Incidental Mutation 'R4900:Or8b9'
ID 376098
Institutional Source Beutler Lab
Gene Symbol Or8b9
Ensembl Gene ENSMUSG00000066749
Gene Name olfactory receptor family 8 subfamily B member 9
Synonyms Olfr877, MOR161-5, GA_x6K02T2PVTD-31540342-31541277
MMRRC Submission 042504-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.076) question?
Stock # R4900 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 37766116-37767051 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 37766608 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 165 (F165L)
Ref Sequence ENSEMBL: ENSMUSP00000150698 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086063] [ENSMUST00000213956]
AlphaFold Q8VF62
Predicted Effect probably benign
Transcript: ENSMUST00000086063
AA Change: F165L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000083230
Gene: ENSMUSG00000066749
AA Change: F165L

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.4e-49 PFAM
Pfam:7tm_1 41 291 6.5e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213956
AA Change: F165L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.5%
  • 20x: 93.1%
Validation Efficiency 100% (84/84)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 77 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930590J08Rik T C 6: 91,895,091 (GRCm39) V262A probably benign Het
Abtb2 A G 2: 103,397,349 (GRCm39) E93G possibly damaging Het
Adam5 A C 8: 25,232,172 (GRCm39) probably null Het
Adam5 G A 8: 25,271,619 (GRCm39) T596I probably damaging Het
Adgrb2 T A 4: 129,907,668 (GRCm39) Y1001N probably damaging Het
Aox1 T G 1: 58,344,544 (GRCm39) S546A probably benign Het
Asic2 T C 11: 81,464,280 (GRCm39) probably benign Het
Bcl11b T A 12: 107,955,957 (GRCm39) N64I probably damaging Het
Cacna1g A G 11: 94,350,177 (GRCm39) F556S possibly damaging Het
Cbl A G 9: 44,064,166 (GRCm39) V790A probably benign Het
Cd300c2 A T 11: 114,891,807 (GRCm39) C22* probably null Het
Cdh11 C T 8: 103,374,090 (GRCm39) probably null Het
Ces2g C T 8: 105,693,989 (GRCm39) Q442* probably null Het
Cps1 A T 1: 67,200,063 (GRCm39) T404S probably damaging Het
Csf2rb2 A T 15: 78,170,174 (GRCm39) probably null Het
Csmd2 A G 4: 128,346,318 (GRCm39) Y1526C probably benign Het
Cyp2a12 C T 7: 26,730,640 (GRCm39) Q202* probably null Het
Cyp2c39 G A 19: 39,502,020 (GRCm39) M136I probably benign Het
Cyp2j13 G A 4: 95,947,280 (GRCm39) T257I probably damaging Het
Dnah8 T A 17: 30,965,949 (GRCm39) L2427Q probably damaging Het
Dop1b G T 16: 93,560,318 (GRCm39) probably null Het
Entrep1 A G 19: 23,952,790 (GRCm39) S507P possibly damaging Het
Epcam T C 17: 87,951,049 (GRCm39) V212A possibly damaging Het
Flt1 C A 5: 147,620,749 (GRCm39) A132S probably benign Het
Flvcr2 T A 12: 85,829,756 (GRCm39) V255D probably damaging Het
Galc G T 12: 98,197,731 (GRCm39) T326K probably damaging Het
Gas2l3 CACTCGTCATACT CACT 10: 89,266,820 (GRCm39) probably benign Het
Gen1 A T 12: 11,291,561 (GRCm39) Y808N probably benign Het
Glis1 C T 4: 107,476,761 (GRCm39) A306V probably damaging Het
Gm10638 A G 8: 87,473,028 (GRCm39) probably benign Het
Gm12789 G A 4: 101,846,182 (GRCm39) probably benign Het
Gm27048 C T 8: 81,661,228 (GRCm39) noncoding transcript Het
Gm4204 T C 1: 135,160,556 (GRCm39) noncoding transcript Het
Gm904 A T 13: 50,799,325 (GRCm39) I95F possibly damaging Het
Gvin3 T G 7: 106,197,793 (GRCm39) noncoding transcript Het
Hjurp GT GTT 1: 88,194,246 (GRCm39) probably null Het
Ints11 G A 4: 155,972,887 (GRCm39) D526N probably benign Het
Itfg2 A G 6: 128,393,279 (GRCm39) probably benign Het
Jund T C 8: 71,152,254 (GRCm39) V183A probably damaging Het
Kcnj8 A G 6: 142,512,221 (GRCm39) S129P probably damaging Het
Kcnq3 A G 15: 65,867,259 (GRCm39) S795P probably damaging Het
Lhx8 G T 3: 154,035,925 (GRCm39) A22E probably benign Het
Lrp8 A G 4: 107,664,006 (GRCm39) probably benign Het
Lvrn G T 18: 47,026,768 (GRCm39) A789S probably damaging Het
Lvrn T C 18: 47,014,479 (GRCm39) S526P probably damaging Het
Mga T A 2: 119,794,535 (GRCm39) C2622S possibly damaging Het
Mroh8 T C 2: 157,070,647 (GRCm39) E568G probably benign Het
Ms4a4b C A 19: 11,440,503 (GRCm39) probably benign Het
Muc2 T C 7: 141,303,280 (GRCm39) F99S probably benign Het
Myo5c T A 9: 75,180,825 (GRCm39) I738N probably damaging Het
Naip6 A C 13: 100,433,477 (GRCm39) V1120G probably damaging Het
Ncl T C 1: 86,283,901 (GRCm39) T307A probably benign Het
Npr1 A T 3: 90,363,272 (GRCm39) D869E possibly damaging Het
Nup93 A G 8: 95,013,231 (GRCm39) T36A probably benign Het
Olfml2b C A 1: 170,489,947 (GRCm39) T189N probably damaging Het
Or4c12b A G 2: 89,647,312 (GRCm39) N208S possibly damaging Het
P4htm A C 9: 108,456,427 (GRCm39) W458G probably damaging Het
Pdzrn4 G T 15: 92,668,638 (GRCm39) R930L probably damaging Het
Pgam5 G A 5: 110,408,301 (GRCm39) A240V probably damaging Het
Prex2 T C 1: 11,220,129 (GRCm39) probably benign Het
Ptpru T G 4: 131,515,693 (GRCm39) E897A probably damaging Het
Rapgef2 A T 3: 78,981,670 (GRCm39) N1256K probably benign Het
Rhbdl3 A G 11: 80,210,439 (GRCm39) E64G probably benign Het
Sel1l3 A T 5: 53,289,184 (GRCm39) L879Q probably damaging Het
Siah1a G T 8: 87,451,703 (GRCm39) D260E probably benign Het
Skint6 T C 4: 112,924,667 (GRCm39) I522V probably benign Het
Slco4c1 G A 1: 96,768,953 (GRCm39) P303L probably damaging Het
Smok3c T C 5: 138,062,813 (GRCm39) I100T probably damaging Het
Snx24 C A 18: 53,518,295 (GRCm39) Y141* probably null Het
Tigit A G 16: 43,469,594 (GRCm39) S166P probably damaging Het
Tmem183a C T 1: 134,275,904 (GRCm39) R324Q probably benign Het
Tmie T C 9: 110,696,001 (GRCm39) D130G possibly damaging Het
Uggt1 G A 1: 36,241,936 (GRCm39) R333* probably null Het
Vmn2r111 T C 17: 22,767,637 (GRCm39) N620S possibly damaging Het
Vmn2r12 T A 5: 109,240,852 (GRCm39) N87I probably damaging Het
Vmn2r92 A G 17: 18,404,605 (GRCm39) D583G probably benign Het
Zdhhc17 T C 10: 110,821,819 (GRCm39) D60G possibly damaging Het
Other mutations in Or8b9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01862:Or8b9 APN 9 37,766,477 (GRCm39) missense probably damaging 1.00
IGL02108:Or8b9 APN 9 37,766,234 (GRCm39) missense possibly damaging 0.88
IGL02474:Or8b9 APN 9 37,766,656 (GRCm39) missense probably benign 0.08
R0006:Or8b9 UTSW 9 37,766,516 (GRCm39) missense possibly damaging 0.95
R0893:Or8b9 UTSW 9 37,766,492 (GRCm39) missense probably damaging 1.00
R1051:Or8b9 UTSW 9 37,766,657 (GRCm39) missense probably damaging 0.99
R1432:Or8b9 UTSW 9 37,766,548 (GRCm39) missense possibly damaging 0.79
R1718:Or8b9 UTSW 9 37,766,749 (GRCm39) missense probably benign 0.03
R1864:Or8b9 UTSW 9 37,766,560 (GRCm39) missense probably damaging 1.00
R4120:Or8b9 UTSW 9 37,766,705 (GRCm39) missense possibly damaging 0.66
R4507:Or8b9 UTSW 9 37,766,201 (GRCm39) missense possibly damaging 0.90
R5406:Or8b9 UTSW 9 37,766,515 (GRCm39) missense probably benign 0.02
R6813:Or8b9 UTSW 9 37,766,810 (GRCm39) missense possibly damaging 0.83
R7061:Or8b9 UTSW 9 37,766,942 (GRCm39) missense possibly damaging 0.88
R7315:Or8b9 UTSW 9 37,766,543 (GRCm39) missense probably benign
R7500:Or8b9 UTSW 9 37,766,314 (GRCm39) missense probably damaging 1.00
R8021:Or8b9 UTSW 9 37,766,592 (GRCm39) missense probably damaging 1.00
R8188:Or8b9 UTSW 9 37,766,407 (GRCm39) missense probably benign 0.01
R9093:Or8b9 UTSW 9 37,766,294 (GRCm39) missense probably damaging 1.00
R9331:Or8b9 UTSW 9 37,766,710 (GRCm39) missense probably benign 0.03
R9373:Or8b9 UTSW 9 37,766,750 (GRCm39) missense probably damaging 0.97
R9696:Or8b9 UTSW 9 37,766,671 (GRCm39) missense probably benign 0.35
Z1088:Or8b9 UTSW 9 37,766,614 (GRCm39) missense probably benign 0.31
Z1177:Or8b9 UTSW 9 37,766,794 (GRCm39) missense possibly damaging 0.72
Predicted Primers PCR Primer
(F):5'- CTCCTATGCAGGGTGTATGAC -3'
(R):5'- TAAAGGCTTTCGACCTGCC -3'

Sequencing Primer
(F):5'- GTATGACACAGTTTTTCTTCTTCTGC -3'
(R):5'- GACCTGCCTTCTTTAGAACTAATGTG -3'
Posted On 2016-03-17