Incidental Mutation 'R0282:Or2k2'
ID 37602
Institutional Source Beutler Lab
Gene Symbol Or2k2
Ensembl Gene ENSMUSG00000043385
Gene Name olfactory receptor family 2 subfamily K member 2
Synonyms MOR262-1, GA_x6K02T2N78B-1272842-1273783, Olfr267
MMRRC Submission 038504-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.123) question?
Stock # R0282 (G1)
Quality Score 206
Status Validated
Chromosome 4
Chromosomal Location 58784779-58785720 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 58785344 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 126 (I126T)
Ref Sequence ENSEMBL: ENSMUSP00000150848 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059608] [ENSMUST00000216719]
AlphaFold A2AM35
Predicted Effect probably damaging
Transcript: ENSMUST00000059608
AA Change: I126T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000062002
Gene: ENSMUSG00000043385
AA Change: I126T

DomainStartEndE-ValueType
Pfam:7tm_4 30 307 4e-51 PFAM
Pfam:7tm_1 41 289 5.2e-24 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000216719
AA Change: I126T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Meta Mutation Damage Score 0.3715 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.4%
  • 10x: 96.6%
  • 20x: 93.7%
Validation Efficiency 100% (72/72)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 69 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsbg3 T A 17: 57,192,169 (GRCm39) Y577* probably null Het
Afap1l2 A G 19: 56,904,653 (GRCm39) S549P possibly damaging Het
Alcam A T 16: 52,116,104 (GRCm39) C157S probably damaging Het
Aldh1a1 T C 19: 20,606,413 (GRCm39) probably benign Het
Ano8 G A 8: 71,933,258 (GRCm39) probably benign Het
Atr T C 9: 95,744,851 (GRCm39) V56A probably benign Het
Aurkc T A 7: 7,005,427 (GRCm39) probably null Het
Bnip3 T C 7: 138,499,759 (GRCm39) D76G probably damaging Het
Cbr1 A G 16: 93,407,022 (GRCm39) E246G possibly damaging Het
Ccdc157 G T 11: 4,096,708 (GRCm39) A449D probably damaging Het
Ces3b T A 8: 105,810,483 (GRCm39) V26D probably benign Het
Colgalt2 G T 1: 152,384,312 (GRCm39) A551S possibly damaging Het
Crk G T 11: 75,594,195 (GRCm39) G261C probably damaging Het
Ctbp1 A G 5: 33,408,200 (GRCm39) probably null Het
Ctnna1 G A 18: 35,377,175 (GRCm39) V572I possibly damaging Het
D430041D05Rik T C 2: 104,031,589 (GRCm39) Y1669C probably damaging Het
Dnah8 T C 17: 30,955,130 (GRCm39) F2053S probably damaging Het
Dner G A 1: 84,383,686 (GRCm39) T566M probably damaging Het
Dner A G 1: 84,423,101 (GRCm39) probably benign Het
Edrf1 T C 7: 133,245,751 (GRCm39) V223A probably benign Het
Fam169a A G 13: 97,234,223 (GRCm39) probably benign Het
Fbxl3 G A 14: 103,332,661 (GRCm39) H106Y probably damaging Het
Fiz1 A G 7: 5,012,200 (GRCm39) V106A probably benign Het
Gapvd1 T A 2: 34,578,972 (GRCm39) R654* probably null Het
Gm7589 G A 9: 59,053,288 (GRCm39) noncoding transcript Het
Ifi202b A T 1: 173,804,926 (GRCm39) S9T probably benign Het
Ipmk G C 10: 71,208,661 (GRCm39) S149T probably benign Het
Irgm2 A G 11: 58,110,345 (GRCm39) E24G probably benign Het
Itga2b A C 11: 102,351,672 (GRCm39) V551G probably damaging Het
Itgad C T 7: 127,789,150 (GRCm39) probably benign Het
Kcnh8 T A 17: 53,032,879 (GRCm39) F55L probably damaging Het
Kdr G A 5: 76,110,760 (GRCm39) probably benign Het
Krt35 T C 11: 99,986,573 (GRCm39) Y147C probably damaging Het
Lamc1 A G 1: 153,131,058 (GRCm39) F298L probably benign Het
Lrrk2 T C 15: 91,662,617 (GRCm39) probably benign Het
Matn1 T C 4: 130,673,238 (GRCm39) S69P probably damaging Het
Micall1 G T 15: 79,016,101 (GRCm39) probably benign Het
Msto1 A G 3: 88,818,884 (GRCm39) V257A possibly damaging Het
Mybpc3 G C 2: 90,954,369 (GRCm39) probably benign Het
Mycn A G 12: 12,987,314 (GRCm39) V361A probably benign Het
Myo10 A G 15: 25,793,253 (GRCm39) T1277A probably damaging Het
Myo3a T C 2: 22,250,409 (GRCm39) I92T probably benign Het
Nup50l T C 6: 96,141,797 (GRCm39) T416A probably benign Het
Or10g1 A G 14: 52,647,720 (GRCm39) V203A possibly damaging Het
Or4c104 G A 2: 88,586,800 (GRCm39) T73I probably damaging Het
Or56b1b T A 7: 108,164,684 (GRCm39) Q106L probably damaging Het
Otog C T 7: 45,926,917 (GRCm39) T1222I possibly damaging Het
P4ha1 C T 10: 59,172,970 (GRCm39) T23M probably damaging Het
Pld1 A T 3: 28,132,422 (GRCm39) I537F probably benign Het
Plekhn1 A G 4: 156,312,780 (GRCm39) probably benign Het
Pxdn C A 12: 30,034,439 (GRCm39) S8* probably null Het
Rnf135 A T 11: 80,084,784 (GRCm39) I186F probably damaging Het
Rock2 T C 12: 17,027,887 (GRCm39) probably benign Het
Rph3a C A 5: 121,101,973 (GRCm39) G88* probably null Het
Sarm1 G A 11: 78,365,806 (GRCm39) Q740* probably null Het
Setd1b C A 5: 123,299,080 (GRCm39) probably benign Het
Sidt1 A G 16: 44,102,249 (GRCm39) S304P possibly damaging Het
Slc2a4 A T 11: 69,837,181 (GRCm39) V85E probably damaging Het
Swi5 A G 2: 32,170,766 (GRCm39) Y54H probably damaging Het
Sycp1 A G 3: 102,823,111 (GRCm39) probably benign Het
Tarm1 T C 7: 3,546,006 (GRCm39) Y87C probably damaging Het
Tmem67 G A 4: 12,087,930 (GRCm39) T72M probably damaging Het
Tor1a A G 2: 30,857,737 (GRCm39) Y44H possibly damaging Het
Ttll5 T C 12: 86,042,827 (GRCm39) Y1128H probably benign Het
Usp40 G A 1: 87,908,680 (GRCm39) probably benign Het
Vmn2r18 A T 5: 151,508,668 (GRCm39) M152K probably benign Het
Xirp2 T A 2: 67,343,724 (GRCm39) D1988E probably damaging Het
Zfp420 A G 7: 29,575,105 (GRCm39) I442V probably benign Het
Zyx A G 6: 42,332,939 (GRCm39) E363G probably damaging Het
Other mutations in Or2k2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01687:Or2k2 APN 4 58,785,047 (GRCm39) missense probably damaging 1.00
R0281:Or2k2 UTSW 4 58,784,981 (GRCm39) missense probably damaging 1.00
R1017:Or2k2 UTSW 4 58,785,115 (GRCm39) missense probably damaging 0.98
R1843:Or2k2 UTSW 4 58,785,384 (GRCm39) missense probably benign
R3976:Or2k2 UTSW 4 58,785,164 (GRCm39) missense probably damaging 1.00
R4368:Or2k2 UTSW 4 58,785,153 (GRCm39) missense probably benign 0.00
R5545:Or2k2 UTSW 4 58,785,585 (GRCm39) missense probably benign 0.08
R5659:Or2k2 UTSW 4 58,785,672 (GRCm39) missense probably damaging 1.00
R5668:Or2k2 UTSW 4 58,785,489 (GRCm39) missense probably benign 0.00
R6186:Or2k2 UTSW 4 58,784,948 (GRCm39) missense probably damaging 1.00
R6925:Or2k2 UTSW 4 58,785,647 (GRCm39) missense possibly damaging 0.69
R7502:Or2k2 UTSW 4 58,785,648 (GRCm39) missense probably benign 0.00
R8185:Or2k2 UTSW 4 58,785,542 (GRCm39) missense probably damaging 1.00
R8519:Or2k2 UTSW 4 58,785,203 (GRCm39) missense probably damaging 0.99
R9055:Or2k2 UTSW 4 58,785,374 (GRCm39) missense possibly damaging 0.91
R9152:Or2k2 UTSW 4 58,785,114 (GRCm39) missense probably benign
R9159:Or2k2 UTSW 4 58,785,320 (GRCm39) missense probably benign 0.08
R9623:Or2k2 UTSW 4 58,785,585 (GRCm39) missense possibly damaging 0.84
Predicted Primers PCR Primer
(F):5'- TAACCAGGTCCATGAGCAGGGAAC -3'
(R):5'- AGGAGAAAATGTCACTGTTTGGAGCC -3'

Sequencing Primer
(F):5'- GCTAGTTTTAGCACGGCAAG -3'
(R):5'- ACCCGAGGTTAGAGATTGTTC -3'
Posted On 2013-05-23