryr3	UTSW	2	112,653,130 (GRCm38)	missense	probably damaging	0.98
R8421:Ryr3	UTSW	2	112,996,584 (GRCm38)	missense	probably benign	0.00
R8424:Ryr3	UTSW	2	112,841,894 (GRCm38)	missense	possibly damaging	0.91
R8471:Ryr3	UTSW	2	112,653,780 (GRCm38)	missense	probably damaging	1.00
R8505:Ryr3	UTSW	2	112,675,870 (GRCm38)	missense	probably damaging	0.98
R8535:Ryr3	UTSW	2	112,949,088 (GRCm38)	critical splice donor site	probably null
R8540:Ryr3	UTSW	2	112,800,022 (GRCm38)	missense	probably damaging	1.00
R8722:Ryr3	UTSW	2	112,772,771 (GRCm38)	missense	probably benign	0.12
R8818:Ryr3	UTSW	2	112,831,096 (GRCm38)	missense	probably damaging	1.00
R8819:Ryr3	UTSW	2	112,859,724 (GRCm38)	missense	probably benign	0.01
R8819:Ryr3	UTSW	2	112,635,792 (GRCm38)	missense	probably damaging	1.00
R8820:Ryr3	UTSW	2	112,859,724 (GRCm38)	missense	probably benign	0.01
R8820:Ryr3	UTSW	2	112,635,792 (GRCm38)	missense	probably damaging	1.00
R8852:Ryr3	UTSW	2	112,794,499 (GRCm38)	missense	probably damaging	1.00
R8859:Ryr3	UTSW	2	112,653,219 (GRCm38)	missense	probably damaging	0.98
R8896:Ryr3	UTSW	2	112,753,050 (GRCm38)	nonsense	probably null
R8916:Ryr3	UTSW	2	112,778,290 (GRCm38)	missense	probably damaging	1.00
R8935:Ryr3	UTSW	2	112,678,057 (GRCm38)	missense	probably benign	0.33
R8943:Ryr3	UTSW	2	112,635,324 (GRCm38)	missense	probably damaging	1.00
R8963:Ryr3	UTSW	2	112,836,670 (GRCm38)	critical splice donor site	probably null
R8974:Ryr3	UTSW	2	112,912,279 (GRCm38)	missense	possibly damaging	0.74
R9008:Ryr3	UTSW	2	112,635,403 (GRCm38)	missense	probably damaging	0.98
R9040:Ryr3	UTSW	2	112,954,386 (GRCm38)	missense	probably damaging	1.00
R9041:Ryr3	UTSW	2	112,957,201 (GRCm38)	missense	probably damaging	0.97
R9102:Ryr3	UTSW	2	112,678,561 (GRCm38)	splice site	probably benign
R9167:Ryr3	UTSW	2	112,834,053 (GRCm38)	missense	probably damaging	1.00
R9180:Ryr3	UTSW	2	112,661,636 (GRCm38)	missense	probably damaging	0.99
R9219:Ryr3	UTSW	2	112,912,239 (GRCm38)	missense	possibly damaging	0.62
R9258:Ryr3	UTSW	2	112,653,019 (GRCm38)	missense	probably damaging	0.99
R9300:Ryr3	UTSW	2	112,860,350 (GRCm38)	missense	probably benign
R9320:Ryr3	UTSW	2	112,779,991 (GRCm38)	missense	probably damaging	1.00
R9325:Ryr3	UTSW	2	112,649,295 (GRCm38)	missense	probably damaging	0.96
R9405:Ryr3	UTSW	2	112,834,267 (GRCm38)	missense	probably damaging	1.00
R9414:Ryr3	UTSW	2	112,670,666 (GRCm38)	missense	possibly damaging	0.81
R9489:Ryr3	UTSW	2	112,661,621 (GRCm38)	missense	probably damaging	1.00
R9522:Ryr3	UTSW	2	112,730,414 (GRCm38)	missense	probably benign	0.34
R9526:Ryr3	UTSW	2	112,833,925 (GRCm38)	missense	probably benign
R9529:Ryr3	UTSW	2	112,635,315 (GRCm38)	missense	possibly damaging	0.70
R9605:Ryr3	UTSW	2	112,661,621 (GRCm38)	missense	probably damaging	1.00
R9652:Ryr3	UTSW	2	112,804,702 (GRCm38)	missense	possibly damaging	0.66
R9660:Ryr3	UTSW	2	112,833,729 (GRCm38)	missense	probably benign
R9670:Ryr3	UTSW	2	112,730,500 (GRCm38)	missense	probably benign	0.28
R9673:Ryr3	UTSW	2	112,656,538 (GRCm38)	missense	possibly damaging	0.93
R9710:Ryr3	UTSW	2	112,803,189 (GRCm38)	missense	probably damaging	0.99
R9741:Ryr3	UTSW	2	112,646,926 (GRCm38)	missense	probably benign	0.00
R9772:Ryr3	UTSW	2	112,826,703 (GRCm38)	missense	probably damaging	0.96
RF010:Ryr3	UTSW	2	112,775,670 (GRCm38)	missense	probably damaging	0.97
RF040:Ryr3	UTSW	2	112,910,524 (GRCm38)	critical splice acceptor site	probably benign
RF044:Ryr3	UTSW	2	112,910,524 (GRCm38)	critical splice acceptor site	probably benign
X0057:Ryr3	UTSW	2	112,640,159 (GRCm38)	missense	probably damaging	1.00
X0064:Ryr3	UTSW	2	112,912,302 (GRCm38)	missense	probably benign	0.26
Z1088:Ryr3	UTSW	2	112,900,916 (GRCm38)	missense	probably damaging	1.00
Z1176:Ryr3	UTSW	2	112,728,924 (GRCm38)	missense	probably benign	0.01
Z1176:Ryr3	UTSW	2	112,712,374 (GRCm38)	missense	probably damaging	1.00
Z1176:Ryr3	UTSW	2	112,675,920 (GRCm38)	missense	probably benign	0.05

Predicted Primers

PCR Primer
(F):5'- AGGCTGAAGTCAAAGCTGAAGCATC -3'
(R):5'- TCCAATAGCAAATGCCAGGGCAGG -3'

Sequencing Primer
(F):5'- GCTGTCTCCAGTTAAAAATGCC -3'
(R):5'- ATCAACTCTCTCTGCGGTAAGG -3'

Posted On

2013-05-23