Incidental Mutation 'R0281:Trp53bp1'
| ID |
37496 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Trp53bp1
|
| Ensembl Gene |
ENSMUSG00000043909 |
| Gene Name |
transformation related protein 53 binding protein 1 |
| Synonyms |
53BP1, p53BP1 |
| MMRRC Submission |
038503-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R0281 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
2 |
| Chromosomal Location |
121023762-121101888 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 121100718 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Lysine to Glutamic Acid
at position 89
(K89E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000114457
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000110647]
[ENSMUST00000110648]
[ENSMUST00000131245]
|
| AlphaFold |
P70399 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000110647
AA Change: K89E
PolyPhen 2
Score 0.971 (Sensitivity: 0.77; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000106277
Gene: ENSMUSG00000043909
AA Change: K89E
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
136 |
149 |
N/A |
INTRINSIC |
|
low complexity region
|
158 |
169 |
N/A |
INTRINSIC |
|
low complexity region
|
647 |
661 |
N/A |
INTRINSIC |
|
low complexity region
|
1031 |
1042 |
N/A |
INTRINSIC |
|
low complexity region
|
1099 |
1112 |
N/A |
INTRINSIC |
|
low complexity region
|
1260 |
1272 |
N/A |
INTRINSIC |
|
low complexity region
|
1290 |
1332 |
N/A |
INTRINSIC |
|
Pfam:53-BP1_Tudor
|
1430 |
1551 |
2.5e-80 |
PFAM |
|
low complexity region
|
1581 |
1601 |
N/A |
INTRINSIC |
|
BRCT
|
1673 |
1785 |
7.13e-1 |
SMART |
|
BRCT
|
1813 |
1901 |
1.03e-6 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000110648
AA Change: K89E
PolyPhen 2
Score 0.804 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000106278
Gene: ENSMUSG00000043909
AA Change: K89E
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
136 |
149 |
N/A |
INTRINSIC |
|
low complexity region
|
158 |
169 |
N/A |
INTRINSIC |
|
low complexity region
|
647 |
661 |
N/A |
INTRINSIC |
|
low complexity region
|
1031 |
1042 |
N/A |
INTRINSIC |
|
low complexity region
|
1099 |
1112 |
N/A |
INTRINSIC |
|
low complexity region
|
1260 |
1272 |
N/A |
INTRINSIC |
|
low complexity region
|
1290 |
1332 |
N/A |
INTRINSIC |
|
low complexity region
|
1389 |
1409 |
N/A |
INTRINSIC |
|
Pfam:53-BP1_Tudor
|
1480 |
1601 |
1.5e-80 |
PFAM |
|
low complexity region
|
1631 |
1651 |
N/A |
INTRINSIC |
|
BRCT
|
1723 |
1835 |
7.13e-1 |
SMART |
|
BRCT
|
1863 |
1951 |
1.03e-6 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000124060
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000131245
AA Change: K89E
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000114457
Gene: ENSMUSG00000043909
AA Change: K89E
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
136 |
149 |
N/A |
INTRINSIC |
|
low complexity region
|
158 |
169 |
N/A |
INTRINSIC |
|
low complexity region
|
647 |
661 |
N/A |
INTRINSIC |
|
low complexity region
|
991 |
1002 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000131426
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000136617
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000140285
|
| Meta Mutation Damage Score |
0.0755 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.7%
- 20x: 93.9%
|
| Validation Efficiency |
98% (104/106) |
| MGI Phenotype |
PHENOTYPE: Homozygous mutations in this gene result in growth retardation, immunodeficiency, thymic hypoplasia, and increased incidence of thymic lymphomas. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 101 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4933430I17Rik |
A |
T |
4: 62,464,304 (GRCm39) |
R374* |
probably null |
Het |
| 5930422O12Rik |
A |
T |
8: 33,919,407 (GRCm39) |
R76* |
probably null |
Het |
| A1cf |
G |
A |
19: 31,923,214 (GRCm39) |
A505T |
probably benign |
Het |
| Abcc5 |
T |
A |
16: 20,241,150 (GRCm39) |
I12F |
probably damaging |
Het |
| Abcf2 |
T |
C |
5: 24,771,562 (GRCm39) |
E555G |
probably damaging |
Het |
| Acan |
A |
T |
7: 78,750,033 (GRCm39) |
E1601D |
probably damaging |
Het |
| Acsbg3 |
T |
A |
17: 57,192,169 (GRCm39) |
Y577* |
probably null |
Het |
| Adam2 |
T |
A |
14: 66,275,055 (GRCm39) |
K559N |
probably benign |
Het |
| Akap11 |
A |
C |
14: 78,747,529 (GRCm39) |
D1619E |
possibly damaging |
Het |
| Ankrd11 |
T |
C |
8: 123,622,307 (GRCm39) |
D515G |
probably benign |
Het |
| Ankrd27 |
T |
A |
7: 35,318,796 (GRCm39) |
N562K |
probably damaging |
Het |
| Atp10b |
T |
C |
11: 43,044,131 (GRCm39) |
I119T |
probably benign |
Het |
| Atr |
T |
C |
9: 95,819,619 (GRCm39) |
I2202T |
probably benign |
Het |
| Bltp2 |
C |
T |
11: 78,162,750 (GRCm39) |
L871F |
possibly damaging |
Het |
| Brd4 |
T |
A |
17: 32,432,514 (GRCm39) |
|
probably benign |
Het |
| Catsperg2 |
C |
T |
7: 29,405,996 (GRCm39) |
C634Y |
possibly damaging |
Het |
| Cep192 |
A |
G |
18: 67,961,553 (GRCm39) |
|
probably benign |
Het |
| Cfap65 |
T |
A |
1: 74,966,230 (GRCm39) |
I366F |
probably damaging |
Het |
| Cnga4 |
G |
T |
7: 105,056,875 (GRCm39) |
R326L |
probably damaging |
Het |
| Cntnap5b |
T |
A |
1: 99,999,878 (GRCm39) |
M212K |
probably benign |
Het |
| Col6a6 |
T |
A |
9: 105,661,315 (GRCm39) |
M265L |
probably benign |
Het |
| Cspg4b |
A |
T |
13: 113,505,677 (GRCm39) |
I727F |
probably damaging |
Het |
| Cyp26b1 |
A |
T |
6: 84,551,538 (GRCm39) |
F417Y |
probably damaging |
Het |
| Dhx15 |
A |
T |
5: 52,308,088 (GRCm39) |
M768K |
probably benign |
Het |
| Drc7 |
G |
A |
8: 95,797,881 (GRCm39) |
R433H |
possibly damaging |
Het |
| Duox2 |
C |
T |
2: 122,122,785 (GRCm39) |
V550M |
probably benign |
Het |
| Elmo2 |
A |
G |
2: 165,138,810 (GRCm39) |
L456P |
probably damaging |
Het |
| Fbxo39 |
T |
C |
11: 72,208,356 (GRCm39) |
I236T |
probably benign |
Het |
| Fezf2 |
A |
G |
14: 12,343,977 (GRCm38) |
C305R |
probably damaging |
Het |
| Fndc3b |
C |
A |
3: 27,511,155 (GRCm39) |
C785F |
probably benign |
Het |
| Gm12253 |
T |
C |
11: 58,330,838 (GRCm39) |
|
probably benign |
Het |
| Gnat2 |
T |
A |
3: 108,002,878 (GRCm39) |
Y95* |
probably null |
Het |
| Gopc |
T |
C |
10: 52,226,774 (GRCm39) |
K220E |
probably damaging |
Het |
| Hectd4 |
G |
A |
5: 121,392,314 (GRCm39) |
D193N |
possibly damaging |
Het |
| Hexa |
G |
A |
9: 59,461,509 (GRCm39) |
|
probably null |
Het |
| Hspa4l |
T |
C |
3: 40,739,840 (GRCm39) |
|
probably benign |
Het |
| Hspa5 |
T |
C |
2: 34,664,332 (GRCm39) |
S301P |
probably damaging |
Het |
| Ice1 |
A |
T |
13: 70,752,166 (GRCm39) |
S1307T |
possibly damaging |
Het |
| Igtp |
T |
C |
11: 58,096,880 (GRCm39) |
L17P |
probably damaging |
Het |
| Itk |
T |
C |
11: 46,244,743 (GRCm39) |
Y225C |
probably damaging |
Het |
| Kifc3 |
A |
G |
8: 95,830,088 (GRCm39) |
V560A |
probably damaging |
Het |
| Lama1 |
A |
G |
17: 68,124,564 (GRCm39) |
N2875D |
probably damaging |
Het |
| Lasp1 |
C |
A |
11: 97,697,677 (GRCm39) |
C32* |
probably null |
Het |
| Lcp2 |
T |
A |
11: 34,019,854 (GRCm39) |
|
probably benign |
Het |
| Lhx9 |
C |
T |
1: 138,760,642 (GRCm39) |
G236D |
probably benign |
Het |
| Lrrc38 |
A |
T |
4: 143,076,979 (GRCm39) |
I81F |
probably damaging |
Het |
| Ly6a |
C |
T |
15: 74,867,236 (GRCm39) |
V94M |
probably benign |
Het |
| Map3k13 |
A |
G |
16: 21,732,907 (GRCm39) |
E503G |
probably damaging |
Het |
| Mertk |
T |
C |
2: 128,624,541 (GRCm39) |
|
probably benign |
Het |
| Mrtfb |
T |
A |
16: 13,230,027 (GRCm39) |
I915N |
probably damaging |
Het |
| Msantd2 |
G |
A |
9: 37,434,515 (GRCm39) |
D252N |
possibly damaging |
Het |
| Mtmr12 |
T |
A |
15: 12,257,792 (GRCm39) |
L290* |
probably null |
Het |
| Myo3a |
T |
C |
2: 22,250,409 (GRCm39) |
I92T |
probably benign |
Het |
| Naglu |
T |
A |
11: 100,964,853 (GRCm39) |
N313K |
probably damaging |
Het |
| Nceh1 |
T |
C |
3: 27,276,953 (GRCm39) |
V92A |
possibly damaging |
Het |
| Ncf4 |
A |
G |
15: 78,135,083 (GRCm39) |
T47A |
probably damaging |
Het |
| Nrp1 |
T |
A |
8: 129,187,164 (GRCm39) |
F403L |
probably damaging |
Het |
| Nxph3 |
T |
C |
11: 95,402,082 (GRCm39) |
T111A |
possibly damaging |
Het |
| Obscn |
T |
A |
11: 58,929,441 (GRCm39) |
E6061V |
probably damaging |
Het |
| Obsl1 |
C |
A |
1: 75,469,571 (GRCm39) |
G1149W |
probably damaging |
Het |
| Or14c39 |
A |
G |
7: 86,344,068 (GRCm39) |
T135A |
probably benign |
Het |
| Or2k2 |
A |
T |
4: 58,784,981 (GRCm39) |
V247E |
probably damaging |
Het |
| Or2p2 |
T |
A |
13: 21,256,544 (GRCm39) |
Y309F |
probably benign |
Het |
| Or5b123 |
A |
G |
19: 13,596,849 (GRCm39) |
T65A |
probably benign |
Het |
| Or5d14 |
C |
T |
2: 87,880,756 (GRCm39) |
V71I |
possibly damaging |
Het |
| Or5p68 |
A |
C |
7: 107,946,121 (GRCm39) |
D22E |
probably benign |
Het |
| Or6c70 |
T |
A |
10: 129,710,415 (GRCm39) |
L70F |
possibly damaging |
Het |
| Pde9a |
T |
C |
17: 31,674,080 (GRCm39) |
V55A |
probably damaging |
Het |
| Pip4k2c |
A |
T |
10: 127,041,690 (GRCm39) |
|
probably null |
Het |
| Plvap |
T |
C |
8: 71,964,026 (GRCm39) |
N112S |
probably damaging |
Het |
| Pop1 |
T |
A |
15: 34,530,004 (GRCm39) |
|
probably null |
Het |
| Ppip5k2 |
T |
C |
1: 97,644,278 (GRCm39) |
H1113R |
possibly damaging |
Het |
| Ptprk |
A |
T |
10: 28,449,388 (GRCm39) |
I962F |
probably damaging |
Het |
| Rad51ap2 |
T |
C |
12: 11,507,043 (GRCm39) |
S322P |
possibly damaging |
Het |
| Rasal1 |
A |
G |
5: 120,812,670 (GRCm39) |
T565A |
probably benign |
Het |
| Rbm15 |
C |
A |
3: 107,238,471 (GRCm39) |
R642S |
probably damaging |
Het |
| Rpsa |
G |
A |
9: 119,960,069 (GRCm39) |
E211K |
possibly damaging |
Het |
| Ryr3 |
A |
G |
2: 112,517,155 (GRCm39) |
S3303P |
probably damaging |
Het |
| Scg2 |
T |
A |
1: 79,413,229 (GRCm39) |
N458I |
possibly damaging |
Het |
| Setx |
A |
G |
2: 29,069,655 (GRCm39) |
T2487A |
probably benign |
Het |
| Slc4a5 |
G |
A |
6: 83,244,549 (GRCm39) |
|
probably benign |
Het |
| Slc8a2 |
T |
A |
7: 15,874,914 (GRCm39) |
D387E |
probably benign |
Het |
| Smarcc2 |
A |
G |
10: 128,310,591 (GRCm39) |
T407A |
probably benign |
Het |
| Snap25 |
A |
G |
2: 136,619,384 (GRCm39) |
D179G |
probably damaging |
Het |
| Socs4 |
T |
C |
14: 47,527,325 (GRCm39) |
S74P |
probably benign |
Het |
| Sp6 |
T |
A |
11: 96,912,751 (GRCm39) |
Y155N |
probably benign |
Het |
| Srrt |
C |
T |
5: 137,294,389 (GRCm39) |
|
probably benign |
Het |
| Steap1 |
C |
T |
5: 5,786,431 (GRCm39) |
M335I |
probably benign |
Het |
| Stra6 |
A |
T |
9: 58,052,772 (GRCm39) |
Y250F |
probably benign |
Het |
| Svil |
T |
C |
18: 5,094,582 (GRCm39) |
S1421P |
probably damaging |
Het |
| Tcea3 |
G |
A |
4: 135,998,677 (GRCm39) |
C317Y |
probably damaging |
Het |
| Tmco6 |
T |
C |
18: 36,870,757 (GRCm39) |
L117S |
probably damaging |
Het |
| Trp63 |
T |
A |
16: 25,583,052 (GRCm39) |
|
probably benign |
Het |
| Ube2d2a |
A |
G |
18: 35,933,185 (GRCm39) |
Y74C |
probably damaging |
Het |
| Usp19 |
T |
G |
9: 108,375,708 (GRCm39) |
F885V |
probably damaging |
Het |
| Utp18 |
T |
A |
11: 93,773,003 (GRCm39) |
|
probably benign |
Het |
| Vmn2r116 |
T |
C |
17: 23,620,387 (GRCm39) |
I707T |
possibly damaging |
Het |
| Vmn2r68 |
T |
A |
7: 84,882,457 (GRCm39) |
|
probably benign |
Het |
| Vmn2r68 |
C |
G |
7: 84,882,466 (GRCm39) |
|
probably null |
Het |
| Zfp318 |
C |
T |
17: 46,723,540 (GRCm39) |
P1848S |
probably benign |
Het |
| Zfp984 |
G |
T |
4: 147,839,722 (GRCm39) |
N376K |
probably benign |
Het |
|
| Other mutations in Trp53bp1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00336:Trp53bp1
|
APN |
2 |
121,087,060 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
IGL00690:Trp53bp1
|
APN |
2 |
121,066,476 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00922:Trp53bp1
|
APN |
2 |
121,038,963 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01475:Trp53bp1
|
APN |
2 |
121,100,800 (GRCm39) |
splice site |
probably null |
|
|
IGL01639:Trp53bp1
|
APN |
2 |
121,033,173 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
IGL01662:Trp53bp1
|
APN |
2 |
121,066,506 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01757:Trp53bp1
|
APN |
2 |
121,041,785 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01829:Trp53bp1
|
APN |
2 |
121,046,377 (GRCm39) |
missense |
probably benign |
0.39 |
|
IGL02247:Trp53bp1
|
APN |
2 |
121,067,070 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02349:Trp53bp1
|
APN |
2 |
121,029,555 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02391:Trp53bp1
|
APN |
2 |
121,033,191 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
chives
|
UTSW |
2 |
121,082,349 (GRCm39) |
missense |
probably null |
0.13 |
|
concur
|
UTSW |
2 |
121,100,800 (GRCm39) |
splice site |
probably null |
|
|
confirmation
|
UTSW |
2 |
121,035,594 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
Infra
|
UTSW |
2 |
121,077,980 (GRCm39) |
critical splice donor site |
probably null |
|
|
Legume
|
UTSW |
2 |
121,029,523 (GRCm39) |
missense |
probably damaging |
0.99 |
|
lentil
|
UTSW |
2 |
121,082,349 (GRCm39) |
missense |
probably null |
0.13 |
|
lentil2
|
UTSW |
2 |
121,038,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Profundus
|
UTSW |
2 |
121,038,284 (GRCm39) |
missense |
probably damaging |
1.00 |
|
split_pea
|
UTSW |
2 |
121,059,087 (GRCm39) |
nonsense |
probably null |
|
|
verily
|
UTSW |
2 |
121,041,794 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT1430001:Trp53bp1
|
UTSW |
2 |
121,101,756 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0045:Trp53bp1
|
UTSW |
2 |
121,034,978 (GRCm39) |
missense |
probably benign |
|
|
R0060:Trp53bp1
|
UTSW |
2 |
121,035,006 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0060:Trp53bp1
|
UTSW |
2 |
121,035,006 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0103:Trp53bp1
|
UTSW |
2 |
121,067,240 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0103:Trp53bp1
|
UTSW |
2 |
121,067,240 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0386:Trp53bp1
|
UTSW |
2 |
121,035,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0427:Trp53bp1
|
UTSW |
2 |
121,066,498 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0505:Trp53bp1
|
UTSW |
2 |
121,100,450 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0522:Trp53bp1
|
UTSW |
2 |
121,082,349 (GRCm39) |
missense |
probably null |
0.13 |
|
R0523:Trp53bp1
|
UTSW |
2 |
121,082,349 (GRCm39) |
missense |
probably null |
0.13 |
|
R0525:Trp53bp1
|
UTSW |
2 |
121,082,349 (GRCm39) |
missense |
probably null |
0.13 |
|
R0543:Trp53bp1
|
UTSW |
2 |
121,082,349 (GRCm39) |
missense |
probably null |
0.13 |
|
R0559:Trp53bp1
|
UTSW |
2 |
121,058,282 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0573:Trp53bp1
|
UTSW |
2 |
121,058,653 (GRCm39) |
splice site |
probably benign |
|
|
R0593:Trp53bp1
|
UTSW |
2 |
121,101,009 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R0648:Trp53bp1
|
UTSW |
2 |
121,066,188 (GRCm39) |
missense |
probably benign |
0.20 |
|
R0680:Trp53bp1
|
UTSW |
2 |
121,082,349 (GRCm39) |
missense |
probably null |
0.13 |
|
R0732:Trp53bp1
|
UTSW |
2 |
121,078,745 (GRCm39) |
missense |
probably null |
0.96 |
|
R0905:Trp53bp1
|
UTSW |
2 |
121,034,799 (GRCm39) |
splice site |
probably benign |
|
|
R1377:Trp53bp1
|
UTSW |
2 |
121,101,123 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1415:Trp53bp1
|
UTSW |
2 |
121,066,665 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1725:Trp53bp1
|
UTSW |
2 |
121,082,481 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R1971:Trp53bp1
|
UTSW |
2 |
121,035,517 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2045:Trp53bp1
|
UTSW |
2 |
121,034,964 (GRCm39) |
missense |
probably benign |
|
|
R2143:Trp53bp1
|
UTSW |
2 |
121,046,545 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2282:Trp53bp1
|
UTSW |
2 |
121,100,754 (GRCm39) |
nonsense |
probably null |
|
|
R2296:Trp53bp1
|
UTSW |
2 |
121,039,728 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R3106:Trp53bp1
|
UTSW |
2 |
121,067,133 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3792:Trp53bp1
|
UTSW |
2 |
121,030,810 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3793:Trp53bp1
|
UTSW |
2 |
121,030,810 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3946:Trp53bp1
|
UTSW |
2 |
121,059,107 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4001:Trp53bp1
|
UTSW |
2 |
121,035,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4327:Trp53bp1
|
UTSW |
2 |
121,087,131 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4585:Trp53bp1
|
UTSW |
2 |
121,038,432 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4630:Trp53bp1
|
UTSW |
2 |
121,038,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4744:Trp53bp1
|
UTSW |
2 |
121,041,794 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4751:Trp53bp1
|
UTSW |
2 |
121,058,290 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4754:Trp53bp1
|
UTSW |
2 |
121,038,360 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4755:Trp53bp1
|
UTSW |
2 |
121,059,087 (GRCm39) |
nonsense |
probably null |
|
|
R4850:Trp53bp1
|
UTSW |
2 |
121,035,594 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R4870:Trp53bp1
|
UTSW |
2 |
121,087,122 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4879:Trp53bp1
|
UTSW |
2 |
121,033,084 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4924:Trp53bp1
|
UTSW |
2 |
121,051,701 (GRCm39) |
nonsense |
probably null |
|
|
R4962:Trp53bp1
|
UTSW |
2 |
121,101,027 (GRCm39) |
missense |
probably benign |
0.12 |
|
R5019:Trp53bp1
|
UTSW |
2 |
121,100,800 (GRCm39) |
splice site |
probably null |
|
|
R5111:Trp53bp1
|
UTSW |
2 |
121,041,868 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5149:Trp53bp1
|
UTSW |
2 |
121,046,598 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5252:Trp53bp1
|
UTSW |
2 |
121,074,464 (GRCm39) |
missense |
probably benign |
0.40 |
|
R5533:Trp53bp1
|
UTSW |
2 |
121,038,227 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5642:Trp53bp1
|
UTSW |
2 |
121,067,143 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5773:Trp53bp1
|
UTSW |
2 |
121,074,395 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5819:Trp53bp1
|
UTSW |
2 |
121,038,873 (GRCm39) |
nonsense |
probably null |
|
|
R5886:Trp53bp1
|
UTSW |
2 |
121,035,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5908:Trp53bp1
|
UTSW |
2 |
121,067,304 (GRCm39) |
missense |
probably benign |
0.06 |
|
R6012:Trp53bp1
|
UTSW |
2 |
121,087,083 (GRCm39) |
missense |
probably benign |
0.07 |
|
R6351:Trp53bp1
|
UTSW |
2 |
121,100,426 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6406:Trp53bp1
|
UTSW |
2 |
121,101,093 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6575:Trp53bp1
|
UTSW |
2 |
121,059,084 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6619:Trp53bp1
|
UTSW |
2 |
121,077,980 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6626:Trp53bp1
|
UTSW |
2 |
121,038,284 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6754:Trp53bp1
|
UTSW |
2 |
121,101,057 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R6765:Trp53bp1
|
UTSW |
2 |
121,039,790 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6806:Trp53bp1
|
UTSW |
2 |
121,059,147 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6860:Trp53bp1
|
UTSW |
2 |
121,029,594 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6991:Trp53bp1
|
UTSW |
2 |
121,038,521 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7278:Trp53bp1
|
UTSW |
2 |
121,029,516 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7339:Trp53bp1
|
UTSW |
2 |
121,066,950 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7357:Trp53bp1
|
UTSW |
2 |
121,041,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7477:Trp53bp1
|
UTSW |
2 |
121,066,827 (GRCm39) |
missense |
probably benign |
0.34 |
|
R7577:Trp53bp1
|
UTSW |
2 |
121,067,119 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R7643:Trp53bp1
|
UTSW |
2 |
121,078,295 (GRCm39) |
splice site |
probably null |
|
|
R7728:Trp53bp1
|
UTSW |
2 |
121,038,380 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7806:Trp53bp1
|
UTSW |
2 |
121,035,542 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7955:Trp53bp1
|
UTSW |
2 |
121,066,225 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R8099:Trp53bp1
|
UTSW |
2 |
121,030,230 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8200:Trp53bp1
|
UTSW |
2 |
121,066,657 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8282:Trp53bp1
|
UTSW |
2 |
121,029,523 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9136:Trp53bp1
|
UTSW |
2 |
121,067,092 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R9152:Trp53bp1
|
UTSW |
2 |
121,029,056 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9292:Trp53bp1
|
UTSW |
2 |
121,046,177 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9340:Trp53bp1
|
UTSW |
2 |
121,100,460 (GRCm39) |
missense |
probably benign |
0.40 |
|
R9475:Trp53bp1
|
UTSW |
2 |
121,039,761 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9616:Trp53bp1
|
UTSW |
2 |
121,066,657 (GRCm39) |
missense |
probably benign |
0.30 |
|
R9675:Trp53bp1
|
UTSW |
2 |
121,087,089 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9779:Trp53bp1
|
UTSW |
2 |
121,066,469 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF046:Trp53bp1
|
UTSW |
2 |
121,046,482 (GRCm39) |
frame shift |
probably null |
|
|
Z1088:Trp53bp1
|
UTSW |
2 |
121,084,126 (GRCm39) |
missense |
probably benign |
0.04 |
|
Z1177:Trp53bp1
|
UTSW |
2 |
121,074,541 (GRCm39) |
missense |
probably benign |
0.33 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCTGAGGTAACCGTTCAATGACCTG -3'
(R):5'- AGTGAGTGATGATGCCCTGTTCAAG -3'
Sequencing Primer
(F):5'- ACCGTTCAATGACCTGACTGATG -3'
(R):5'- CTTTTGGATAAAGTTGGTGGGGAAC -3'
|
| Posted On |
2013-05-23 |
Incidental Mutation