Mutagenetix > Incidental Mutation

Incidental Mutation 'R4872:Dync1h1'

376681

Institutional Source

Beutler Lab

Gene Symbol

Dync1h1

Ensembl Gene

ENSMUSG00000018707

Gene Name

dynein cytoplasmic 1 heavy chain 1

Synonyms

9930018I23Rik, Dnchc1, dynein heavy chain, retrograde transport, Swl, MAP1C, Loa, Dnec1

MMRRC Submission

042482-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R4872 (G1)

Quality Score

213

Status

Validated

Chromosome

Chromosomal Location

110601452-110666945 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 110658126 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Asparagine at position 3700 (T3700N)

Ref Sequence

ENSEMBL: ENSMUSP00000018851 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000018851]

AlphaFold

no structure available at present

PDB Structure

Microtubule binding domain from mouse cytoplasmic dynein as a fusion with seryl-tRNA synthetase [X-RAY DIFFRACTION]
High affinity dynein microtubule binding domain - tubulin complex [ELECTRON MICROSCOPY]
Low affinity dynein microtubule binding domain - tubulin complex [ELECTRON MICROSCOPY]
Structure of the entire stalk region of the dynein motor domain [X-RAY DIFFRACTION]

Predicted Effect

probably damaging
Transcript: ENSMUST00000018851
AA Change: T3700N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000018851
Gene: ENSMUSG00000018707
AA Change: T3700N

Domain	Start	End	E-Value	Type
low complexity region	46	61	N/A	INTRINSIC
low complexity region	83	95	N/A	INTRINSIC
Pfam:DHC_N1	237	830	1.9e-145	PFAM
coiled coil region	1171	1198	N/A	INTRINSIC
Pfam:DHC_N2	1317	1721	3.3e-116	PFAM
AAA	1899	2043	5.39e-2	SMART
low complexity region	2102	2116	N/A	INTRINSIC
AAA	2214	2365	2.13e0	SMART
low complexity region	2394	2405	N/A	INTRINSIC
AAA	2585	2735	8.6e-7	SMART
Blast:AAA	2777	2811	2e-13	BLAST
AAA	2927	3093	4.79e-5	SMART
Pfam:MT	3197	3534	1.1e-44	PFAM
Pfam:AAA_9	3554	3778	8.5e-75	PFAM
Pfam:Dynein_heavy	3919	4642	4.3e-163	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000107660

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000166185

Predicted Effect

unknown
Transcript: ENSMUST00000167395
AA Change: T238N

SMART Domains

Protein: ENSMUSP00000126117
Gene: ENSMUSG00000018707
AA Change: T238N

Domain	Start	End	E-Value	Type
Pfam:MT	1	178	5.3e-18	PFAM
Pfam:AAA_9	154	252	3.6e-24	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000170024

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000171535

Meta Mutation Damage Score

0.6467

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 96.9%
20x: 94.1%

Validation Efficiency

98% (81/83)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Dyneins are a group of microtubule-activated ATPases that function as molecular motors. They are divided into two subgroups of axonemal and cytoplasmic dyneins. The cytoplasmic dyneins function in intracellular motility, including retrograde axonal transport, protein sorting, organelle movement, and spindle dynamics. Molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains.This gene encodes a member of the cytoplasmic dynein heavy chain family. [provided by RefSeq, Oct 2008]
PHENOTYPE: Mice homozygous for either the Cra1 or Loa ENU mutation exhibit neonatal lethality with reduced anterior horn cell number, abnormal motor neuron innervation, neuronal inclusions, and abnormal axonal transport. Heterozygotes display motor neuron degeneration and muscle spasms. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 73 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcd2	C	A	15: 91,191,311 (GRCm38)	V100L	probably benign	Het
Acad11	G	A	9: 104,086,266 (GRCm38)		probably benign	Het
Actb	C	T	5: 142,905,552 (GRCm38)		probably benign	Het
Ano9	G	A	7: 141,107,204 (GRCm38)	A374V	probably damaging	Het
Baz2b	T	C	2: 59,942,759 (GRCm38)		probably null	Het
Bpifb9b	T	A	2: 154,313,631 (GRCm38)	L350Q	probably damaging	Het
Cd27	T	A	6: 125,234,318 (GRCm38)		probably null	Het
Cd72	A	G	4: 43,449,563 (GRCm38)		probably benign	Het
Cdadc1	A	T	14: 59,564,524 (GRCm38)	S516T	probably benign	Het
Chst5	T	A	8: 111,890,560 (GRCm38)	I143F	possibly damaging	Het
Col20a1	T	C	2: 180,997,363 (GRCm38)	V452A	possibly damaging	Het
Cox11	C	A	11: 90,644,403 (GRCm38)	Q227K	probably benign	Het
Cpa6	A	G	1: 10,595,618 (GRCm38)		probably null	Het
Dnase1l1	C	T	X: 74,277,038 (GRCm38)		probably null	Het
Dpm2	T	C	2: 32,571,191 (GRCm38)		probably benign	Het
Frem1	A	C	4: 82,963,150 (GRCm38)	N1273K	probably damaging	Het
Fry	T	C	5: 150,394,239 (GRCm38)		probably null	Het
Gm10306	G	T	4: 94,556,832 (GRCm38)		probably benign	Het
Gm5565	T	C	5: 146,158,103 (GRCm38)	T278A	probably benign	Het
Gm8180	A	G	14: 43,782,345 (GRCm38)	I40T	probably benign	Het
Iah1	T	C	12: 21,317,425 (GRCm38)	V44A	probably benign	Het
Iqgap3	C	T	3: 88,113,128 (GRCm38)	P360S	probably damaging	Het
Klhl28	T	A	12: 64,957,122 (GRCm38)	I206F	possibly damaging	Het
Krt13	A	G	11: 100,121,506 (GRCm38)		probably benign	Het
Lipo2	T	A	19: 33,749,514 (GRCm38)	D41V	probably benign	Het
Lrig2	C	G	3: 104,491,526 (GRCm38)	V229L	possibly damaging	Het
Lrrc32	C	T	7: 98,498,520 (GRCm38)	T169I	probably damaging	Het
Lrriq1	T	C	10: 103,178,788 (GRCm38)	N1053S	possibly damaging	Het
Mfng	C	T	15: 78,764,388 (GRCm38)	R163H	probably benign	Het
Mgat4c	G	C	10: 102,388,738 (GRCm38)	R271P	probably damaging	Het
Mylk	A	G	16: 34,914,990 (GRCm38)	N780S	possibly damaging	Het
N4bp1	T	C	8: 86,861,048 (GRCm38)	T421A	probably benign	Het
Nat8f1	T	C	6: 85,910,313 (GRCm38)	T222A	probably benign	Het
Nsun2	T	C	13: 69,543,873 (GRCm38)		probably benign	Het
Oas2	T	A	5: 120,738,534 (GRCm38)	D448V	probably damaging	Het
Olfr129	C	A	17: 38,055,576 (GRCm38)	V6F	probably benign	Het
Olfr168	A	T	16: 19,530,633 (GRCm38)	C96S	probably damaging	Het
Olfr992	T	C	2: 85,400,428 (GRCm38)	Y35C	probably damaging	Het
Pgm2l1	T	A	7: 100,227,997 (GRCm38)	L25Q	probably damaging	Het
Pigp	A	T	16: 94,365,450 (GRCm38)	V133D	probably benign	Het
Pnkp	C	T	7: 44,862,403 (GRCm38)	S113L	probably damaging	Het
Pomt2	C	T	12: 87,110,107 (GRCm38)	D752N	possibly damaging	Het
Ppat	T	C	5: 76,926,793 (GRCm38)	K65E	probably damaging	Het
Ptprn2	T	C	12: 117,161,694 (GRCm38)	L616P	probably damaging	Het
Rad54l2	A	G	9: 106,717,892 (GRCm38)	S289P	probably damaging	Het
Rbm39	G	A	2: 156,177,346 (GRCm38)	R31C	possibly damaging	Het
Rhbdf2	C	A	11: 116,601,945 (GRCm38)	V417L	probably benign	Het
Rnf157	T	A	11: 116,355,472 (GRCm38)	E255D	possibly damaging	Het
Rpl6l	A	T	10: 111,126,443 (GRCm38)		noncoding transcript	Het
Sec24c	A	G	14: 20,693,745 (GRCm38)	D1006G	probably damaging	Het
Sh3bp1	G	T	15: 78,908,037 (GRCm38)	A401S	probably benign	Het
Slc17a8	A	T	10: 89,576,505 (GRCm38)	D539E	probably benign	Het
Slc38a9	T	A	13: 112,689,564 (GRCm38)	S136R	probably damaging	Het
Smoc2	A	C	17: 14,369,033 (GRCm38)	T255P	probably benign	Het
Smyd2	T	C	1: 189,896,650 (GRCm38)	D152G	probably damaging	Het
Stab1	A	G	14: 31,140,393 (GRCm38)	V2328A	probably damaging	Het
Taar2	A	G	10: 23,940,693 (GRCm38)	I44V	probably benign	Het
Tbc1d4	T	C	14: 101,444,708 (GRCm38)	K1251E	probably benign	Het
Thada	G	A	17: 84,446,599 (GRCm38)	L315F	probably damaging	Het
Trbv14	T	C	6: 41,135,325 (GRCm38)	S19P	probably benign	Het
Ttc39c	T	C	18: 12,687,116 (GRCm38)		probably benign	Het
Ttc39d	A	G	17: 80,217,098 (GRCm38)	I395M	probably benign	Het
Ttn	T	C	2: 76,718,384 (GRCm38)	E31891G	probably damaging	Het
Ubr3	T	C	2: 69,970,183 (GRCm38)	V950A	probably damaging	Het
Uhrf1bp1	G	T	17: 27,890,136 (GRCm38)	D1110Y	probably benign	Het
Usp9y	T	A	Y: 1,307,920 (GRCm38)	K2305N	probably damaging	Het
Vmn1r158	G	A	7: 22,790,754 (GRCm38)	T10I	possibly damaging	Het
Vmn2r78	T	A	7: 86,954,708 (GRCm38)	I698K	possibly damaging	Het
Vmn2r86	G	T	10: 130,453,591 (GRCm38)	T145K	probably damaging	Het
Vmn2r-ps159	G	T	4: 156,334,397 (GRCm38)		noncoding transcript	Het
Zfp51	T	C	17: 21,464,671 (GRCm38)	V516A	probably benign	Het
Zfp654	A	T	16: 64,785,782 (GRCm38)	S686T	probably benign	Het
Zfp846	T	A	9: 20,590,815 (GRCm38)	C55S	probably benign	Het

Other mutations in Dync1h1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01291:Dync1h1	APN	12	110,649,104 (GRCm38)	missense	probably benign	0.31
IGL01299:Dync1h1	APN	12	110,614,107 (GRCm38)	missense	probably benign	0.04
IGL01321:Dync1h1	APN	12	110,625,607 (GRCm38)	splice site	probably benign
IGL01324:Dync1h1	APN	12	110,626,865 (GRCm38)	missense	probably damaging	0.99
IGL01327:Dync1h1	APN	12	110,616,692 (GRCm38)	splice site	probably benign
IGL01371:Dync1h1	APN	12	110,638,851 (GRCm38)	missense	probably benign	0.05
IGL01598:Dync1h1	APN	12	110,658,128 (GRCm38)	missense	probably damaging	0.99
IGL01782:Dync1h1	APN	12	110,614,940 (GRCm38)	missense	probably damaging	1.00
IGL01791:Dync1h1	APN	12	110,658,930 (GRCm38)	missense	probably damaging	0.99
IGL01797:Dync1h1	APN	12	110,652,196 (GRCm38)	critical splice donor site	probably null
IGL02040:Dync1h1	APN	12	110,637,124 (GRCm38)	missense	probably benign	0.21
IGL02096:Dync1h1	APN	12	110,632,820 (GRCm38)	missense	possibly damaging	0.68
IGL02164:Dync1h1	APN	12	110,662,559 (GRCm38)	missense	probably damaging	1.00
IGL02216:Dync1h1	APN	12	110,663,002 (GRCm38)	missense	probably damaging	0.98
IGL02298:Dync1h1	APN	12	110,640,888 (GRCm38)	missense	probably damaging	1.00
IGL02422:Dync1h1	APN	12	110,640,210 (GRCm38)	missense	possibly damaging	0.68
IGL02610:Dync1h1	APN	12	110,659,232 (GRCm38)	nonsense	probably null
IGL02643:Dync1h1	APN	12	110,659,272 (GRCm38)	unclassified	probably benign
IGL03076:Dync1h1	APN	12	110,657,893 (GRCm38)	missense	probably damaging	1.00
IGL03292:Dync1h1	APN	12	110,666,555 (GRCm38)	splice site	probably null
IGL03293:Dync1h1	APN	12	110,628,734 (GRCm38)	missense	probably benign	0.12
IGL03299:Dync1h1	APN	12	110,619,210 (GRCm38)	missense	possibly damaging	0.49
chinashop	UTSW	12	110,658,134 (GRCm38)	missense	probably damaging	1.00
Gesund	UTSW	12	110,616,404 (GRCm38)	missense	probably benign	0.35
gymnast	UTSW	12	110,618,368 (GRCm38)	missense	probably damaging	1.00
Lightfoot	UTSW	12	110,617,920 (GRCm38)	missense	probably damaging	1.00
Lissom	UTSW	12	110,632,820 (GRCm38)	missense	possibly damaging	0.68
Strong	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
waters	UTSW	12	110,629,679 (GRCm38)	missense	probably damaging	1.00
ANU05:Dync1h1	UTSW	12	110,649,104 (GRCm38)	missense	probably benign	0.31
H8562:Dync1h1	UTSW	12	110,616,807 (GRCm38)	missense	probably benign	0.01
R0082:Dync1h1	UTSW	12	110,636,446 (GRCm38)	missense	probably benign
R0110:Dync1h1	UTSW	12	110,639,944 (GRCm38)	missense	probably benign	0.42
R0130:Dync1h1	UTSW	12	110,618,674 (GRCm38)	missense	probably benign	0.16
R0233:Dync1h1	UTSW	12	110,640,980 (GRCm38)	missense	probably benign	0.45
R0233:Dync1h1	UTSW	12	110,640,980 (GRCm38)	missense	probably benign	0.45
R0242:Dync1h1	UTSW	12	110,649,851 (GRCm38)	missense	possibly damaging	0.67
R0242:Dync1h1	UTSW	12	110,649,851 (GRCm38)	missense	possibly damaging	0.67
R0408:Dync1h1	UTSW	12	110,631,692 (GRCm38)	missense	probably benign
R0450:Dync1h1	UTSW	12	110,639,944 (GRCm38)	missense	probably benign	0.42
R0611:Dync1h1	UTSW	12	110,632,788 (GRCm38)	missense	probably damaging	0.97
R0612:Dync1h1	UTSW	12	110,616,496 (GRCm38)	missense	probably damaging	1.00
R0624:Dync1h1	UTSW	12	110,651,747 (GRCm38)	unclassified	probably benign
R0685:Dync1h1	UTSW	12	110,657,192 (GRCm38)	missense	probably damaging	1.00
R0747:Dync1h1	UTSW	12	110,629,284 (GRCm38)	missense	probably damaging	0.99
R0747:Dync1h1	UTSW	12	110,612,411 (GRCm38)	missense	probably benign
R0843:Dync1h1	UTSW	12	110,665,213 (GRCm38)	missense	possibly damaging	0.81
R0970:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1161:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1211:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1214:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1215:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1227:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1230:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1232:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1237:Dync1h1	UTSW	12	110,665,959 (GRCm38)	missense	probably benign	0.00
R1274:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1275:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1289:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1290:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1331:Dync1h1	UTSW	12	110,649,264 (GRCm38)	missense	probably damaging	0.98
R1340:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1383:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1394:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1396:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1397:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1413:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1432:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1500:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1661:Dync1h1	UTSW	12	110,656,357 (GRCm38)	missense	probably damaging	1.00
R1678:Dync1h1	UTSW	12	110,665,662 (GRCm38)	critical splice acceptor site	probably null
R1698:Dync1h1	UTSW	12	110,626,992 (GRCm38)	missense	possibly damaging	0.88
R1767:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1776:Dync1h1	UTSW	12	110,632,928 (GRCm38)	splice site	probably benign
R1812:Dync1h1	UTSW	12	110,662,900 (GRCm38)	missense	possibly damaging	0.46
R1831:Dync1h1	UTSW	12	110,614,059 (GRCm38)	missense	probably damaging	1.00
R1832:Dync1h1	UTSW	12	110,614,059 (GRCm38)	missense	probably damaging	1.00
R1856:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1857:Dync1h1	UTSW	12	110,662,625 (GRCm38)	missense	probably damaging	0.96
R1879:Dync1h1	UTSW	12	110,624,636 (GRCm38)	missense	probably benign	0.04
R1892:Dync1h1	UTSW	12	110,646,304 (GRCm38)	missense	probably damaging	1.00
R1909:Dync1h1	UTSW	12	110,662,629 (GRCm38)	missense	probably damaging	1.00
R1962:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1974:Dync1h1	UTSW	12	110,625,732 (GRCm38)	missense	possibly damaging	0.80
R1999:Dync1h1	UTSW	12	110,666,423 (GRCm38)	critical splice donor site	probably null
R2073:Dync1h1	UTSW	12	110,614,592 (GRCm38)	missense	probably damaging	1.00
R2091:Dync1h1	UTSW	12	110,649,588 (GRCm38)	missense	probably benign	0.07
R2113:Dync1h1	UTSW	12	110,629,986 (GRCm38)	missense	probably damaging	1.00
R2128:Dync1h1	UTSW	12	110,640,882 (GRCm38)	missense	probably damaging	1.00
R2134:Dync1h1	UTSW	12	110,656,631 (GRCm38)	missense	possibly damaging	0.68
R2496:Dync1h1	UTSW	12	110,641,220 (GRCm38)	missense	possibly damaging	0.65
R2680:Dync1h1	UTSW	12	110,643,247 (GRCm38)	missense	probably damaging	1.00
R2890:Dync1h1	UTSW	12	110,616,891 (GRCm38)	missense	probably damaging	1.00
R2964:Dync1h1	UTSW	12	110,641,026 (GRCm38)	critical splice donor site	probably null
R3705:Dync1h1	UTSW	12	110,640,586 (GRCm38)	missense	possibly damaging	0.80
R3708:Dync1h1	UTSW	12	110,643,129 (GRCm38)	missense	probably damaging	0.96
R3735:Dync1h1	UTSW	12	110,631,675 (GRCm38)	missense	probably benign
R3736:Dync1h1	UTSW	12	110,631,675 (GRCm38)	missense	probably benign
R3882:Dync1h1	UTSW	12	110,629,058 (GRCm38)	missense	probably benign	0.41
R3971:Dync1h1	UTSW	12	110,665,965 (GRCm38)	missense	probably benign	0.00
R4017:Dync1h1	UTSW	12	110,643,190 (GRCm38)	missense	probably damaging	1.00
R4032:Dync1h1	UTSW	12	110,618,049 (GRCm38)	nonsense	probably null
R4355:Dync1h1	UTSW	12	110,632,899 (GRCm38)	missense	possibly damaging	0.55
R4514:Dync1h1	UTSW	12	110,657,139 (GRCm38)	missense	possibly damaging	0.76
R4586:Dync1h1	UTSW	12	110,649,483 (GRCm38)	missense	probably benign	0.30
R4619:Dync1h1	UTSW	12	110,638,844 (GRCm38)	missense	probably benign	0.09
R4659:Dync1h1	UTSW	12	110,628,767 (GRCm38)	missense	possibly damaging	0.50
R4676:Dync1h1	UTSW	12	110,662,541 (GRCm38)	missense	probably damaging	0.99
R4688:Dync1h1	UTSW	12	110,655,528 (GRCm38)	missense	probably damaging	0.99
R4732:Dync1h1	UTSW	12	110,649,507 (GRCm38)	nonsense	probably null
R4733:Dync1h1	UTSW	12	110,649,507 (GRCm38)	nonsense	probably null
R4780:Dync1h1	UTSW	12	110,661,196 (GRCm38)	missense	probably damaging	1.00
R4846:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4861:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4861:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4865:Dync1h1	UTSW	12	110,639,801 (GRCm38)	missense	possibly damaging	0.84
R4873:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4874:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4875:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4927:Dync1h1	UTSW	12	110,662,855 (GRCm38)	missense	possibly damaging	0.82
R4949:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4954:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4956:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4957:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4958:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4984:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4985:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4988:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R5029:Dync1h1	UTSW	12	110,618,010 (GRCm38)	missense	possibly damaging	0.46
R5032:Dync1h1	UTSW	12	110,626,892 (GRCm38)	nonsense	probably null
R5036:Dync1h1	UTSW	12	110,630,535 (GRCm38)	missense	probably damaging	1.00
R5037:Dync1h1	UTSW	12	110,640,907 (GRCm38)	missense	probably benign	0.09
R5105:Dync1h1	UTSW	12	110,617,932 (GRCm38)	missense	probably damaging	0.99
R5122:Dync1h1	UTSW	12	110,629,680 (GRCm38)	missense	probably damaging	1.00
R5156:Dync1h1	UTSW	12	110,628,830 (GRCm38)	missense	probably benign	0.00
R5290:Dync1h1	UTSW	12	110,615,068 (GRCm38)	missense	probably benign	0.03
R5453:Dync1h1	UTSW	12	110,632,665 (GRCm38)	missense	probably benign	0.12
R5540:Dync1h1	UTSW	12	110,660,950 (GRCm38)	missense	probably benign	0.00
R5613:Dync1h1	UTSW	12	110,632,820 (GRCm38)	missense	possibly damaging	0.68
R5626:Dync1h1	UTSW	12	110,641,141 (GRCm38)	missense	probably benign	0.01
R5652:Dync1h1	UTSW	12	110,665,988 (GRCm38)	missense	possibly damaging	0.70
R5655:Dync1h1	UTSW	12	110,629,062 (GRCm38)	missense	probably benign	0.03
R5686:Dync1h1	UTSW	12	110,616,404 (GRCm38)	missense	probably benign	0.35
R5772:Dync1h1	UTSW	12	110,646,273 (GRCm38)	nonsense	probably null
R5806:Dync1h1	UTSW	12	110,651,653 (GRCm38)	missense	probably damaging	1.00
R5891:Dync1h1	UTSW	12	110,614,220 (GRCm38)	critical splice donor site	probably null
R5921:Dync1h1	UTSW	12	110,618,368 (GRCm38)	missense	probably damaging	1.00
R5965:Dync1h1	UTSW	12	110,632,778 (GRCm38)	missense	probably benign
R6113:Dync1h1	UTSW	12	110,620,414 (GRCm38)	missense	probably benign
R6119:Dync1h1	UTSW	12	110,628,006 (GRCm38)	missense	possibly damaging	0.82
R6154:Dync1h1	UTSW	12	110,617,993 (GRCm38)	missense	probably damaging	1.00
R6339:Dync1h1	UTSW	12	110,646,205 (GRCm38)	missense	probably damaging	0.97
R6522:Dync1h1	UTSW	12	110,616,737 (GRCm38)	missense	probably damaging	0.99
R6531:Dync1h1	UTSW	12	110,617,920 (GRCm38)	missense	probably damaging	1.00
R6554:Dync1h1	UTSW	12	110,649,848 (GRCm38)	missense	probably benign	0.06
R6672:Dync1h1	UTSW	12	110,658,134 (GRCm38)	missense	probably damaging	1.00
R6746:Dync1h1	UTSW	12	110,651,653 (GRCm38)	missense	probably damaging	1.00
R6785:Dync1h1	UTSW	12	110,629,679 (GRCm38)	missense	probably damaging	1.00
R6857:Dync1h1	UTSW	12	110,658,547 (GRCm38)	missense	possibly damaging	0.94
R6863:Dync1h1	UTSW	12	110,652,180 (GRCm38)	missense	probably benign	0.07
R6881:Dync1h1	UTSW	12	110,624,561 (GRCm38)	missense	probably damaging	1.00
R6892:Dync1h1	UTSW	12	110,638,901 (GRCm38)	missense	probably benign	0.00
R7015:Dync1h1	UTSW	12	110,666,087 (GRCm38)	nonsense	probably null
R7096:Dync1h1	UTSW	12	110,657,078 (GRCm38)	missense	probably damaging	0.99
R7173:Dync1h1	UTSW	12	110,601,739 (GRCm38)	missense	probably benign
R7224:Dync1h1	UTSW	12	110,617,762 (GRCm38)	missense	possibly damaging	0.93
R7295:Dync1h1	UTSW	12	110,664,749 (GRCm38)	critical splice donor site	probably null
R7308:Dync1h1	UTSW	12	110,665,162 (GRCm38)	missense	possibly damaging	0.91
R7346:Dync1h1	UTSW	12	110,635,642 (GRCm38)	missense	probably damaging	1.00
R7359:Dync1h1	UTSW	12	110,624,602 (GRCm38)	missense	probably benign	0.00
R7405:Dync1h1	UTSW	12	110,634,220 (GRCm38)	missense	probably damaging	1.00
R7439:Dync1h1	UTSW	12	110,636,453 (GRCm38)	missense	probably damaging	1.00
R7441:Dync1h1	UTSW	12	110,636,453 (GRCm38)	missense	probably damaging	1.00
R7472:Dync1h1	UTSW	12	110,665,675 (GRCm38)	missense	probably damaging	0.99
R7532:Dync1h1	UTSW	12	110,651,577 (GRCm38)	missense	probably benign	0.00
R7543:Dync1h1	UTSW	12	110,614,107 (GRCm38)	missense	probably benign	0.04
R7555:Dync1h1	UTSW	12	110,630,625 (GRCm38)	missense	probably benign	0.03
R7632:Dync1h1	UTSW	12	110,660,893 (GRCm38)	missense	probably benign	0.10
R7701:Dync1h1	UTSW	12	110,618,646 (GRCm38)	missense	probably damaging	1.00
R7704:Dync1h1	UTSW	12	110,665,766 (GRCm38)	missense	probably damaging	1.00
R7808:Dync1h1	UTSW	12	110,655,459 (GRCm38)	missense	possibly damaging	0.53
R7891:Dync1h1	UTSW	12	110,643,156 (GRCm38)	missense	probably benign	0.02
R7895:Dync1h1	UTSW	12	110,616,457 (GRCm38)	missense	probably damaging	1.00
R7913:Dync1h1	UTSW	12	110,628,734 (GRCm38)	missense	probably benign	0.12
R8164:Dync1h1	UTSW	12	110,616,360 (GRCm38)	missense	possibly damaging	0.91
R8257:Dync1h1	UTSW	12	110,636,474 (GRCm38)	missense	probably damaging	1.00
R8346:Dync1h1	UTSW	12	110,665,792 (GRCm38)	missense	probably benign	0.21
R8432:Dync1h1	UTSW	12	110,618,142 (GRCm38)	missense	probably benign	0.00
R8510:Dync1h1	UTSW	12	110,616,743 (GRCm38)	missense	possibly damaging	0.94
R8731:Dync1h1	UTSW	12	110,640,584 (GRCm38)	missense	possibly damaging	0.93
R8739:Dync1h1	UTSW	12	110,614,580 (GRCm38)	missense	probably damaging	1.00
R8756:Dync1h1	UTSW	12	110,616,827 (GRCm38)	missense	probably benign	0.06
R8855:Dync1h1	UTSW	12	110,635,899 (GRCm38)	missense	probably damaging	1.00
R8866:Dync1h1	UTSW	12	110,635,899 (GRCm38)	missense	probably damaging	1.00
R8885:Dync1h1	UTSW	12	110,616,738 (GRCm38)	missense	probably damaging	1.00
R8893:Dync1h1	UTSW	12	110,642,043 (GRCm38)	missense	probably damaging	1.00
R8913:Dync1h1	UTSW	12	110,658,168 (GRCm38)	missense	probably benign	0.14
R8937:Dync1h1	UTSW	12	110,618,037 (GRCm38)	missense	probably damaging	1.00
R8958:Dync1h1	UTSW	12	110,620,371 (GRCm38)	missense	probably benign	0.00
R9000:Dync1h1	UTSW	12	110,639,963 (GRCm38)	missense	probably benign
R9036:Dync1h1	UTSW	12	110,639,752 (GRCm38)	missense	probably benign
R9090:Dync1h1	UTSW	12	110,616,876 (GRCm38)	missense	probably benign	0.06
R9108:Dync1h1	UTSW	12	110,656,272 (GRCm38)	intron	probably benign
R9161:Dync1h1	UTSW	12	110,658,589 (GRCm38)	missense	probably benign	0.01
R9185:Dync1h1	UTSW	12	110,635,503 (GRCm38)	missense	probably benign	0.33
R9271:Dync1h1	UTSW	12	110,616,876 (GRCm38)	missense	probably benign	0.06
R9436:Dync1h1	UTSW	12	110,616,541 (GRCm38)	missense	probably damaging	1.00
R9478:Dync1h1	UTSW	12	110,658,703 (GRCm38)	missense	probably benign	0.02
R9547:Dync1h1	UTSW	12	110,658,371 (GRCm38)	missense	probably damaging	1.00
R9561:Dync1h1	UTSW	12	110,649,099 (GRCm38)	missense	probably damaging	0.99
R9586:Dync1h1	UTSW	12	110,616,541 (GRCm38)	missense	probably damaging	1.00
R9609:Dync1h1	UTSW	12	110,640,928 (GRCm38)	missense	probably benign	0.01
Z1088:Dync1h1	UTSW	12	110,629,917 (GRCm38)	frame shift	probably null
Z1177:Dync1h1	UTSW	12	110,658,517 (GRCm38)	nonsense	probably null
Z1177:Dync1h1	UTSW	12	110,641,177 (GRCm38)	frame shift	probably null
Z1177:Dync1h1	UTSW	12	110,637,554 (GRCm38)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TCGGTGACCAAGACATAGACC -3'
(R):5'- ATTTGTGTCACTCTGCCACTGG -3'

Sequencing Primer
(F):5'- AGACATAGACCTGTCACCATCCTTTG -3'
(R):5'- ACTGGGGAGCAGTGTCAC -3'

Posted On

2016-03-17