Incidental Mutation 'R4880:Tex14'
ID 375235
Institutional Source Beutler Lab
Gene Symbol Tex14
Ensembl Gene ENSMUSG00000010342
Gene Name testis expressed gene 14
Synonyms
MMRRC Submission 042489-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.159) question?
Stock # R4880 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 87295891-87446649 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 87377121 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 155 (I155N)
Ref Sequence ENSEMBL: ENSMUSP00000054444 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060835] [ENSMUST00000156483]
AlphaFold Q7M6U3
Predicted Effect possibly damaging
Transcript: ENSMUST00000060835
AA Change: I155N

PolyPhen 2 Score 0.946 (Sensitivity: 0.80; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000054444
Gene: ENSMUSG00000010342
AA Change: I155N

DomainStartEndE-ValueType
ANK 22 51 7.99e2 SMART
ANK 55 84 6.36e-3 SMART
ANK 88 117 3.49e0 SMART
Pfam:Pkinase 251 504 3.5e-19 PFAM
Pfam:Pkinase_Tyr 254 503 8.1e-28 PFAM
coiled coil region 659 684 N/A INTRINSIC
coiled coil region 740 776 N/A INTRINSIC
low complexity region 1219 1236 N/A INTRINSIC
coiled coil region 1289 1309 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000156483
SMART Domains Protein: ENSMUSP00000118114
Gene: ENSMUSG00000010342

DomainStartEndE-ValueType
ANK 34 63 7.99e2 SMART
ANK 67 96 6.36e-3 SMART
Meta Mutation Damage Score 0.1333 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.7%
  • 20x: 93.5%
Validation Efficiency 98% (89/91)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is necessary for intercellular bridges in germ cells, which are required for spermatogenesis. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2011]
PHENOTYPE: Males homozygous for a targeted allele are infertile due to spermatogenic failure. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 76 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610021A01Rik T C 7: 41,276,529 (GRCm39) I744T possibly damaging Het
Adgrb1 T A 15: 74,458,871 (GRCm39) F1324L possibly damaging Het
Adm A G 7: 110,228,326 (GRCm39) H230R probably benign Het
Ank2 A T 3: 126,840,475 (GRCm39) probably null Het
Arih1 A T 9: 59,344,168 (GRCm39) F156L possibly damaging Het
Atf6b A G 17: 34,873,529 (GRCm39) H660R probably damaging Het
Bcl9l C A 9: 44,420,007 (GRCm39) Q1101K probably benign Het
Ccdc174 G A 6: 91,876,572 (GRCm39) probably benign Het
Ccdc65 A C 15: 98,620,538 (GRCm39) probably null Het
Cela2a T C 4: 141,549,598 (GRCm39) N59S probably benign Het
Cfap157 A T 2: 32,668,261 (GRCm39) V393E probably damaging Het
Chd1 T C 17: 17,594,916 (GRCm39) F17S probably damaging Het
Cpne3 T C 4: 19,540,827 (GRCm39) I183V probably benign Het
Cyp2d11 C A 15: 82,276,306 (GRCm39) V122L probably benign Het
Dcaf8 C A 1: 172,015,056 (GRCm39) probably benign Het
Dchs1 T A 7: 105,404,937 (GRCm39) D2535V probably benign Het
Eif4a2 G T 16: 22,927,650 (GRCm39) probably benign Het
Fzd4 T A 7: 89,057,109 (GRCm39) D385E probably benign Het
Galnt13 C A 2: 54,950,584 (GRCm39) Q422K probably damaging Het
Gnptab C T 10: 88,268,413 (GRCm39) Q507* probably null Het
Hoxa7 A G 6: 52,194,014 (GRCm39) probably benign Het
Htra1 T A 7: 130,563,813 (GRCm39) V228D probably damaging Het
Idi2l A T 13: 8,990,702 (GRCm39) probably null Het
Ifi203 T A 1: 173,756,716 (GRCm39) probably benign Het
Iqca1l T C 5: 24,754,750 (GRCm39) D340G probably benign Het
Irs1 TGGGGTGGACATCGAACTGAAGGAG TG 1: 82,265,453 (GRCm39) 913 probably null Het
Itga2b G T 11: 102,348,548 (GRCm39) probably benign Het
Itgb1 G T 8: 129,442,631 (GRCm39) R272L probably damaging Het
Kif9 A G 9: 110,330,703 (GRCm39) E343G probably damaging Het
Klhl5 T C 5: 65,316,244 (GRCm39) V97A probably damaging Het
Lama5 C A 2: 179,818,861 (GRCm39) probably benign Het
Lamb2 A G 9: 108,361,226 (GRCm39) probably null Het
Lrp1b T A 2: 41,660,931 (GRCm39) Y59F probably benign Het
Mmrn1 A G 6: 60,953,423 (GRCm39) E568G probably benign Het
Mreg A G 1: 72,201,495 (GRCm39) Y166H probably damaging Het
Myh7 C A 14: 55,216,045 (GRCm39) V1323F probably benign Het
Nr1i3 T A 1: 171,043,951 (GRCm39) I91K probably damaging Het
Nsfl1c T A 2: 151,348,230 (GRCm39) D206E probably damaging Het
Or11g24 T C 14: 50,662,758 (GRCm39) Y261H possibly damaging Het
Or13c3 A T 4: 52,856,411 (GRCm39) M34K probably damaging Het
Or2ak5 G A 11: 58,611,107 (GRCm39) L256F probably benign Het
Or4k44 A T 2: 111,367,698 (GRCm39) L312* probably null Het
Or5k17 A C 16: 58,746,463 (GRCm39) L157W probably damaging Het
Or8b54 T A 9: 38,686,843 (GRCm39) C97* probably null Het
Pcdhb7 C T 18: 37,475,284 (GRCm39) T140I probably benign Het
Pcdhgb5 T G 18: 37,865,641 (GRCm39) S479A probably benign Het
Pcsk5 T A 19: 17,425,054 (GRCm39) Y1583F probably damaging Het
Pias1 T C 9: 62,820,080 (GRCm39) R296G probably benign Het
Plscr1l1 A G 9: 92,236,665 (GRCm39) E108G probably damaging Het
Polr1e T A 4: 45,022,280 (GRCm39) C100S probably damaging Het
Rpap1 C A 2: 119,614,346 (GRCm39) R17L probably damaging Het
Rtn1 C T 12: 72,264,232 (GRCm39) V192I possibly damaging Het
Ryr2 G A 13: 11,767,104 (GRCm39) P1262L probably damaging Het
Slc4a7 G T 14: 14,757,342 (GRCm38) D396Y probably damaging Het
Slc5a8 T C 10: 88,727,886 (GRCm39) Y118H probably damaging Het
Slc7a6os T A 8: 106,937,247 (GRCm39) Q71L probably benign Het
Sphkap A G 1: 83,266,538 (GRCm39) V127A probably damaging Het
Srpk1 A G 17: 28,810,199 (GRCm39) S580P probably damaging Het
Syne2 A G 12: 76,026,593 (GRCm39) I3474V probably damaging Het
Tchh A G 3: 93,351,130 (GRCm39) D190G possibly damaging Het
Tenm4 T A 7: 96,555,025 (GRCm39) probably null Het
Tm7sf3 A T 6: 146,511,358 (GRCm39) V377E possibly damaging Het
Tnfsf9 T A 17: 57,412,433 (GRCm39) M1K probably null Het
Tns2 C T 15: 102,020,474 (GRCm39) T780I probably damaging Het
Trdn T A 10: 33,347,575 (GRCm39) D639E probably benign Het
Trmt10a A G 3: 137,857,972 (GRCm39) E173G possibly damaging Het
Ttn G A 2: 76,649,119 (GRCm39) P10984S possibly damaging Het
Tubb6 C T 18: 67,534,386 (GRCm39) T95M possibly damaging Het
Uroc1 G T 6: 90,334,519 (GRCm39) R577L probably damaging Het
Vmn2r86 T A 10: 130,289,484 (GRCm39) D137V probably benign Het
Xkr7 T C 2: 152,896,873 (GRCm39) Y576H probably damaging Het
Zfp410 A G 12: 84,384,449 (GRCm39) N355D probably damaging Het
Zfp59 C A 7: 27,543,742 (GRCm39) D22E probably damaging Het
Zfp64 C T 2: 168,736,297 (GRCm39) R460H probably damaging Het
Zfp655 T C 5: 145,181,168 (GRCm39) V342A probably damaging Het
Zfp990 G A 4: 145,264,490 (GRCm39) G496E probably benign Het
Other mutations in Tex14
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00272:Tex14 APN 11 87,426,469 (GRCm39) missense probably damaging 0.98
IGL00494:Tex14 APN 11 87,446,310 (GRCm39) missense probably damaging 1.00
IGL01604:Tex14 APN 11 87,400,524 (GRCm39) missense possibly damaging 0.63
IGL02690:Tex14 APN 11 87,377,100 (GRCm39) missense probably benign 0.11
IGL02888:Tex14 APN 11 87,418,738 (GRCm39) critical splice donor site probably null
IGL03073:Tex14 APN 11 87,426,435 (GRCm39) missense probably damaging 0.99
IGL03109:Tex14 APN 11 87,434,191 (GRCm39) missense probably damaging 1.00
IGL03047:Tex14 UTSW 11 87,427,530 (GRCm39) missense probably damaging 1.00
R0141:Tex14 UTSW 11 87,383,857 (GRCm39) splice site probably null
R0455:Tex14 UTSW 11 87,405,131 (GRCm39) missense possibly damaging 0.93
R0624:Tex14 UTSW 11 87,411,525 (GRCm39) missense probably benign 0.19
R0718:Tex14 UTSW 11 87,390,439 (GRCm39) missense probably benign 0.20
R1077:Tex14 UTSW 11 87,410,571 (GRCm39) splice site probably benign
R1118:Tex14 UTSW 11 87,413,343 (GRCm39) missense probably benign 0.07
R1120:Tex14 UTSW 11 87,429,502 (GRCm39) splice site probably benign
R1168:Tex14 UTSW 11 87,427,568 (GRCm39) missense probably benign 0.11
R1190:Tex14 UTSW 11 87,385,934 (GRCm39) splice site probably null
R1470:Tex14 UTSW 11 87,440,355 (GRCm39) splice site probably benign
R1563:Tex14 UTSW 11 87,427,634 (GRCm39) missense probably damaging 0.99
R1607:Tex14 UTSW 11 87,445,754 (GRCm39) missense probably damaging 1.00
R1696:Tex14 UTSW 11 87,402,371 (GRCm39) missense possibly damaging 0.49
R1873:Tex14 UTSW 11 87,390,431 (GRCm39) missense probably damaging 1.00
R1894:Tex14 UTSW 11 87,365,274 (GRCm39) missense probably damaging 1.00
R1911:Tex14 UTSW 11 87,385,861 (GRCm39) missense probably damaging 1.00
R1955:Tex14 UTSW 11 87,400,447 (GRCm39) missense probably damaging 1.00
R1971:Tex14 UTSW 11 87,402,431 (GRCm39) missense probably damaging 1.00
R1990:Tex14 UTSW 11 87,440,296 (GRCm39) missense probably damaging 1.00
R1991:Tex14 UTSW 11 87,440,296 (GRCm39) missense probably damaging 1.00
R1993:Tex14 UTSW 11 87,427,581 (GRCm39) missense possibly damaging 0.57
R2106:Tex14 UTSW 11 87,377,076 (GRCm39) missense possibly damaging 0.47
R2118:Tex14 UTSW 11 87,410,569 (GRCm39) splice site probably benign
R2860:Tex14 UTSW 11 87,365,243 (GRCm39) missense probably damaging 1.00
R2861:Tex14 UTSW 11 87,365,243 (GRCm39) missense probably damaging 1.00
R4016:Tex14 UTSW 11 87,429,449 (GRCm39) splice site probably null
R4089:Tex14 UTSW 11 87,403,029 (GRCm39) missense probably damaging 1.00
R4158:Tex14 UTSW 11 87,407,595 (GRCm39) missense probably benign 0.06
R4533:Tex14 UTSW 11 87,427,655 (GRCm39) nonsense probably null
R4713:Tex14 UTSW 11 87,427,691 (GRCm39) missense probably damaging 0.99
R4758:Tex14 UTSW 11 87,405,311 (GRCm39) missense probably benign 0.00
R4953:Tex14 UTSW 11 87,427,727 (GRCm39) critical splice donor site probably null
R5092:Tex14 UTSW 11 87,405,668 (GRCm39) missense probably benign 0.03
R5119:Tex14 UTSW 11 87,324,639 (GRCm39) missense probably damaging 1.00
R5322:Tex14 UTSW 11 87,402,298 (GRCm39) missense probably benign 0.04
R5470:Tex14 UTSW 11 87,442,430 (GRCm39) missense probably damaging 0.99
R5607:Tex14 UTSW 11 87,413,404 (GRCm39) missense probably benign 0.00
R5642:Tex14 UTSW 11 87,405,046 (GRCm39) missense probably benign
R5643:Tex14 UTSW 11 87,426,452 (GRCm39) missense probably damaging 1.00
R5786:Tex14 UTSW 11 87,405,121 (GRCm39) missense probably damaging 0.97
R6478:Tex14 UTSW 11 87,405,199 (GRCm39) missense probably benign
R6560:Tex14 UTSW 11 87,388,688 (GRCm39) missense possibly damaging 0.95
R6661:Tex14 UTSW 11 87,385,842 (GRCm39) missense probably damaging 1.00
R7037:Tex14 UTSW 11 87,388,741 (GRCm39) missense probably damaging 1.00
R7156:Tex14 UTSW 11 87,375,545 (GRCm39) missense probably damaging 0.99
R7465:Tex14 UTSW 11 87,405,256 (GRCm39) missense possibly damaging 0.48
R7675:Tex14 UTSW 11 87,400,504 (GRCm39) missense probably damaging 1.00
R7725:Tex14 UTSW 11 87,385,868 (GRCm39) missense probably damaging 0.99
R7911:Tex14 UTSW 11 87,424,428 (GRCm39) critical splice donor site probably null
R8015:Tex14 UTSW 11 87,400,426 (GRCm39) missense probably benign 0.13
R8226:Tex14 UTSW 11 87,375,585 (GRCm39) missense probably damaging 0.96
R8283:Tex14 UTSW 11 87,365,241 (GRCm39) missense probably damaging 1.00
R8292:Tex14 UTSW 11 87,388,664 (GRCm39) missense probably damaging 1.00
R8833:Tex14 UTSW 11 87,383,878 (GRCm39) missense probably benign 0.22
R8932:Tex14 UTSW 11 87,324,675 (GRCm39) missense possibly damaging 0.65
R9023:Tex14 UTSW 11 87,365,239 (GRCm39) missense
R9144:Tex14 UTSW 11 87,413,423 (GRCm39) critical splice donor site probably null
R9610:Tex14 UTSW 11 87,377,084 (GRCm39) missense probably damaging 1.00
R9611:Tex14 UTSW 11 87,377,084 (GRCm39) missense probably damaging 1.00
RF018:Tex14 UTSW 11 87,405,572 (GRCm39) missense probably benign 0.01
X0017:Tex14 UTSW 11 87,426,375 (GRCm39) nonsense probably null
Z1176:Tex14 UTSW 11 87,390,419 (GRCm39) missense possibly damaging 0.95
Z1176:Tex14 UTSW 11 87,375,633 (GRCm39) missense probably benign 0.08
Z1177:Tex14 UTSW 11 87,404,981 (GRCm39) missense probably damaging 0.96
Predicted Primers PCR Primer
(F):5'- CTGGAACAATCTGTGGTTGTTC -3'
(R):5'- AGCCTCAACCTTTCAACCTG -3'

Sequencing Primer
(F):5'- AGTGGCCCGCTTTTGAC -3'
(R):5'- CAACCTGTTATGCTGCTAAAGAG -3'
Posted On 2016-03-17