Incidental Mutation 'R4878:Adgrg3'
ID 375065
Institutional Source Beutler Lab
Gene Symbol Adgrg3
Ensembl Gene ENSMUSG00000060470
Gene Name adhesion G protein-coupled receptor G3
Synonyms Gpr97, Pb99, A030001G24Rik
MMRRC Submission 042487-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4878 (G1)
Quality Score 225
Status Validated
Chromosome 8
Chromosomal Location 95017692-95045250 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to T at 95035086 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Asparagine to Isoleucine at position 159 (N159I)
Ref Sequence ENSEMBL: ENSMUSP00000051079 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051259]
AlphaFold Q8R0T6
Predicted Effect possibly damaging
Transcript: ENSMUST00000051259
AA Change: N159I

PolyPhen 2 Score 0.858 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000051079
Gene: ENSMUSG00000060470
AA Change: N159I

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
GPS 209 256 3.45e-11 SMART
Pfam:7tm_2 260 509 5.1e-33 PFAM
low complexity region 520 531 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211974
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211994
Predicted Effect unknown
Transcript: ENSMUST00000212570
AA Change: N122I
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 93.8%
Validation Efficiency 96% (70/73)
MGI Phenotype PHENOTYPE: Homozygous null mice display normal B and T cell development. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl4 C A 4: 144,613,845 (GRCm38) H47N possibly damaging Het
Agrn A T 4: 156,170,845 (GRCm38) L1449Q probably damaging Het
Anks6 C T 4: 47,030,795 (GRCm38) G601S probably damaging Het
Atg2a A T 19: 6,250,244 (GRCm38) E694V probably damaging Het
Ccndbp1 T A 2: 121,014,691 (GRCm38) L363* probably null Het
Cdh16 A T 8: 104,618,064 (GRCm38) D478E probably damaging Het
Cep295 A T 9: 15,334,956 (GRCm38) W735R probably benign Het
Cnnm2 C T 19: 46,859,083 (GRCm38) P682S probably benign Het
Daam2 C A 17: 49,460,710 (GRCm38) R951L probably damaging Het
Dmxl1 T A 18: 49,851,476 (GRCm38) F180I probably damaging Het
Dnajc6 T C 4: 101,599,034 (GRCm38) probably benign Het
Efemp2 A T 19: 5,480,761 (GRCm38) probably benign Het
Emilin1 A G 5: 30,917,066 (GRCm38) D217G probably benign Het
Enpep A T 3: 129,276,771 (GRCm38) M829K probably benign Het
Epb41l4a A G 18: 33,798,572 (GRCm38) V623A probably damaging Het
Erlin2 T A 8: 27,027,166 (GRCm38) probably null Het
Fbln2 T C 6: 91,256,995 (GRCm38) probably null Het
Gga3 A T 11: 115,591,321 (GRCm38) I157N probably damaging Het
Gm884 A G 11: 103,617,891 (GRCm38) probably benign Het
Gtpbp6 C T 5: 110,107,311 (GRCm38) probably benign Het
Hps4 T C 5: 112,375,368 (GRCm38) V584A probably benign Het
Ighv1-50 T C 12: 115,119,947 (GRCm38) Y51C probably benign Het
Kif13b T C 14: 64,806,154 (GRCm38) L1801P probably benign Het
Kif16b T C 2: 142,848,003 (GRCm38) I330V probably damaging Het
Klb A T 5: 65,348,490 (GRCm38) R27W probably damaging Het
Lrif1 A T 3: 106,735,640 (GRCm38) K169M probably damaging Het
Met A G 6: 17,549,059 (GRCm38) D970G probably damaging Het
Mical3 A T 6: 120,969,387 (GRCm38) M1051K possibly damaging Het
Mios A G 6: 8,215,094 (GRCm38) N97D probably benign Het
Msh5 G A 17: 35,038,456 (GRCm38) R321C probably damaging Het
Mybpc1 T C 10: 88,551,430 (GRCm38) Q473R possibly damaging Het
Ncoa1 C T 12: 4,275,004 (GRCm38) G970D probably damaging Het
Neb T C 2: 52,219,394 (GRCm38) Y232C probably damaging Het
Nefh A G 11: 4,941,333 (GRCm38) S429P probably damaging Het
Notch3 C T 17: 32,147,085 (GRCm38) G1014D probably damaging Het
Nup107 A T 10: 117,751,418 (GRCm38) C859S probably benign Het
Olfr1033 A G 2: 86,041,455 (GRCm38) I47V probably benign Het
Olfr136 T G 17: 38,335,627 (GRCm38) F157V probably benign Het
Olfr412 T C 11: 74,364,848 (GRCm38) Y60H probably damaging Het
Otud7b T A 3: 96,136,510 (GRCm38) probably benign Het
Pde1a A T 2: 79,878,139 (GRCm38) S312T probably benign Het
Piwil1 G T 5: 128,740,981 (GRCm38) R94L probably damaging Het
Pnma2 G A 14: 66,917,054 (GRCm38) W309* probably null Het
Ppef2 A C 5: 92,228,740 (GRCm38) probably null Het
Rabac1 T A 7: 24,969,967 (GRCm38) Q212L possibly damaging Het
Rad51 T C 2: 119,120,492 (GRCm38) probably benign Het
Rbm48 A T 5: 3,591,853 (GRCm38) probably benign Het
Rft1 C T 14: 30,677,804 (GRCm38) S315L probably benign Het
Rgs13 C T 1: 144,171,479 (GRCm38) M1I probably null Het
Rhbg A C 3: 88,247,453 (GRCm38) S215A probably benign Het
Rufy2 A T 10: 63,002,211 (GRCm38) N379I probably damaging Het
Slc17a1 T C 13: 23,880,654 (GRCm38) L367P probably damaging Het
Slc25a39 G A 11: 102,403,675 (GRCm38) R308C probably benign Het
Smo A G 6: 29,753,571 (GRCm38) T149A probably benign Het
Sqle A G 15: 59,316,085 (GRCm38) K81E probably benign Het
Tfpi A G 2: 84,452,555 (GRCm38) probably null Het
Tnk2 A G 16: 32,679,630 (GRCm38) D572G probably damaging Het
Ubr5 A T 15: 38,006,564 (GRCm38) M1149K probably benign Het
Utrn T A 10: 12,727,758 (GRCm38) Q626L probably damaging Het
Virma T A 4: 11,544,971 (GRCm38) H1643Q probably damaging Het
Wnt3 G T 11: 103,808,205 (GRCm38) G46C possibly damaging Het
Zkscan7 G T 9: 122,890,800 (GRCm38) G184* probably null Het
Other mutations in Adgrg3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01096:Adgrg3 APN 8 95,039,593 (GRCm38) missense possibly damaging 0.90
IGL01724:Adgrg3 APN 8 95,039,425 (GRCm38) missense probably benign 0.04
IGL02111:Adgrg3 APN 8 95,034,999 (GRCm38) missense probably damaging 0.96
IGL02142:Adgrg3 APN 8 95,039,855 (GRCm38) missense probably damaging 1.00
IGL02577:Adgrg3 APN 8 95,039,927 (GRCm38) missense probably damaging 0.99
IGL02940:Adgrg3 APN 8 95,033,456 (GRCm38) missense possibly damaging 0.48
IGL03395:Adgrg3 APN 8 95,035,073 (GRCm38) missense probably damaging 1.00
R0111:Adgrg3 UTSW 8 95,035,110 (GRCm38) splice site probably benign
R0288:Adgrg3 UTSW 8 95,039,940 (GRCm38) missense possibly damaging 0.92
R0403:Adgrg3 UTSW 8 95,036,922 (GRCm38) missense probably benign 0.07
R1553:Adgrg3 UTSW 8 95,040,268 (GRCm38) missense possibly damaging 0.90
R1667:Adgrg3 UTSW 8 95,033,373 (GRCm38) nonsense probably null
R1686:Adgrg3 UTSW 8 95,033,369 (GRCm38) missense probably benign 0.02
R1872:Adgrg3 UTSW 8 95,033,442 (GRCm38) missense possibly damaging 0.87
R1882:Adgrg3 UTSW 8 95,040,315 (GRCm38) missense probably benign 0.03
R1924:Adgrg3 UTSW 8 95,035,934 (GRCm38) missense probably benign
R1998:Adgrg3 UTSW 8 95,036,668 (GRCm38) missense probably damaging 1.00
R2090:Adgrg3 UTSW 8 95,039,930 (GRCm38) missense possibly damaging 0.54
R2696:Adgrg3 UTSW 8 95,021,074 (GRCm38) missense probably benign 0.01
R3846:Adgrg3 UTSW 8 95,040,421 (GRCm38) missense probably benign 0.07
R4013:Adgrg3 UTSW 8 95,035,099 (GRCm38) splice site probably benign
R4405:Adgrg3 UTSW 8 95,036,908 (GRCm38) missense probably benign 0.15
R4622:Adgrg3 UTSW 8 95,040,525 (GRCm38) missense probably damaging 1.00
R5101:Adgrg3 UTSW 8 95,036,935 (GRCm38) missense probably benign 0.00
R5309:Adgrg3 UTSW 8 95,039,864 (GRCm38) missense probably benign 0.00
R5312:Adgrg3 UTSW 8 95,039,864 (GRCm38) missense probably benign 0.00
R5353:Adgrg3 UTSW 8 95,035,928 (GRCm38) missense probably damaging 0.99
R5820:Adgrg3 UTSW 8 95,039,593 (GRCm38) missense possibly damaging 0.90
R6240:Adgrg3 UTSW 8 95,039,916 (GRCm38) missense probably benign 0.23
R6272:Adgrg3 UTSW 8 95,036,261 (GRCm38) missense noncoding transcript
R7110:Adgrg3 UTSW 8 95,034,963 (GRCm38) missense possibly damaging 0.62
R7645:Adgrg3 UTSW 8 95,034,764 (GRCm38) intron probably benign
R8178:Adgrg3 UTSW 8 95,035,047 (GRCm38) missense probably damaging 0.98
R8397:Adgrg3 UTSW 8 95,040,513 (GRCm38) missense probably benign 0.01
R8730:Adgrg3 UTSW 8 95,039,928 (GRCm38) missense probably benign 0.09
R8951:Adgrg3 UTSW 8 95,034,734 (GRCm38) intron probably benign
R9100:Adgrg3 UTSW 8 95,036,263 (GRCm38) intron probably benign
R9523:Adgrg3 UTSW 8 95,039,558 (GRCm38) missense probably benign 0.06
R9583:Adgrg3 UTSW 8 95,033,443 (GRCm38) missense probably benign 0.00
R9589:Adgrg3 UTSW 8 95,033,465 (GRCm38) missense possibly damaging 0.87
X0017:Adgrg3 UTSW 8 95,017,770 (GRCm38) start codon destroyed probably null 0.53
Predicted Primers PCR Primer
(F):5'- ACTGGAGTGGTAGTGGCATC -3'
(R):5'- TGTGCACACCTGGACATCATAC -3'

Sequencing Primer
(F):5'- CTTGGGGCTGGCATCCTAAG -3'
(R):5'- TCATACACAGTCAGCAGGTG -3'
Posted On 2016-03-17